{"id":7937,"date":"2023-08-17T15:00:00","date_gmt":"2023-08-17T07:00:00","guid":{"rendered":"https:\/\/www.geneclub.net.cn\/index.php\/2023\/08\/17\/9899101-2\/"},"modified":"2026-04-07T16:45:54","modified_gmt":"2026-04-07T08:45:54","slug":"9899101-2","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2023\/08\/17\/9899101-2\/","title":{"rendered":"\u672a\u6765\u5df2\u6765\uff0c\u57fa\u56e0\u4ea7\u4e1a5\u5927\u524d\u6cbf\u70ed\u70b9\u65b0\u52a8\u5411"},"content":{"rendered":"<p><!-- wechat_content_hash: bce31d04035a188e --><\/p>\n<p>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBJ4sibF985CB53GqXpdUXJY1ibXic4tk7cicKMPtgyMRqWYUopq6yOghicWK3LOe3qL8V3Rjia4kHVKgsA.jpeg\" 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Joakim Lundeberg \u8bbe\u8ba1\u4e86\u8868\u9762\u4e0a\u8986\u76d6\u7740\u5e26\u6709\u6761\u5f62\u7801\u5be1\u6838\u82f7\u9178\u7684\u8f7d\u73bb\u7247\uff0c\u5c06\u7ec4\u7ec7\u5207\u7247\u7684\u4f4d\u7f6e\u4fe1\u606f\u4fdd\u7559\uff0c\u7136\u540e\u518d\u5bf9\u7ec4\u7ec7\u4e2d RNA \u6d4b\u5e8f\uff0c\u5b9e\u73b0\u7a7a\u95f4\u4f4d\u7f6e\u7684\u57fa\u56e0\u8868\u8fbe\u8c31\uff0c\u57fa\u4e8e\u6b64\u6280\u672f\u521b\u5efa\u4e86Spatial Transcriptomics\u516c\u53f8\u30022018\u5e74\u5e9510x Genomics \u6536\u8d2d Spatial Transcriptomics \u5e76\u53d1\u5e0310x Genomics Visium\u5e73\u53f0\uff0c\u5e26\u52a8\u4e86\u7a7a\u95f4\u7ec4\u5b66\u4ea7\u4e1a\u53d1\u5c55\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u5b66\u672f\u4e0a\uff0c2020 \u5e74\uff0c\u8036\u9c81\u5927\u5b66\u6a0a\u8363\u56e2\u961f\uff08\u6768\u660e\u7389\u7b49\uff09\u53d1\u5e03 DBiT-seq\uff0810\u03bcm \u5206\u8fa8\u7387\uff09\uff0c\u5b9e\u73b0\u5e73\u5747\u6bcf\u4e2a\u6570\u636e\u70b9 2068 \u4e2a\u57fa\u56e0\u4ee5\u53ca 22 \u79cd\u86cb\u767d\u8d28\u7684\u6d4b\u5e8f\u68c0\u6d4b\u30022021 \u5e74\uff0c\u54c8\u4f5b\u5927\u5b66\u4ee5\u53caBroad \u7814\u7a76\u6240\u5f00\u53d1\u51fa slide-DNA-seq \u6280\u672f\uff08~10\u03bcm\uff09\uff0c\u5bf9\u805a\u82ef\u4e59\u70ef\u73e0\u5b50\u6dfb\u52a0\u7a7a\u95f4\u4f4d\u7f6e\u7684\u6761\u5f62\u7801\uff0c\u6bcf\u4e2a\u73e0\u5b50\u53ef\u4ee5\u68c0\u6d4b\u5230\u7684 DNA \u5e8f\u5217\u8fbe 165-421\u4e2a\u30022022 \u5e74\uff0c\u534e\u76db\u987f\u5927\u5b66\u53e4\u826f\u624d\u56e2\u961f\u53d1\u5e03Pixel-seq \u6280\u672f\uff08~1\u03bcm\uff09\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u4ea7\u4e1a\u754c\u4e0a\uff0c10x Genomics Visium \u5e73\u53f0\u53d1\u8868\u767e\u4f59\u7bc7\u8bba\u6587\uff0c\u5e94\u7528\u4e8e\u4eba\u7c7b\u5fc3\u810f\u53d1\u80b2\u3001\u809d\u810f\u80bf\u7624\u3001\u65b0\u51a0\u75c5\u4eba\u5668\u5b98\u75c5\u53d8\u7684\u5206\u5b50\u673a\u7406\u30022020-2021\u5e74Illumina \u7684 Seq-Scope \u6280\u672f\uff080.5\u03bcm\uff09\u548c\u534e\u5927\u63a8\u51fa\u7684 Stereo-seq\uff08500 nm\uff09\u5728Cell \u53d1\u5e03\uff1b2022 \u5e74\uff0c\u6df1\u5733\u534e\u5927\u751f\u547d\u79d1\u5b66\u7814\u7a76\u9662\u4e0e16\u4e2a\u56fd\u5bb680\u591a\u4f4d\u79d1\u5b66\u5bb6\u6210\u7acb\u65f6\u7a7a\u7ec4\u5b66\u8054\u76df\uff08STOC\uff09\uff0c\u5728\u56fd\u5bb6\u57fa\u56e0\u5e93\u5e73\u53f0\u53d1\u5e03 STOC Database\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u4ee3\u8868\u4f01\u4e1a Akoya \u57282022\u5e74\u8425\u6536 7490 \u4e07\u7f8e\u5143\uff08\u540c\u6bd4+36%\uff09\uff0c\u4e0eACD Bio\u5408\u4f5c\u5c06\u86cb\u767d\u4e0eRNA\u7ed3\u5408\uff0c\u4e0e Agilent \u5408\u4f5c mIHC \u6280\u672f\u7684\u4e34\u5e8a\u8f6c\u5316\uff1bNanoString \u7684 2022 \u5e74\u8425\u65361.17\u4ebf\u7f8e\u5143\uff08\u540c\u6bd4-7%\uff09\uff0c\u4e0e Visionpharm \u5408\u4f5c\u5c06AI\u7b97\u6cd5\u5bf9HE\u5207\u7247\u56fe\u50cf\u6570\u636e\u5206\u6790\uff1b\u6b64\u5916\u534e\u4eba\u79d1\u5b66\u5bb6\u5e84\u5c0f\u5a01\u53c2\u4e0e\u521b\u5efa\u7684 Vizgen\u5b8c\u6210C\u8f6e\u878d\u8d448520\u4e07\u7f8e\u5143\uff1b\u56fd\u5185\u4ee3\u8868\u6027\u673a\u6784\u5305\u62ec\u58a8\u5353\u751f\u7269\u3001\u4f2f\u8c6a\u751f\u7269\u3001\u4e07\u4e58\u57fa\u56e0\u3001\u767e\u8fc8\u5ba2\u7b49\u3002<\/div>\n<div>\u00a0<\/div>\n<p>\u2756\u524d\u6cbf\u70ed\u70b9\u4e8c\uff1a\u86cb\u767d\u8d28\u7ec4<\/p>\n<div>\u86cb\u767d\u8d28\u7ec4\u4ee5\u9ad8\u901a\u91cf\u4e3a\u7279\u70b9\uff0c\u57fa\u4e8e\u5fae\u9635\u5217\u3001\u8d28\u8c31\u7b49\u6280\u672f\u7814\u7a76\u3002\u6b64\u57fa\u56e0\u84dd\u76ae\u4e66\u8ba8\u8bba\u7684\u86cb\u767d\u8d28\u7ec4\u5b66\uff0c\u4e00\u662f\u5df2\u5b9e\u73b0\u7528 NGS \u6280\u672f\u6765\u8868\u5f81\u86cb\u767d\u8d28\u7ec4\uff0c\u4e8c\u662f\u57fa\u56e0\u7ec4\u4e0e\u86cb\u767d\u8d28\u7ec4\u5fc5\u7136\u878d\u5408\u3002\u76ee\u524d\uff0c\u86cb\u767d\u8d28\u7ec4\u5b66\u504f\u79d1\u7814\u670d\u52a1\uff0c\u57fa\u56e0\u6167\u9884\u6d4b\uff0c2023\u5e74\u86cb\u767d\u8d28\u7ec4\u5b66\u5e02\u573a\u89c4\u6a21\u7ea6\u4e3a 