{"id":7879,"date":"2025-04-16T17:10:00","date_gmt":"2025-04-16T09:10:00","guid":{"rendered":"https:\/\/www.geneclub.net.cn\/index.php\/2025\/04\/16\/994998\/"},"modified":"2026-04-07T16:10:49","modified_gmt":"2026-04-07T08:10:49","slug":"994998","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2025\/04\/16\/994998\/","title":{"rendered":"\u57fa\u56e0\u6167\uff1a\u4e00\u89c8\u57fa\u56e0\u68c0\u6d4b\u6280\u672f\u548c\u5173\u952e\u8bbe\u5907"},"content":{"rendered":"<p><!-- wechat_content_hash: c1ba324ecc984fee --><\/p>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBJ4sibF985CB53GqXpdUXJY1ibXic4tk7cicKMPtgyMRqWYUopq6yOghicWK3LOe3qL8V3Rjia4kHVKgsA.jpeg\" alt=\"RmFicvQBAkgBJ4sibF985CB53GqXpdUXJY1ibXic4tk7cicKMPtgyMRqWYUopq6yOghicWK3LOe3qL8V3Rjia4kHVKgsA\"\/><\/figure><\/div>\n\n<p>\u8fd9\u662f\u57fa\u56e0\u6167\u51fa\u54c1\u7684\u884c\u4e1a\u62a5\u544a\u300a\u57fa\u56e0\u884c\u4e1a\u84dd\u76ae\u4e662024\u300b\uff08<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&amp;mid=2247515881&amp;idx=1&amp;sn=a9ce769e0cd3e89486388afaca2172c0&amp;chksm=eb710c5edc0685485ce4ab317cfe5dd055f1f2ddc0ad7440fe1a89254a8bece7c941e38d6424&amp;scene=21#wechat_redirect\">\u8be6\u60c5\u94fe\u63a5<\/a>\uff09\u8fde\u8f7d\uff0c2025\u5e74\u57fa\u56e0\u6167\u8fde\u7eed\u7b2c\u516b\u5e74\u542f\u52a8\u300a\u57fa\u56e0\u884c\u4e1a\u84dd\u76ae\u4e66\u300b\uff08\u4e2d\u82f1\u53cc\u8bed\u7248\uff09\uff0c\u6b22\u8fce\u51a0\u540d\u5408\u4f5c\uff0c\u52a9\u529b\u751f\u547d\u79d1\u6280\u666e\u60e0\u548c\u4ea7\u4e1a\u878d\u5408\u3002<\/p>\n<div>\uff08\u6ce8\uff1a\u539f\u6587\u5b8c\u7a3f\u4e8e2024\u5e747\u6708\uff0c\u520a\u4e8e\u57fa\u56e0\u61672024\u5e749\u6708\u53d1\u5e03\u7684\u300a\u57fa\u56e0\u884c\u4e1a\u84dd\u76ae\u4e66\uff082024-2025\uff09\u300b\u3002\u4ee5\u4e0b\u4e3a\u6458\u5f55\uff0c\u7565\u6709\u6539\u52a8\u3002\u4ec5\u7528\u4e8e\u884c\u7814\u3002\uff09<\/div>\n<p style=\"text-align: center;\">01\u00a0\u603b\u89c8<\/p>\n<p>\u57fa\u56e0\u68c0\u6d4b\u662f\u57fa\u56e0\u884c\u4e1a\u7684\u5e95\u5c42\u6838\u5fc3\u6280\u672f\uff0c\u4e0d\u4ec5\u662fPCR\u3001\u6d4b\u5e8f\u4eea\u3001\u57fa\u56e0\u82af\u7247\u626b\u63cf\u4eea\u7b49\u57fa\u56e0\u68c0\u6d4b\u751f\u4ea7\u8bbe\u5907\u7684\u6838\u5fc3\uff0c\u4e5f\u662f\u57fa\u56e0\u7f16\u8f91\u3001\u57fa\u56e0\u5408\u6210\u7684\u5148\u5bfc\u7a0b\u5e8f\u3002<\/p>\n<p>\u57fa\u56e0\u68c0\u6d4b\u7684\u672c\u8d28\u662f\u901a\u8fc7\u7269\u7406\u548c\u5316\u5b66\u7b49\u65b9\u6cd5\u8bfb\u53d6\u6838\u9178\u6837\u672c\uff0c\u901a\u8fc7\u5149\u5b66\u6216\u7535\u4fe1\u53f7\u8f6c\u6362\u751f\u6210\u57fa\u56e0\u5e8f\u5217\u6570\u636e\u3002<\/p>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgB2Nsavd8Y9yRtX1Ribgdncdxkz4hyNCK5ywiaYFvmnSp3oz8HJLEXLBmmvXwXiaW33cr1Z4aNAG0l8g.png\" alt=\"RmFicvQBAkgB2Nsavd8Y9yRtX1Ribgdncdxkz4hyNCK5ywiaYFvmnSp3oz8HJLEXLBmmvXwXiaW33cr1Z4aNAG0l8g\"\/><\/figure><\/div>\n\n<p>\u5e38\u7528\u57fa\u56e0\u68c0\u6d4b\u6280\u672f\u5305\u62ec\u6d4b\u5e8f\u3001PCR\u3001\u57fa\u56e0\u82af\u7247 \/ \u5fae\u9635\u5217\u3001\u8367\u5149\u539f\u4f4d\u6742\u4ea4(FISH)\u4ee5\u53ca\u5149\u5b66\u56fe\u8c31\u3001\u6838\u9178\u8d28\u8c31\u3001\u7b49\u6e29\u6269\u589e\u7b49\u3002\u4e0d\u540c\u6280\u672f\u5bf9\u5e94\u4e0d\u540c\u7684\u8bbe\u5907\uff0c\u9002\u7528\u4e0d\u540c\u5e94\u7528\u573a\u666f\uff0c\u4f8b\u5982\u6d4b\u5e8f\u4eea\u3001PCR\/qPCR\/dPCR \u4eea\u3001\u57fa\u56e0\u82af\u7247\u626b\u63cf\u4eea\u7b49\u3002\u5c06\u7b49\u6e29\u6269\u589e\u3001\u7b80\u5316\u7248\u6838\u9178\u8d28\u8c31\u7b49\u6280\u672f\u88c5\u8f7d\u5230\u5fae\u6d41\u63a7\u82af\u7247\u7684\u5206\u5b50 POCT(Point-of-Care Testing)\u4e5f\u662f\u91cd\u8981\u7684\u4fbf\u643a\u5f0f\u5feb\u901f\u68c0\u6d4b\u5de5\u5177\u3002<\/p>\n<p>\uff08\u6ce8\uff1a\u56e0\u4e3a\u7bc7\u5e45\u6709\u9650\uff0c\u8fd9\u91cc\u7740\u91cd\u6982\u8ff0\u6700\u5e38\u7528\u7684PCR\u6280\u672f\u4ee5\u53ca\u6700\u5177\u53d1\u5c55\u524d\u666f\u7684\u6d4b\u5e8f\u6280\u672f\u3002\u57fa\u56e0\u82af\u7247\u3001\u6838\u9178\u8d28\u8c31\u7b49\u5176\u4ed6\u6280\u672f\u8bf7\u5173\u6ce8\u57fa\u56e0\u6167\u672a\u6765\u53d1\u5e03\u7684\u884c\u4e1a\u84dd\u76ae\u4e66\uff0c\u5173\u6ce8\u53ca\u5408\u4f5c\u652f\u6301\u3002)<\/p>\n<p style=\"text-align: center;\">02\u00a0PCR\u6280\u672f<\/p>\n<p>PCR\uff08\u805a\u5408\u9176\u94fe\u5f0f\u53cd\u5e94\uff09\u6280\u672f\u7684\u6838\u5fc3\u662f\u5728\u4f53\u5916\u6a21\u62df DNA \u590d\u5236\uff0c\u901a\u8fc7 DNA \u805a\u5408\u9176\u5bf9\u7279\u5b9a DNA \u5e8f\u5217\u8fdb\u884c\u5feb\u901f\u3001 \u5448\u6307\u6570\u7ea7\u7684\u6269\u589e\u3002<\/p>\n<p>PCR \u672c\u8eab\u662f\u4e00\u9879\u72ec\u7acb\u7684\u6280\u672f\uff0c\u4ece\u5b9a\u6027\u7684 PCR\u3001\u76f8\u5bf9\u5b9a\u91cf\u7684 qPCR \u53d1\u5c55\u5230\u7edd\u5bf9\u5b9a\u91cf\u7684 dPCR\uff1bPCR \u4e5f\u662f\u9ad8\u901a\u91cf\u6d4b\u5e8f\u7b49\u68c0\u6d4b\u4e2d\u7528\u4e8eDNA\u6269\u589e\u7684\u91cd\u8981\u73af\u8282\u3002<\/p>\n<p>\u81ea1984 \u5e74\uff0c\u51ef\u5229\u00b7\u7a46\u5229\u65af(Kary Mullis)\u53d1\u660e PCR \u6280\u672f\u5e76\u56e0\u6b64\u83b7\u5f97\u8bfa\u8d1d\u5c14\u5316\u5b66\u5316\u5b66\u5956\uff0c\u81f3\u4eca\u5df2\u670940\u4f59\u5e74\u7684\u5386\u53f2\u3002<\/p>\n<p>PCR\u6280\u672f\u53d1\u5c55\u7684\u91cd\u8981\u91cc\u7a0b\u7891<\/p>\n<p>\u25cf1984\u5e74\uff0c\u51ef\u5229\u00b7\u7a46\u5229\u65af(Kary Mullis)\u5728\u00a0Cetus\u00a0\u516c\u53f8\u5de5\u4f5c\u671f\u95f4\u5b9e\u73b0\u4e86\u00a0PCR\u00a0\u6280\u672f\uff0c\u56e0 \u6b64\u8363\u83b7\u00a01993\u00a0\u5e74\u7684\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u3002<\/p>\n<p>\u25cf\u00a01988\u00a0\u5e74\uff0cRandal Saiki\u00a0\u53ca\u5176\u56e2\u961f\u5728\u6c34\u751f\u55dc\u70ed\u6746\u83cc(Taq)\u4e2d\u63d0\u53d6\u5230\u4e00\u79cd\u8010\u9ad8\u6e29\u00a0DNA\u805a\u5408\u9176\u2014\u2014\u5373\u540e\u6765\u77e5\u540d\u7684\u00a0Taq DNA\u00a0\u805a\u5408\u9176\u2014\u2014\u6781\u5927\u63d0\u9ad8\u4e86\u00a0PCR\u00a0\u7684\u6269\u589e\u6548\u7387\u3002<\/p>\n<p>\u25cf\u00a01996\u00a0\u5e74\uff0cHeid\u00a0\u7b49\u79d1\u5b66\u5bb6\u5728\u00a0Taq\u00a0\u9176\u7684\u00a05&#8242;\u00a0\u6838\u9178\u9176\u6d3b\u6027\u7684\u7279\u70b9\u4e0a\u57fa\u4e8e\u8367\u5149\u5171\u632f\u80fd\u91cf\u8f6c \u79fb(FRET)\u539f\u7406\u8bbe\u8ba1\u00a0Taqman\u00a0\u63a2\u9488\u2014\u2014\u5373\u00a05&#8242;\u00a0\u7aef\u6807\u8bb0\u8367\u5149\u62a5\u544a\u57fa\u56e2\uff0c3&#8242;\u00a0\u7aef\u6807\u8bb0\u8367\u5149\u6dec\u706d\u57fa\u56e2\uff0c\u5229\u7528\u00a0Taq\u00a0\u9176\u7684\u00a05&#8242;-3&#8242;\u00a0\u5916\u5207\u9176\u6d3b\u6027\uff0c\u5728\u00a0PCR\u00a0\u8fc7\u7a0b\u4e2d\u6c34\u89e3\u4e0e\u9776\u5e8f\u5217\u7ed3\u5408\u7684\u5be1\u6838\u82f7\u9178\u63a2\u9488\uff0c\u4f7f\u8367\u5149\u57fa\u56e2\u5f97\u4ee5\u6e38\u79bb\uff0c\u91ca\u653e\u8367\u5149\u4fe1\u53f7\u5373\u4e0e\u76ee\u6807\u00a0DNA\u00a0\u5e8f\u5217\u4e92\u8865\u7684\u5355\u94fe\u5be1\u6838\u82f7\u9178\uff0c\u8fd9\u5c31\u662f\u5e7f\u6cdb\u5e94\u7528\u7684\u5b9e\u65f6\u5b9a\u91cf\u00a0PCR(Real