![\"RmFicvQBAkgBJ4sibF985CB53GqXpdUXJY1ibXic4tk7cicKMPtgyMRqWYUopq6yOghicWK3LOe3qL8V3Rjia4kHVKgsA\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBJ4sibF985CB53GqXpdUXJY1ibXic4tk7cicKMPtgyMRqWYUopq6yOghicWK3LOe3qL8V3Rjia4kHVKgsA.jpeg\")
<\/figure><\/div>\n\n2023-2024\u5e74\uff0c\u6df1\u5733\u3001\u5929\u6d25\u53d1\u5e03\u4e86\u57fa\u56e0\u548c\u7ec6\u80de\u4ea7\u4e1a\u4fc3\u8fdb\u6761\u4f8b\uff0c\u6e56\u5357\u7701\u7684\u76f8\u5173\u6761\u4f8b\u9884\u8ba1\u57282025\u5e74\u53d1\u5e03\u3002\u5317\u4eac\u3001\u4e0a\u6d77\u7b49\u5730\u53d1\u5e03\u57fa\u56e0\u6cbb\u7597\u4ea7\u4e1a\u96c6\u7fa4\u5b9e\u65bd\u65b9\u6848\uff0c\u6cb3\u5317\u3001\u5b89\u5fbd\u3001\u5e38\u5dde\u3001\u829c\u6e56\u7b49\u5730\u53d1\u5e03\u4ee5\u57fa\u56e0\u5408\u6210\u4e3a\u6838\u5fc3\u7684\u5408\u6210\u751f\u7269\/\u751f\u7269\u5236\u9020\u4ea7\u4e1a\u884c\u52a8\u65b9\u6848\u3002<\/p>\n
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1. \u751f\u80b2\u5065\u5eb7<\/p>\n 2023 \u5e74 10 \u6708\uff0c\u6d59\u6c5f\u7701\u9996\u4f8b\u5e94\u7528\u4e09\u4ee3\u6d4b\u5e8f\u6280\u672f\u7684\u5355\u57fa\u56e0\u75c5\u80da\u80ce\u690d\u5165\u524d\u9057\u4f20\u8bca\u65ad\u6280\u672f\u7684\u8bd5\u7ba1\u5a74\u513f \u5b9d\u5b9d\u5728\u90b5\u9038\u592b\u533b\u9662\u4ea7\u79d1\u5065\u5eb7\u51fa\u751f;<\/p>\n \u6211\u56fd\u6700\u5927\u7684\u8f85\u52a9\u751f\u6b96\u4e2d\u5fc3\u4e4b\u4e00\u7684\u4e2d\u4fe1\u6e58\u96c5\u7684PGT\u79fb\u690d\u5468\u671f\u6570\u622a\u81f32023\u5e7410\u6708\u8fbe\u523026868 \u4e2a\uff0c\u4e34\u5e8a\u598a\u5a20\u7387\u7ea663.4%\u30022024 \u5e74\uff0c\u7ee7\u5317\u4eac\u540e\uff0c\u4e0a\u6d77\u3001\u6c5f\u897f\u3001\u5c71\u4e1c\u3001\u5185\u8499\u53e4\u3001\u7518\u8083\u7b49\u5730\u5ba3\u5e03\u90e8\u5206\u8f85\u52a9\u751f\u6b96\u6240\u4ea7\u751f\u7684\u8d39\u7528\u7eb3\u5165\u533b\u4fdd\u652f\u4ed8\u8303\u56f4\u3002<\/p>\n 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\u4e2a\u6708\u7684\u5973\u7ae5\u6700\u521d\u8868\u73b0\u4e3a\u773c\u7403\u9707\u98a4\u548c\u5171\u6d4e\u5931\u8c03\uff0c\u968f\u540e\u53d1\u5c55\u4e3a\u4e0a\u81c2\u5f1b\u7f13\u6027\u9ebb\u75f9\u548c\u9888\u90e8\u808c\u8089\u65e0\u529b\uff0c\u5728\u9996\u6b21\u51fa\u73b0\u75c7\u72b6\u7684 