{"id":7930,"date":"2023-09-11T11:20:00","date_gmt":"2023-09-11T03:20:00","guid":{"rendered":"https:\/\/www.geneclub.net.cn\/index.php\/2023\/09\/11\/545155\/"},"modified":"2026-03-31T16:46:32","modified_gmt":"2026-03-31T08:46:32","slug":"545155","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2023\/09\/11\/545155\/","title":{"rendered":"\u9ed1\u77f3\u5728\u534e\u8bbe\u7acb\u57fa\u91d1\uff0cFDA\u6279\u51c623andMe\u7684BRCA1\/2\u68c0\u6d4b\u5347\u7ea7\u7248 | \u57fa\u56e0\u884c\u4e1a\u7b80\u62a5244\u671f"},"content":{"rendered":"<p><!-- wechat_content_hash: 63788b6faf101738 --><\/p>\n<p>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgATrWjpPIAhJWs5fhBPbW6RQRW37C6g6LvwDmztiaQKOxFSkPkK3NmnZwf3NT3p9t2MKvnBxPxSvLA.png\" alt=\"RmFicvQBAkgATrWjpPIAhJWs5fhBPbW6RQRW37C6g6LvwDmztiaQKOxFSkPkK3NmnZwf3NT3p9t2MKvnBxPxSvLA\"\/><\/figure><\/div>\n\n<p 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Illumina\u8463\u4e8b\u4f1a\u4efb\u547dJacob Thaysen\u535a\u58eb\u4e3a\u65b0\u4efbCEO<\/p>\n<p>2023\u5e749\u67085\u65e5\uff0cDNA\u6d4b\u5e8f\u63d0\u4f9b\u5546Illumina\u5ba3\u5e03\u5176\u8463\u4e8b\u4f1a\u5df2\u4efb\u547dJacob Thaysen\u535a\u58eb\uff0c\u539f\u5b89\u6377\u4f26\u79d1\u6280\u9ad8\u7ea7\u526f\u603b\u88c1\u3001\u751f\u547d\u79d1\u5b66\u4e0e\u5e94\u7528\u5e02\u573a\u96c6\u56e2\u603b\u88c1\uff0c\u4e3a\u516c\u53f8\u9996\u5e2d\u6267\u884c\u5b98\uff0c\u8be5\u4efb\u547d\u5c06\u4e8e2023\u5e749\u670825\u65e5\u751f\u6548\u3002<\/p>\n<div>\u53c2\u8003\u4fe1\u606f&gt;&gt;<\/div>\n<div>https:\/\/mp.weixin.qq.com\/s\/AuXBkNDABMF5FFr9ezAc7Q<\/div>\n<div>\u00a0<\/div>\n<p>\u2756 \u57fa\u56e0\u7f16\u8f91\u516c\u53f8\u8212\u6850\u533b\u7597\u5b8c\u6210A\u8f6e\u878d\u8d44<\/p>\n<p>2023\u5e749\u67085\u65e5\uff0c\u73e0\u6d77\u8212\u6850\u533b\u7597\u79d1\u6280\u6709\u9650\u516c\u53f8\uff08\u8212\u6850\u533b\u7597\uff09\u5ba3\u5e03\u5b8c\u6210A\u8f6e\u878d\u8d44\u3002\u672c\u8f6e\u878d\u8d44\u7531\u9655\u6295\u6210\u957f\u9886\u6295\uff0c\u7ca4\u79d1\u96c6\u56e2\u3001\u51ef\u5f97\u57fa\u91d1\u3001\u534e\u8bfa\u533b\u7597\u57fa\u91d1\u5171\u540c\u53c2\u4e0e\u6295\u8d44\u3002\u672c\u8f6e\u878d\u8d44\u8d44\u91d1\u5c06\u52a9\u529b\u8212\u6850\u533b\u7597\u5feb\u901f\u63a8\u8fdb\u57fa\u56e0\u7f16\u8f91\u8bca\u65ad\u4ea7\u54c1\u5546\u4e1a\u5316\u548c\u521b\u65b0\u836f\u7269IND\u4e2d\u7f8e\u7533\u62a5\uff0c\u4e0d\u65ad\u63d0\u5347\u516c\u53f8\u6280\u672f\u521b\u65b0\u80fd\u529b\u3002<\/p>\n<div>\u53c2\u8003\u4fe1\u606f&gt;&gt;<\/div>\n<div>https:\/\/mp.weixin.qq.com\/s\/CyfA3dr8G7ZPaJCwdxsRzA<\/div>\n<div>\u00a0<\/div>\n<p>\u2756 \u5408\u6210\u751f\u7269\u5b66\u516c\u53f8\u67ef\u6cf0\u4e9a\u751f\u7269\u5b8c\u62102.5\u4ebf\u5143\u4eba\u6c11\u5e01B\u8f6e\u878d\u8d44<\/p>\n<p>\u8fd1\u65e5\uff0c\u5408\u6210\u751f\u7269\u5b66\u516c\u53f8\u4e0a\u6d77\u67ef\u6cf0\u4e9a\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\uff08\u67ef\u6cf0\u4e9a\u751f\u7269\uff09\u5b8c\u62102.5\u4ebf\u5143\u4eba\u6c11\u5e01B\u8f6e\u878d\u8d44\uff0c\u7531\u6052\u65ed\u8d44\u672c\u548c\u65af\u9053\u8d44\u672c\u8054\u5408\u9886\u6295\uff0c\u6cb3\u5357\u6c47\u878d\u3001\u98df\u82af\u8d44\u672c\u8ddf\u6295\uff0c\u5143\u542f\u8d44\u672c\u62c5\u4efb\u72ec\u5bb6\u8d22\u52a1\u987e\u95ee\u3002\u67ef\u6cf0\u4e9a\u751f\u7269\u6210\u7acb\u4e8e2021\u5e749\u6708\uff0c\u8fd12\u5e74\u65f6\u95f4\u5185\u5b8c\u6210\u56db\u8f6e\u878d\u8d44\uff0c\u7d2f\u8ba1\u878d\u8d44\u89c4\u6a21\u8fd15\u4ebf\u5143\u4eba\u6c11\u5e01\u3002<\/p>\n<div>\u53c2\u8003\u4fe1\u606f&gt;&gt;<\/div>\n<div>https:\/\/mp.weixin.qq.com\/s\/KLwlhbWipE7NUm0CaCvWIA<\/div>\n<div>\u00a0<\/div>\n<p>\u8fde\u7eed\u516d\u5e74\u53d1\u5e03\u57fa\u56e0\u884c\u4e1a\u84dd\u76ae\u4e66\u540e<\/p>\n<p>\u57fa\u56e0\u6167\u542f\u52a8\u300a\u7ec6\u80de\u548c\u57fa\u56e0\u6cbb\u7597\u84dd\u76ae\u4e66\u300b<\/p>\n<p>\u6b22\u8fce\u5b66\u4f1a\u3001\u56ed\u533a\u53ca\u4f01\u4e1a\u5408\u4f5c\u8054\u5408\u53d1\u5e03<\/p>\n<p>\u90ae\u7bb1\uff1ainfo@genonet.cn<\/p>\n<p>\u7535\u8bdd\uff1a400-088-0992<\/p>\n<\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCZGKTGoicgpwZT6m9iceKvyicicQjbFFIWw6DFLLkaUpuVOXTI8YBGI0ZNUAqzvKr97T7230ztd8QfXw.png\" alt=\"RmFicvQBAkgCZGKTGoicgpwZT6m9iceKvyicicQjbFFIWw6DFLLkaUpuVOXTI8YBGI0ZNUAqzvKr97T7230ztd8QfXw\"\/><\/figure><\/div>\n\n<div>\u786c\u79d1\u6280<\/div>\n<div>\u2756 \u590d\u65e6\u5927\u5b66\u3001\u4e2d\u56fd\u8ba1\u91cf\u9662\u7b49\u8054\u5408\u7814\u5236\u7684\u591a\u7ec4\u5b66\u6807\u51c6\u7269\u8d28\u201c\u4e2d\u534e\u5bb6\u7cfb1\u53f7\u201d\u6700\u65b0\u6210\u679c\u53d1\u5e03\n<p>2023\u5e749\u67087\u65e5\uff0c\u590d\u65e6\u5927\u5b66\/\u4e0a\u6d77\u56fd\u9645\u4eba\u7c7b\u8868\u578b\u7ec4\u7814\u7a76\u9662\u8054\u5408\u4e2d\u56fd\u8ba1\u91cf\u79d1\u5b66\u7814\u7a76\u9662\uff0c\u56fd\u5bb6\u536b\u5065\u59d4\u4e34\u5e8a\u68c0\u9a8c\u4e2d\u5fc3\u5171\u540c\u7814\u53d1\u7684\u5168\u7403\u9996\u5957\u591a\u7ec4\u5b66\u6807\u51c6\u7269\u8d28\u201c\u4e2d\u534e\u5bb6\u7cfb1\u53f7\u201d\u7684\u6700\u65b0\u7814\u7a76\u6210\u679c\u5728Nature