{"id":7893,"date":"2024-11-27T21:23:00","date_gmt":"2024-11-27T13:23:00","guid":{"rendered":"https:\/\/www.geneclub.net.cn\/index.php\/2024\/11\/27\/554954\/"},"modified":"2026-04-07T16:12:46","modified_gmt":"2026-04-07T08:12:46","slug":"554954","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2024\/11\/27\/554954\/","title":{"rendered":"\u7efc\u8ff0\uff1a\u57fa\u56e0\u68c0\u6d4b\u5728\u80bf\u7624\u65e9\u7b5b\u3001\u4f34\u968f\u8bca\u65ad\u548c\u590d\u53d1\u76d1\u6d4b\u4e2d\u7684\u5e94\u7528"},"content":{"rendered":"<p><!-- wechat_content_hash: 716b430d1a5b70d9 --><\/p>\n<p>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBJ4sibF985CB53GqXpdUXJY1ibXic4tk7cicKMPtgyMRqWYUopq6yOghicWK3LOe3qL8V3Rjia4kHVKgsA.jpeg\" 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class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDkkd1iaVVCRZxDOWia6X7wiaYfnuKEVSwib6stohs1u7pPaIWbREYNJvcnHWJZrX3DQdtmkhTiaia9hJMA.jpg\" alt=\"RmFicvQBAkgDkkd1iaVVCRZxDOWia6X7wiaYfnuKEVSwib6stohs1u7pPaIWbREYNJvcnHWJZrX3DQdtmkhTiaia9hJMA\"\/><\/figure><\/div>\n\n<p style=\"text-align: center;\">\u56fe\uff1a2022\u5e74\u6211\u56fd\u6076\u6027\u80bf\u7624\u53d1\u751f\u7387\uff08\u5de6\u56fe\uff09\u548c\u6b7b\u4ea1\u7387\uff08\u53f3\u56fe\uff09\u53ca\u987a\u4f4d\uff08\u6765\u6e90\/He Jie et al.,JNCC, 2024\uff09<\/p>\n<p>\u968f\u7740\u764c\u75c7\u9632\u6cbb\u7684\u6218\u7565\u9ad8\u5ea6\u3001\u516c\u4f17\u610f\u8bc6\u548c\u7cbe\u51c6\u533b\u7597\u6280\u672f\u7684\u63d0\u5347\uff0c\u6211\u56fd\u6076\u6027\u80bf\u7624\u76845\u5e74\u603b\u4f53\u751f\u5b58\u7387\u4ece2015\u5e74\u768440.5%\u4e0a\u5347\u52302022\u5e74\u768443.7%\uff0c\u4f46\u4e0e\u53d1\u8fbe\u56fd\u5bb6\u4ecd\u5b58\u5728\u7ea625\u4e2a\u767e\u5206\u70b9\u7684\u5dee\u8ddd\u3002<\/p>\n<p>\u764c\u75c7\u7684\u672c\u8d28\u662f\u57fa\u56e0\u5f02\u5e38\u75be\u75c5\uff0c\u7531\u4e0d\u53d7\u63a7\u5236\u7684\u7684\u7ec6\u80de\u589e\u6b96\u5f15\u8d77\u3002\u76ee\u524d\u764c\u75c7\u6cbb\u7597\u4ee5\u624b\u672f\uff08\u5916\u79d1\u5207\u9664\uff09\u3001\u653e\u7597\uff08\u653e\u5c04\u6cbb\u7597\uff09\u3001\u5316\u7597\uff08\u5316\u5b66\u836f\u7269\u6cbb\u7597\uff09\u4e3a\u4e3b\uff0c\u8fd8\u5305\u62ec\u514d\u75ab\u6cbb\u7597\u7b49\u65b0\u5174\u6cbb\u7597\u624b\u6bb5\u3002\u7531\u4e8e\u764c\u75c7\u7ec6\u80de\u5177\u5907\u514d\u75ab\u9003\u9038\u3001\u6613\u8f6c\u79fb\uff08\u4e0d\u5177\u6709\u4f20\u67d3\u6027\uff09\u7b49\u7279\u70b9\uff0c\u4f7f\u5f97\u75c5\u7a0b\u7684\u9884\u540e\u5dee\u3002\u8fd9\u4e2a\u95ee\u9898\u53ef\u4ee5\u901a\u8fc7\u5206\u5b50\u5206\u578b\u548c\u65e9\u7b5b\u65e9\u8bca\u6280\u672f\u6765\u6539\u5584\u3002<\/p>\n<p>\u7531\u4e8e\u90e8\u5206\u764c\u79cd\u7684\u7ec4\u7ec7\u53d6\u6837\u56f0\u96be\u4e14\u5728\u65e9\u671f\u96be\u4ee5\u53d1\u73b0\u6f5c\u5728\u7684\u764c\u75c7\uff0c\u4f7f\u5f97\u75c5\u7406\u8bca\u65ad\u76f8\u5bf9\u53d7\u9650\u3002\u968f\u7740\u57fa\u56e0\u6280\u672f\u9010\u6e10\u6210\u719f\uff0c\u80bf\u7624\u5206\u5b50\u5206\u578b\u901a\u8fc7\u5bf9\u80bf\u7624\u9a71\u52a8\u57fa\u56e0\u53d8\u5f02\u7684\u68c0\u6d4b\u548c\u7279\u5f81\u8c31\u7684\u89e3\u6790\uff0c\u5728\u4e34\u5e8a\u4e0a\u53ef\u4ee5\u5bf9\u80bf\u7624\u8fdb\u884c\u7cbe\u51c6\u7684\u5206\u5b50\u5206\u578b\u5e76\u6316\u6398\u7279\u5f02\u5173\u952e\u6307\u6807\u8fdb\u884c\u9884\u540e\u8bc4\u4ef7\u76d1\u6d4b\u3002\u5206\u5b50\u5206\u578b\u4e5f\u63a8\u52a8\u80bf\u7624\u5206\u7c7b\u7531\u7ec4\u7ec7\u5f62\u6001\u5b66\u5411\u5206\u5b50\u7279\u5f81\u8f6c\u53d8\uff0c\u5373\u4e00\u79cd\u80bf\u7624\u53ef\u80fd\u6709\u591a\u79cd\u4e9a\u578b\u5e76\u643a\u5e26\u4e0d\u540c\u7684\u7a81\u53d8\u57fa\u56e0\uff0c\u4e0d\u540c\u7684\u80bf\u7624\u53ef\u80fd\u643a\u5e26\u76f8\u540c\u7684\u7a81\u53d8\u57fa\u56e0\uff0c\u5bf9\u5e94\u5728\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\u4e0a\u7684\u7bee\u5f0f\u8bd5\u9a8c\u4e0e\u4f1e\u5f0f\u8bd5\u9a8c\u3002\u540c\u65f6\u5206\u5b50\u5206\u578b\u4e5f\u53ef\u4ee5\u53d1\u73b0\u65e9\u671f\u7684\u764c\u75c7\u3002\u00a0<\/p>\n<p>\u80bf\u7624\u4e0e\u57fa\u56e0\u591a\u79cd\u53d8\u5f02\u76f8\u5173\uff0c\u5305\u62ec\uff1aDNA 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class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDkkd1iaVVCRZxDOWia6X7wiaYiaRPhzPibv8YaqbZlq3TqwKKk0icCc5ia2ejbycsQ4vDJDqfomIR4AhceA.png\" alt=\"RmFicvQBAkgDkkd1iaVVCRZxDOWia6X7wiaYiaRPhzPibv8YaqbZlq3TqwKKk0icCc5ia2ejbycsQ4vDJDqfomIR4AhceA\"\/><\/figure><\/div>\n\n<p style=\"text-align: center;\">\u56fe\uff1a\u5927\u89c4\u6a21\u764c\u75c7\u65e9\u7b5b\u9879\u76ee\u7684\u5173\u952e\u6307\u6807\uff08\u6765\u6e90\/ 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Hanahan\u548cRobert 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RNA(exRNA)\u7b49\u3002\u5176\u4e2d\uff0cctDNA\u68c0\u6d4b\u6280\u672f\u76f8\u5bf9\u76f8\u5bf9\u6210\u719f\uff0c\u7531\u4e8e\u662f\u80bf\u7624\u7ec6\u80de\u91ca\u653e\u5230\u4eba\u4f53\u5faa\u73af\u7cfb\u7edf\u7684\u6e38\u79bbDNA\uff0c\u7247\u6bb5\u5c0f\uff0c\u542b\u91cf\u6781\u4f4e\uff0c\u5bf9\u6280\u672f\u5e73\u53f0\u8981\u6c42\u8f83\u9ad8\u3002\u4ece\u6280\u672f\u5e73\u53f0\u4e0a\uff0c\u57fa\u4e8ePCR\u7684\u6db2\u4f53\u6d3b\u68c0\u7387\u5148\u83b7\u5f97\u4e34\u5e8a\u51c6\u5165\u6ce8\u518c\u8bc1\uff0c\u4e3b\u8981\u7528\u4e8e\u5355\u764c\u79cd\uff1b\u57fa\u4e8eNGS\u6280\u672f\u7684\u68c0\u6d4b\u4e3b\u8981\u7528\u4e8e\u6cdb\u764c\u79cd\uff0c\u5177\u5907\u66f4\u5feb\u7684\u53d1\u5c55\u901f\u5ea6\u548c\u53ef\u80fd\u66f4\u5927\u7684\u5e02\u573a\u524d\u666f\u3002ctDNA\u68c0\u6d4b\u4ee5\u57fa\u56e0\u7a81\u53d8\u6807\u5fd7\u7269\u4e3a\u4e3b\uff0c\u6309\u7167\u57fa\u56e0\u53ca\u4f4d\u70b9\u6570\u91cf\u5c42\u9762\uff0c\u4f9d\u6b21\u53ef\u4ee5\u9009\u62e9\u5c0fPanel\u3001\u5927Panel\u3001WES\u548cWGS\u7b49\uff1b\u9664\u4e86\u57fa\u56e0\u7a81\u53d8\uff0c\u7532\u57fa\u5316\u68c0\u6d4b\u8fd1\u5e74\u53d1\u5c55\u8f83\u5feb\uff08\u56fd\u5185\u670910\u4f59\u4e2a\u4ea7\u54c1\u83b7\u6279\uff09\uff1b\u7247\u6bb5\u5316\u7279\u5f81\u68c0\u6d4b\u662f\u8fd1\u5e74\u7684\u65b0\u5174\u6280\u672f\u3002\u00a0<\/p>\n<p>\u6839\u636e\u4e2d\u534e\u533b\u5b66\u4f1a\u68c0\u9a8c\u533b\u5b66\u5206\u4f1a\u3001\u56fd\u5bb6\u536b\u751f\u5065\u5eb7\u59d4\u5458\u4f1a\u4e34\u5e8a\u68c0\u9a8c\u4e2d\u5fc3\u5171\u540c\u5236\u5b9a\u7684\u300a\u6db2\u4f53\u6d3b\u68c0\u5728\u4e34\u5e8a\u80bf\u7624\u8bca\u7597\u5e94\u7528\u548c\u533b\u5b66\u68c0\u9a8c\u5b9e\u8df5\u4e2d\u7684\u4e13\u5bb6\u5171\u8bc6\u300b\uff0c\u5bf9\u4e8e\u68c0\u6d4b\u60a3\u8005ctDNA\u662f\u5426\u542b\u6709\u5df2\u77e5\u7684\u3001\u5355\u4e2a\u9776\u5411\u6cbb\u7597\u654f\u611f\u6216\u8010\u836f\u578b\u7a81\u53d8\u65f6\u5efa\u8bae\u4f7f\u7528ARMS\uff08\u6269\u589e\u963b\u6ede\u7a81\u53d8\u7cfb\u7edfPCR\uff09\uff1b\u68c0