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2023-2024\u5e74\u7684\u6d77\u5916\u4e34\u5e8a\u57fa\u56e0\u8bca\u65ad\u53ca\u7b5b\u67e5\u51c6\u5165\u7684\u65b0\u4ea7\u54c1\u7684\u6570\u91cf\u964d\u4f4e\uff0c\u4f46\u4e3b\u8981\u96c6\u4e2d\u5728\u5177\u6709\u521b\u65b0\u6027\u7684\u4ea7\u54c1\u4e0a\u3002FDA\u901a\u8fc7DeNovo\u5ba1\u67e5\u7a0b\u5e8f\u6279\u51c6\u4e86Invitae\u516c\u53f8\u7684\u9996\u6b3e\u9057\u4f20\u6027\u80bf\u7624\u57fa\u56e0\u68c0\u6d4b\u4ea7\u54c1\uff08II\u7c7b\uff0c47\u4e2a\u57fa\u56e0\uff0c\u8986\u76d622\u79cd\u9057\u4f20\u6027\u80bf\u7624\u7efc\u5408\u5f81\uff09\u3002\u540c\u65f6\uff0c\u9ed8\u6c99\u4e1c\uff08MSD\uff09\u7684\u6297PD-1\u5355\u6297\u5e15\u535a\u5229\u73e0\u5355\u6297\uff08\u201cK\u836f\u201d\uff09\u83b7\u5f97FDA\u7684\u5b8c\u5168\u6279\u51c6\uff0c\u9488\u5bf9\u9ad8\u5ea6\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\uff08MSI-H\uff09\u6216\u9519\u914d\u4fee\u590d\u7f3a\u9677\u578b\uff08dMMR\uff09\u5b9e\u4f53\u7624\uff0c\u8fd9\u5c06\u8fdb\u4e00\u6b65\u62d3\u5c55\u4e86\u76f8\u5173\u57fa\u56e0\u68c0\u6d4b\u4ea7\u54c1\u7684\u5e94\u7528\u3002<\/p>\n \u5728\u57fa\u56e0\u7f16\u8f91\u9886\u57df\uff0c2023\u5e74\uff0c\u82f1\u56fd\u7387\u5148\u5728\u6b27\u6d32\u56fd\u5bb6\u653e\u5bbd\u57fa\u56e0\u7f16\u8f91\uff0c\u9881\u5e03\u300a\u57fa\u56e0\u6280\u672f\u6cd5\u6848\u300b\u5141\u8bb8\u5728\u82f1\u683c\u5170\u4f7f\u7528\u57fa\u56e0\u7f16\u8f91\u5bf9\u52a8\u690d\u7269\u8fdb\u884c\u7cbe\u51c6\u80b2\u79cd\u5e76\u5546\u4e1a\u5316\uff0c\u514d\u4e8e\u57fa\u56e0\u6539\u9020\u751f\u7269\uff08GMOs\uff09\u7684\u76d1\u7ba1\u8981\u6c42\uff0c\u540c\u65f6\u5728\u6b27\u6d32\u5176\u4ed6\u5730\u533a\u57fa\u56e0\u7f16\u8f91\u4e0e\u8f6c\u57fa\u56e0\u53d7\u5230\u4e00\u6837\u53d7\u5230\u66f4\u4e25\u683c\u76d1\u7ba1\uff1b2024\u5e74\uff0c\u7f8e\u56fdFDA\u53d1\u5e03\u57fa\u56e0\u7f16\u8f91\u690d\u7269\u98df\u54c1\u4e0a\u5e02\u524d\u81ea\u613f\u901a\u62a5\u7684\u884c\u4e1a\u6307\u5357\uff1b\u745e\u58eb\u8054\u90a6\u73af\u5883\u5c40\u6279\u51c6\u57fa\u56e0\u7f16\u8f91\u6625\u5927\u9ea6\u9996\u6b21\u8fdb\u884c\u4e3a\u671f\u4e09\u5e74\u7684\u7530\u95f4\u8bd5\u9a8c\u3002\u00a0<\/p>\n \u5728\u57fa\u56e0\u6cbb\u7597\u9886\u57df\uff0c\u622a\u81f32024\u5e74\uff0c\u8d85\u8fc750\u6b3e\u57fa\u56e0\u6cbb\u7597\u836f\u7269\u83b7\u6279\uff08\u5305\u62ec\u4f53\u5916\u57fa\u56e0\u7597\u6cd5\u3001\u57fa\u4e8e\u75c5\u6bd2\u8f7d\u4f53\u7684\u4f53\u5185\u57fa\u56e0\u7597\u6cd5\u3001\u5c0f\u6838\u9178\u836f\u7269\u7b49\uff09\u3002\u5176\u4e2d\uff0c\u8fd1\u5e74\u8fd1\u5e74\u503c\u5f97\u5173\u6ce8\u7684\u57fa\u56e0\u7597\u6cd5\u5305\u62ec\uff1a\u9996\u4e2a\u9488\u5bf9\u8425\u517b\u4e0d\u826f\u578b\u5927\u75b1\u6027\u8868\u76ae\u677e\u89e3\u75c7\uff08DEB\uff09\u7684\u57fa\u56e0\u7597\u6cd5Vyjuvek\uff0c\u9488\u5bf9\u5f02\u67d3\u6027\u8111\u767d\u8d28\u8425\u517b\u4e0d\u826f\u513f\u7ae5\u60a3\u8005\u7684\u57fa\u56e0\u7597\u6cd5Lenmeldy\u83b7\u5f97FDA\u6279\u51c6\u4e0a\u5e02\uff1b\u52a0\u62ff\u5927\u536b\u751f\u90e8\u6279\u51c6\u8840\u53cb\u75c5B\u6210\u4eba\u60a3\u8005\u7684\u57fa\u56e0\u7597\u6cd5Beqvez\uff1b\u9700\u6ce8\u610f\u7684\u662f\uff0c\u9996\u4e2a\u9488\u5bf9\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\uff08DMD\uff09\u7684\u57fa\u56e0\u7597\u6cd5Elevidys\u57282023\u5e746\u6708\u83b7\u5f97FDA\u52a0\u901f\u6279\u51c6\u540e\uff08\u4e34\u65f6\u6388\u6743\uff09\uff0c\u572810\u6708\u88ab\u5ba3\u5e03III\u671f\u9a8c\u8bc1\u6027\u4e34\u5e8a\u7814\u7a76\u672a\u8fbe\u4e3b\u8981\u7ec8\u70b9\uff0c\u8fd9\u6b3e\u7597\u6cd5\u662fSarepta\u4ece\u7f57\u6c0f\u4ee511.5\u4ebf\u7f8e\u5143\u9996\u4ed8\u6b3e\u548c17\u4ebf\u7f8e\u5143\u91cc\u7a0b\u7891\u4ed8\u6b3e\u7684\u4ea4\u6613\u989d\u83b7\u5f97Elevidys\u5728\u7f8e\u56fd\u4ee5\u5916\u5730\u533a\u7684\u5546\u4e1a\u5316\u6743\u5229\u3002\u00a0<\/p>\n \u5728\u6570\u636e\u5b89\u5168\u548c\u751f\u7269\u5b89\u5168\u65b9\u9762\uff0c\u6b27\u7f8e\u8fd1\u5e74\u8f83\u5173\u6ce8\u672c\u571f\u4ea7\u4e1a\u4fdd\u62a4\uff0c\u5bc6\u96c6\u51fa\u53f0\u4e86\u76f8\u5173\u653f\u7b56\u6587\u4ef6\u3002\u4f8b\u5982\u7f8e\u56fd2024\u5e74\u9881\u5e03\u300a\u5173\u4e8e\u9632\u6b62\u53d7\u5173\u6ce8\u56fd\u5bb6\u8bbf\u95ee\u7f8e\u56fd\u4eba\u7684\u5927\u91cf\u654f\u611f\u4e2a\u4eba\u6570\u636e\u548c\u7f8e\u56fd\u653f\u5e9c\u76f8\u5173\u6570\u636e\u7684\u884c\u653f\u547d\u4ee4\u300b\uff0c\u5c06\u53ef\u80fd\u5f71\u54cd\u4e1a\u5185\u5927\u91cf\u516c\u5f00\u57fa\u56e0\u6570\u636e\u5e93\u7684\u8bbf\u95ee\u3002\u6b27\u76df\u4e8e2023\u5e746\u6708\u53d1\u5e03\u300a\u6b27\u6d32\u7ecf\u6d4e\u5b89\u5168\u6218\u7565\u300b\uff0c\u79f0\u53ef\u4ee5\u8003\u8651\u5bf9\u751f\u7269\u6280\u672f\u3001\u4eba\u5de5\u667a\u80fd\u7b49\u6280\u672f\u5b9e\u65bd\u51fa\u53e3\u7ba1\u5236\u3002<\/p>\n <\/p>\n \uff08\u4e09\uff09\u56fd\u5916\u57fa\u56e0\u4ea7\u4e1a\u73b0\u72b6\u6982\u89c8\u00a0<\/p>\n \u4ece\u5168\u7403\u89d2\u5ea6\uff0c\u5f97\u76ca\u4e8e\u6280\u672f\u7684\u8fdb\u6b65\uff0c\u57fa\u56e0\u53ca\u76f8\u5173\u751f\u547d\u79d1\u5b66\u53d1\u73b0\u548c\u4ea7\u4e1a\u6709\u4e00\u5b9a\u7684\u8fdb\u5c55\uff0c\u540c\u65f6\u884c\u4e1a\u7684\u5e73\u53f0\u8bbe\u65bd\u548c\u9769\u547d\u6027\u7a81\u7834\u6709\u5f85\u8fdb\u4e00\u6b65\u6295\u5165\u3002\u00a0<\/p>\n \u5728\u79d1\u5b66\u53d1\u73b0\u65b9\u9762\uff0c\u957f\u8bfb\u957f\u6d4b\u5e8f\u3001\u57fa\u56e0\u7f16\u8f91\u7b49\u65b0\u5174\u6280\u672f\u548c\u5927\u89c4\u6a21\u4eba\u7fa4\u6570\u636e\u83b7\u5f97\u5bf9\u751f\u547d\u66f4\u9ad8\u7684\u5206\u8fa8\u7387\u548c\u66f4\u591a\u7ef4\u7684\u8ba4\u77e5\u53ca\u6539\u9020\u3002\u4f8b\u5982\uff0c\u5728\u201c\u7aef\u7c92\u5230\u7aef\u7c92\uff08T2T\uff09\u201d\u8054\u76df\u53d1\u5e03\u6700\u65b0\u7248\u4eba\u7c7b\u53c2\u8003\u57fa\u56e0\u7ec4T2T-CHM13\u540e\uff0cT2T\u8054\u76df\u7ed3\u5408PacBio HiFi\u548cONT\u957f\u8bfb\u957f\u6d4b\u5e8f\u6280\u672f\u53d1\u5e03\u4eba\u7c7bY\u67d3\u8272\u4f53\u5b8c\u6574\u5e8f\u5217\uff08Rhie, A et al. Nature,2023\uff09\uff1b\u82cf\u683c\u5170\u764c\u75c7\u7814\u7a76\u6240\u548c\u7f8e\u56fd\u7eaa\u5ff5\u65af\u9686\u51ef\u7279\u7433\u764c\u75c7\u4e2d\u5fc3\uff08MSK\uff09\u56e2\u961f\u8054\u5408\u901a\u8fc7\u5c06\u7ebf\u7c92\u4f53\uff08mtDNA\uff09\u7f16\u7801\u57fa\u56e0\u53d8\u5f02\u5f15\u5165\u5c0f\u9f20\u9ed1\u8272\u7d20\u7624\u6a21\u578b\uff0c\u53d1\u73b0mtDNA\u7a81\u53d8\u9ad8\u6c34\u5e73\uff08>50%\uff09\u60a3\u8005\u5bf9\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u7597\u6cd5\u7684\u53cd\u5e94\u7387\u63d0\u9ad8\u7ea62.5\u500d\uff08Mahmood et al. Nat Cancer ,2024\uff09\u3002\u7f8e\u56fdAll of Us\u9879\u76ee\u516c\u5e03\u7f8e\u56fd\u5404\u5730\u8d8524\u4e07\u4e2a\u57fa\u56e0\u7ec4\u6570\u636e\uff08Nature 627, 