Time Quantitative PCR\uff0cRT-qPCR)\u3002\u7f57\u6c0f\u7684\u00a0LightCycler\u00a0\u662fqPCR\u00a0\u7684\u4ee3\u8868\u4ea7\u54c1\u4e4b\u4e00\u3002\u5728\u5927\u89c4\u6a21\u6838\u9178\u68c0\u6d4b\u8fc7\u7a0b\u4e2d\uff0cqPCR\u00a0\u662f\u6838\u5fc3\u751f\u4ea7\u5e73\u53f0\uff0c\u4ee5\u5176\u7b80\u5355\u64cd\u4f5c\u3001\u6210\u672c\u4f4e\u3001\u5468\u671f\u77ed\u3001\u8f83\u9ad8\u7684\u7279\u5f02\u6027\u548c\u654f\u611f\u6027\u53d1\u6325\u7740\u91cd\u8981\u7684\u5feb\u901f\u68c0\u6d4b\u4f5c\u7528\u3002\u76ee\u524d\u591a\u91cd\u00a0PCR\u00a0\u7b49 \u884d\u751f\u6280\u672f\u548c\u4ea7\u54c1\u5728\u4e0d\u65ad\u8fed\u4ee3\u3002qPCR\u00a0\u7684\u5c40\u9650\u662f\u53ea\u80fd\u68c0\u6d4b\u5df2\u77e5\u5e8f\u5217\uff0c\u5bf9\u4e8e\u672a\u77e5\u5e8f\u5217\u4ee5\u53ca\u6838\u9178\u53d8\u5f02\u7684\u5168\u9762\u5206\u6790\uff0c\u9700\u8981\u4f9d\u8d56\u6d4b\u5e8f\u7b49\u6280\u672f\u624b\u6bb5\u66f4\u5168\u9762\u5730\u63d0\u4f9b\u5e8f\u5217\u4fe1\u606f\u548c\u7ed3\u6784\u6027\u53d8\u5f02\u72b6\u51b5\u3002<\/p>\n<p>\u25cf\u00a01999\u5e74\uff0cKenneth Kinzler\u00a0\u4e0eBert Vogelstein\u00a0\u7b49\u63d0\u51fa\u6570\u5b57\u00a0PCR(dPCR)\u6280\u672f\u3002\u8fd9\u79cd\u6280\u672f\u901a\u8fc7\u5c06\u6807\u51c6\u7684\u00a0PCR\u00a0\u53cd\u5e94\u4f53\u7cfb\u5206\u914d\u5230\u5927\u91cf\u5fae\u5c0f\u7684\u53cd\u5e94\u5355\u5143\u4e2d\uff0c\u6bcf\u4e2a\u53cd\u5e94\u5355\u5143\u4e2d\u53ef\u80fd\u5305\u542b\u6216\u4e00\u4e2a\u6216\u591a\u4e2a\u9776\u6807\u5206\u5b50(\u6a21\u677f)\uff0c\u4ece\u800c\u5b9e\u73b0\u5355\u5206\u5b50\u6c34\u5e73\u7684\u6a21\u677f\u00a0PCR\u00a0\u6269\u589e\u3002\u901a\u8fc7\u7edf\u8ba1\u9633 \u6027\u53cd\u5e94\u5355\u5143\u7684\u6570\u91cf\uff0c\u53ef\u4ee5\u7cbe\u51c6\u8ba1\u7b97\u51fa\u9776\u6807\u5206\u5b50\u7684\u62f7\u8d1d\u6570\uff0c\u5b9e\u73b0\u7edd\u5bf9\u5b9a\u91cf\u3002\u4f2f\u4e50\u751f\u547d(Bio-Rad)\u7684\u00a0QX200 Droplet Digital PCR\u00a0\u7cfb\u7edf\u662f\u00a0dPCR\u00a0\u7684\u4ee3\u8868\u4ea7\u54c1\u4e4b\u4e00\u3002\u76f8\u5bf9\u00a0qPCR\uff0cdPCR\u00a0\u4e0d\u4f9d\u8d56\u4e8e\u6807\u51c6\u66f2\u7ebf\u6216\u53c2\u7167\u6837\u672c\uff0c\u5bf9\u00a0PCR\u00a0\u6291\u5236\u5242\u7684\u6297\u6027\u66f4\u5f3a\u3002\u4e0e\u00a0NGS\u00a0\u76f8\u6bd4\uff0cdPCR\u00a0\u80fd\u68c0\u6d4b\u7a00\u6709\u7a81\u53d8(\u4f8b\u5982\u00a00.001%)\u4ee5\u53ca\u75c5\u6bd2\u8f7d\u91cf\u8f83\u4f4e\u7684\u6837\u672c\u3002dPCR\u00a0\u7684\u5c40\u9650\u662f\u5bf9\u5927\u7684\u7ed3\u6784\u53d8\u5f02\u7684\u68c0\u6d4b\u80fd\u529b\u6709\u9650\u4e14\u53ea\u80fd\u68c0\u6d4b\u5df2\u77e5\u5e8f\u5217\u3002<\/p>\n<p style=\"text-align: center;\">03\u00a0\u6d4b\u5e8f\u6280\u672f<\/p>\n<p>\u6d4b\u5e8f\u6280\u672f\u662f\u76ee\u524d\u53d1\u5c55\u6700\u5feb\u3001\u6700\u5177\u6709\u524d\u666f\u7684\u57fa\u56e0\u68c0\u6d4b\u6280\u672f\u4e4b\u4e00\u3002\u4ece Sanger \u6d4b\u5e8f(\u4fd7\u79f0\u201c\u4e00 \u4ee3\u6d4b\u5e8f\u201d)\u3001\u9ad8\u901a\u91cf\u57fa\u56e0\u6d4b\u5e8f(NGS\uff0c\u201c\u4e8c\u4ee3\u6d4b\u5e8f\u201d)\u5230\u5355\u5206\u5b50\u6d4b\u5e8f(\u201c\u4e09\u4ee3\u6d4b\u5e8f\u201d) \u3002<\/p>\n<p>\u4e0d\u540c\u4ee3\u9645\u7684\u6d4b\u5e8f\u6280\u672f\u76f8\u4e92\u8865\u5145\uff0c\u5404\u6709\u4f18\u52a3\u548c\u9002\u7528\u573a\u666f\uff0c\u4e0d\u662f\u8fed\u4ee3\u5173\u7cfb\u3002<\/p>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgB2Nsavd8Y9yRtX1RibgdncdNcuVmfOMZwJW4uHxWicibvQqibCUJEHJv6iaIBs5lZhyREAQibTxbrRPl8g.png\" alt=\"RmFicvQBAkgB2Nsavd8Y9yRtX1RibgdncdNcuVmfOMZwJW4uHxWicibvQqibCUJEHJv6iaIBs5lZhyREAQibTxbrRPl8g\"\/><\/figure><\/div>\n\n<p>\u56fe\uff1a\u57fa\u56e0\u6d4b\u5e8f\u6280\u672f\u53ca\u5e73\u53f0\u53d1\u5c55\u91cc\u7a0b\u7891 \u00a0 \u00a0\u6765\u6e90\uff1a\u57fa\u56e0\u6167\uff08\u8f6c\u8f7d\u8bf7\u6ce8\u660e\u51fa\u5904\uff09<\/p>\n<p>\u6d4b\u5e8f\u6280\u672f\u53d1\u5c55\u7684\u91cd\u8981\u91cc\u7a0b\u7891<\/p>\n<p>\u25cf\u00a01971\u00a0\u5e74\uff0c\u5434\u745e\u5148\u751f\u53d1\u5e03\u5f15\u7269\u5ef6\u4f38(primer extension)\u6280\u672f\uff0c\u89e3\u51b3\u4e86\u00a0DNA\u00a0\u5e8f\u5217\u5206\u6790\u7684\u53ef\u884c\u6027\u95ee\u9898\uff0c\u8fd9\u6210\u4e3a\u4e86\u00a0Sanger\u00a0\u6cd5\u6d4b\u5e8f\u7684\u91cd\u8981\u4e00\u6b65\uff0c\u4e5f\u88ab\u7528\u4e8e\u00a0Kary Mullis\u00a0\u7684\u00a0PCR\u00a0\u548c\u5b9a\u70b9\u7a81\u53d8\u6280\u672f\uff0c\u8fd9\u4e24\u9879\u6280\u672f\u5747\u83b7\u5f97\u4e86\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u3002<\/p>\n<p>\u25cf\u00a01977\u00a0\u5e74\uff0c\u5728\u5434\u745e\u5148\u751f\u7684\u5f15\u7269\u5ef6\u4f38\u6280\u672f\u7684\u57fa\u7840\u4e0a\uff0cFrederick Sanger\u00a0\u7b49\u53d1\u660e\u4e86\u00a0Sanger\u53cc\u8131\u6c27\u94fe\u7ec8\u6b62\u6d4b\u5e8f\u6cd5\uff0c\u901a\u8fc7\u5b9e\u73b0\u00a0DNA\u00a0\u590d\u5236\u53ca\u5408\u6210\u8fc7\u7a0b\uff0c\u80fd\u591f\u76f4\u63a5\u5728\u51dd\u80f6\u4e0a\u6309\u987a\u5e8f\u76f4\u89c2\u8bfb\u53d6\u6d4b\u5e8f\u6a21\u677f\uff0c\u5e76\u5728\u540c\u5e74\u63a8\u51fa\u7b2c\u4e00\u6b3e\u00a0Sanger\u00a0\u6d4b\u5e8f\u4eea\u3002<\/p>\n<p>\u5177\u4f53\u6b65\u9aa4\u662f\uff0c\u5728\u00a0DNA\u00a0\u94fe\u5408\u6210\u8fc7\u7a0b\u4e2d\u52a0\u5165\u53cc\u8131\u6c27\u6838\u82f7\u9178(ddNTP)\u548c\u666e\u901a\u7684\u5355\u8131\u6c27\u6838\u82f7\u9178(dNTP)\uff0cdNTP\u00a0\u548c\u8367\u5149\u6807\u8bb0\u7684\u00a0ddNTP\u6309\u78b1\u57fa\u4e92\u8865\u7684\u539f\u5219\u88ab\u805a\u5408\u5230\u65b0\u5408\u6210\u7684\u00a0DNA\u00a0\u94fe\u4e0a;\u5f53\u805a\u5408\u5230\u00a0ddNTP\uff0cDNA\u00a0\u94fe\u5408\u6210\u5c31\u7ec8\u6b62;\u56db\u4e2a\u72ec\u7acb\u7684\u53cd\u5e94\u4e2d\u5206\u522b\u4f7f\u7528\u5e26\u6709\u4e0d\u540c\u7684\u8367\u5149\u6807\u8bb0\u7684\u00a0ddNTP\uff0c\u901a\u8fc7\u51dd\u80f6\u7535\u6cf3\u5206\u79bb\u4e0d\u540c\u957f\u5ea6\u7684DNA\u00a0\u7247\u6bb5\uff0c\u6bcf\u4e2a\u7247\u6bb5\u7684\u957f\u5ea6\u5bf9\u5e94\u4e8e\u7ec8\u6b62\u7684\u7279\u5b9a\u78b1\u57fa\u4f4d\u7f6e\uff0c\u6700\u540e\u6839\u636e\u8367\u5149\u4fe1\u53f7\u7684\u987a\u5e8f\u6765\u786e\u5b9a\u00a0DNA\u00a0\u7684\u5e8f\u5217\u3002<\/p>\n<p>\u25cf\u00a01986\u00a0\u5e74\uff0c\u52a0\u5dde\u7406\u5de5\u5b66\u9662\u7684\u00a0Leroy Hood\u00a0\u53d1\u660e\u4e86\u56db\u8272\u8367\u5149\u6cd5\uff0c\u4f7f\u5f97\u00a0SBS\u00a0\u6d4b\u5e8f\u6280\u672f\u8d70\u5411\u81ea\u52a8\u5316\uff0c\u63a8\u51fa\u7b2c\u4e00\u53f0\u5546\u54c1\u5316\u7684\u5e73\u677f\u7535\u6cf3\u5168\u81ea\u52a8\u6d4b\u5e8f\u4eea\u00a0ABI 370A\u3002<\/p>\n<p>\u25cf\u00a01998\u00a0\u5e74\uff0cABI\u00a0\u516c\u53f8\u57fa\u4e8e\u5f00\u53d1\u7684\u6bdb\u7ec6\u7ba1\u51dd\u80f6\u7535\u6cf3\u6280\u672f\uff0c\u5728\u6b64\u524d\u63a8\u51fa\u7684\u00a0ABI Prism 310\u30013100\u00a0\u7b49\u673a\u578b\u7684\u57fa\u7840\u4e0a\uff0c\u53d1\u5e03\u00a0ABI Prism 3700\u00a0\u6bdb\u7ec6\u7ba1\u6d4b\u5e8f\u4eea\uff0c\u5b9e\u73b0\u6d4b\u5e8f\u89c4\u6a21\u5316\u3002<\/p>\n<p>\u25cf\u00a02005\u00a0\u5e74\uff0c454 