\u6d4b\u5df2\u77e5\u7684\u90e8\u5206\u6216\u5168\u90e8\u4e34\u5e8a\u836f\u7269\u6cbb\u7597\u9776\u70b9\u8c31\u6216\u8010\u836f\u6307\u793a\u9776\u70b9\u8c31\uff0c\u6216\u53d1\u73b0\u60a3\u8005\u57fa\u56e0\u672a\u77e5\u7a81\u53d8\u3001\u63a2\u7d22\u4e34\u5e8a\u4ef7\u503c\u4e0e\u76f8\u5173\u673a\u5236\u65f6\u5efa\u8bae\u4f7f\u7528NGS\u3002<\/p>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDkkd1iaVVCRZxDOWia6X7wiaYxuQvxkG4icqv6E8ziaes2FNWiauXb8ib2U41OY4wLWv4T8LI8NdSYcYoMg.png\" alt=\"RmFicvQBAkgDkkd1iaVVCRZxDOWia6X7wiaYxuQvxkG4icqv6E8ziaes2FNWiauXb8ib2U41OY4wLWv4T8LI8NdSYcYoMg\"\/><\/figure><\/div>\n\n<p>\u56fe\uff1a\u4e0d\u540c\u6db2\u4f53\u6d3b\u68c0\u65b9\u6cd5\u7684\u521d\u6b65\u6bd4\u8f83\uff08\u6765\u6e90\/\u57fa\u56e0\u6167\u6574\u7406\u81ea\u516c\u5f00\u8d44\u6599\uff09<\/p>\n<p>\u5176\u4ed6\u6db2\u4f53\u6d3b\u68c0\u65b9\u6cd5\u4e5f\u5728\u5feb\u901f\u53d1\u5c55\u4e2d\uff0c2021\u5e74NMPA\u6279\u51c6\u56fd\u5185\u9996\u5f20CTC\u4e09\u7c7b\u6ce8\u518c\u8bc1\u8bbe\u5907\u201cCytoSorter\u00ae\u5faa\u73af\u80bf\u7624\u7ec6\u80de\u68c0\u6d4b\u7cfb\u7edf\u201d\uff08\u57fa\u4e8e\u7eb3\u7c73\u5fae\u6d41\u63a7\u548c\u514d\u75ab\u6355\u83b7\uff09\uff0c\u76ee\u524d\u5c1a\u65e0\u5bf9\u5e94\u65e9\u7b5b\u8bd5\u5242\u76d2\u83b7\u6279\uff1b\u5916\u6ccc\u4f53\u662f\u4e00\u79cd\u7531\u6d3b\u7ec6\u80de\u5206\u6ccc\u5230\u7ec6\u80de\u5916\u7684\u5c0f\u56ca\u6ce1\uff08\u76f4\u5f84\u7ea6\u4e3a30-150nm\uff09\uff0c\u7531\u4e8e\u5176\u7ec4\u7ec7\u7279\u5f02\u6027\u4ee5\u53ca\u6d3b\u7ec6\u80de\u52a8\u6001\u4fe1\u606f\u53cd\u5e94\u7684\u654f\u611f\u6027\uff0c\u7406\u8bba\u4e0a\u80fd\u63d0\u9ad8\u9633\u6027\u9884\u6d4b\u503c\uff08PPV\uff09\u30022024\u5e741\u6708\u7531\u601d\u8def\u8fea\u8bca\u65ad\u7814\u53d1\u7684\u5916\u6ccc\u4f53\u5375\u5de2\u764c\u68c0\u6d4b\u8bd5\u5242\u76d2\u83b7\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u4e0a\u5e02\u3002\u6839\u636e\u601d\u8def\u8fea\u5b98\u65b9\u516c\u5e03\u7684\u56db\u4e2a\u4e34\u5e8a\u4e2d\u5fc3\u5f00\u5c55\u7684\u6ce8\u518c\u4e34\u5e8a\u7814\u7a76\u6570\u636e\u663e\u793a\uff0c\u5728\u4e0a\u76ae\u6027\u5375\u5de2\u764c\u548c\u9644\u4ef6\u826f\u6027\u5305\u5757\u7684\u9274\u522b\u8bca\u65ad\u4e2d\u7279\u5f02\u6027\u8fbe\u523090.2%\uff0c\u5728I\u671f\u5375\u5de2\u764c\u4e2d\u8bca\u65ad\u7684\u654f\u611f\u602789.7%\u3002\u00a0<\/p>\n<p>\u6839\u636e\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u533b\u7597\u5668\u68b0\u6280\u672f\u5ba1\u8bc4\u4e2d\u5fc32021 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\u4e07\u4f8b\u91d1\u9675\u961f\u5217\uff0c2024\u5e74\u534e\u5927\u57fa\u56e0\u4e0e\u54c8\u5c14\u6ee8\u5e02\u5408\u4f5c80\u4e07\u9002\u68c0\u4eba\u7fa4\u6d88\u5316\u7cfb\u7edf\u80bf\u7624\u53ca\u201c\u56db\u9ad8\u201d\u68c0\u6d4b\u7b49\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u4e09\u3001\u80bf\u7624\u4f34\u968f\u8bca\u65ad<\/p>\n<p>\uff08\u4e00\uff09\u9700\u6c42<\/p>\n<p>\u9776\u5411\u6cbb\u7597\u662f\u80bf\u7624\u6cbb\u7597\u4e2d\u9664\u4e86\u624b\u672f\u3001\u653e\u7597\u3001\u5316\u7597\u4e4b\u5916\u7684\u91cd\u8981\u65b9\u6cd5\u3002\u4e3a\u4e86\u7ed9\u4e34\u5e8a\u764c\u75c7\u60a3\u8005\u7b5b\u9009\u5b89\u5168\u6709\u6548\u7684\u9776\u5411\u6cbb\u7597\u65b9\u6848\uff0c\u4ee5\u53ca\u5728\u836f\u7269\u7814\u53d1\u4e2d\u7b5b\u9009\u5bf9\u7279\u5b9a\u65b9\u6848\u6709\u6548\u7684\u60a3\u8005\uff0c\u5373\u8bde\u751f\u4e86\u4f34\u968f\u8bca\u65ad\uff0c\u57fa\u4e8e\u751f\u7269\u6807\u8bb0\u7269\u8fdb\u884c\u4e2a\u6027\u5316\u8bca\u7597\u30022015-2019\u5e74\u95f4\uff0c\u6b27\u76df\u548c\u7f8e\u56fd\u6279\u51c6\u7684\u836f\u7269\u5e73\u5747\u670965%\u57fa\u4e8e\u751f\u7269\u6807\u5fd7\u7269\u8fdb\u884c\u7814\u53d1\uff0c\u4f34\u968f\u8bca\u65ad\u4ea7\u54c1\u5df2\u5728\u6211\u56fd\u5728\u5185\u7684\u591a\u4e2a\u56fd\u5bb6\u5730\u533a\u7eb3\u5165\u533b\u4fdd\u3002\u5305\u62ecFDA\u4ee5\u53caNMPA\u7b49\u673a\u6784\u5747\u53d1\u5e03\u4e86\u4e0e\u6297\u80bf\u7624\u836f\u7269\u540c\u6b65\u7814\u53d1\u7684\u4f34\u968f\u8bca\u65ad\u8bd5\u5242\u7684\u76f8\u5173\u89c4\u5b9a\u3002<\/p>\n<p>\uff08\u4e8c\uff09\u5b9a\u4e49<\/p>\n<p>\u4f34\u968f\u8bca\u65ad\uff08Companion Diagnostics, CDx\uff09\u4ece\u82f1\u6587\u76f4\u8bd1\u800c\u6765\uff0c\u5b57\u9762\u610f\u601d\u662f\u4f34\u968f\u7740\u6cbb\u7597\u65b9\u6848\u9009\u62e9\u8fdb\u884c\u7684\u8bca\u65ad; \u4ece\u4f5c\u7528\u4e0a\u8fd1\u4f3c\u4e8e\u7528\u836f\u6307\u5bfc\uff0c\u4ece\u57fa\u56e0\u7b49\u6807\u5fd7\u7269\u7b49\u4fe1\u606f\u6765\u786e\u5b9a\u60a3\u8005\u662f\u5426\u9002\u5408\u67d0\u79cd\u7279\u5b9a\u7684\u836f\u7269\u6216\u6cbb\u7597\u65b9\u6848\u3001\u53ef\u80fd\u7684\u526f\u4f5c\u7528\u4ee5\u53ca\u76d1\u6d4b\u6cbb\u7597\u53cd\u5e94\u3002\u5373\u5728\u5408\u9002\u7684\u65f6\u95f4\u4e3a\u5408\u9002\u7684\u60a3\u8005\u5728\u5408\u9002\u7684\u5242\u91cf\u4e0b\u4f7f\u7528\u5408\u9002\u7684\u836f\u7269\uff0c\u4e3a\u836f\u7269\u5b89\u5168\u6027\u53ca\u6709\u6548\u6027\u63d0\u4f9bIVD\u4fe1\u606f\u3002\u00a0<\/p>\n<p>\u4f34\u968f\u8bca\u65ad\u548c\u836f\u7269\u57fa\u56e0\u7ec4\u7c7b\u4f3c\uff0c\u4f46\u672c\u8d28\u4e0d\u540c\u3002\u4f34\u968f\u8bca\u65ad\u662f\u4e00\u79cd\u9009\u62e9\u6cbb\u7597\u65b9\u6848\u7684\u68c0\u6d4b\u624b\u6bb5\uff0c\u76f8\u5173\u68c0\u6d4b\u8bd5\u5242\u76d2\u4ea7\u54c1\u662f\u533b\u7597\u5668\u68b0\u3002\u836f\u7269\u57fa\u56e0\u7ec4\u7814\u7a76\u8303\u56f4\u66f4\u5e7f\uff0c\u7814\u7a76\u4e2a\u4f53\u57fa\u56e0\u5dee\u5f02\u5982\u4f55\u5f71\u54cd\u836f\u7269\u7684\u4f5c\u7528\uff0c\u5305\u62ec\u836f\u7269\u7684\u6709\u6548\u6027\u3001\u836f\u7269\u526f\u4f5c\u7528\u3001\u836f\u7269\u4ee3\u8c22\uff08\u4e0e\u8ba1\u91cf\u8c03\u6574\u6709\u5173\uff09\u7b49\u3002<\/p>\n<p>\u76ee\u524d\uff0c\u4e34\u5e8a\u6210\u719f\u5e94\u7528\u7684\u4f34\u968f\u8bca\u65ad\u6807\u5fd7\u7269\u5305\u62ecDNA\u7a81\u53d8\u3001\u57fa\u56e0\u878d\u5408\u3001PD-1\/PD-L1\uff1b\u521d\u6b65\u5e94\u7528\u7684\u7532\u57fa\u5316\u3001MSI\uff08\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\uff09\u3001TMB\uff08\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\uff09\u3001MRD\uff08\u5fae\u5c0f\u6b8b\u7559\u75c5\u7076\uff09\u3001HRD\uff08\u540c\u6e90\u91cd\u7ec4\u7f3a\u9677\uff09\u7b49\u3002<\/p>\n<p>\uff08\u4e09\uff09\u5e94\u7528<\/p>\n<p>\u5168\u7403\u9996\u4e2a\u4f34\u968f\u8bca\u65ad\u4ea7\u54c1\u57281998\u5e74\u83b7\u6279\u30022011-2013\u5e74\uff0c\u7f8e\u56fd\u3001\u65e5\u672c\u53ca\u6b27\u76df\u5206\u522b\u53d1\u5e03\u4f34\u968f\u8bca\u65ad\u76f8\u5173\u6307\u5357\uff0c\u6211\u56fd\u4e8e2020\u5e74\u53d1\u5e03\u9996\u4e2a\u4f34\u968f\u8bca\u65ad\u7684\u6307\u5bfc\u539f\u5219\u3002<\/p>\n<p>\u4f34\u968f\u8bca\u65ad\u4ea7\u54c1\u4e34\u5e8a\u51c6\u5165\u7684\u91cc\u7a0b\u7891<\/p>\n<p>1998 \u5e74\uff0cFDA \u6279\u51c6\u9996\u4e2a\u4f34\u968f\u8bca\u65ad\u8bd5\u5242\uff1aDako\u516c\u53f8(Roche)\u7684 Herceptest\uff1b<\/p>\n<p>2011 \u5e74\uff0cFDA\u53d1\u5e03\u300a\u4f53\u5916\u4f34\u968f\u8bca\u65ad\u8bd5\u5242\u6307\u5bfc\u539f\u5219(\u8349\u6848)\u300b\u300b\u5e76\u4e8e2014\u5e74\u6b63\u5f0f\u53d1\u5e03\uff1bFDA\u6279\u51c6\u9996\u4e2a\u57fa\u4e8e PCR \u7684 CDx\uff1a\u7f57\u6c0f\u8bca\u65ad\u7684 cobas 4800 BRAF V600 \u7a81\u53d8\u68c0\u6d4b\uff1b<\/p>\n<p>2013\u5e74,\u65e5\u672c\u836f\u54c1\u548c\u533b\u7597\u5668\u68b0\u7ba1\u7406\u5c40(PMDA) \u53d1\u5e03\u300a\u4f34\u968f\u8bca\u65ad\u8bd5\u5242\u4e0e\u836f\u7269\u7533\u8bf7\u5ba1\u6279\u901a\u77e5\u300b\u3002\u622a\u81f32024\u5e745\u670817\u65e5\u6279\u51c6\u4e86\u9488\u5bf940\u79cd\u75be\u75c5\u53ca\u75c5\u75c7\u7684CDx\u4ea7\u54c1\uff0c\u4ea7\u54c1\u6765\u81eaRoche\u3001Myriad\u3001FMI\u3001Guardant Health\u7b49\u673a\u6784\uff1b<\/p>\n<p>2016 \u5e74\uff0cFDA \u6279\u51c6\u9996\u4e2a\u57fa\u4e8e NGS \u7684\u4f34\u968f\u8bca\u65ad\u4ea7\u54c1\uff1aFMI\u7684 FoundationFocus CDxBRCA \uff1b<\/p>\n<p>2017\u5e74\uff0c\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40(EMA)\u5728\u65b0\u7248\u4f53\u5916\u8bca\u65ad\u8bd5\u5242\u6cd5\u89c4\uff082017\/746\/EU\uff09\u9996\u6b21\u660e\u786eCDx\u7684\u5b9a\u4e49\uff08\u4e4b\u524d\u4ee5CE\u8ba4\u8bc1\u6d41\u901a\uff09\uff0c\u57282022\u5e74\u6b63\u5f0f\u5b9e\u65bd\u540e\uff082022-2024\u9646\u7eed\u66f4\u65b0\uff09\u6279\u51c6\u9996\u4e2aCDx\uff1b<\/p>\n<p>2017 \u5e74\uff0cFDA \u6279\u51c6\u9996\u4e2a\u6cdb\u764c\u79cd(\u8986\u76d6\u6240\u6709\u5b9e\u4f53\u7624)\u5927 Panel \u4f34\u968f\u8bca\u65ad\u8bd5\u5242\uff1aFoundationOne CDx (F1CDx) (324 \u4e2a\u57fa\u56e0\u7684\u7a81\u53d8\u3001\u878d\u5408\u3001MSI\u3001TMB)\uff1b<\/p>\n<p>2018 \u5e74 1 \u6708\uff0c\u6211\u56fd\u9996\u4e2a\u4f34\u968f\u8bca\u65ad\u4ea7\u54c1\u83b7\u6279\uff1a\u827e\u5fb7\u751f\u7269\u7684 Super-ARMS\u00aeEGFR(\u57fa\u4e8e PCR);<\/p>\n<p>2018 \u5e74 7 \u6708\uff0c\u6211\u56fd\u9996\u4e2a\u57fa\u4e8eNGS\u6280\u672f\u7684\u80bf\u7624\u4f34\u968f\u8bca\u65ad\u4ea7\u54c1\u83b7\u6279\uff1a\u71c3\u77f3\u533b\u5b66\u7684\u4eba EGFR\/ALK\/ BRAF\/KRAS \u57fa\u56e0\u7a81\u53d8\u8054\u5408\u68c0\u6d4b(\u53ef\u9006\u672b\u7aef\u7ec8\u6b62\u6d4b\u5e8f\u6cd5);<\/p>\n<p>2018 \u5e74 11 \u6708\uff0c\u6211\u56fd\u9996\u4e2a NGS \u6cdb\u80bf\u7624\u4f34\u968f\u8bca\u65ad\u83b7\u6279\uff1a\u827e\u5fb7\u751f\u7269\u7684\u4eba\u7c7b10\u57fa\u56e0\u7a81\u53d8\u8054\u5408\u68c0\u6d4b\u8bd5\u5242\u76d2(\u53ef\u9006\u672b\u7aef\u7ec8\u6b62\u6d4b\u5e8f\u6cd5)\uff1b<\/p>\n<p>2019 \u5e74 6 \u6708\uff0c\u5317\u4eac\u5e02\u5c06\u4f34\u968f\u8bca\u65ad\u9879\u76ee\u7eb3\u5165\u4e59\u7c7b\u533b\u4fdd;<\/p>\n<p>2019 \u5e74 8 \u6708\uff0c\u6211\u56fd\u9996\u4e2a PD-1 \u5355\u6297\u4f34\u968f\u8bca\u65ad\u83b7\u6279\uff1a\u7f57\u6c0f\u8bca\u65ad\u7684 PD-L1 IHC 22C3 pharmDx;<\/p>\n<p>2020\u5e74 8\u6708\uff0cFDA\u6279\u51c6\u9996\u4e2a\u57fa\u4e8eNGS\u6280\u672f\u7684\u6db2\u4f53\u6d3b\u68c0\u4f34\u968f\u8bca\u65ad\u4ea7\u54c1\uff1aGuardant 360 CDx\uff1b<\/p>\n<p>2020\u5e74 8\u6708\uff0c\u6211\u56fd\u56fd\u5bb6\u836f\u76d1\u5c40\u533b\u7597\u5668\u68b0\u6280\u672f\u5ba1\u8bc4\u4e2d\u5fc3(CDME)\u53d1\u5e03\u9996\u4e2a\u4f34\u968f\u8bca\u65ad\u7684\u6307\u5bfc\u539f\u5219\u300a\u5df2\u4e0a\u5e02\u6297\u80bf\u7624\u836f\u7269\u7684\u4f34\u968f\u8bca\u65ad\u8bd5\u5242\u4e34\u5e8a\u8bd5\u9a8c\u6307\u5bfc\u539f\u5219(\u5f81\u6c42\u610f\u89c1\u7a3f)\u300b;<\/p>\n<p>2021 \u5e74 11 \u6708\uff0c\u6211\u56fdCMDE\u53d1\u5e03\u300a\u6297\u80bf\u7624\u836f\u7269\u7684\u975e\u539f\u7814\u4f34\u968f\u8bca\u65ad\u8bd5\u5242\u4e34\u5e8a\u8bd5\u9a8c\u6ce8\u518c\u5ba1\u67e5\u6307\u5bfc\u539f\u5219\u300b\u548c\u300a\u4f7f\u7528\u4f53\u5916\u8bca\u65ad\u8bd5\u5242\u5883\u5916\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u7684\u6ce8\u518c\u5ba1\u67e5\u6307\u5bfc\u539f\u5219\u300b;<\/p>\n<p>2022 \u5e74 3 \u6708\uff0c\u6211\u56fd\u6279\u51c6\u9996\u4e2a\u56fd\u4ea7 PD-L1 \u68c0\u6d4b\u8bd5\u5242\u76d2\uff08\u514d\u75ab\u6cbb\u7597\u836f\u7269\u4f34\u968f\u8bca\u65ad\uff09: \u827e\u5fb7\u751f\u7269\u7684\u201cPD-L1\u6297\u4f53\u8bd5\u5242\uff08\u514d\u75ab\u7ec4\u7ec7\u5316\u5b66\u6cd5\uff09\u201d\uff1b<\/p>\n<p>2022 \u5e74 6 \u6708\uff0c\u6211\u56fdCMDE \u53d1\u5e03\u300a\u4e0e\u6297\u80bf\u7624\u836f\u7269\u540c\u6b65\u7814\u53d1\u7684\u539f\u7814\u4f34\u968f\u8bca\u65ad\u8bd5\u5242\u4e34\u5e8a\u8bd5\u9a8c\u6ce8\u518c\u5ba1\u67e5\u6307\u5bfc\u539f\u5219\u300b\u3002<\/p>\n<p>\u6839\u636e\u77e5\u540d\u57fa\u56e0\u4ea7\u4e1a\u54a8\u8be2\u673a\u6784\u57fa\u56e0\u6167\u7edf\u8ba1\uff0c\u622a\u81f32024\u5e745\u67081\u65e5FDA\u5171\u6279\u51c661\u4e2a\u4f34\u968f\u8bca\u65ad\u4ea7\u54c1\uff0c\u5bf9\u5e9471\u79cd\u836f\u7269\uff08\u53ca\u7ec4\u5408\uff09\u548c31\u79cd\u764c\u79cd\uff08\u540c\u7c7b\u5408\u5e76\uff09\uff0c\u524d\u4e94\u5927\u764c\u79cd\u662f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u4e73\u817a\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u9ed1\u8272\u7d20\u7624\u548c\u6025\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\u7b49\uff1b\u524d\u4e94\u5927\u751f\u7269\u6807\u8bb0\u7269\u662fEGFR\u3001HER2\u3001BRAF\u3001KRAS \u548cPD-L1 \u3002<\/p>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDkkd1iaVVCRZxDOWia6X7wiaYLLwbgXhuicPGa13txr3qxSpGb5nrEt47y8yc3nG8pwxIBvCHfibc9QOw.png\" alt=\"RmFicvQBAkgDkkd1iaVVCRZxDOWia6X7wiaYLLwbgXhuicPGa13txr3qxSpGb5nrEt47y8yc3nG8pwxIBvCHfibc9QOw\"\/><\/figure><\/div>\n\n<p style=\"text-align: center;\">\u56fe\uff1a\u622a\u81f32024\u5e745\u67081\u65e5FDA\u6279\u51c6\u7684\u4f34\u968f\u8bca\u65ad\u8bd5\u5242\u7684\u764c\u79cd\uff08\u4e0a\u56fe\uff09\u53ca\u6807\u8bb0\u7269\uff08\u4e0b\u56fe\uff09\u7edf\u8ba1\uff08\u6765\u6e90\/\u57fa\u56e0\u6167\u6839\u636e\u516c\u5f00\u6570\u636e\u5236\u56fe\uff09<\/p>\n<p>\u4f34\u968f\u8bca\u65ad\u7684\u5f00\u53d1\u65b9\u6cd5\u5305\u62ec\u540c\u6b65\uff08Co-development\uff09\u548c\u6865\u63a5\uff08Bridging\uff09\u4ee5\u53ca\u8ddf\u968f\uff08follow-on\uff09\u3002\u4f34\u968f\u8bca\u65ad\u4f01\u4e1a\u4e0e\u836f\u4f01\u901a\u8fc7\u540c\u6b65\u7814\u53d1\u5b9e\u73b0\u66f4\u7ecf\u6d4e\u7684\u540c\u65f6\u83b7\u6279\uff0c\u8fd9\u4e5f\u662f\u76ee\u524d\u76d1\u7ba1\u90e8\u95e8\u9f13\u52b1\u7684\uff0c\u4f46\u8d39\u7528\u4ee5\u53ca\u6837\u672c\u8981\u6c42\u9ad8\uff1b\u5982\u679c\u6ca1\u6709\u6ce8\u518c\u8fdb\u5ea6\u5b8c\u5168\u5339\u914d\u7684\u4f34\u968f\u8bca\u65ad\u7814\u53d1\uff0c\u901a\u5e38\u662f\u91c7\u7528CTA\uff08Clinical Trial