150 \u4ebf\u7f8e\u5143\uff0c\u590d\u5408\u589e\u957f\u7387\u8d85\u8fc7 40%\u3002<\/div>\n<div>\u201c\u86cb\u767d\u8d28\u7ec4\u201d\u662f\u7531\u6fb3\u5927\u5229\u4e9aMarc Wilkins\u4e8e1994\u5e74\u5728\u610f\u5927\u5229\u7684\u4e00\u4e2a\u7814\u8ba8\u4f1a\u4e0a\u63d0\u51fa\u7684\u3002\u4e0e\u57fa\u56e0\u7ec4\u4e0d\u540c\u7684\u662f\uff0c\u86cb\u767d\u8d28\u7ec4\u968f\u7740\u73af\u5883\u3001\u65f6\u95f4\u8f83\u4e3a\u654f\u611f\u5730\u53d8\u5316\uff0c\u66f4\u590d\u6742\uff0c\u4f46\u66f4\u63a5\u8fd1\u8868\u578b\u7aef\u3002<\/div>\n<div>\u00a0<\/div>\n<div>Olink \u516c\u53f8\u662f\u57fa\u56e0\u7ec4\u4e0e\u86cb\u767d\u8d28\u7ec4\u5b66\u878d\u5408\u7684\u4f7c\u4f7c\u8005\u3002Olink \u57fa\u4e8e\u7279\u6709\u7684\u8d85\u591a\u91cd\u514d\u75ab\u5206\u6790\u6280\u672fPEA\uff0c\u901a\u8fc7\u5e26\u6709\u72ec\u7279\u5be1\u6838\u82f7\u9178\u6807\u7b7e\u7684\u4e00\u5bf9\u6297\u4f53\u4e0e\u6eb6\u6db2\u4e2d\u7684\u76ee\u6807\u86cb\u767d\u7ed3\u5408\u6765\u5b9e\u73b0\u57fa\u4e8e\u4eb2\u548c\u529b\u7684\u86cb\u767d\u8d28\u7ec4\u6d4b\u91cf\uff0cPEAP\u53ef\u57fa\u4e8eqPCR\uff08\u4f4e\u901a\u91cf\uff09\u6216 NGS\uff08\u9ad8\u901a\u91cf\uff09\u8bfb\u53d6\u30022021 \u5e74\u5251\u6865\u5927\u5b66\u56e2\u961f\u57fa\u4e8eOlink PEA \u6280\u672f\u521b\u5efa\u4e86\u57fa\u4e8e 1859 \u4e2a\u8fde\u63a5\u7684\u201c\u57fa\u56e0-\u86cb\u767d\u8d28-\u75be\u75c5\u201d\u56fe\u8c31\u3002<\/div>\n<div>\u00a0<\/div>\n<div>Somalogic \u516c\u53f8\u73b0\u670921\u4e2aLDT\u68c0\u6d4b\u4ea7\u54c1\uff0c\u8986\u76d6\u514d\u75ab\u3001\u80bf\u7624\u3001\u795e\u7ecf\u7b49\u5e38\u89c1\u75be\u75c5\u9886\u57df\uff0c\u63d0\u4f9b\u4e34\u5e8a\u524d\u670d\u52a1\u3002Quanterix \u57fa\u4e8e\u8367\u5149\u514d\u75ab\u4e13\u5229Simoa Bead\u53d1\u5e03HD-X\u7cfb\u7edf\uff0c\u5728\u65b0\u51a0\u671f\u95f4\u83b7\u5f97FDA\u7684EUA\u6388\u6743\u8fdb\u5165\u5e02\u573a\uff0c\u57fa\u4e8e\u6570\u5b57\u5316\u7eb3\u7c73\u6d41\u4f53\u6297\u4f53\u6c89\u79ef\u6280\u672f\u53d1\u5e03SR-X\u7cfb\u7edf\uff0c\u636e\u5b98\u65b9\u6d88\u606f\u7075\u654f\u5ea6\u6bd4\u4f20\u7edf\u514d\u75ab\u5206\u6790\u9ad8\u51fa1000\u500d\uff0c\u53ef\u540c\u65f6\u68c0\u6d4b\u6700\u591a10\u79cd\u6807\u5fd7\u7269\u4e14\u517c\u5bb9100\u9879\u68c0\u6d4b\u5206\u6790\u3002\u6b64\u5916\u53ef\u4ee5\u5173\u6ce8\u63a8\u51fa\u57fa\u4e8e\u8367\u5149\u6210\u50cf\u7684\u7a7a\u95f4\u86cb\u767d\u8d28\u7ec4\u5b66\u6280\u672f\u7684Akoya\u516c\u53f8\uff08CODEX\u3001Phenoptics \u5e73\u53f0\uff09\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u86cb\u767d\u8d28\u7ec4\u5b66\u7684\u5546\u4e1a\u5316\u8fdb\u7a0b\u8f83\u5feb\uff0cOlink 2022 \u5e74\u8425\u6536 1.398 \u4ebf\u5143\uff08\u540c\u6bd4+47%\uff09\uff0c\u8bd5\u5242\u76d2\u5360\u6bd4 40%\uff1bSomalogic 2022 \u5e74\u8425\u65369766\u4e07\u7f8e\u5143\uff08\u540c\u6bd4+20%\uff09\uff1b2022\u5e741\u6708 Illumina \u5ba3\u5e03\u4e0e SomaLogic 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class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_png\/RmFicvQBAkgB5W5ICbmuwpHobBBEsfUyPu6tLpEOXgwMH57Jia2CTBYacSzCmZa6zSlaAr7rEjNYIJwNiaSY8egXQ\/640?wx_fmt=png&amp;wxfrom=5&amp;wx_lazy=1&amp;wx_co=1\" alt=\"640?wx_fmt=png&amp;wxfrom=5&amp;wx_lazy=1&amp;wx_co=1\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe\uff1a\u57fa\u56e0\u6cbb\u7597\u4ee3\u8868\u6027\u4ea7\u54c1\u53ca\u4f01\u4e1a\u8fdb\u5c55\uff08\u6765\u6e90\/\u57fa\u56e0\u6167\uff09<\/div>\n<div>\u57fa\u56e0\u7597\u6cd5\u8fd1\u5e74\u8f83\u4e3a\u91cd\u78c5\u7684\u4ea7\u54c1\uff0c\u662f2022\u5e74FDA\u6279\u51c6\u4e86bluebird\u516c\u53f8\u7684Zynteglo\u57fa\u56e0\u7597\u6cd5\uff0c\u7528\u4e8e\u6cbb\u7597\u03b2-\u5730\u4e2d\u6d77\u8d2b\u8840\u60a3\u8005\uff08\u7b80\u79f0\u201c\u5730\u8d2b\u201d\uff09\uff1b\u5730\u8d2b\u4e5f\u662f\u6211\u56fd\u57fa\u56e0\u6cbb\u7597\u4f01\u4e1a\u7684\u7684\u4e3b\u8981\u4ea7\u54c1\u7ba1\u7ebf\u4e4b\u4e00\uff0c\u5305\u62ec\u535a\u96c5\u8f91\u56e0\u3001\u745e\u98ce\u751f\u7269\u3001\u79be\u6c90\u57fa\u56e0\u7b49\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u7531\u4e8e80%\u4ee5\u4e0a\u7684\u7f55\u89c1\u75c5\u662f\u7531\u57fa\u56e0\u7a81\u53d8\u5f15\u8d77\u7684\uff0c\u7f55\u89c1\u75c5\u662f\u57fa\u56e0\u7597\u6cd5\u4e3b\u8981\u7684\u5e94\u7528\u573a\u666f\u4e5f\u5f97\u5230\u201c\u5b64\u513f\u836f\u201d\u7684\u653f\u7b56\u9f13\u52b1\u3002\u5168\u7403\u524d20\u5927\u836f\u4f01\u5747\u5e03\u5c40\u7f55\u89c1\u75c5\u57fa\u56e0\u7597\u6cd5\uff0c\u4ec52020\u5e74\u6295\u5165\u8fd1300\u4ebf\u7f8e\u5143\uff1b2023\u5e745\u6708\uff0cFDA\u6279\u51c6\u9996\u4e2a\u5916\u7528\u57fa\u56e0\u6cbb\u7597\u4ea7\u54c1\u2014\u2014Krystal 