Life Sciences\u00a0\u516c\u53f8\u57fa\u4e8e\u7126\u78f7\u9178\u6d4b\u5e8f\u6cd5\uff0c\u901a\u8fc7\u751f\u7269\u53d1\u5149\u8bfb\u53d6\u00a0dNTP\u00a0\u5728DNA\u00a0\u805a\u5408\u53cd\u5e94\u65f6\u91ca\u653e\u51fa\u7684\u7126\u78f7\u9178\uff0c\u518d\u901a\u8fc7\u9176\u4fc3\u53cd\u5e94\u88ab\u8f6c\u5316\u6210\u00a0ATP\uff0cATP\u00a0\u968f\u540e\u9a71\u52a8\u8367\u5149\u7d20 \u9176\u53cd\u5e94\uff0c\u4ea7\u751f\u5149\u4fe1\u53f7\u7136\u540e\u786e\u5b9a\u00a0DNA\u00a0\u5e8f\u5217\uff0c\u4e0d\u9700\u8981\u8367\u5149\u6807\u8bb0\u7684\u5f15\u7269\u00a0\/\u00a0\u63a2\u9488\u548c\u7535\u6cf3\uff0c\u63a8\u51fa\u7b2c\u4e00\u6b3e\u9ad8\u901a\u91cf\u6d4b\u5e8f(NGS)\u7cfb\u7edf\u00a0Genome Sequencer 20 System(\u201cGS20\u201d)(454\u00a0\u516c\u53f8\u540e\u4ee5\u00a01.4\u4ebf\u7f8e\u5143\u73b0\u91d1\u88ab\u7f57\u6c0f\u6536\u8d2d)\u3002\u7126\u78f7\u9178\u6d4b\u5e8f\uff0c\u91c7\u7528\u4e73\u6db2\u00a0PCR\u00a0\u6784\u5efa\u6587\u5e93\u3002<\/p>\n<p>\u25cf\u00a02006\u00a0\u5e74\uff0cSolexa\u00a0\u516c\u53f8\u63a8\u51fa\u00a0Genome Analyzer(\u201cGA\u201d)\u6d4b\u5e8f\u4eea\uff0c\u57fa\u4e8e\u53ef\u9006\u7ec8\u6b62\u6cd5\uff0c\u901a\u8fc7\u00a03&#8242;\u00a0\u7aef\u53ef\u9006\u6027\u7684\u4fee\u9970\u548c\u53bb\u4fee\u9970\u5b9e\u73b0\u672b\u7aef\u5faa\u73af\u5408\u6210\u6d4b\u5e8f\uff0cDNA\u00a0\u7247\u6bb5\u901a\u8fc7\u6865\u5f0f\u6269\u589e\u5728\u56fa\u76f8\u5e73\u9762(\u901a\u8fc7\u662f\u73bb\u7247\u6216\u82af\u7247)\u4e0a\u751f\u6210\u5bc6\u96c6\u7684\u00a0DNA\u00a0\u7c07\uff0c\u6bcf\u4e2a\u7c07\u542b\u6709\u6765\u81ea\u5355\u4e2a\u00a0DNA\u00a0\u7247\u6bb5\u7684\u4f17\u591a\u62f7\u8d1d\uff0c\u7a81\u7834\u6027\u5730\u6269\u5927\u4e86\u6d4b\u5e8f\u901a\u91cf\u3002<\/p>\n<p>2007\u00a0\u5e74\uff0c\u7f8e\u56fd\u00a0Illumina\u00a0\u516c\u53f8\u4ee5\u00a06\u00a0\u4ebf\u7f8e\u5143\u6536\u8d2dSolexa\uff0c\u63a8\u51fa\u53cc\u901a\u9053\u00a0SBS\u00a0(Sequencing by Synthesis)\u6280\u672f\uff0c\u7b80\u5316\u4e86\u6838\u82f7\u9178\u68c0\u6d4b\u8fc7\u7a0b\uff0c\u4fdd\u6301\u4e86\u4e0e\u539f\u59cb\u56db\u901a\u9053\u00a0SBS\u00a0\u6280\u672f\u76f8\u540c\u7684\u6570\u636e\u51c6\u786e\u6027\u3002<\/p>\n<p>\u25cf\u00a02007\u00a0\u5e74\uff0cApplied Biosystems\u00a0\u901a\u8fc7\u8fde\u63a5\u6d4b\u5e8f\u6cd5\u53d1\u5e03\u00a0ABI SOLiD\u00a0\u7cfb\u7edf\uff0c\u7279\u522b\u4e4b\u5904\u662f \u4ee5\u00a0DNA\u00a0\u8fde\u63a5\u9176\u53d6\u4ee3\u00a0DNA\u00a0\u805a\u5408\u9176\uff0c\u5bf9\u6bcf\u4e2a\u78b1\u57fa\u8bfb\u4e24\u6b21\u6765\u63d0\u9ad8\u51c6\u786e\u7387(2008\u00a0\u5e74\uff0cABI\u00a0\u516c\u53f8 \u4e0e\u00a0Invitrogen\u00a0\u5408\u5e76\u4e3a\u00a0Life Technologies\u00a0\u516c\u53f8\uff0cLife Technologies\u00a0\u4e8e\u00a02013\u00a0\u5e74\u88ab\u00a0Thermo Fisher\u6536\u8d2d)\u3002<\/p>\n<p>\u25cf\u00a02010\u00a0\u5e74\uff0cIon Torrent\u00a0\u53d1\u5e03\u7684\u00a0Ion Personal Genome Machine(PGM)\u6d4b\u5e8f\u4eea\uff0c\u901a\u8fc7\u534a \u5bfc\u4f53\u68c0\u6d4b\u6d4b\u5e8f\u53cd\u5e94\u8fc7\u7a0b\u4e2d\u00a0H+\u00a0\u6d53\u5ea6\u53d8\u5316\uff0c\u8bbe\u8ba1\u5de7\u5999\uff0c\u4f53\u79ef\u5c0f\uff0c\u662f\u7b2c\u4e00\u4ee3\u684c\u9762\u578b\u6d4b\u5e8f\u4eea\u4ee3\u8868(2010\u00a0\u5e74\uff0cIon Torrent\u00a0\u4ee5\u00a03.75\u00a0\u4ebf\u7f8e\u5143\u73b0\u91d1\u548c\u80a1\u7968\u7b49\u88ab\u00a0Life