Assay\uff09\u7b5b\u9009\u5165\u7ec4\uff0c\u901a\u8fc7\u6865\u63a5\u65b9\u5f0f\u5f00\u53d1\uff0c\u6765\u8bc4\u4f30\u836f\u7269\u5728CDx\u5b9a\u4e49\u7684\u4eba\u7fa4\u4e2d\u7684\u836f\u6548\uff0c\u590d\u6742\u5ea6\u66f4\u9ad8\uff0c\u6837\u672c\u91cf\u8981\u6c42\u5927\u3002\u66f4\u7ec6\u5206\u7684\u60c5\u51b5\uff0c\u53ef\u4ee5\u5206\u4e3a\u4ee5\u4e0b\u56db\u79cd\u5f00\u53d1\u7b56\u7565\u3002\u00a0<\/p>\n<p>\u5728\u7f8e\u56fd\u3001\u6b27\u76df\u53ca\u6fb3\u5927\u5229\u4e9a\u7b49\u56fd\u5bb6\uff0c\u901a\u5e38\u628a\u4f34\u968f\u8bca\u65ad\uff08CDx\uff09\u5f52\u7c7b\u4e3aIII\u7c7bIVD\uff0cCDx\u4ea7\u54c1\u4e0e\u76f8\u5173\u836f\u7269\u540c\u65f6\u5f00\u53d1\u6ce8\u518c\uff0c\u6bd4\u5728\u836f\u7269\u6279\u51c6\u540e\u6ce8\u518c\u7684\u65f6\u95f4\u66f4\u77ed\u3002\u65e5\u672c\u628aCDx\u5f52\u7c7b\u4e3aII\u7c7b\u6216III\u7c7b\u533b\u7597\u5668\u68b0\uff0c\u6ce8\u518c\u65f6\u95f4\u5927\u7ea6\u662f9\u4e2a\u6708\uff0c\u57fa\u672c\u90fd\u53ef\u4ee5\u62a5\u9500\u3002<\/p>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDkkd1iaVVCRZxDOWia6X7wiaYS8O9HeV3j6bYyHso2OQgEKqlENXALyp0ibotfty5O2IadKC1icEqqFwQ.png\" alt=\"RmFicvQBAkgDkkd1iaVVCRZxDOWia6X7wiaYS8O9HeV3j6bYyHso2OQgEKqlENXALyp0ibotfty5O2IadKC1icEqqFwQ\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe\uff1a\u6b27\u6d32\u4f34\u968f\u8bca\u65ad\u4e0e\u836f\u7269\u5f00\u53d1\u4e4b\u95f4\u7684\u5468\u671f\u5173\u8054\uff08\u6765\u6e90\/ DOI: 10.1002\/cpt.2928\uff09<\/div>\n<div>\u00a0<\/div>\n<p>\uff08\u56db\uff09\u6280\u672f<\/p>\n<p>\u4e0d\u540c\u6280\u672f\u5404\u6709\u4f18\u52a3\uff0c\u901a\u5e38\u6839\u636e\u751f\u7269\u6807\u5fd7\u7269\u7684\u7c7b\u578b\u3001\u6210\u672c\u3001\u5468\u671f\u7b49\u9009\u62e9\u4e0d\u540c\u7684\u4f34\u968f\u8bca\u65ad\u6280\u672f\u5e73\u53f0\u3002\u9488\u5bf9\u86cb\u767d\u8d28\u751f\u7269\u5927\u5206\u5b50\u7684\u4f34\u968f\u8bca\u65ad\u6280\u672f\u5e73\u53f0\u4e3b\u8981\u662f\u514d\u75ab\u7ec4\u5316\uff08Immunohistochemistry\uff0cIHC\uff09\u3001\u6d41\u5f0f\u7ec6\u80de\u3001\u5316\u5b66\u53d1\u5149\u7b49\uff1b\u9488\u5bf9\u57fa\u56e0\u7b49\u5c0f\u5206\u5b50\u7684\u4f34\u968f\u8bca\u65ad\u5e73\u53f0\u5305\u62ec\u8367\u5149\u539f\u4f4d\u6742\u4ea4\uff08Fluorescence In Situ Hybridization\uff0cFISH\uff09\u3001PCR\u548cNGS\u7b49\uff0c\u6b64\u5916\uff0cSanger\u6d4b\u5e8f\u3001\u5355\u5206\u5b50\u6d4b\u5e8f\u3001\u5355\u7ec6\u80de\u6d4b\u5e8f\u7b49\u65b0\u5174\u6280\u672f\u4e5f\u6709\u76f8\u5e94\u7684\u5e94\u7528\u3002\u672c\u7ae0\u8282\u4ee5\u9488\u5bf9\u57fa\u56e0\u6807\u8bb0\u7269\u4e3a\u4e3b\u8fdb\u884c\u5206\u6790\u3002<\/p>\n<p>\u5728\u83b7\u6279\u7684\u4f34\u968f\u8bca\u65ad\u4ea7\u54c1\u4e2d\uff0c\u8f83\u5e38\u7528\u7684\u6280\u672f\u5e73\u53f0\u662fPCR\uff0cFDA\u76f4\u52302020\u5e74\u624d\u6279\u51c6\u9996\u4e2aNGS\u6db2\u4f53\u6d3b\u68c0\u4f34\u968f\u8bca\u65ad\u4ea7\u54c1\uff0c\u4f46NGS\u4ee5\u9ad8\u901a\u91cf\u548c\u65b0\u57fa\u56e0\u53d1\u73b0\u7b49\u7279\u70b9\u800c\u4ee5\u9010\u5e74\u589e\u52a0\u6bd4\u4f8b\u88ab\u91c7\u7528\u3002\u6839\u636e\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u533b\u7597\u5668\u68b0\u6280\u672f\u5ba1\u8bc4\u4e2d\u5fc3\uff0c\u57fa\u4e8eNGS\u68c0\u6d4b\u4ebaFFPE\u7ec4\u7ec7\u6837\u672c\u7684\u80bf\u7624\u57fa\u56e0\u53d8\u5f02\u68c0\u6d4b\u4f34\u968f\u8bca\u65ad\u8bd5\u5242\uff0c\u68c0\u6d4b\u7684\u53d8\u5f02\u57fa\u56e0\u53ca\u4f4d\u70b9\u4e3b\u8981\u5305\u62ec\u4e24\u7c7b\uff1a\u6309\u7167\u76f8\u5173\u6307\u5bfc\u539f\u5219\u5177\u6709\u4f34\u968f\u8bca\u65ad\u4e34\u5e8a\u8bc1\u636e\u7684\u4e3a\u4e00\u7ea7\u4f4d\u70b9\uff1b\u5c1a\u65e0\u660e\u786e\u4f34\u968f\u8bca\u65ad\u610f\u4e49\uff0c\u4f46\u56fd\u5185\u5916\u6743\u5a01\u6307\u5357\u660e\u786e\u5730\u4e2d\u63d0\u51fa\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u4e14\u4e34\u5e8a\u533b\u751f\u53ef\u5e94\u7528\u7684\u4e3a\u4e8c\u7ea7\u4f4d\u70b9\u3002\u4e0e\u6297\u80bf\u7624\u836f\u7269\u540c\u6b65\u5f00\u53d1\u7684\u4e14\u5177\u6709\u4e34\u5e8a\u8bd5\u9a8c\u8bc1\u636e\u7684\u4e3a\u4e8c\u7ea7\u4f4d\u70b9\uff0c\u836f\u7269\u4e0a\u5e02\u540e\u53d8\u66f4\u4e3a\u4e00\u7ea7\u4f4d\u70b9\u3002\u9488\u5bf9\u8840\u6d46\u7b49\u6e38\u79bbDNA\u68c0\u6d4b\u7684\u4f34\u968f\u8bca\u65ad\u8bd5\u5242\u65e0\u660e\u786e\u89c4\u5b9a\u3002<\/p>\n<p>\uff08\u4e94\uff09\u4ea7\u4e1a<\/p>\n<p>\u80bf\u7624\u4f34\u968f\u8bca\u65ad\u4ee5\u201cLDT+IVD\u201d\u8054\u5408\u7684\u5f62\u5f0f\u5f00\u5c55\u4e1a\u52a1\u5408\u4f5c\uff0c\u4e3b\u8981\u6e20\u9053\u662f\u533b\u9662\u53ca\u836f\u4f01\u3002\u4e0e\u80bf\u7624\u65e9\u7b5b\u4fa7\u91cd\u4e8e LDT \u6a21\u5f0f\u4e0d\u540c\u7684\u662f\uff0c\u7531\u4e8e\u4f34\u968f\u8bca\u65ad\u7684\u836f\u7269\u7597\u6548\u8bc4\u4f30\u7528\u9014\u4ee5\u53ca\u5728\u7814\u53d1\u53ca\u6ce8\u518c\u4e0a\u8f83\u4e3a\u6210\u719f\uff0c\u76ee\u524d\u5728\u9662\u7aef\u4fa7\u91cdIVD\u6a21\u5f0f\uff0c\u548c\u836f\u4f01\u5408\u4f5c\u7684\u4e3b\u8981\u65b9\u5411\u4e5f\u662f\u57fa\u4e8eIVD\u7684\u7814\u53d1\u53ca\u6ce8\u518c\u8def\u5f84\u3002\u5728\u4ea7\u54c1\u672a\u53d6\u5f97\u6ce8\u518c\u5236\u8bc1\u524d\u91c7\u7528LDT\u6a21\u5f0f\uff0c\u5f53\u4e0b\u8fd9\u79cd\u60c5\u51b5\u5c45\u591a\u3002\u00a0<\/p>\n<p>\u57fa\u4e8e\u5546\u4e1a\u6a21\u5f0f\uff0c\u4f34\u968f\u8bca\u65ad\u7684\u652f\u4ed8\u65b9\u4e3b\u8981\u662f\u9662\u7aef\u60a3\u8005\u53ca\u836f\u4f01\uff0c\u548c\u533b\u4fdd\u6709\u8f83\u5927\u5173\u8054\u3002\u76ee\u524d\u6211\u56fd\u4e3b\u8981\u4ec5\u4ee5\u5317\u4eac\u4e3a\u4ee3\u8868\u7684\u57ce\u5e02\u5c06\u80bf\u7624\u57fa\u56e0\u68c0\u6d4b\u7eb3\u5165\u533b\u4fdd\uff08\u57fa\u4e8ePCR\u6280\u672f\uff09\u3002\u540c\u65f6\u6211\u4eec\u770b\u5230\uff0c\u56fd\u5bb6\u536b\u5065\u59d4\u9881\u5e03\u7684\u300a\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u6307\u5bfc\u539f\u5219\uff082018\u5e74\u7248\uff09\u300b\u660e\u786e\u6307\u51fa\uff1a\u5bf9\u4e8e\u6709\u660e\u786e\u9776\u70b9\u7684\u836f\u7269\uff0c\u987b\u9075\u5faa\u57fa\u56e0\u68c0\u6d4b\u540e\u65b9\u53ef\u4f7f\u7528\u7684\u539f\u5219\u3002\u4ee5\u80ba\u764c\u4e3a\u4f8b\uff0c\u76ee\u524d\u56fd\u5185\u4e0a\u5e02\u7684\u9488\u5bf9\u80ba\u764c\u7684\u9a71\u52a8\u57fa\u56e0 EGFR\u3001ALK\u3001ROS1\u3001BRAF \u7684\u9776\u5411\u836f\u7269\u5747\u88ab\u7eb3\u5165\u533b\u4fdd\u62a5\u9500\u8303\u56f4\u4e4b\u5185\u3002\u8fd9\u5bf9\u4e8e\u4f34\u968f\u8bca\u65ad\u7684\u5f00\u53d1\u548c\u7eb3\u5165\u533b\u4fdd\u5177\u6709\u79ef\u6781\u7684\u4fc3\u8fdb\u4f5c\u7528\u3002<\/p>\n<p>\u5728\u6d77\u5916\uff0c\u65e5\u672c\u5bf9Myriad BRACAnalysis\u548cFoundationOne\u7b49\u4ea7\u54c1\u7eb3\u5165\u62a5\u9500\uff0c\u5176\u4e2dMyriad