2024\uff09\u4ee5\u53ca\u82f1\u56fd\u751f\u7269\u6837\u672c\u5e93\uff08UKB\uff09\u5f00\u653e50\u4e07\u4eba\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\uff08WGS\uff09\u6570\u636e\uff0c\u5c06\u4fc3\u8fdb\u5168\u7403\u7684\u57fa\u56e0\u6280\u672f\u4ea4\u6d41\u3001\u534f\u4f5c\u548c\u5f00\u53d1\u5e94\u7528\uff0c\u7279\u522b\u662f\u4e3a\u5e38\u89c1\u75be\u75c5\u7684\u75c5\u56e0\u7814\u7a76\u548c\u6f5c\u5728\u6cbb\u7597\u9776\u70b9\u9009\u62e9\u65b9\u9762\u63d0\u4f9b\u91cd\u8981\u7684\u57fa\u56e0\u7ec4\u5b66\u8bc1\u636e\u3002\u00a0<\/p>\n \u5728\u6280\u672f\u4e0a\uff0c\u57fa\u56e0\u7ec4\u3001\u5355\u7ec6\u80de\u7ec4\u3001\u7a7a\u95f4\u7ec4\u5b66\u7b49\u76f8\u5173\u57fa\u56e0\u6280\u672f\u9010\u6b65\u8fed\u4ee3\uff0c\u5e76\u4e0e\u4eba\u5de5\u667a\u80fd\uff08AI\uff09\u7ed3\u5408\u6df1\u5ea6\u53d1\u6398\u591a\u7ec4\u5b66\u751f\u7269\u4fe1\u606f\u3002\u745e\u5178\u5361\u7f57\u6797\u65af\u533b\u5b66\u9662\u56e2\u961f\u53d1\u660e\u5728\u5355\u7ec6\u80de\u6c34\u5e73\u68c0\u6d4b\u67d3\u8272\u4f53\u5916\u73af\u72b6DNA\uff08eccDNA\uff09\u7684\u6280\u672fscCircle-seq\uff0c\u53ef\u4ee5\u68c0\u6d4b\u7f55\u89c1\u7684eccDNA\uff08Chen et al. Nat Commun, 2024\uff09\uff1b\u65b0\u52a0\u5761\u57fa\u56e0\u7ec4\u7814\u7a76\u6240\u7684\u56e2\u961f\u53d1\u5e03\u53ef\u5bf9\u7ec6\u80de\u7c7b\u578b\u548c\u57fa\u56e0\u8868\u8fbe\u8fdb\u884c\u539f\u4f4d\u5206\u6790\u7684\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u5b66\u65b9\u6cd5FISHnCHIPs\uff0c\u83b7\u5f97\u4e0e\u5355\u57fa\u56e0FISH\u76f8\u4f3c\u7684\u7a7a\u95f4\u4fe1\u606f\uff0c\u4e14\u7075\u654f\u5ea6\u63d0\u9ad82-20\u500d\uff08Zhou et al. Nat Commu,2024\uff09\uff1b\u5e94\u5bf9\u5927\u89c4\u6a21\u7a7a\u95f4\u7ec4\u5b66\u6570\u636e\u5904\u7406\u7684\u5f00\u653e\u5f0f\u548c\u901a\u7528\u6570\u636e\u6846\u67b6SpaticalData\u5728Nature Methods\u4e0a\u53d1\u5e03\uff0c\u57fa\u4e8e\u901a\u8fc7\u7edf\u4e00\u548c\u53ef\u6269\u5c55\u7684\u591a\u5e73\u53f0\u6570\u636e\u683c\u5f0f\u548c\u7a0b\u5e8f\u63a5\u53e3\uff0c\u65b9\u4fbf\u79d1\u5b66\u5bb6\u8fdb\u884c\u7a7a\u95f4\u6ce8\u91ca\u548c\u8de8\u6a21\u6001\u805a\u5408\u53ca\u6df1\u5ea6\u5b66\u4e60\u6a21\u578b\u8bad\u7ec3\uff08Marconato et al. Nat Methods\uff0c2024\uff09\uff1b\u82f1\u4f1f\u8fbe\uff08NVIDIA\uff09\u7684\u6700\u65b0\u7684BioNeMo\u6a21\u578b\u901a\u8fc7\u5206\u6790\u7ec6\u80de\u529f\u80fd\u76f8\u5173\u7684DNA\u548cRNA\u5e8f\u5217\u53ef\u4ee5\u9884\u6d4b\u836f\u7269\u5206\u5b50\u7ed3\u5408\u53ca\u86cb\u767d\u8d28\u7ed3\u6784\u53d8\u5316\uff0c\u8ba1\u5212\u901a\u8fc7AWS