Technologies\u00a0\u6536\u8d2d)\u3002<\/p>\n<p>\u25cf\u00a02015\u00a0\u5e74\uff0c\u534e\u5927\u667a\u9020\u91c7\u7528\u4f18\u5316\u7684\u8054\u5408\u63a2\u9488\u951a\u5b9a\u805a\u5408\u6280\u672f(cPAS)\u548c\u6539\u8fdb\u7684\u00a0DNA\u00a0\u7eb3 \u7c73\u7403(DNB)\uff0c\u901a\u8fc7\u7ebf\u6027\u6269\u589e\u964d\u4f4e\u5355\u62f7\u8d1d\u7684\u9519\u8bef\u7387\uff0c\u53d1\u5e03\u00a0DNBSEQ\u00a0\u6d4b\u5e8f\u4eea\u7cfb\u5217\u3002<\/p>\n<p>\u25cf\u00a0\u53d7\u00a0SBS\u00a0\u7684\u542f\u53d1\uff0c2019\u00a0\u5e74\uff0cGenapSys\u00a0\u57fa\u4e8e\u7535\u5fae\u6d41\u4f53\u534a\u5bfc\u4f53(CMOS)\u82af\u7247\uff0c\u53d1\u5e03GenapSys Sequencer;2021\u00a0\u5e74\uff0cSingular Genomics\u00a0\u516c\u53f8\u63a8\u51fa\u4e86\u00a0G4\u00a0\u6d4b\u5e8f\u4eea\u3002<\/p>\n<p>\u25cf\u00a02022\u00a0\u5e74\u662f\u6d4b\u5e8f\u4eea\u4ea7\u54c1\u7684\u70ed\u70b9\u5e74\u4efd\u3002\u4f8b\u5982\uff0c\u5143\u7d20\u751f\u7269(Element Bioscience)\u516c\u53f8\u53d1 \u5e03\u4e86\u00a0AVITI\u00a0\u53f0\u5f0f\u00a0DNA\u00a0\u6d4b\u5e8f\u4eea\uff1b2022\u00a0\u5e74\uff0cUltima Genomics\u00a0\u57fa\u4e8e\u00a0200mm\u00a0\u7684\u5f00\u653e\u5f0f\u7845\u6676\u5706\u53d1 \u5e03\u00a0UG 100TM\u00a0\u6d4b\u5e8f\u4eea;\u8d5b\u7eb3\u751f\u7269\u53d1\u5e03\u00a0S100\u00a0\u6d4b\u5e8f\u4eea(2024\u00a0\u5e74\u83b7\u6279)\uff0c\u8d5b\u9646\u533b\u7597\u53d1\u5e03\u7b2c\u4e00\u6b3e\u9ad8\u901a\u91cf\u6d4b\u5e8f\u4eea\u00a0Salus Pro\uff1bUltima Genomics\u00a0\u53d1\u5e03\u00a0UG 100\u00a0\u6d4b\u5e8f\u4eea\u3002<\/p>\n<p>\u25cf\u00a0\u5355\u5206\u5b50\u6d4b\u5e8f\u662f\u901a\u8fc7\u5355\u5206\u5b50\u7684\u68c0\u6d4b\u88c5\u7f6e\u76f4\u63a5\u8bfb\u53d6\u78b1\u57fa\uff0c\u65e0\u9700\u00a0PCR\u00a0\u6269\u589e(\u51cf\u5c11\u504f\u597d)\u4e14\u63d0\u9ad8\u8bfb\u957f\u3002<\/p>\n<p>\u65e9\u671f\u4ee3\u8868\u4f01\u4e1a\u00a0Helicos BioSciences\u00a0\u4e8e\u00a02008\u00a0\u5e74\u53d1\u5e03\u00a0SMS\u00a0\u6280\u672f\uff0c\u5728\u00a0SBS\u00a0\u52a0\u4e0a\u8d85\u654f\u611f\u7684\u8367\u5149\u68c0\u6d4b\u88c5\u7f6e\u3002<\/p>\n<p>PacBio\u00a0\u7684\u6838\u5fc3\u662f\u57fa\u4e8e\u96f6\u819c\u6ce2\u5bfc\u5b54(ZMW)\uff0c\u6bcf\u4e2a\u5355\u5143\u767e\u4e07\u7ea7 \u6570\u91cf\u7684\u5b54\u4e0a\u56fa\u5b9a\u00a0DNA\u00a0\u94fe\u53ca\u00a0dNTP\uff0c\u7ed3\u5408\u65f6\u88ab\u6fc0\u5149\u7167\u5c04\u53d1\u51fa\u8367\u5149\u7136\u540e\u8f6c\u6362\u6210\u78b1\u57fa\u4fe1\u53f7\uff0c\u5b9e\u73b0\u5355\u5206\u5b50\u5b9e\u65f6\u6d4b\u5e8f(SMRT)\uff0c2010\u00a0\u5e74\u63a8\u51fa\u7b2c\u4e00\u6b3e\u5546\u4e1a\u5316\u7684\u6d4b\u5e8f\u7cfb\u7edf\u00a0PacBio RS\uff1bOxford Nanopore Technologies(ONT)\u7684\u7eb3\u7c73\u5b54\u6d4b\u5e8f\uff0c\u5c06\u6838\u9178\u901a\u8fc7\u751f\u7269\u7eb3\u7c73\u5b54(\u86cb\u767d\u8d28\u6784\u6210\u7684\u7eb3 \u7c73\u82af\u7247)\u65f6\u7684\u7535\u4fe1\u53f7\u5b9e\u65f6\u6d4b\u5e8f\uff0c\u4e8e2014\u00a0\u5e74\u53d1\u5e03\u7b2c\u4e00\u6b3e\u6d4b\u5e8f\u8bbe\u5907\u00a0MinION\u3002<\/p>\n<p>2021\u00a0\u5e74\uff0c\u9f50\u78b3\u79d1\u6280\u53d1\u5e03\u4e86\u56fd\u5185\u9996\u53f0\u7eb3\u7c73\u5b54\u57fa\u56e0\u6d4b\u5e8f\u4eea\u00a0QNome-3841\u3002<\/p>\n<div>\u76ee\u524d 454 \u6d4b\u5e8f\u4eea\u3001SOLiD \u7cfb\u7edf\u3001HeliScope \u7b49\u6d4b\u5e8f\u5e73\u53f0\u9000\u51fa\u4e86\u5e02\u573a\u3002\u4e3b\u6d41\u6d4b\u5e8f\u6280\u672f\u53ca\u54c1\u724c\u5305\u62ec\u5982\u4e0b:<\/div>\n<p>\u25cf\u00a0\u53ef\u9006\u672b\u7aef\u7ec8\u6b62\u6d4b\u5e8f\u6cd5(Illumina\u00a0\u7684\u6d4b\u5e8f\u4eea\u7cfb\u5217)\u25cf\u00a0\u8054\u5408\u63a2\u9488\u951a\u5b9a\u805a\u5408\u6d4b\u5e8f\u6cd5(\u4ee5\u00a0DNBSEQ\u00a0\u6280\u672f\u4e3a\u6838\u5fc3\u7684\u534e\u5927\u667a\u9020\u6d4b\u5e8f\u4eea)<\/p>\n<p>\u25cf\u00a0\u534a\u5bfc\u4f53\u6d4b\u5e8f\u6cd5(Ion