5 \u4e2a\u6708\u5185\uff0c\u901a\u8fc7\u5916\u663e\u5b50\u7ec4\u6d4b\u5e8f\u68c0\u6d4b\u5230 SLC52A2 \u57fa\u56e0\u7684\u4e24\u79cd\u529f\u80fd\u6027\u53d8\u5f02\uff0c\u786e\u8bca\u4e3a BVVL \u7efc\u5408\u5f81\uff0c\u57fa\u4e8e\u57fa\u56e0\u529f\u80fd\u5bf9\u5e94\u7ed9\u4e88\u6838\u9ec4\u7d20(\u53c8\u79f0\u4e3a\u7ef4\u751f\u7d20 B2)\u6cbb\u7597\uff0c\u5728\u6700\u521d\u7684 2-4 \u5468\u5185\uff0c\u4e34\u5e8a\u4e0a\u8fc5\u901f\u5f97\u5230\u79ef\u6781\u53cd\u9988\uff0c\u5728\u63a5\u4e0b\u6765\u7684 8 \u4e2a\u6708\u7684\u4e34\u5e8a\u968f\u8bbf\u4e2d\u8868\u73b0\u7a33\u5b9a\u30022021 \u5e74\uff0c\u4e1c\u839e\u5e02\u513f\u7ae5\u533b\u9662\u51fa\u73b0\u7c7b\u4f3c\u7684\u901a\u8fc7\u7ef4\u751f\u7d20 B2 \u6cbb\u7597 4 \u5c81 \u7537\u7ae5\u57fa\u56e0 SLC52A2 \u53d8\u5f02\u7684\u4e34\u5e8a\u6848\u4f8b\u3002<\/p>\n \u5b64\u513f\u836f\u662f\u7f55\u89c1\u75c5\u6cbb\u7597\u7684\u4e3b\u8981\u8def\u5f84\uff0c2023 \u5e74FDA\u6279\u51c6\u7684 55 \u79cd\u65b0\u836f\u4e2d\u5b64\u513f\u836f \u5360 51%\u3002\u622a\u81f3 2023 \u5e74 3 \u6708 1 \u65e5\uff0c\u6211\u56fd\u5171\u6709 69 \u79cd\u7f55\u89c1\u75c5\u836f\u7269\u7eb3\u5165\u533b\u4fdd\u62a5\u9500\u8303\u56f4\uff0c\u8986\u76d6 29 \u79cd\u7f55\u89c1\u75c5\u3002\u7ec6\u80de\u548c\u57fa\u56e0\u6cbb\u7597\u662f\u5b64\u513f\u836f\u7b49\u751f\u7269\u836f\u7684\u65b0\u5174\u4e14\u91cd\u8981\u7684\u6280\u672f\u3002\u622a\u81f32024\u5e744\u6708\uff0c\u6211\u56fd\u5171\u6279\u51c6\u4e86 7 \u79cd\u7ec6\u80de\u548c\u57fa\u56e0\u6cbb\u7597\u4ea7\u54c1\uff0cFDA \u5171\u6279\u51c6\u4e86 37 \u79cd\u7ec6\u80de\u548c\u57fa\u56e0\u6cbb\u7597\u3002\u9996\u4e2a CRISPR \u57fa\u56e0\u7f16\u8f91\u7597\u6cd5\u5728 2023 \u5e74\u83b7\u5f97 FDA \u6279\u51c6\u4e0a\u5e02\u3002<\/p>\n 3. \u80bf\u7624\u7528\u836f\u53ca\u65e9\u7b5b<\/p>\n \u7f8e\u56fd FDA \u5df2\u6279\u51c6\u8d85\u8fc7 80 \u79cd\u9488\u5bf9\u80bf\u7624\u57fa\u56e0\u7a81\u53d8\u3001\u8986\u76d6 30 \u591a\u79cd\u764c\u75c7\u7c7b\u578b\u7684\u9776\u5411\u6cbb\u7597\u836f\u7269\u548c\u514d\u75ab\u6cbb\u7597\u836f\u7269\uff0c\u4e14\u89c4\u5b9a\u9776\u5411\u836f\u7269\u514d\u75ab\u836f\u7269\u4e0e\u4f34\u968f\u8bca\u65ad\u8bd5\u5242\u540c\u6b65\u4e0a\u5e02\u3002\u6211\u56fd\u5df2\u6279\u51c6\u8d85\u8fc7 18 \u79cd\u4e0e\u80bf\u7624\u8bca\u7597\u76f8\u5173\u7684\u57fa\u4e8e NGS \u7684\u4f53\u5916\u8bca\u65ad\u8bd5\u5242\u3002<\/p>\n 2022 \u5e74 \u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08CSCO\uff09 \u80bf\u7624\u751f\u7269\u6807\u5fd7\u7269\u59d4\u5458\u4f1a\u53d1\u8d77\u7684\u201c\u4e2d\u56fd\u80bf\u7624 NGS \u5927\u578b\u5e94\u7528\u8c03\u7814\u201d\u4e2d\uff0c\u6839\u636e 30 \u4e2a\u7701\u5e02 2053 \u4e2a\u6709\u6548\u6837\u672c\u7684\u8c03\u7814\u53d1\u73b0\uff0c\u9ad8\u901a\u91cf\u57fa\u56e0\u6d4b\u5e8f\uff08NGS\uff09\u68c0\u8d2f\u7a7f\u80bf\u7624\u60a3\u8005\u8bca\u7597\u5168\u7a0b\uff0c\u8fbe\u5230 71.3% \u7684\u6bd4\u4f8b\u3002<\/p>\n 2021 \u5e74\uff0c\u9e4d\u8fdc\u751f\u7269\u4e0e\u626c\u5dde \u5e02\u9097\u6c5f\u533a\u5408\u4f5c\u542f\u52a8\u5168\u533a 20 \u4e07\u540d 40-74 \u5c81\u7684\u6237\u7c4d\u5c45\u6c11\u7684\u7ed3\u76f4\u80a0\u764c\u7b5b\u67e5\u6c11\u751f\u5de5\u7a0b\uff1b2022 \u5e74\uff0c\u4e16\u548c\u57fa\u56e0\u4e0e\u5357\u4eac\u5e02\u6c5f\u5317\u65b0\u533a\u516c\u5171\u536b\u751f\u670d\u52a1\u4e2d\u5fc3\u5408\u4f5c\u542f\u52a8\u7ea6 10 \u4e07\u4f8b\u91d1\u9675\u961f\u5217\uff1b2024 \u5e74\uff0c\u534e\u5927\u57fa\u56e0\u4e0e\u54c8\u5c14\u6ee8\u5e02\u5408\u4f5c 80 \u4e07\u9002\u68c0\u4eba\u7fa4\u6d88\u5316\u7cfb\u7edf\u80bf\u7624\u53ca\u201c\u56db\u9ad8\u201d\u68c0\u6d4b\u7b49\u3002<\/p>\n 2022 \u5e74\uff0c\u534e\u897f\u533b\u9662\u8054\u5408\u53d1\u8d77\u7684\u80ba\u764c\u9884\u540e\u524d\u77bb\u961f\u5217\u7814\u7a76 LUNGCA \u663e\u793a\uff0c\u957f\u671f\u76d1\u6d4b\u5fae\u5c0f\u6b8b\u7559\u75c5\u7076\uff08MRD)\u76f8\u8f83\u4e8e\u4f20\u7edf\u5f71\u50cf\u5b66\u63d0\u524d 273 \u5929\u53d1\u73b0\u590d\u53d1\u3002<\/p>\n 4. \u516c\u5171\u536b\u751f<\/p>\n \u8fd1 20 \u591a\u5e74\u6765\uff0c\u88ab WHO \u8ba4\u5b9a\u4e3a\u201c\u56fd\u9645\u5173\u6ce8\u7684\u7a81\u53d1\u516c\u5171\u536b\u751f\u4e8b\u4ef6\u201d\u9891\u7387\u9010\u6e10\u8d8b\u9ad8\uff1aSARS(2002 \u5e74)\u3001 \u7532\u578b H1N1 \u6d41\u611f(2009 \u5e74)\u3001\u57c3\u535a\u62c9\u75c5\u6bd2(2013 \u5e74)\u3001\u5be8\u5361\u75c5\u6bd2(2015 \u5e74)\u3001\u65b0\u578b\u51a0\u72b6 \u75c5\u6bd2(2019 \u5e74)\u3001\u7334\u75d8(2022 \u5e74)\u7b49\u3002<\/p>\n \u57fa\u4e8e\u75c5\u6bd2\u7684\u6784\u9020\uff0c\u76ee\u524d\u75c5\u539f\u5fae\u751f\u7269\u7684\u5206\u5b50\u8bca\u65ad\u4e3b\u8981\u4ece\u57fa\u56e0\u6c34\u5e73\u8fdb\u884c\u8bca\u65ad\uff0c\u5373\u6838\u9178\u68c0\u6d4b\u30022020 \u5e74\uff0c\u6211\u56fd\u6240\u6709\u4e09\u7ea7\u533b\u9662\u4ee5\u53ca\u53bf\u533b\u9662\u88ab\u8981\u6c42\u8fbe\u5230\u5feb\u901f\u7684\u6838\u9178\u68c0\u6d4b\u6761\u4ef6\u3002<\/p>\n \u6839\u636e\u56fd\u5bb6\u536b\u751f\u5065\u5eb7\u59d4\u4e34\u5e8a\u68c0\u9a8c\u4e2d\u5fc3\u53d1\u5e03\u7684\u300a2023 \u5e74\u5168\u56fd\u8840\u6db2\u5fae\u751f\u7269 cfDNA \u5b8f\u57fa\u56e0\u7ec4\u9ad8\u901a\u91cf\u6d4b\u5e8f\u5ba4\u95f4\u8d28\u91cf\u8bc4\u4ef7\u9884\u7814\u6d3b\u52a8\u7ed3\u679c\u62a5\u544a\u300b\uff0c\u5408\u683c\u7684102\u5bb6\u673a\u6784\u4e2d\uff0c\u5305\u62ec\u533b\u9662 58 \u5bb6\uff0c\u72ec\u7acb\u533b\u5b66\u68c0\u9a8c\u5b9e\u9a8c\u5ba4(ICL)44 \u5bb6\u3002<\/p>\n 5. \u751f\u7269\u80b2\u79cd<\/p>\n \u6839\u636e\u8054\u5408\u56fd\u7cae\u98df\u53ca\u519c\u4e1a\u7ec4\u7ec7(FAO)\u7684\u62a5\u544a\uff0c\u5230 2050 \u5e74\uff0c\u7cae\u98df\u4ea7\u91cf\u5fc5\u987b\u589e\u52a0 70% \u624d\u80fd\u6ee1\u8db3\u5168\u7403\u5c4a\u65f6\u603b\u8ba1\u7ea6 90 \u4ebf\u4f59\u4eba\u7684\u9700\u6c42\uff1b\u800c\u5728\u53d1\u5c55\u4e2d\u56fd\u5bb6\uff0c80% \u7684\u7cae\u98df\u4ea7\u91cf\u589e\u957f\u5c06\u6765\u81ea\u79cd\u690d\u6548\u7387\u7684\u63d0\u9ad8\u3002<\/p>\n \u80b2\u79cd\u9886\u57df\u7ecf\u5386\u4e86\u4e09\u6b21\u201c\u7eff\u8272\u9769\u547d\u201d\u3002\u5206\u522b\u662f\u77ee\u79c6\u57fa\u56e0\u7684\u53d1\u6398\u4e0e\u57f9\u80b2\u65b9\u9762\u3001\u6742\u4ea4\u80b2\u79cd\u548c\u73b0\u4ee3\u5206\u5b50\u80b2\u79cd\uff0c\u548c\u57fa\u56e0\u79d1\u6280\u606f\u606f\u76f8\u5173\u3002<\/p>\n \u57fa\u56e0\u7f16\u8f91\u5728\u6211\u56fd\u8fd1\u5e74\u83b7\u5f97\u8f83\u5927\u6280\u672f\u7a81\u7834\u53ca\u54c1\u79cd\u8ba4\u5b9a\u30022023 \u5e74\uff0c\u9ad8\u6cb9\u9178\u5927\u8c46\u4f5c\u4e3a\u9996\u4e2a\u690d\u7269\u83b7\u5f97\u519c\u4e1a\u519c\u6751\u90e8\u7684\u519c\u4e1a\u57fa\u56e0\u7f16\u8f91\u5b89\u5168\u8bc1\u4e66\uff1b2024 \u5e74\uff0c\u7389\u7c73\u548c\u5c0f\u9ea6\u4f5c\u4e3a\u4e3b\u7cae\u9996\u6b21\u83b7\u5f97\u690d\u7269\u57fa\u56e0\u7f16\u8f91\u5b89\u5168\u8bc1\u4e66\u3002\u4ee5\u57fa\u56e0\u56e0\u7f16\u8f91\u7684\u77ee\u6746\u7389\u7c73\u4e3a\u4f8b\uff0c\u830e\u79c6\u66f4\u7c97\u58ee\uff0c\u6297\u98ce\u80fd\u529b\u589e\u5f3a\uff0c \u66f4\u8010\u5bc6\u690d\uff0c\u6700\u9ad8\u53ef\u5b9e\u73b0\u589e\u4ea7 10%\u3002<\/p>\n 6. \u751f\u7269\u591a\u6837\u6027<\/p>\n \u81ea 2004 \u5e74\u751a\u81f3\u66f4\u65e9\u65f6\u671f\uff0c\u57fa\u56e0\u6280\u672f\u88ab\u8ba8\u8bba\u7528\u4e8e\u751f\u7269\u591a\u6837\u6027\u4fdd\u62a4(\u79f0\u4e4b\u4e3a\u751f\u6001\u4fdd\u62a4\u57fa\u56e0\u7ec4\uff0cConservation genomics)\u30022007 \u5e74\u4ee5\u6765\uff0c\u968f\u7740\u9ad8\u901a\u91cf\u6d4b\u5e8f\u6280\u672f\u7684\u8fdb\u5c55\uff0c \u8d85\u8fc7 3300 \u591a\u79cd\u7269\u79cd\u7684\u57fa\u56e0\u7ec4\u5f97\u4ee5\u6d4b\u5e8f\u3002<\/p>\n \u5bf9\u4e8e\u4eba\u7fa4\u7684\u591a\u6837\u6027\uff0c2023-2024\u5e74\uff0c\u7f8e\u56fd All of Us \u9879\u76ee\u516c\u5e03\u7f8e\u56fd\u5404\u5730\u8d85 24 \u4e07\u4e2a\u57fa\u56e0\u7ec4 \u6570\u636e\uff0c\u82f1\u56fd\u751f\u7269\u6837\u672c\u5e93(UKB)\u5f00\u653e 50 \u4e07\u4eba\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f(WGS) \u6570\u636e\u3002<\/p>\n \u5bf9\u4e8e\u81ea\u7136\u751f\u7269\u7684\u591a\u6837\u6027\uff0c\u79d1\u5b66\u5bb6\u901a\u8fc7\u9057\u4f20\u6807\u8bb0\u9884\u4f30\u79cd\u7fa4\u5927\u5c0f\u4e0e\u591a\u6837\u6027\uff0c\u901a\u8fc7\u53e4 DNA\u8fdb\u884c\u5316\u77f3\u548c\u6587\u7269\u8bc4\u4f30\uff1b\u901a\u8fc7\u73af\u5883 DNA(eDNA)\u8bc4\u4f30\u751f\u7269\u591a\u6837\u6027\u548c\u76d1\u6d4b\u5916\u6765\u7269\u79cd\u5165\u4fb5\uff1b\u901a\u8fc7\u57fa\u56e0\u7f16\u8f91\u548c\u57fa\u56e0\u5408\u6210\u7b49\u6280\u672f\uff0c\u8fdb\u884c\u751f\u7269\u8d44\u6e90\u7684\u5b58\u50a8\u53ca\u66ff\u6362\u5229\u7528\u3002<\/p>\n 