BRACAnalysis\u53ef\u62a5\u9500202,000\u65e5\u5143\u3002\u6211\u56fd\u4f01\u4e1a\u827e\u5fb7\u751f\u7269\u7684\u80ba\u764cROS1\u57fa\u56e0\u68c0\u6d4b\u4f34\u968f\u8bca\u65ad\u4ea7\u54c1\u81ea2017\u5e74\u7eb3\u5165\u65e5\u672c\u533b\u4fdd\u3002\u7f8e\u56fd\u4e8e2017\u5e74\u6279\u51c6FMI\u7684F1CDx\u7684\u540c\u65f6\u7eb3\u5165\u533b\u4fdd\uff0cCMS\u660e\u786e\u7c7b\u4f3cIVD\u7eb3\u5165\u533b\u4fdd\u7684\u4ea7\u54c1\u9002\u7528\u4e8e\u60a3\u6709\u665a\u671f\u764c\u75c7(\u5373\u590d\u53d1\uff0c\u8f6c\u79fb\u6216\u665a\u671fIV\u671f\u764c\u75c7)\u4e14\u5bfb\u6c42\u8fdb\u4e00\u6b65\u6cbb\u7597\u7684\u53d7\u76ca\u4eba\u3002\u5728\u6b27\u6d32\uff0c\u9664\u4e86\u6bd4\u5229\u65f6\u3001\u6fb3\u5927\u5229\u4e9a\u6709\u660e\u786e\u7684\u62a5\u9500\u653f\u7b56\uff08CDx\u4e0e\u836f\u7269\u540c\u65f6\u62a5\u9500\uff09\uff0c\u5927\u591a\u6570\u6b27\u6d32\u56fd\u5bb6\u7684CDx\u533b\u4fdd\u653f\u7b56\u4ecd\u5728\u63a8\u8fdb\u4e2d\u3002\u00a0<\/p>\n<p>\u4f34\u968f\u8bca\u65ad\u9886\u57df\u4ee3\u8868\uff08\u4ee5\u4ea7\u54c1\u83b7\u8bc1\u4e3a\u4e3b\uff09\u7684\u56fd\u5916\u4f01\u4e1a\u5305\u62ecFMI\uff08Roche\uff09\uff0cGuardant Health\uff0cMyriad\u3001Dako\u3001Qiagen\u3001Abbott\u3001Ventana\u7b49\uff0c\u56fd\u5185\u4ee3\u8868\u4f01\u4e1a\u5305\u62ecNGS\u9886\u57df\u7684\u71c3\u77f3\u533b\u5b66\u3001\u5409\u56e0\u52a0\u3001\u6cdb\u751f\u5b50\u3001\u4e16\u548c\u57fa\u56e0\u3001\u6850\u6811\u57fa\u56e0\u3001\u6d77\u666e\u6d1b\u65af\u3001\u5143\u7801\u57fa\u56e0\u7b49\uff1bPCR\u9886\u57df\u7684\u827e\u5fb7\u751f\u7269\u3001\u4e3a\u771f\u751f\u7269\u3001\u900f\u666f\u751f\u547d\u3001\u98de\u6714\u751f\u7269\u7b49\u3002\u5728\u4e1a\u7ee9\u8868\u73b0\u4e0a\uff0c\u4ee5\u7f57\u6c0f\u8bca\u65ad\u4e3a\u4f8b\uff0c2023\u5e74\u5728\u75c5\u7406\u8bca\u65ad\u9886\u57df\u8425\u6536\u589e\u957f14%\uff0c\u6bd4\u6574\u4f53\u8425\u6536\u589e\u957f\u7387\u591a8\u4e2a\u767e\u5206\u70b9\uff0c\u589e\u957f\u4e3b\u8981\u6765\u81ea\u4f34\u968f\u548c\u9ad8\u7ea7\u67d3\u8272\u4e1a\u52a1\u7684\u589e\u957f\u3002\u71c3\u77f3\u533b\u5b66\u76842024\u5e74\u7b2c\u4e00\u5b63\u5ea6\u7684\u8d22\u62a5\u663e\u793a\uff0c\u5728\u836f\u4f01\u5408\u4f5c\u4e1a\u52a1\u4e0a\u7684\u8425\u65362060\u4e07\u5143\uff08\u540c\u6bd4\u4e0b\u964d29%\uff09\uff0c\u65b0\u5408\u540c\u7b7e\u7ea6\u989d\u8fbe\u52302.18\u4ebf\u5143\uff08\u540c\u6bd4\u589e\u957f190%\uff09\uff0c\u53cd\u6620\u4e86\u80bf\u7624\u4f34\u968f\u8bca\u65ad\u9886\u57df\u7684\u8f83\u5927\u589e\u957f\u6f5c\u529b\u3002<\/p>\n<p>\u5728\u80bf\u7624\u4f34\u968f\u8bca\u65ad\u9886\u57df\uff0c\u672a\u6765\u5efa\u8bae\u5173\u6ce8\u4ee5\u4e0b\u65b9\u9762\u3002<\/p>\n<p>\u6280\u672f\u5c42\u9762\uff1a\u9700\u8981\u8fdb\u4e00\u6b65\u89c4\u8303\u5404\u9879\u6280\u672f\u7684\u8bc1\u636e\u4f18\u5148\u7a0b\u5ea6\u3001\u751f\u7269\u6807\u8bb0\u7269\u7684\u9608\u503c\uff0c\u6765\u63d0\u9ad8\u4f34\u968f\u8bca\u65ad\u4ea7\u54c1\u5728\u4e34\u5e8a\u4e0a\u7684\u901a\u7528\u6027\u3002\u5efa\u8bae\u5173\u6ce8\u7684\u65b0\u5174\u4f34\u968f\u8bca\u65ad\u6280\u672f\uff1a\u6570\u5b57PCR\u3001\u51b0\u51bb\u514d\u75ab\u7ec4\u5316\u3001\u591a\u91cd\u8367\u5149\u514d\u75ab\u7ec4\u5316\u3001\u8d28\u8c31\u6d41\u5f0f\u3001\u5355\u7ec6\u80de\u6d4b\u5e8f\u7b49\u3002\u00a0<\/p>\n<p>\u6a21\u5f0f\u5c42\u9762\uff1a\u5efa\u8bae\u4e34\u5e8a\u673a\u6784\u52a0\u5927\u91cd\u89c6\u751f\u7269\u6807\u5fd7\u7269\u7b49\u65b0\u5174\u6280\u672f\u7684\u63a8\u5e7f\uff0c\u76f8\u5173\u673a\u6784\u52a0\u5927\u533b\u7814\u4f01\u7684\u5bf9\u8bdd\u548c\u878d\u5408\u7b49\u3002\u6839\u636e2020\u5e74\u4e00\u9879\u9488\u5bf9\u65b0\u8bca\u65ad\u7684\u665a\u671fNSCLC\u60a3\u8005\u7684\u5927\u6837\u672c\u7814\u7a76\u53d1\u73b0\uff0c\u8d85\u8fc71\/5\u60a3\u8005\u5728\u4e00\u7ebf\u6cbb\u7597\u524d\u672a\u63a5\u53d7\u6307\u5357\u63a8\u8350\u7684\u9776\u70b9\u57fa\u56e0\u68c0\u6d4b\uff0c\u800c\u73b0\u6210\u7684\u9776\u5411\u836f\u6cbb\u7597\u65b9\u6848\u53ef\u4ee5\u8986\u76d6\u8d85\u8fc73\/5\u7684\u665a\u671fNSCLC\u60a3\u8005\u3002\u00a0<\/p>\n<p>\u5236\u5ea6\u5c42\u9762\uff1a\u5efa\u8bae\u8fdb\u4e00\u6b65\u51fa\u53f0\u4fc3\u8fdb\u9776\u5411\u836f\u7684\u7814\u53d1\u7684\u6cd5\u89c4\uff0c\u589e\u52a0\u80bf\u7624\u60a3\u8005\u66f4\u591a\u53ef\u6cbb\u7597\u65b9\u6848\u7684\u9009\u9879\uff1b\u9f13\u52b1\u4f01\u4e1a\u8054\u5408\u533b\u9662\u6216\u7275\u5934LDT\uff0c\u4e3a\u4e34\u5e8a\u533b\u751f\u63d0\u4f9b\u63d0\u4f9b\u66f4\u591a\u5143\u3001\u7cbe\u51c6\u7684\u5206\u5b50\u68c0\u6d4b\u4fe1\u606f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u56db\u3001MRD\u68c0\u6d4b<\/p>\n<p>MRD\u6709\u65f6\u4e5f\u88ab\u5f52\u4e3a\u4f34\u968f\u8bca\u65ad\uff0c\u4f46\u7531\u4e8e\u5728\u590d\u53d1\u76d1\u6d4b\u7684\u72ec\u7279\u4ef7\u503c\u6210\u4e3a\u8fd1\u5e74\u70ed\u95e8\uff0c\u6545\u5355\u72ec\u9610\u8ff0\u3002<\/p>\n<p>\uff08\u4e00\uff09\u9700\u6c42<\/p>\n<p>MRD\u662f\u5bfc\u81f4\u80bf\u7624\u590d\u53d1\u7684\u4e3b\u8981\u539f\u56e0\u4e4b\u4e00\uff0c\u53ef\u4ee5\u901a\u8fc7ctDNA\u7b49\u5206\u5b50\u6807\u8bb0\u7269\u8fdb\u884c\u65e9\u671f\u76d1\u6d4b\uff0c\u662f\u8840\u6db2\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u4e34\u5e8a\u5e38\u7528\u68c0\u6d4b\u624b\u6bb5\uff0c\u8fd1\u5e74\u5ef6\u4f38\u5230\u5b9e\u4f53\u7624\u5e94\u7528\u7684\u63a2\u7d22\u3002<\/p>\n<p>\u00a02017\u5e74\uff0c\u65af\u5766\u798f\u5927\u5b66Maximilian Diehn\u5728Cancer Discovery\u4e0a\u53d1\u5e03\u7684\u7814\u7a76\u6210\u679c\u663e\u793a\uff0c\u572894%\u7684\u53ef\u8bc4\u4f30\u7684\u80ba\u764c\u590d\u53d1\u60a3\u8005\u4e2d\uff0c\u57fa\u4e8ectDNA\u7684MRD\u5728\u7b2c1\u6b21\u6cbb\u7597\u540e\u7684\u8840\u6837\u4e2d\u5c31\u88ab\u68c0\u6d4b\u51fa\u6765\uff0c\u901a\u8fc7MRD\u68c0\u6d4b\u53d1\u73b072%\u60a3\u8005\uff0c\u6bd4\u5f71\u50cf\u5b66\u68c0\u67e5\u5e73\u5747\u63d0\u524d\u7ea6 5.2 \u4e2a\u6708\uff08PMID: 28899864\uff09\uff1b2022\u5e74\u534e\u897f\u533b\u9662\u8054\u5408\u53d1\u8d77\u7684\u80ba\u764c\u9884\u540e\u524d\u77bb\u961f\u5217\u7814\u7a76LUNGCA\u663e\u793a\uff0c\u672f\u540e\u5173\u952e\u70b9MRD\u68c0\u6d4b\u5bf9RFS\u9884\u6d4b\u7684\u76f8\u5bf9\u8d21\u732e\u5ea6\u9ad8\u4e8eTNM\u5206\u671f\u7b49\u4e34\u5e8a\u53d8\u91cf\u7684\u603b\u548c\uff0c\u957f\u671f\u76d1\u6d4bMRD\u76f8\u8f83\u4e8e\u4f20\u7edf\u5f71\u50cf\u5b66\u63d0\u524d273\u5929\u53d1\u73b0\u590d\u53d1\uff0c\u6cbb\u7597\u540e\u76d1\u6d4b\u671fctDNA MRD\u9633\u6027\u9884\u6d4b\u503c\u4e3a100%\uff0c\u9634\u6027\u9884\u6d4b\u503c\u4e3a91.8%\u3002\u00a0<\/p>\n<p>\uff08\u4e8c\uff09\u5b9a\u4e49<\/p>\n<p>MRD \u6307\u5fae\u5c0f\u6b8b\u7559\u75c5\u7076(Minimal Residual Disease)\uff0c\u4e5f\u88ab\u79f0\u4e4b\u4e3a\u5206\u5b50\u6b8b\u7559\u75c5\u7076(Molecular Residual Disease)\u6216\u53ef\u6d4b\u91cf\u6b8b\u7559\u75c5\u7076(Measurable Residual Disease)\uff0c\u662f\u6307\u7ecf\u8fc7\u6cbb\u7597\u540e\uff0c\u5f71\u50cf\u5b66\u6216\u4f20\u7edf\u5b9e\u9a8c\u5ba4\u65b9\u6cd5\u4e0d\u80fd\u53d1\u73b0\uff0c\u4f46\u901a\u8fc7\u6db2\u4f53\u6d3b\u68c0\u53d1\u73b0\u7684\u80bf\u7624\u6765\u6e90\u5206\u5b50\u5f02\u5e38\uff0c\u4ee3\u8868\u7740\u80bf\u7624\u7684\u6301\u7eed\u5b58\u5728\u548c\u4e34\u5e8a\u8fdb\u5c55\u53ef\u80fd\u3002<\/p>\n<p>\u65e9\u5728 