Torrent\u00a0\u7cfb\u5217\u6d4b\u5e8f\u4eea)<\/p>\n<p>\u25cf\u00a0\u5355\u5206\u5b50\u8367\u5149\u6d4b\u5e8f(\u4ee5\u96f6\u819c\u6ce2\u5bfc\u5b54\u548c\u8367\u5149\u4fe1\u53f7\u4e3a\u6838\u5fc3\u7684\u00a0PacBio\u00a0\u6d4b\u5e8f\u4eea)<\/p>\n<p>\u25cf\u00a0\u5355\u5206\u5b50\u7eb3\u7c73\u5b54\u6d4b\u5e8f(\u4ee5\u7eb3\u7c73\u5b54\u86cb\u767d\u548c\u7535\u4fe1\u53f7\u4e3a\u6838\u5fc3\u7684\u00a0ONT\u3001\u9f50\u78b3\u79d1\u6280\u3001\u534e\u5927\u5e8f\u98ce)<\/p>\n<p>\u25cf\u00a0\u5176\u4ed6\u65b0\u5174\u6280\u672f(GenapSys\uff0cSingular\uff0cElement Bioscience\uff0cUltima\u00a0\u7b49\u4ee3\u8868\u6d4b\u5e8f\u4f01\u4e1a)<\/p>\n<p>\u6d4b\u5e8f\u6280\u672f\u5c3d\u7ba1\u5546\u4e1a\u5316\u8fdb\u7a0b\u5df2\u6709 38 \u5e74\uff0c\u4f46\u5e7f\u6cdb\u7684\u5927\u89c4\u6a21\u5e94\u7528\u4ec5\u5386\u7ecf16 \u5e74\u3002\u767e\u7f8e\u5143\u5168\u57fa\u56e0\u7ec4\u65f6\u4ee3\u6b63\u6316\u6398\u5927\u5065\u5eb7\u7b49\u5c42\u9762\u66f4\u5e7f\u6cdb\u7684\u5e94\u7528\u6f5c\u529b\uff0c\u5728\u4ea7\u5b66\u7814\u7528\u6df1\u5165\u534f\u4f5c\u548c\u5236\u5ea6\u5b8c\u5584\u57fa\u7840\u4e0a\uff0c\u6709\u671b\u5728\u672a\u67655-8\u5e74\u666e\u60e0\uff0c\u201c\u98de\u5165\u5bfb\u5e38\u767e\u59d3\u5bb6\u201d\u3002<\/p>\n<p>\u5728\u6280\u672f\u65b9\u9762\uff0c\u4ee5 Illumina \u4e3a\u4ee3\u8868\u7684 NGS \u516c\u53f8\u901a\u8fc7\u6539\u8fdb SBS \u6280\u672f\u52a0\u901f\u4e86\u6d4b\u5e8f\u4eea\u7684\u5546\u4e1a \u5316\u548c\u89c4\u6a21\u5316\u5e94\u7528\uff1b<\/p>\n<p>\u4ee5\u534e\u5927\u667a\u9020\u4e3a\u4ee3\u8868\u7684\u56fd\u4ea7\u6d4b\u5e8f\u516c\u53f8\uff0c\u901a\u8fc7\u521b\u65b0\u7684\u8054\u5408\u63a2\u9488\u951a\u5b9a\u805a\u5408\u6d4b\u5e8f\u3001 \u591a\u7ec4\u5b66\u878d\u5408\u4ee5\u53ca\u6c11\u751f\u5de5\u7a0b\u7b49\u5e94\u7528\uff0c\u8fdb\u4e00\u6b65\u52a0\u901f\u964d\u4f4e\u4e86\u6d4b\u5e8f\u6210\u672c\uff1b<\/p>\n<p>\u4ee5 ONT\u3001PacBio\u3001\u9f50\u78b3\u79d1\u6280\u548c\u534e\u5927\u5e8f\u98ce\u4e3a\u4ee3\u8868\u7684\u5355\u5206\u5b50\u6d4b\u5e8f\u516c\u53f8\uff0c\u8fd1\u5e74\u6765\u52a0\u5927\u4ece\u79d1\u7814\u5411\u4e34\u5e8a\u3001\u4f20\u611f\u67d3\u7b49\u9886\u57df\u7684\u5e94\u7528 \u529b\u5ea6\u3002<\/p>\n<p>\u8fd1\u5e74\u4e00\u4e9b\u521b\u65b0\u6d4b\u5e8f\u4eea\u4f01\u4e1a\u9646\u7eed\u53d1\u5e03\uff0c\u5305\u62ec GenapSys\uff0cSingular\uff0cElement Bioscience\u3001Ultima\u3001\u771f\u8fc8\u751f\u7269\u3001\u8d5b\u9646\u533b\u7597\u3001\u4eca\u662f\u79d1\u6280\u7b49\uff0c\u5728\u6d4b\u5e8f\u8d28\u91cf\u3001\u5f39\u6027\u6846\u67b6\u3001\u53cd\u5e94\u8868\u9762\u7b49\u65b9\u9762\u5c55\u9732\u51fa\u65b0\u5174\u751a\u81f3\u9769\u547d\u6027 \u6280\u672f\uff0c\u52a0\u901f\u4e86\u6280\u672f\u826f\u6027\u7ade\u4e89(\u800c\u975e\u4ea7\u54c1\u540c\u8d28\u5316)\u53ca\u4ea7\u4e1a\u751f\u6001\u7684\u5f62\u6210\u3002<\/p>\n<p>\u4f8b\u5982\uff0cUltima \u91c7\u7528\u9769 \u547d\u6027\u7684\u5f00\u653e\u5f0f 200mm \u7845\u6676\u5706\u57fa\u677f\u521b\u5efa\u53cd\u5e94\u8868\u9762\uff0c\u4e0d\u518d\u4f9d\u8d56\u5bc6\u5c01\u7684\u6d41\u901a\u6c60\uff0c\u5b9e\u73b0\u4e86 100 \u7f8e \u5143\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\uff0c\u5373\u7ea6 1 \u7f8e\u5143 \/Gb\u3002\u6b64\u5916\uff0c\u805a\u5408\u9176\u4f7f\u7528\u91cf\u51cf\u5c11 300 \u500d\uff0c\u901a\u8fc7\u6d41\u5f0f\u5316\u5b66\u63d0\u9ad8\u4e86 