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C+\u00a0\u8f6e\u878d\u8d44\uff0c\u9886\u6295\u7684\u8d44\u672c\u4e2d\u5305\u62ec\u4e09\u5bb6\u56fd\u6709\u8d44\u672c\u30022023\u5e748\u67087\u65e5\uff0c\u8f89\u5927\u57fa\u56e0\u5ba3\u5e03\u5176\u81ea\u4e3b\u7814\u53d1\u7684\u65b0\u578b\u773c\u79d1\u57fa\u56e0\u6cbb\u7597\u836f\u7269HG004\u83b7\u5f97\u4e86\u7f8e\u56fdFDA\u6388\u4e88\u7684\u7f55\u89c1\u513f\u79d1\u75be\u75c5\u8ba4\u5b9a\u2014\u2014\u6cbb\u7597\u7531RPE65\u7a81\u53d8\u5f15\u8d77\u7684\u9057\u4f20\u6027\u89c6\u7f51\u819c\u75be\u75c5\u3002<\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBe49kI9lABSLVicMV9iaAPkZKbZ4bBRVwP7c1icV9qm9gHfwTSNU3OeRZMibClQLlKrQ5Umq53UC1CqQ.png\" alt=\"RmFicvQBAkgBe49kI9lABSLVicMV9iaAPkZKbZ4bBRVwP7c1icV9qm9gHfwTSNU3OeRZMibClQLlKrQ5Umq53UC1CqQ\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe\uff1a2017-2024\u5e74\u83b7\u6279\u53ca\u53ef\u80fd\u83b7\u6279\u7684\u7ec6\u80de\u6cbb\u7597\u53ca\u57fa\u56e0\u6cbb\u7597\u4ea7\u54c1<\/div>\n<div style=\"text-align: center;\">\uff08\u6765\u6e90\/\u9ea6\u80af\u9521\u5b98\u7f51\uff09<\/div>\n<div>2023-2024\u5e74\u662f\u7ec6\u80de\u53ca\u57fa\u56e0\u6cbb\u7597\u7684\u5173\u952e\u9636\u6bb5\u3002\u4eceIII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4ea7\u54c1\u7ba1\u7ebf\u6765\u770b\uff0c\u5728\u4e0d\u4e45\u7684\u5c06\u6765\uff0c\u83b7\u6279\u6570\u91cf\u53ef\u80fd\u4f1a\u5927\u5e45\u4e0a\u5347\u3002\u4ec5\u5728 2024 \u5e74\uff0c\u9884\u8ba1\u5c06\u6709\u591a\u8fbe 21 \u9879\u7ec6\u80de\u7597\u6cd5\u548c 31 \u9879\u57fa\u56e0\u6cbb\u7597\u542f\u52a8\uff08\u5305\u62ec\u8d85\u8fc7 29 \u79cdAAV\u7597\u6cd5\uff09\u3002<\/div>\n<div>\u9ea6\u80af\u9521\u9884\u8ba1\uff0c\u5728\u80bf\u7624\u5b66\u9886\u57df\uff0c\u7ec6\u80de\u7597\u6cd5\u6709\u671b\u57282030\u5e74\u6210\u4e3a\u4ec5\u6b21\u4e8e\u6297\u4f53\u548c\u5c0f\u5206\u5b50\u7684\u7b2c\u4e09\u5927\u7ec6\u5206\u5e02\u573a\uff0c2021-2030\u5e74\u7684\u9500\u552e\u989d\u590d\u5408\u5e74\u589e\u957f\u7387\u4e3a35%\u3002<\/div>\n<p>\u7ec6\u80de\u548c\u57fa\u56e0\u6cbb\u7597\u7684\u6700\u65b0\u76d1\u7ba1\u653f\u7b56\u3001\u6838\u5fc3\u6280\u672f\u3001\u4ee3\u8868\u4f01\u4e1a\u3001\u4ea7\u4e1a\u56fe\u8c31\u662f\u4ec0\u4e48\uff1f\u66f4\u591a\u5185\u5bb9\