2007 \u5e74\uff0c\u82f1\u56fd\u8d1d\u5c14\u6cd5\u65af\u7279\u5973\u738b\u5927\u5b66\u7684 Alexandra Irvine \u548c Mary Mcmullin \u5bf9\u6b64\u505a\u8fc7\u63cf\u8ff0\uff08PMID: 17288299\uff09\uff0c\u5728\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u60a3\u8005\u63a5\u53d7\u6cbb\u7597\u540e\uff0c\u4e00\u5c0f\u90e8\u5206\u4f1a\u590d\u53d1\uff0c\u590d\u53d1\u6e90\u4e8e\u6301\u7eed\u5b58\u5728\u7684\u3001\u542b\u91cf\u6781\u4f4e\u3001\u4ec5\u80fd\u901a\u8fc7\u5206\u5b50\u68c0\u6d4b\u7684\u6076\u6027\u80bf\u7624\u7ec6\u80de\uff0c\u5373 MRD\u3002\u56fd\u5185\u5916\u7684MRD\u961f\u5217\u7814\u7a76\u53ef\u4ee5\u5173\u6ce8DYNAMIC\u3001GALAXY\u3001TRACERx\u3001MERMADI\u3001CATHAYA\u3001MEDAL\u7b49\u961f\u5217\u3002<\/p>\n<p>\uff08\u4e09\uff09\u5e94\u7528<\/p>\n<p>MRD\u4f5c\u4e3a\u56f4\u672f\u671f\u6cbb\u7597\u6548\u679c\u548c\u590d\u53d1\u76d1\u6d4b\u7684\u91cd\u8981\u65b9\u6cd5\uff0c\u5bf9\u65e9\u4e2d\u671f\u7684\u764c\u75c7\u60a3\u8005\u9884\u540e\u76d1\u6d4b\u975e\u5e38\u91cd\u8981\uff0c\u4e5f\u4e3a\u4e2a\u6027\u5316\u6cbb\u7597\u65b9\u6848\u548c\u4f18\u5316\u968f\u8bbf\u7ba1\u7406\u63d0\u4f9b\u79d1\u5b66\u4f9d\u636e\u3002<\/p>\n<p>\u65e9\u57282018\u5e74\uff0cMRD\u7684\u8840\u6db2\u7624NGS\u4ea7\u54c1\u5df2\u83b7\u5f97FDA\u6279\u51c6\uff0c\u7075\u654f\u5ea6\u8fbe\u523010-6\uff0c\u5373\u53ef\u4ee5\u68c0\u6d4b\u5230\u4f4e\u4e8e1\/100\u4e07\u4e2a\u6d53\u5ea6\u6b8b\u7559\u764c\u7ec6\u80de\u3002MRD\u5728\u5b9e\u4f53\u7624\u65b9\u9762\u5e94\u7528\u8fd8\u5728\u4e0d\u65ad\u7a81\u7834\uff0c\u76ee\u524dFDA\u6388\u4e88\u90e8\u5206\u4ea7\u54c1\u7a81\u7834\u6027\u8bbe\u5907\u8ba4\u5b9a\uff0c\u56fd\u5185\u591a\u4e2a\u5b9e\u4f53\u7624MRD\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u5305\u62ec\u7ed3\u76f4\u80a0\u764c\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u4e73\u817a\u764c\u3001\u80c3\u764c\u7b49\uff0c\u5e76\u53d1\u5e03\u591a\u4e2aMRD\u4e13\u5bb6\u5171\u8bc6\u3002<\/p>\n<p>MRD\u5e94\u7528\u53d1\u5c55\u7684\u91cc\u7a0b\u7891<\/p>\n<p>2018\u5e74\uff0cFDA\u6279\u51c6Adaptive Biotechnologies\u516c\u53f8ClonoSEQ\u00ae\uff0c\u57fa\u4e8e\u591a\u91cdPCR\u6269\u589eBCR\/TCR VDJ\u514b\u9686\u91cd\u6392\u7684NGS\u65b9\u6cd5\u7528\u4e8e\u5bf9\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5(ALL)\u6216\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\uff08MM\uff09\u60a3\u8005\u8fdb\u884cMRD\u68c0\u6d4b\uff1b<\/p>\n<p>2019\u5e74\uff0cFDA\u6388\u4e88Nater\u516c\u53f8\u7684\u4ea7\u54c1Signatera\u2122\u7a81\u7834\u6027\u8bbe\u5907\u8ba4\u5b9a\uff08BDD\uff09\uff0c\u7528\u4e8e\u5b9a\u91cf\u68c0\u6d4b\u764c\u75c7\u60a3\u8005\u672f\u540e\u8840\u6d46ctDNA;2021\u5e74\u518d\u6b21\u6388\u4e88Signatera\u4e24\u4e2aBDD\uff0c\u4f5c\u4e3a\u4e24\u4e2a\u764c\u75c7\u836f\u7269III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4f34\u968f\u8bca\u65ad\uff1b\u540c\u5e74\uff0c\u7f8e\u56fdInivata\u516c\u53f8\u7684RaDaRTM \u5b9e\u4f53\u7624MRD\u68c0\u6d4b\u4ea7\u54c1\u83b7\u5f97FDA BDD\u8ba4\u5b9a\uff1b<\/p>\n<p>2020\u5e74\uff0cFDA\u518d\u6b21\u6279\u51c6ClonoSEQ \u00ae\uff0c\u7528\u4e8e\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08CLL\uff09\u60a3\u8005\u7684MRD\u68c0\u6d4b\uff1b<\/p>\n<p>2021\u5e743\u6708\uff0c\u6211\u56fd\u9996\u4e2aMRD\u5171\u8bc6\u300a\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u5206\u5b50\u6b8b\u7559\u75c5\u7076\u4e13\u5bb6\u5171\u8bc6\u300b\u5728\u7b2c18\u5c4a\u4e2d\u56fd\u80ba\u764c\u9ad8\u5cf0\u8bba\u575b\u4e0a\u53d1\u5e03\uff1b<\/p>\n<p>2021\u5e7411\u6708\uff0c\u56fd\u5bb6\u836f\u76d1\u5c40\u836f\u5ba1\u4e2d\u5fc3\u53d1\u5e03\u300a\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5e94\u7528\u5fae\u5c0f\u6b8b\u7559\u75c5\u7684\u6280\u672f\u6307\u5bfc\u539f\u5219\u300b;<\/p>\n<p>2024\u5e744\u6708\uff0cFDA\u80bf\u7624\u836f\u7269\u54a8\u8be2\u59d4\u5458\u4f1a\uff08ODAC\uff09\u6839\u636e\u4e24\u9879\u72ec\u7acb\u7684\u7814\u7a76EVIDENCE\u548cI2TEAMM\u7684\u7ed3\u679c\uff0c\u5ba3\u5e03\u540c\u610f\u5c06\u5fae\u5c0f\u6b8b\u7559\u75c5\u7076\uff08MRD\uff09\u4f5c\u4e3a\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u836f\u7269\u7814\u53d1\u7684\u4e34\u5e8a\u8bd5\u9a8c\u52a0\u901f\u6279\u51c6\u7ec8\u70b9;<\/p>\n<p>2024\u5e7411\u6708\uff0c\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u5317\u4eac\u534f\u548c\u533b\u9662\u5434\u7115\u6587\u6559\u6388\u7275\u5934\u53d1\u5e03\u300a\u5b9e\u4f53\u7624\u5206\u5b50\u6b8b\u7559\u75c5\u7076\uff08MRD\uff09\u68c0\u6d4b\u5171\u8bc6\u300b.<\/p>\n<p>\uff08\u56db\uff09\u6280\u672f<\/p>\n<p>CTC\uff08\u5faa\u73af\u80bf\u7624\u7ec6\u80de\uff09\u548cctDNA\uff08\u5faa\u73af\u80bf\u7624DNA\uff09\u662fMRD\u68c0\u6d4b\u7684\u4e3b\u8981\u751f\u7269\u6807\u5fd7\u7269\u3002\u5176\u4e2dctDNA\u8fd1\u5e74\u6210\u4e3a\u7126\u70b9\uff0c\u4e3b\u8981\u68c0\u6d4b\u57fa\u56e0\u7a81\u53d8\uff08SNV\u3001InDel\u3001CNV\u3001SV\uff09\u3001\u8868\u89c2\u9057\u4f20\u5b66\u6539\u53d8\uff08\u7532\u57fa\u5316\uff09\u7b49\uff0c\u9700\u8981\u5173\u6ce8\u548c\u80bf\u7624\u4f53\u79ef\u5927\u5c0f\u76f8\u5173\u7684ctDNA\u7a81\u53d8\u9891\u7387\uff08VAF\uff09\u4ee5\u53ca\u4e0d\u540c\u764c\u79cd\u68c0\u6d4b\u7684MRD\u9608\u503c\u3002\u00a0<\/p>\n<p>MRD ctDNA\u68c0\u6d4b\u7684\u6280\u672f\u5305\u62ec\u5b9e\u65f6PCR(qPCR)\u3001\u6570\u5b57PCR\uff08dPCR\uff09\u548c\u9ad8\u901a\u91cf\u6d4b\u5e8f\uff08NGS\uff09\u3002\u6d41\u5f0f\u7ec6\u80de\u672f\uff08Flow Cytometry, FCM\uff09\u4f5c\u4e3a\u91cd\u8981\u7684\u6280\u672f\u624b\u6bb5\u53ef\u4ee5\u76f4\u63a5\u68c0\u6d4b\u80bf\u7624\u7ec6\u80de\u7684MRD\uff0c\u7075\u654f\u5ea6\u53ef\u4ee5\u8fbe\u523010-3~10-4\uff0c\u662f\u5f53\u524d\u4e34\u5e8a\u8840\u6db2\u7624MRD\u68c0\u6d4b\u5e38\u7528\u7684\u65b9\u6cd5\uff1b\u9488\u5bf9\u5b9e\u4f53\u7624\uff0c\u5728ctDNA\u4e30\u5ea6\u22650.02%\u7684\u6761\u4ef6\u4e0b\uff0c\u53ef\u4ee5\u91c7\u7528\u6db2\u4f53\u6d3b\u68c0\u7684\u65b9\u6cd5\u8fdb\u884cMRD\u68c0\u6d4b\uff0c\u76ee\u524d\u4e3b\u8981\u91c7\u7528NGS\u8fdb\u884c\u5b9e\u4f53\u7624MRD ctDNA\u68c0\u6d4b\u3002\u7531\u4e8e\u80bf\u7624\u7ec6\u80de\u7684\u9ad8\u5ea6\u5f02\u8d28\u6027\u53ca\u542b\u91cf\u8f83\u4f4e\u7684\u7a81\u53d8\uff0c\u56e0\u6b64\u6d4b\u5e8f\u6df1\u5ea6\u8f83\u9ad8\uff08\u5171\u8bc6\u5efa\u8bae\u81f3\u5c1130,000x\u751a\u81f3100,000x\uff09\uff0c\u8981\u6ce8\u610f\u8fdb\u884c\u80cc\u666f\u566a\u97f3\u7eaf\u5316\u3002\u00a0<\/p>\n<p>MRD\u68c0\u6d4b\u7684\u6280\u672f\u8def\u7ebf\u5305\u62ecTumor-informed assays\u548cTumor-na\u00efve