Biotechnology\u671f\u520a\u53d1\u5e03\u3002\u540c\u671f2\u7bc7\u8bba\u6587\u5206\u522b\u805a\u7126\uff1a\u201c\u4f7f\u7528\u57fa\u4e8e\u4e2d\u534e\u5bb6\u7cfb1\u53f7\u6807\u51c6\u7269\u8d28\u7684\u76f8\u5bf9\u5b9a\u91cf\u8fdb\u884c\u591a\u7ec4\u5b66\u6570\u636e\u6574\u5408\u201d\u548c\u201c\u4e2d\u534e\u5bb6\u7cfb1\u53f7 RNA\u6807\u51c6\u7269\u8d28\u4e0e\u57fa\u4e8e\u6bd4\u503c\u7684\u5206\u6790\u65b9\u6cd5\u63d0\u9ad8\u4e86\u8f6c\u5f55\u7ec4\u6570\u636e\u7684\u8d28\u91cf\u201d\u3002\u8fd9\u6807\u5fd7\u7740\u4e2d\u56fd\u79d1\u5b66\u754c\u81ea\u4e3b\u7814\u5236\u3001\u83b7\u6279\u4e3a\u201c\u56fd\u5bb6\u4e00\u7ea7\u6807\u51c6\u7269\u8d28\u201d\u7684\u201c\u4e2d\u534e\u5bb6\u7cfb1\u53f7\uff08Quartet\uff09\u201d\u591a\u7ec4\u5b66\u6807\u51c6\u7269\u8d28\u7684\u7814\u53d1\u548c\u6548\u7528\u5f97\u5230\u4e86\u56fd\u9645\u540c\u884c\u7684\u8ba4\u53ef\uff0c\u5f00\u521b\u4e86\u751f\u7269\u533b\u5b66\u201c\u5ea6\u91cf\u8861\u201d\u65b0\u4f53\u7cfb\u3002<\/p>\n<div>\u53c2\u8003\u4fe1\u606f&gt;&gt;<\/div>\n<div>https:\/\/www.nature.com\/articles\/s41587-023-01934-1<\/div>\n<div>https:\/\/www.nature.com\/articles\/s41587-023-01867-9<\/div>\n<p>\u2756 \u56fd\u5185\u9996\u4e2a\u57fa\u56e0\u7f16\u8f91\u6cbb\u7597\u75c5\u6bd2\u6027\u89d2\u819c\u708e\u4e34\u5e8a\u7ed3\u679c\u516c\u5e03<\/p>\n<p>2023\u5e748\u670831\u65e5\uff0c\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u773c\u8033\u9f3b\u5589\u79d1\u533b\u9662\u6d2a\u4f73\u65ed\u4e3b\u4efb\u533b\u5e08\u4e0e\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u7cfb\u7edf\u751f\u7269\u533b\u5b66\u7814\u7a76\u9662\u8521\u5b87\u4f3d\u7814\u7a76\u5458\u5728MolecularTherapy\u671f\u520a\u53d1\u8868\u7814\u7a76\u8bba\u6587\u3002\u8be5\u7814\u7a76\u5bf93\u540d\u4f34\u6709\u6025\u6027\u89d2\u819c\u7a7f\u5b54\u7684\u5355\u7eaf\u75b1\u75b9\u75c5\u6bd2\u6027\u89d2\u819c\u708e(HSK)\u60a3\u8005\u8fdb\u884c\u4e86HELP\u6cbb\u7597\u8054\u5408\u89d2\u819c\u79fb\u690d\uff0c\u901a\u8fc718\u4e2a\u6708\u7684\u968f\u8bbf\uff0c3\u540d\u60a3\u8005\u5747\u672a\u53d1\u751f\u5355\u7eaf\u75b1\u75b9\u75c5\u6bd21\u578b(HSV-1)\u590d\u53d1\uff0c\u4e14\u6ca1\u6709\u68c0\u6d4b\u5230CRISPR\u8bf1\u5bfc\u7684\u8131\u9776\u6548\u5e94\u3002HELP\u77ac\u65f6\u9776\u5411\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u4f7f\u7528\u7c7b\u75c5\u6bd2\u8f7d\u4f53(VLP)\uff0c\u4ee5mRNA\u5f62\u5f0f\u9012\u9001CRISPR-Cas9\u57fa\u56e0\u7f16\u8f91\u5de5\u5177\uff0cCas9\u9176\u5728\u4f53\u5185\u505c\u7559\u65f6\u95f4\u77ed\uff0c\u53ef\u964d\u4f4e\u8131\u9776\u98ce\u9669\u3001\u51cf\u5c11\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n<div>\u53c2\u8003\u4fe1\u606f&gt;&gt;<\/div>\n<div>https:\/\/doi.org\/10.1016\/j.ymthe.2023.08.021<\/div>\n<div>\u65b0\u4ea7\u54c1<\/div>\n<div>\u2756 \u9ed8\u6c99\u4e1cPD-1\u6291\u5236\u5242\u53ef\u745e\u8fbe\u00ae\u83b7\u6279NMPA\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027MSI-H\/dMMR\u578b\u665a\u671f\u5b9e\u4f53\u7624\u6cbb\u7597\u65b0\u9002\u5e94\u8bc1\n<p>2023\u5e749\u67088\u65e5\uff0c\u9ed8\u6c99\u4e1c\u5ba3\u5e03\u5176PD-1\u6291\u5236\u5242\u5e15\u535a\u5229\u73e0\u5355\u6297\uff08\u5546\u54c1\u540d\uff1a\u53ef\u745e\u8fbe\u00ae\uff09\u5df2\u83b7\u5f97NMPA\u6279\u51c6\u7528\u4e8e\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u5fae\u536b\u661f\u9ad8\u5ea6\u4e0d\u7a33\u5b9a\u578b\uff08MSI-H\uff09\u6216\u9519\u914d\u4fee\u590d\u57fa\u56e0\u7f3a\u9677\u578b\uff08dMMR\uff09\u6210\u4eba\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\uff0c\u5176\u4e2d\u5305\u62ec\u65e2\u5f80\u63a5\u53d7\u8fc7\u6c1f\u5c3f\u5627\u5576\u7c7b\u3001\u5965\u6c99\u5229\u94c2\u548c\u4f0a\u7acb\u66ff\u5eb7\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u7684\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\uff0c\u53ca\u65e2\u5f80\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u4e14\u65e0\u6ee1\u610f\u66ff\u4ee3\u6cbb\u7597\u65b9\u6848\u7684\u5176\u4ed6\u5b9e\u4f53\u7624\u3002\u6b64\u6b21\u65b0\u9002\u5e94\u8bc1\u7684\u83b7\u6279\u662f\u57fa\u4e8e\u5168\u7403II\u671f\u4e34\u5e8a\u8bd5\u9a8cKEYNOTE-158\u548cKEYNOTE-164\u7684\u6570\u636e\u3002<\/p>\n<div>\u53c2\u8003\u4fe1\u606f&gt;&gt;<\/div>\n<div><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MjM5ODI4OTI2NA==&amp;mid=2651972841&amp;idx=1&amp;sn=523a44d323cbf70615e1a9935640d536&amp;scene=21#wechat_redirect\">https:\/\/mp.weixin.qq.com\/s\/D9-tFzxtCN79t69V6v0XIQ<\/a><\/div>\n<p>\u2756 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FDA\u6279\u51c623andMe\u7684BRCA1\/2\u68c0\u6d4b\u8bd5\u5242\u76d2\u5347\u7ea7\u7248\uff0c\u65b0\u589e41\u79cd\u53d8\u5f02<\/p>\n<p>2023\u5e748\u670831\u65e5\uff0c\u57fa\u56e0\u68c0\u6d4b\u516c\u53f823andMe\u5ba3\u5e03\u5176\u83b7\u5f97FDA 510(k) \u6279\u51c6\uff0c\u4ee5\u6269\u5c55\u5176\u73b0\u6709\u7684 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