HealthOmics\u5e73\u53f0\u63d0\u4f9b\u57fa\u4e8e\u4e91\u7684\u4f01\u4e1a\u670d\u52a1\uff1b\u5728\u57fa\u56e0\u7f16\u8f91\u65b9\u9762\uff0c\u7f8e\u56fdAI\u86cb\u767d\u8d28\u8bbe\u8ba1\u521d\u521b\u516c\u53f8Profluent Bio\u53d1\u5e03\u5168\u7403\u9996\u4e2a\u5f00\u6e90\u7684AI\u751f\u4ea7\u7684\u57fa\u56e0\u7f16\u8f91\u5668OpenCRISPR-1\u3002\u5728\u57fa\u56e0\u5408\u6210\u65b9\u9762\uff0c\u7531\u4e2d\u56fd\u3001\u7f8e\u56fd\u3001\u82f1\u56fd\u3001\u65b0\u52a0\u5761\u3001\u6fb3\u5927\u5229\u4e9a\u7b49\u591a\u56fd\u4e8e2011\u5e74\u8054\u5408\u542f\u52a8\u7684\u201c\u9175\u6bcd\u57fa\u56e0\u7ec4\u5408\u6210\u8ba1\u5212\uff08Sc2.0 Project\uff09\u57282023\u5e7411\u6708\u53d6\u5f97\u91cc\u7a0b\u7891\u7a81\u7834\uff0cSc2.0\u56e2\u961f\u5df2\u5408\u6210\u9175\u6bcd\u7684\u5168\u90e816\u6761\u67d3\u8272\u4f53\uff0c\u4ee5\u53ca\u4e00\u4e2a\u5168\u65b0\u5408\u6210\u7684tRNA\u67d3\u8272\u4f53\uff0c\u5e76\u6784\u5efa\u4e86\u4e00\u79cd\u5305\u542b50%\u5408\u6210DNA\u7684\u9175\u6bcd\u83cc\u682a\uff0c\u8868\u73b0\u51fa\u6d3b\u8dc3\u7684\u589e\u6b96\u548c\u6b63\u5e38\u7684\u7ec6\u80de\u5f62\u6001\u3001\u957f\u5ea6\u548c\u5f62\u72b6\uff08Yu Zhao et al. Cell, 2023\uff09\u3002\u8377\u5170\u764c\u75c7\u7814\u7a76\u4e2d\u5fc3\u7684Wouter Scheper\u8054\u5408\u5408\u4f5c\u56e2\u961f\u5f00\u53d1\u4e00\u9879\u6280\u672f\u5b9e\u73b0\u4e00\u7f8e\u5143\u5408\u6210T\u7ec6\u80de\u53d7\u4f53\uff08TCR\uff09\u57fa\u56e0\uff0c\u521b\u5efa\u4e86\u591a\u514b\u9686\u5408\u6210\u578bTILs\uff0c\u4e3a\u5b9e\u4f53\u7624\u60a3\u8005\u521b\u5efa\u4e2a\u6027\u5316\u7684\u7ec6\u80de\u7597\u6cd5\u6253\u4e0b\u57fa\u7840\u3002\u00a0<\/p>\n \u5728\u5e94\u7528\u65b9\u9762\uff0c2024\u5e744\u6708\uff0cFDA\u80bf\u7624\u836f\u7269\u59d4\u5458\u4f1a\u5ba3\u5e03\u540c\u610f\u5c06MRD\uff08\u5fae\u5c0f\u6b8b\u7559\u75c5\u7076\uff09\u4f5c\u4e3a\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u4e34\u5e8a\u8bd5\u9a8c\u52a0\u901f\u6279\u51c6\u7ec8\u70b9\u3002\u5355\u5206\u5b50\u6d4b\u5e8f\u5c55\u73b0\u51fa\u9057\u4f20\u75c5\u8bca\u65ad\u65b9\u9762\u7684\u5e94\u7528\u6f5c\u529b\uff1bEditas Medicine\u516c\u53f8\u516c\u5e03\u7528\u4e8e\u6cbb\u7597Leber \u5148\u5929\u6027\u9ed1\u8499\uff08LCA\uff09\u7684\u57fa\u56e0\u7f16\u8f91\u7597\u6cd5EDIT-101\u7684I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\uff0c\u572814\u540d\u8bd5\u9a8c\u53c2\u4e0e\u8005\u4e2d\u8fd1\u4e00\u534a\u4eba\u7684\u62a5\u544a\u89c6\u529b\u83b7\u5f97\u660e\u663e\u6539\u5584\uff0c\u5305\u62ec2\u540d\u513f\u7ae5\u3002\u00a0<\/p>\n \u5728\u4ea7\u4e1a\u65b9\u9762\uff0c\u4f5c\u4e3a\u7edd\u5927\u90e8\u5206\u5c1a\u672a\u76c8\u5229\u7684\u57fa\u56e0\u6280\u672f\u4f01\u4e1a\uff0c\u5728\u8fc7\u53bb\u4e00\u5e74\u53d7\u5230\u73b0\u91d1\u6d41\u53ca\u7814\u53d1\u6295\u5165\u76f8\u5173\u7684\u91cd\u5927\u6311\u6218\uff0c\u5728\u65b0\u4ea7\u54c1\u3001\u6295\u878d\u8d44\u548c\u4e0a\u5e02\u7b49\u65b9\u9762\u8fdb\u5c55\u76f8\u5bf9\u8d8b\u7f13\uff0c\u5e76\u8d2d\u6301\u7eed\u53d1\u9175\u548c\u53d1\u751f\u3002\u4f8b\u5982\uff0c\u4ee535\u4ebf\u7f8e\u5143\u57282021\u5e74\u4e0a\u5e02\u768423andMe\u9762\u4e34\u9000\u5e02\uff1b\u77e5\u540d\u7684\u57fa\u56e0\u68c0\u6d4b\u516c\u53f8Invitae\u4e8e2024\u5e744\u6708\u88ab\u7f8e\u56fd\u7b2c\u4e09\u65b9\u72ec\u7acb\u5b9e\u9a8c\u5ba4\uff08ICL\uff09\u5de8\u5934LabCorp\u4ee52.39\u4ebf\u7f8e\u5143\u6536\u8d2d\uff1b\u540c\u6708\uff0c\u5e03\u9c81\u514b\uff08Bruker\uff09\u516c\u53f8\u5ba3\u5e03\u4ee53.93\u4ebf\u7f8e\u5143\u7684\u73b0\u91d1\u6536\u8d2dNanoString\uff0c\u540e\u8005\u7684\u57fa\u56e0\u8868\u8fbe\u5206\u5b50\u548c\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u5b66\u8865\u5145\u524d\u8005\u7684\u7a7a\u95f4\u86cb\u767d\u8d28\u7ec4\u5b66\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u65b0\u5174\u9886\u57df\u7684\u4f01\u4e1a\u4e5f\u5448\u73b0\u4e00\u5b9a\u7684\u589e\u957f\uff0c\u4f8b\u5982\u6db2\u4f53\u6d3b\u68c0\u516c\u53f8Freeome\u4e8e2024\u5e742\u6708\u5b8c\u6210\u7531\u7f57\u6c0f\u8bca\u65ad\u9886\u6295\u3001Quest\u7b49\u8ddf\u6295\u76842.54\u4ebf\u7f8e\u5143\u7684\u878d\u8d44\u3002<\/p>\n <\/p>\n \u56fd\u5185\u57fa\u56e0\u884c\u4e1a\u5e02\u573a\u73af\u5883\u3001\u76d1\u7ba1\u53ca\u73b0\u72b6<\/p>\n \uff08\u4e00\uff09\u5e02\u573a\u73af\u5883<\/p>\n \uff081\uff09\u5e02\u573a\u9700\u6c42<\/p>\n 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\uff082\uff09\u5b8f\u89c2\u56e0\u7d20<\/p>\n 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