assays\u3002\u524d\u8005\u4e3b\u8981\u662f\u53c2\u8003\u7ec4\u7ec7\u7a81\u53d8\u4fe1\u606f\u8fdb\u884c\u5b9a\u5236\u5316panel\u7684\u8d85\u6df1\u5ea6\u6d4b\u5e8f\uff0c\u540e\u8005\u662f\u56fa\u5b9apanel\u6216WES\u6d4b\u5e8f\u3002<\/p>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDkkd1iaVVCRZxDOWia6X7wiaYLthicCHiaW0uw784YUHOgticXytPEpMp2c6MCOlXph3OBdfPBZjfFb0nw.png\" alt=\"RmFicvQBAkgDkkd1iaVVCRZxDOWia6X7wiaYLthicCHiaW0uw784YUHOgticXytPEpMp2c6MCOlXph3OBdfPBZjfFb0nw\"\/><\/figure><\/div>\n\n<p style=\"text-align: center;\">\u56fe\uff1aMRD\u68c0\u6d4b\u7684\u6280\u672f\u8def\u7ebf\u5bf9\u6bd4\uff08\u6765\u6e90\/\u57fa\u56e0\u6167\uff09<\/p>\n<p>\u9700\u8981\u5173\u6ce8\u7684\u662f\uff0c2024\u5e74ASCO\u4f1a\u8bae\u4e0a\u53d1\u5e03\u7684\u4e34\u5e8a\u8bd5\u9a8cCOBRA\u7ed3\u679c\uff0c\u5728\u9488\u5bf9\u201c\u4e34\u5e8a\u4f4e\u5371&amp;ctDNA+\u201d\u7684\u9884\u540e\u7814\u7a76\u4e0d\u53ca\u9884\u671f\uff1b\u57282024\u5e74v1\u7248\u7684\u7ed3\u76f4\u80a0\u764cNCCN\u6307\u5357\u4e2d\u63d0\u53ca\u4e0d\u63a8\u8350\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e4b\u5916\u4f7f\u7528ctDNA\u8fdb\u884c\u9884\u6d4b\u3002\u4e1a\u754c\u8ba4\u4e3a\u8fd9\u4e0e\u6280\u672f\u8def\u7ebf\u53ef\u80fd\u6709\u5173\uff0c\u5728\u6280\u672f\u6301\u7eed\u5347\u7ea7\u7684\u8fc7\u7a0b\u4e2d\u5bf9MRD\u7684\u4ef7\u503c\u4ecd\u4fdd\u6301\u8f83\u9ad8\u4fe1\u5fc3\u3002\u4f8b\u5982\uff0c2024\u5e74\uff0c\u5409\u56e0\u52a0\u5b8c\u6210\u4e0e\u5434\u4e00\u9f99\u6559\u6388\u5408\u4f5c\u5173\u4e8e\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u65e9\u4e2d\u671f\u3001\u5c40\u665a\u671f\u548c\u665a\u671fMRD\u7814\u7a76\uff0c\u5206\u522b\u5728Cancer Discovery\u3001Cancer Cell\u3001JAMA Oncology\u4e0a\u53d1\u5e03\uff0c\u53d1\u73b0\u665a\u671f\u9a71\u52a8\u57fa\u56e0\u9633\u6027\u80ba\u764c\u7684\u60a3\u8005\uff0c\u539f\u672c\u8fde\u7eed\u7528\u836f\u6a21\u5f0f\u53d8\u4e3a\u5bc6\u5207\u76d1\u6d4b\u4e0b\u95f4\u65ad\u7528\u836f\u6a21\u5f0f\uff0c\u603b\u4f53\u60a3\u8005PFS\uff08\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff09\u8fbe18.4\u4e2a\u6708\u3002\u00a0<\/p>\n<p>\u9664\u4e86NGS\u5e73\u53f0\uff0c\u57fa\u4e8ePCR\u7684\u591a\u57fa\u56e0\u7532\u57fa\u5316\u6280\u672f\u8fd1\u5e74\u4e5f\u5c55\u73b0\u51fa\u4e34\u5e8a\u5e94\u7528\u6f5c\u5728\u4ef7\u503c\u3002\u9e4d\u8fdc\u751f\u7269\u8054\u5408\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662\u3001\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u4ec1\u6d4e\u533b\u9662\u5f00\u5c55\u9996\u4e2a\u57fa\u4e8ePCR\u7684\u8840\u6db2ctDNA\u591a\u57fa\u56e0\u7532\u57fa\u5316\u6280\u672f\u5e94\u7528\u7ed3\u76f4\u80a0\u590d\u53d1\u76d1\u6d4b\uff0c\u53d1\u73b0\u672f\u524dctDNA\u9633\u6027\u60a3\u8005\uff0c\u672f\u540e\u590d\u53d1\u6982\u7387\u9ad8\u4e8e\u672f\u524dctDNA\u9634\u6027\u60a3\u8005\uff0822.0%\uff1e4.7%\uff09\uff1b\u6839\u6cbb\u6027\u5207\u9664\u672f\u540e\u4e00\u4e2a\u6708\uff0cctDNA\u9633\u6027\u60a3\u8005\u590d\u53d1\u6982\u7387\u662f\u9634\u6027\u60a3\u8005\u768417.5\u500d\u3002\u503c\u5f97\u5173\u6ce8\u7684\u662f\uff0c\u57fa\u4e8ePCR\u7684ctDNA\u591a\u57fa\u56e0\u7532\u57fa\u5316\u68c0\u6d4b\uff0c\u5728\u68c0\u6d4b\u8d39\u7528\u548c\u62a5\u544a\u5468\u671f\u4e0a\u6709\u8f83\u5927\u63d0\u5347\u3002<\/p>\n<p>\uff08\u4e94\uff09\u4ea7\u4e1a<\/p>\n<p>\u76ee\u524dMRD\u68c0\u6d4b\u7684\u4ed8\u8d39\u4e3b\u8981\u4ee5\u7528\u6237\u4e2a\u4eba\u652f\u4ed8\u4e3a\u4e3b\uff0c\u5728\u90e8\u5206\u5730\u533a\u88ab\u7eb3\u5165\u533b\u4fdd\u3002Adaptive Biotechnologies\u7684clonoSEQ\u5728\u83b7\u6279\u540e\u7684\u7b2c\u4e8c\u5e74\uff082019\u5e74\uff09\u88ab\u7eb3\u5165\u7f8e\u56fd\u533b\u4fdd\u3002Natera\u516c\u53f8\u7684Signatera\u4ea7\u54c1\u7684\u8180\u80f1\u764c\u590d\u53d1\u76d1\u6d4b\u3001\u4e73\u817a\u764c\u590d\u53d1\u76d1\u6d4b\u5206\u522b\u4e8e2022\u5e74\u30012023\u5e74\u83b7\u5f97\u7f8e\u56fd\u533b\u4fdd\u8986\u76d6\u3002Signatera\u548cGuardant Health\u516c\u53f8\u7684Guardant Reveal\u4ea7\u54c1\u57282023\u5e74\u5148\u540e\u83b7\u5f97\u7f8e\u56fd\u5546\u4e1a\u4fdd\u9669\u84dd\u76fe\u516c\u53f8\uff08Blue Shield of Louisiana\uff09\u7684\u627f\u4fdd\u3002\u00a0<\/p>\n<p>MRD\u9886\u57df\u4ee3\u8868\u6027\u7684\u56fd\u5916\u4f01\u4e1a\u5305\u62ecNaera\u3001Guardant Health\u3001Freeome\u3001Adaptive Biotechnologie\u3001NeoGenomics\u7b49\uff0c\u56fd\u5185\u4f01\u4e1a\u5305\u62ec\u9e4d\u8fdc\u751f\u7269\u3001\u4e16\u548c\u57fa\u56e0\u3001\u5409\u56e0\u52a0\u3001\u81fb\u548c\u79d1\u6280\u3001\u534e\u5927\u57fa\u56e0\u3001\u81f3\u672c\u533b\u7597\u7b49\u3002\u00a0<\/p>\n<p>MRD\u8d5b\u9053\u7684\u4e1a\u7ee9\u57282023\u5e74\u6574\u4f53\u8868\u73b0\u7a81\u51fa\u3002\u6839\u636e\u516c\u5f00\u4fe1\u606f\uff0cGuardant Health \u8868\u793a2023\u5e74MRD\u68c0\u6d4b\u91cf\u540c\u6bd4\u589e\u957f90%\uff0c\u9884\u8ba1\u5168\u7f8e1500\u4e07\u540d\u60a3\u8005\u548c200\u4ebf\u7f8e\u5143\u7684\u5e02\u573a\uff1b\u8840\u6db2\u764c\u75c7\u7b5b\u67e5\u4f5c\u4e3a\u672a\u6765\u7684\u4e24\u5927\u4e1a\u52a1\u91cd\u70b9\u4e4b\u4e00\u3002Natera\u9884\u8ba12024\u5e74\u5168\u5e74\u8425\u653614.2-14.5\u4ebf\u7f8e\u5143\uff0c2024\u5e74\u7b2c\u4e00\u5b63\u5ea6\u8425\u6536\u540c\u6bd4\u589e\u957f52%\uff0cMRD\u4ea7\u54c1Signatera\u83b7\u5f97\u7a7a\u524d\u7684\u589e\u957f\uff0c\u5355\u4ef7\u63d0\u9ad8\u52301000\u7f8e\u5143\u4e0a\u3002\u4e13\u6ce8MRD\u7684Freeome\u516c\u53f8\u57282023\u5e74\u5b8c\u6210\u7531\u7f57\u6c0f\u8bca\u65ad\u9886\u6295\u3001Quest\u7b49\u8ddf\u6295\u76842.54\u4ebf\u7f8e\u5143\u7684\u878d\u8d44\uff0c\u5f3a\u8c03\u4e86\u57fa\u4e8e\u591a\u7ec4\u5b66\u3001\u673a\u5668\u5b66\u4e60\u548c\u771f\u5b9e\u4e16\u754c\u6570\u636e\u7684\u591a\u7ec4\u5b66\u5e73\u53f0\u4e0a\u63a8\u8fdb\u764c\u75c7\u65e9\u671f\u68c0\u6d4b\u3002\u00a0<\/p>\n<p>2020\u5e74\uff0c\u6211\u56fd\u9996\u4e2a\u80ba\u764c\u5546\u4e1a\u5316MRD\u68c0\u6d4b\u4e0a\u5e02\u2014\u2014\u81fb\u548c\u79d1\u6280\u7684\u201c\u6717\u5fae\u535a\u201d\u30022021\u5e74\uff0c\u534e\u5927\u57fa\u56e0\u72ec\u5bb6\u5c06Natera\u7684 Signatera\u4ea7\u54c1\u5f15\u5165\u4e2d\u56fd\uff0c\u901a\u8fc7\u56fd\u4ea7\u6d4b\u5e8f\u5e73\u53f010\u4e07x\u8d85\u6df1\u5ea6\u6d4b\u5e8f\uff0c\u68c0\u6d4b\u9650\u8fbe0.009%\uff0c2023\u5e74\u80bf\u7624\u590d\u53d1\u76d1\u6d4b\u4e1a\u52a1\u8425\u4e1a\u6536\u5165\u540c\u6bd4\u589e\u957f\u7ea6 58%\u3002<\/p>\n<p>\u5728MRD\u68c0\u6d4b\u9886\u57df\uff0c\u672a\u6765\u5efa\u8bae\u5173\u6ce8\u4ee5\u4e0b\u65b9\u9762\u3002<\/p>\n<p>\u6280\u672f\u5c42\u9762\uff1a\u8fdb\u4e00\u6b65\u8fed\u4ee3ctDNA\u3001\u7532\u57fa\u5316\u7b49\u591a\u5143\u6280\u672f\u7684\u4ea7\u54c1\u7814\u53d1\uff0c\u52a0\u5927\u524d\u77bb\u6027\u961f\u5217\u7814\u7a76\u6295\u5165\u4ee5\u8fdb\u884c\u6280\u672f\u9a8c\u8bc1\u548c\u4e34\u5e8a\u5e94\u7528\u9a8c\u8bc1\u3002\u00a0<\/p>\n<p>\u6a21\u5f0f\u5c42\u9762\uff1aMRD\u4e0e\u5176\u4ed6\u6280\u672f\u7ec4\u5408\u6784\u5efa\u80bf\u7624\u57fa\u56e0\u68c0\u6d4b\u7efc\u5408\u65b9\u6848\u30022020\u5e74\uff0c Exact Sciences\u6536\u8d2dAshion\uff08\u5e0c\u671b\u4e4b\u57ce\u764c\u75c7\u6cbb\u7597\u4e2d\u5fc3\u8f6c\u5316\u57fa\u56e0\u7ec4\u7814\u7a76\u6240\u8f6c\u5316\uff09\u83b7\u5f97MRD\u68c0\u6d4b\u6280\u672fTARDIS\u30022021\u5e74\uff0cNeoGenomics\u4ee53.9\u4ebf\u7f8e\u5143\u6536\u8d2dInivata\u5207\u5165MRD\u68c0\u6d4b\u3002\u00a0<\/p>\n<p>\u5236\u5ea6\u5c42\u9762\uff1a\u52a0\u901fMRD\u7684\u4e34\u5e8a\u51c6\u5165\uff0c\u57fa\u56e0\u6167\u9884\u8ba1\u81f3\u5c11\u9700\u89812\u5e74\u65f6\u95f4\u3002\u5177\u5907\u6838\u5fc3MRD\u6280\u672f\u7684\u4ea7\u54c1\u53ca\u4f01\u4e1a\u6807\u7684\u662f\u6781\u5177\u4ef7\u503c\u6295\u8d44\u5e76\u8d2d\u7684\u6807\u7684\u3002<\/p>\n<p>\u3010\u81f4\u8c22\u3011<\/p>\n<p>\u9ec4\u8377\u51e4\u9662\u58eb\u3001\u5362\u5149\u7407\u6559\u6388\u4f5c\u5e8f\u63a8\u8350\u3002\u611f\u8c22\u661f\u4e91\u57fa\u56e0\u3001\u534e\u5927\u667a\u9020\u3001\u8d5b\u798f\u57fa\u56e0\u3001\u9e4d\u8fdc\u751f\u7269\u5bf9\u300a\u57fa\u56e0\u884c\u4e1a\u84dd\u76ae\u4e66\uff082024-2025\uff09\u300b\u7684\u5927\u529b\u652f\u6301\uff0c\u5f97\u4ee5\u516c\u5f00\u53d1\u5e03\u548c\u4f20\u64ad\u3002<\/p>\n<p>\u3010\u8bf4\u660e\u3011<\/p>\n<p>\u300a\u57fa\u56e0\u884c\u4e1a\u84dd\u76ae\u4e66\u300b\u7531\u57fa\u56e0\u6167\u8054\u5408\u5408\u4f5c\u4f19\u4f34\u5411\u516c\u4f17\u514d\u8d39\u3001\u516c\u5f00\u53d1\u5e03\u7535\u5b50\u7248\u53ca\u7eb8\u8d28\u7248\uff0c\u5747\u672a\u5bf9\u5916\u9500\u552e\u6216\u6388\u6743\u4efb\u4f55\u7b2c\u4e09\u65b9\u9500\u552e\u3002<\/p>\n<p>\u00a0\u300a\u57fa\u56e0\u884c\u4e1a\u84dd\u76ae\u4e662024\u300b<\/p>\n<p>\u00a0\u4ea7\u4e1a\u521b\u65b0\u6848\u4f8b\uff08\u56db\uff09\uff1a\u9e4d\u8fdc\u751f\u7269<\/p>\n<p>\uff08\u2193\u4e0a\u4e0b\u6ed1\u52a8\u67e5\u770b\u8be6\u60c5\uff09<\/p>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDkkd1iaVVCRZxDOWia6X7wiaYyMdUG59heYjSzcpBPiaJOuRWuF1Ie7HFJ2fDVmrfzjHqAdlseCicRVyQ.jpg\" alt=\"RmFicvQBAkgDkkd1iaVVCRZxDOWia6X7wiaYyMdUG59heYjSzcpBPiaJOuRWuF1Ie7HFJ2fDVmrfzjHqAdlseCicRVyQ\"\/><\/figure><\/div>\n\n<\/p>\n<p>\u300a\u57fa\u56e0\u884c\u4e1a\u84dd\u76ae\u4e662025\u300b\u542f\u52a8\u5408\u4f5c\u00a0<\/p>\n<p>\u9996\u53d1\u4e2d\u82f1\u53cc\u8bed\u7248\uff0c\u00a0\u8fde\u7eed\u7b2c8\u5e74\u7b56\u5212\u00a0<\/p>\n<p>\u00a090%\u7684\u5934\u90e8\u57fa\u56e0\u673a\u6784\u66fe\u53c2\u4e0e\u5408\u4f5c\u00a0<\/p>\n<p>\u00a0\u6b22\u8fce\u4f01\u4e1a\/\u56ed\u533a\/\u5b66\u4f1a\u7b49\u8054\u5408\u53d1\u5e03<\/p>\n<p>\u8054\u7cfb\uff1alily@genonet.cn\u00a0<\/p>\n<p>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgD8WY0PaUkJEejy8xHAVGK9ShqKDbic2VLFyQiaGOrfTJrHsG9526FdJaIGBexenraUZHaDC2o9elnw.jpg\" alt=\"RmFicvQBAkgD8WY0PaUkJEejy8xHAVGK9ShqKDbic2VLFyQiaGOrfTJrHsG9526FdJaIGBexenraUZHaDC2o9elnw\"\/><\/figure><\/div>\n\n<\/p>\n<p>\u00a0 \u57fa\u56e0\u6167\u84dd\u76ae\u4e66\u7cfb\u5217\u53d1\u5e03\u60c5\u51b5\u4e3e\u4f8b\u00a0\u00a0<\/p>\n<\/p>\n<p>\uff08\u2193\u4e0a\u4e0b\u6ed1\u52a8\u67e5\u770b\u8be6\u60c5\uff09<\/p>\n<\/p>\n<p>\u300a\u57fa\u56e0\u884c\u4e1a\u84dd\u76ae\u4e66\uff082024-2025\u300b<\/p>\n<\/p>\n<div><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&amp;mid=2247515881&amp;idx=1&amp;sn=a9ce769e0cd3e89486388afaca2172c0&amp;chksm=eb710c5edc0685485ce4ab317cfe5dd055f1f2ddc0ad7440fe1a89254a8bece7c941e38d6424&amp;token=141761245&amp;lang=zh_CN&amp;scene=21#wechat_redirect\" \/><\/p>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBybHf5z5cicHF6cYWoPuNQcpgtL718yicBzGF7SQulfNkbxhILAwWoLK7Iic4KHVXmUc4IT7wNRgksg.jpg\" alt=\"RmFicvQBAkgBybHf5z5cicHF6cYWoPuNQcpgtL718yicBzGF7SQulfNkbxhILAwWoLK7Iic4KHVXmUc4IT7wNRgksg\"\/><\/figure><\/div>\n\n<p><\/a><\/div>\n<p>\u4f5c\u5e8f\u4e13\u5bb6<\/p>\n<p>\u9ec4\u8377\u51e4\u9662\u58eb<\/p>\n<p>\u5362\u5149\u7407\u6559\u6388<\/p>\n<\/p>\n<p>\u300a2023\u57fa\u56e0\u884c\u4e1a\u84dd\u76ae\u4e66\u300b<\/p>\n<\/p>\n<div><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&amp;mid=2247514191&amp;idx=1&amp;sn=e949065bd02f2c70e083d064ad2e86f3&amp;chksm=eb710af8dc0683ee4630d1c82045982122f51da8844816891bd9f3d660970bda66de687cf808&amp;token=141761245&amp;lang=zh_CN&amp;scene=21#wechat_redirect\" \/><\/p>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBybHf5z5cicHF6cYWoPuNQcBUPpJeGsicWiaCNr8bD4bR3XiaURAr6PkFOkHzH1CIkUajSxRuE5R4MPA.jpg\" alt=\"RmFicvQBAkgBybHf5z5cicHF6cYWoPuNQcBUPpJeGsicWiaCNr8bD4bR3XiaURAr6PkFOkHzH1CIkUajSxRuE5R4MPA\"\/><\/figure><\/div>\n\n<p><\/a><\/div>\n<p>\u4f5c\u5e8f\u4e13\u5bb6<\/p>\n<p>\u8a79\u542f\u654f\u9662\u58eb<\/p>\n<\/p>\n<p>\u300a2022\u57fa\u56e0\u884c\u4e1a\u84dd\u76ae\u4e66\u300b<\/p>\n<div><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&amp;mid=2247512551&amp;idx=1&amp;sn=c85f663051563e930d706360d5f2408b&amp;chksm=eb710350dc068a46711605a979ec7f399ad86f8a1e6c1899e32ec0a031badd801f44b1c49b8b&amp;token=141761245&amp;lang=zh_CN&amp;scene=21#wechat_redirect\" \/><\/p>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBybHf5z5cicHF6cYWoPuNQcxFczqKU14GpPZeicxXicBC7R1ncP5GGh5fP7jnhIicLxGuicRNOJtV41ow.jpg\" alt=\"RmFicvQBAkgBybHf5z5cicHF6cYWoPuNQcxFczqKU14GpPZeicxXicBC7R1ncP5GGh5fP7jnhIicLxGuicRNOJtV41ow\"\/><\/figure><\/div>\n\n<p><\/a><\/div>\n<p>\u4f5c\u5e8f\u4e13\u5bb6<\/p>\n<p>\u9648\u6da6\u751f\u9662\u58eb<\/p>\n<\/p>\n<p>\u300aDNA\u5b58\u50a8\u84dd\u76ae\u4e66\u300b<\/p>\n<div><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&amp;mid=2247510463&amp;idx=1&amp;sn=d11a8107fbcb0043e1bd6b6a706ef483&amp;chksm=eb711b08dc06921e16498e95da853084ca941dd3f4035f51d3a92ababc27a8c348d5850d1d39&amp;scene=21#wechat_redirect\" \/><\/p>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgAqW1PExUUyVdMN1Aibd1YNZjAn175VO199G77eFbXibNowG6j3tc11WwZiaNZnTCY790QVSgqVJSdicA.png\" alt=\"RmFicvQBAkgAqW1PExUUyVdMN1Aibd1YNZjAn175VO199G77eFbXibNowG6j3tc11WwZiaNZnTCY790QVSgqVJSdicA\"\/><\/figure><\/div>\n\n<p><\/a><\/div>\n<p>\u4f5c\u5e8f\u4e13\u5bb6<\/p>\n<p>\u6b27\u9633\u9880\u9662\u58eb<\/p>\n<p>\u5143\u82f1\u8fdb\u9662\u58eb<\/p>\n<p>\u6768\u7115\u660e\u9662\u58eb<\/p>\n<p>\u6a0a\u6625\u6d77\u9662\u58eb<\/p>\n<\/p>\n<p>\u300a2021\u57fa\u56e0\u884c\u4e1a\u84dd\u76ae\u4e66\u300b<\/p>\n<div><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&amp;mid=2247502763&amp;idx=1&amp;sn=813b24d0006192fe74eaaa6e8caa0254&amp;chksm=eb71791cdc06f00a1b22b0248fa0acb54a3aef9a68a27566e9524c1b712e187854741492da23&amp;scene=21#wechat_redirect\" \/><\/p>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgAqW1PExUUyVdMN1Aibd1YNZerUHIKbZzhAJSib3GrENeAsW7rXZS9AD1qLOUkibcWsrKSsJ4LibFFmuw.jpeg\" 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