SNV \u68c0\u6d4b\u7684\u51c6\u786e\u6027\u3002<\/p>\n<div>\u5728\u6d4b\u5e8f\u9886\u57df\u7684\u6280\u672f\u5c42\u9762\uff0c\u53ef\u4ee5\u5173\u6ce8\u7684\u662f\uff1a<\/div>\n<div>\uff081\uff09\u6d4b\u5e8f\u8d28\u91cf\u8fdb\u5165 Q40 \u65f6\u4ee3\u30022024 \u5e74\u57fa\u56e0\u7ec4\u751f\u7269\u5b66\u6280\u672f\u8fdb\u5c55\u5927\u4f1a(AGBT)\u4e0a\uff0cIllumina \u5ba3 \u5e03 XLEAP-SBS \u5316\u5b66\u5c06\u4f7f\u7528\u5728 NextSeg 1000\/2000 \u4e0a\u5e76\u4f7f\u5f97 Q40 \u62a5\u544a\u6210\u4e3a\u53ef\u80fd\uff0c\u4e0e SomaLogic \u5408\u4f5c\u5f00\u53d1\u57fa\u4e8e NGS \u7684 SomaScan \u68c0\u6d4b Illumina Protein Prep\u3002\u534e\u5927\u667a\u9020\u5ba3\u5e03\u5c06\u5347\u7ea7\u8bd5\u5242\u5230 StandardMPS 2.0\uff0c\u4ee5\u4fdd\u8bc1\u8d85\u8fc7 90% \u7684\u8bfb\u6570\u8fbe\u5230 Q40 \u6d4b\u5e8f\u8d28\u91cf\uff1bUltima \u5ba3\u5e03\u63a8\u51fa ppmSeq \u5316\u5b66\u5b9e\u73b0 Q60 \u78b1\u57fa\u66ff\u6362\u51c6\u786e\u6027\u3002<\/div>\n<div>\uff082\uff09\u57fa\u56e0\u7ec4\u878d\u5408\u8f6c\u5f55\u7ec4\u3001\u8868\u89c2\u7ec4\u3001\u86cb\u767d\u7ec4\u3001\u7a7a\u95f4\u7ec4\u5b66\u4ee5\u53ca\u7ec6\u80de\u6210\u50cf\u7b49\u6280\u672f\u7b49\u751f\u547d\u591a\u7ec4\u5b66\u3002Element Biosciences \u7684 AVITI24 \u5e73\u53f0\u663e\u793a\u540c\u65f6\u5b9e\u73b0\u9ad8\u590d\u6742\u6027\u7684 RNA \u548c\u86cb\u767d\u8d28\u8868\u8fbe\u6c34\u5e73\u7684\u539f\u4f4d\u8bc4\u4f30\uff1bSingular Genomics \u5728\u539f\u672c\u7684\u6d4b\u5e8f\u57fa\u7840\u4e0a\u5347\u7ea7\u4e3a G4X \u539f\u4f4d\u7a7a\u95f4\u6d4b\u5e8f\u4eea\uff0c\u5229\u7528\u5feb\u901f 4 \u8272 SBS \u5316\u5b66\u540c\u65f6\u6d4b\u91cf FFPE \u7ec4\u7ec7\u7684\u76f4\u63a5 RNA \u6d4b\u5e8f\u3001\u9776\u5411\u8f6c\u5f55\u7ec4\u5b66\u3001\u86cb\u767d\u8d28\u7ec4\u5b66\u548c\u8367\u5149 H&amp;E \u8fdb\u884c\u6d4b\u91cf\uff0c\u5b9e\u73b0\u4e9a\u5fae\u7c73\u5206\u8fa8\u7387\u548c\u8d85\u9ad8\u901a\u91cf\u3002<\/div>\n<div>\uff083\uff09\u5f00\u6e90\u6d4b\u5e8f\u4eea\u3002\u4e54\u7eb3\u68ee\u00b7\u7f57\u65af\u4f2f\u683c(Jonathan Rothberg)\u5728 2024 \u5e74 1 \u6708\u5ba3\u5e03\u6210\u7acb\u5f00\u6e90\u6d4b\u5e8f\u4eea\u516c\u53f8 454.bio\uff0c\u901a\u8fc7\u5f00\u6e90\u5927\u8bed\u8a00\u6a21\u578b(LLM)\u8ba1\u5212\u5f00\u53d1 99 \u7f8e\u5143\u7684\u5bb6\u7528\u6d4b\u5e8f\u4eea\u3002\u7f57\u6c0f\u8bca\u65ad\u4e8e 2024 \u5e74 5 \u6708\u5ba3\u5e03\u5f00\u53d1\u57fa\u4e8e\u81a8\u80c0\/\u6269\u5c55\u6d4b\u5e8f SBX \u5316\u5b66\u7684\u7eb3\u7c73\u5b54\u6d4b\u5e8f\u4eea\uff0c\u6700\u5feb\u4e8e 2025 \u5e74\u53d1\u5e03\u3002<\/div>\n<div>\u5728\u6d4b\u5e8f\u9886\u57df\u7684\u4ea7\u54c1\u5c42\u9762\uff0c\u57fa\u4e8e\u6280\u672f\u8fed\u4ee3\u548c\u6210\u672c\u964d\u4f4e\u7684\u903b\u8f91\uff0c\u6d4b\u5e8f\u4eea\u662f\u76ee\u524d\u57fa\u56e0\u9886\u57df\u83b7\u5f97\u8d44\u672c\u91cd\u70b9\u5173\u6ce8\u7684\u9886\u57df\u4e4b\u4e00\uff0c\u5305\u62ec\u5143\u7d20\u751f\u7269\u3001\u9f50\u78b3\u79d1\u6280\u3001\u8d5b\u7eb3\u751f\u7269\u7b49\u6301\u7eed\u83b7\u5f97\u6570\u4ebf\u7ea7\u7684\u878d\u8d44\u3002<\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgB2Nsavd8Y9yRtX1RibgdncdDZCTKoiacFZYYxTibWNgHNHlz0SdrCOqN605AO20w9v4UibEicSQ1ZOyzA.png\" alt=\"RmFicvQBAkgB2Nsavd8Y9yRtX1RibgdncdDZCTKoiacFZYYxTibWNgHNHlz0SdrCOqN605AO20w9v4UibEicSQ1ZOyzA\"\/><\/figure><\/div>\n\n<div>\u5728\u57fa\u56e0\u6d4b\u5e8f\u7684\u5236\u5ea6\u5c42\u9762\uff0c\u7531\u4e8e 2022 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