7. \u751f\u7269\u5236\u9020<\/p>\n 2000\u5e74\uff0c\u79d1\u5b66\u5bb6\u57fa\u4e8e\u5229\u7528\u7ec6\u83cc\u57fa\u56e0\u5143\u4ef6\u6784\u5efa\u4e86\u903b\u8f91\u7ebf\u8def\uff0c\u5728\u201c\u5408\u6210\u5316\u5b66\u201d\u57fa\u7840\u4e0a\u5f00\u62d3\u201c\u5408\u6210\u751f\u7269\u5b66\u201d\u9886\u57df\uff1b2010\u5e74\u524d\u540e\uff0c\u57fa\u56e0\u6d4b\u5e8f\u3001\u9176\u5b9a\u5411\u3001\u6838\u9178\u5408\u6210\u3001\u57fa\u56e0\u7f16\u8f91\u7b49\u6280\u672f\u5f00\u542f\u201c\u4eba\u5de5\u5408\u6210\u751f\u547d\u201d\u65f6\u4ee3\uff0c\u672a\u6765\u8fdb\u4e00\u6b65\u8fc8\u5411\u201c\u7ec6\u80de\u5de5\u5382\u201d\uff0c\u5373\u901a\u8fc7\u4eba\u5de5\u64cd\u4f5c\u6216\u5408\u6210\u5927\u80a0\u6746\u83cc\u7b49\u5fae\u751f\u7269\u4f5c\u4e3a\u201c\u7ec6\u80de\u5de5\u5382\u201d\u6765\u751f\u4ea7\u4eba\u7c7b\u6240\u9700\u3002<\/p>\n \u5168\u7403\u77e5\u540d\u54a8\u8be2\u673a\u6784\u9ea6\u80af\u9521\u8ba4\u4e3a\u672a\u6765\u5168\u740360%\u7684\u7269\u8d28\u751f\u4ea7\u53ef\u901a\u8fc7\u751f\u7269\u5236\u9020\u65b9\u5f0f\u5b9e\u73b0\uff0c\u9884\u8ba1\u52302025\u5e74\u5408\u6210\u751f\u7269\u4e0e\u751f\u7269\u5236\u9020\u7684\u7ecf\u6d4e\u4ef7\u503c\u5c06\u8fbe\u52301000\u4ebf\u7f8e\u5143\uff0c\u9884\u8ba1\u672a\u676510\u5e74\uff0c\u57fa\u4e8e\u5408\u6210\u751f\u7269\u548c\u751f\u7269\u5236\u9020\u4ea7\u751f\u7684\u4ef7\u503c\u5c06\u8fbe\u5230\u6bcf\u5e74\u7ea62\u4e07\u4ebf\u7f8e\u5143\u7684\u7ecf\u6d4e\u4ef7\u503c\u3002<\/p>\n 2021\u5e74\u5168\u7403\u5408\u6210\u751f\u7269\u5b66\u878d\u8d44\u989d\u7ea6\u4e3a180\u4ebf\u7f8e\u5143\uff0c\u51e0\u4e4e\u76f8\u5f53\u4e8e\u8fc7\u53bb10\u5e74\u6240\u6709\u878d\u8d44\u989d\u7684\u603b\u548c\u3002<\/p>\n \u57fa\u56e0\u79d1\u6280\u4ea7\u4e1a\u7684\u524d\u666f\u5982\u4f55\uff1f<\/p>\n \u6839\u636e\u57fa\u56e0\u6167\u53c2\u4e0e\u76f8\u5173\u90e8\u59d4\u7684\u767d\u76ae\u4e66\uff0c\u5b9a\u4e49\u57fa\u56e0\u6280\u672f\u4e3a\u672a\u6765\u4ea7\u4e1a\uff0c\u662f\u672a\u6765\u5065\u5eb7\u548c\u672a\u6765\u519c\u4e1a\u7684\u91cd\u8981\u652f\u67f1\u3002<\/p>\n 1. 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