uff0c\u656c\u8bf7\u5173\u6ce8\u57fa\u56e0\u6167\u8fd1\u671f\u542f\u52a8\u7684\u300a\u7ec6\u80de\u548c\u57fa\u56e0\u6cbb\u7597\u84dd\u76ae\u4e66\u300b\uff0c\u6b22\u8fce\u5b66\u4f1a\u3001\u4f01\u4e1a\u3001\u4e34\u5e8a\u53ca\u79d1\u7814\u673a\u6784\u7b49\u53c2\u4e0e\u5408\u4f5c\u8054\u5408\u53d1\u5e03\u652f\u6301\uff08\u90ae\u7bb1\uff1ainfo@genonet.cn\uff1b\u7535\u8bdd\uff1a400-088-0992\uff09\uff0c\u63a8\u52a8\u751f\u547d\u79d1\u6280\u666e\u60e0\u548c\u4ea7\u4e1a\u878d\u5408\u53d1\u5c55\u3002<\/p>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCZGKTGoicgpwZT6m9iceKvyicicQjbFFIWw6DFLLkaUpuVOXTI8YBGI0ZNUAqzvKr97T7230ztd8QfXw.png\" alt=\"RmFicvQBAkgCZGKTGoicgpwZT6m9iceKvyicicQjbFFIWw6DFLLkaUpuVOXTI8YBGI0ZNUAqzvKr97T7230ztd8QfXw\"\/><\/figure><\/div>\n\n<\/p>\n<p>\u2756\u00a0\u524d\u6cbf\u70ed\u70b9\u4e94\uff1aDNA \u5b58\u50a8<\/p>\n<p>\u7531\u4e8e\u76ee\u524d\u7684\u6570\u636e\u5b58\u50a8\u5a92\u4ecb\u65e0\u6cd5\u5b8c\u5168\u5339\u914d\u5927\u6570\u636e\u751f\u4ea7\u7684\u80fd\u529b\u53ca\u5b58\u50a8\u9700\u6c42\uff0c\u4ee5DNA\u5408\u6210\u548c\u6d4b\u5e8f\u6280\u672f\uff08\u5bf9\u5e94\u4fe1\u606f\u7cfb\u7edf\u7684\u8f93\u5165\u548c\u8f93\u51fa\uff09\u4e3a\u57fa\u7840\uff0cDNA \u5b58\u50a8\u7531\u6b64\u4ea7\u751f\u3002<\/p>\n<\/p>\n<p>DNA \u5b58\u50a8\u7684\u672c\u8d28\u662f\u5c06DNA\u7684\u56db\u79cd\u78b1\u57fa\uff08A\u3001G\u3001C\u3001T\uff09\u6765\u6620\u5c040\u548c1\uff0c\u901a\u8fc7\u4fe1\u606f\u7f16\u7801\u6765\u8fdb\u884c\u5b58\u50a8\u3002\u8fd9\u662f\u4e00\u4e2a\u6570\u5b57\u4fe1\u53f7\u5230\u5316\u5b66\u4fe1\u53f7\u7684\u8fc7\u7a0b\uff0c\u901a\u5e38\u5305\u62ec\u7f16\u7801\u3001\u5408\u6210\u3001\u4fdd\u5b58\u3001\u83b7\u53d6\u3001\u6d4b\u5e8f\u3001\u89e3\u7801\u7b49\u6b65\u9aa4\u3002<\/p>\n<\/p>\n<p>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_png\/RmFicvQBAkgBjThaXBK5RbIibuoQgaxgZskCXXWWQ2bPv1ibzUuWWRK2zYMphvmoKlYbR7BIdzHW60xP6ARbzvMGA\/640?wx_fmt=png\" alt=\"640?wx_fmt=png\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe\uff1aDNA\u5b58\u50a8\u6d41\u7a0b\uff08\u5236\u56fe\/\u57fa\u56e0\u6167\uff09<\/div>\n<div>DNA \u5b58\u50a8\u6700\u65e9\u53ef\u8ffd\u6eaf\u5230 20 \u4e16\u7eaa 60 \u5e74\u4ee3\uff0c\u63a7\u5236\u8bba\u7684\u521b\u59cb\u4eba\u8bfa\u4f2f\u7279\u7ef4\u7eb3 (Norbert Wiener) \u548c\u79d1\u5b66\u5bb6\u7c73\u54c8\u4f0a\u5c14\u5185\u66fc (Mikhail Neiman) \u51e0\u4e4e\u540c\u65f6\u72ec\u7acb\u63d0\u51fa\u5229\u7528DNA\u53ef\u4ee5\u5b58\u50a8\u6570\u636e\u7684\u6982\u5ff5\u3002<\/div>\n<p>2012\u5e74\uff0c\u54c8\u4f5b\u5927\u5b66\u533b\u5b66\u9662\u7684 George Church \u56e2\u961f\u5f00\u53d1\u4e86\u4e00\u79cd\u5229\u7528\u65b0\u4e00\u4ee3DNA\u5408\u6210\u548c\u6d4b\u5e8f\u6280\u672f\u7684\u65b0DNA\u5b58\u50a8\u7f16\u7801\u65b9\u6848\uff0c\u53ef\u4ee5\u7528\u6765\u7f16\u7801\u4efb\u610f\u6570\u5b57\u4fe1\u606f\u3002\u8fd9\u9879\u7814\u7a76\u5c06\u4e00\u672c\u5305\u542b53426 \u4e2a\u5355\u8bcd\u300111\u4e2aJPG \u56fe\u50cf\u548c1\u4e2aJava\u7a0b\u5e8f\u7684\u4e66\u987a\u5229\u5b58\u8fdb\u4e86DNA\u4e2d\uff0c\u6210\u679c\u53d1\u8868\u5728Science\uff0c\u50ac\u5316\u4e86DNA\u5b58\u50a8\u7684\u4ea7\u4e1a\u5316\uff0c\u57282021-2022\u8fbe\u5230\u7b2c\u4e00\u4e2a\u4ea7\u4e1a\u9ad8\u6f6e\u3002<\/p>\n<p>2021\u5e74\uff0c\u5fae\u8f6f\u8054\u5408 Catalog\u3001Illumina\u3001Quantum\u3001Twist\u548c\u897f\u90e8\u6570\u636e\u7b49\u673a\u6784\u53d1\u8d77\u6210\u7acbDNA\u5b58\u50a8\u8054\u76df\uff0c\u5982\u4eca\u53d1\u5c55\u4e86\u5305\u62ec\u6234\u5c14\u3001IBM\u3001\u8054\u60f3\u3001DNA Script\u3001IMEC\u3001Molecular Assemblies\u3001SIM\u3001Lab2ISC \u5728\u5185\u7684 38 \u5bb6\u6210\u5458\u3002<\/p>\n<div>2022 \u5e74\uff0c\u7531\u6df1\u5733\u534e\u5927\u751f\u547d\u79d1\u5b66\u7814\u7a76\u9662\u3001\u534e\u5927\u667a\u9020\u3001\u6df1\u5733\u56fd\u5bb6\u57fa\u56e0\u5e93\u5171\u540c\u53d1\u8d77\uff0c\u57fa\u56e0\u6167\u7b56\u5212\uff0c\u8054\u5408\u751f\u5de5\u751f\u7269\u3001\u8054\u5ddd\u751f\u7269\u3001\u64ce\u79d1\u751f\u7269\u3001\u817e\u8baf\u533b\u7597\u5065\u5eb7\u7b49\u5171\u540c\u53d1\u5e03\u56fd\u5185\u9996\u90e8\u300aDNA \u5b58\u50a8\u84dd\u76ae\u4e66\u300b\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u6280\u672f\u5c42\u9762\uff0cDNA \u5b58\u50a8\u7684\u6280\u672f\u6838\u5fc3\u662f\u7f16\u7801\u7b97\u6cd5\u3001\u6d4b\u5e8f\u53ca\u5408\u6210\u3002\u56fd\u5185\u7f16\u7801\u7b97\u6cd5\u7684\u4ee3\u8868\u662f\u4e2d\u79d1\u9662\u6df1\u5733\u5148\u8fdb\u6280\u672f\u7814\u7a76\u9662\u6234\u4fca\u5f6a\u56e2\u961f\u5f00\u53d1\u7684\u201c\u609f\u7a7a\u7f16\u7801\u201d\uff0c\u4ee5\u53ca\u5176\u53d1\u5e03\u7684\u5728\u7ebf\u7f16\u89e3\u7801\u8f6f\u4ef6\u201c\u963f\u7ae5\u6728\uff08ATOM1.0\uff09\u201d\uff0c\u7531\u6b64\u5b75\u5316\u51fa\u4e2d\u79d1\u78b3\u5143\u516c\u53f8\uff0c2021 \u5e74\u83b7\u5f97\u6570\u5343\u4e07\u5143\u5929\u4f7f\u8f6e\u878d\u8d44\u3002\u6d4b\u5e8f\u6280\u672f\u7684\u53d1\u5c55\u4e3a DNA \u5b58\u50a8\u7684\u53ef\u884c\u6027\u521b\u9020\u4e86\u57fa\u7840\uff0c\u672a\u6765\u9700\u8981\u89e3\u51b3\u5176\u4e2d\u7684\u78b1\u57fa\u7a81\u53d8\u3001\u5e8f\u5217\u4e22\u5931\u4ee5\u53ca PCR \u6269\u589e\u504f\u597d\u7684\u201c\u4fe1\u606f\u5931\u771f\u201d\u95ee\u9898\u3002<\/div>\n<div>\u00a0<\/div>\n<div>DNA \u5408\u6210\u65b9\u9762\uff0c\u82af\u7247\u5408\u6210\u5b9e\u73b0\u9ad8\u901a\u91cf\u751f\u4ea7\uff0c\u5fae\u8f6f\u548c\u534e\u76db\u987f\u5927\u5b66\u8054\u5408\u7814\u53d1\u5b9e\u73b0\u5408\u6210\u5bc6\u5ea6\u8fbe\u52302500\u4e07\/\u5e73\u65b9\u5398\u7c73\uff0c\u534e\u5927\u843d\u5730\u5e38\u5dde\u642d\u5efa\u5408\u6210\u751f\u7269\u5b66\u5927\u5e73\u53f0\uff0c\u4ea7\u51fa\u5c06\u53ef\u8fbe\u5230\u6bcf\u53f0\u673a\u566810\u4ebf\u78b1\u57fa\/\u5e74\u3002\u9176\u4fc3\u5408\u6210\u662f\u672a\u6765\u91cd\u70b9\u65b9\u5411\u4e4b\u4e00\uff0c\u8fd8\u9700\u8981\u8fdb\u4e00\u6b65\u7814\u53d1\uff0c\u63d0\u9ad8\u901a\u91cf\uff0c\u5e76\u901a\u8fc7\u589e\u52a0\u805a\u5408\u7269\u7684\u957f\u5ea6\u6765\u63d0\u9ad8\u6570\u636e\u5bc6\u5ea6\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u5e94\u7528\u5c42\u9762\uff0cDNA 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\u5408\u6210\u7684\u6210\u672c\uff1b\u53e6\u4e00\u65b9\u9762\u9700\u8981\u5927\u5e45\u63d0\u9ad8\u8bfb\u5199\u901f\u5ea6\uff08\u81f3\u5c11\u662f\u73b0\u5728\u7684100 \u500d\u4ee5\u4e0a\uff09\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u76ee\u524d DNA \u5b58\u50a8\u4f01\u4e1a\u5904\u4e8e\u57fa\u7840\u8bbe\u65bd\u4f18\u5316\u548c\u7cfb\u7edf\u7814\u53d1\u7684\u65e9\u671f\u9636\u6bb5\u3002\u968f\u7740 DNA\u5408\u6210\u65b0\u6280\u672f\u6301\u7eed\u8fdb\u6b65\uff0c\u6d4b\u5e8f\u8d70\u5411 Pb \u7ea7\u89c4\u6a21\uff0c\u5728\u6570\u636e\u5b58\u50a8\u9700\u6c42\u7684\u9a71\u52a8\u4e0b\uff0c\u57fa\u56e0\u6167\u9884\u6d4b\u8fd8\u9700\u7ea6 10 \u5e74\uff0cDNA \u5b58\u50a8\u5c06\u5b9e\u73b0\u771f\u6b63\u7684\u4ea7\u4e1a\u5316\u3002<\/div>\n<div>\u5c55\u671b\u672a\u6765 5~10 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