{"id":11763,"date":"2022-05-19T08:00:00","date_gmt":"2022-05-19T00:00:00","guid":{"rendered":"https:\/\/www.geneclub.net.cn\/index.php\/2022\/05\/19\/555550-2\/"},"modified":"2026-04-07T17:05:42","modified_gmt":"2026-04-07T09:05:42","slug":"555550-2","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2022\/05\/19\/555550-2\/","title":{"rendered":"\u6df1\u5ea6\u8bbf\u8c08\u5317\u5927\u9ad8\u6b4c\uff1a\u5355\u7ec6\u80de\u591a\u7ec4\u5b66\u6570\u636e\u6574\u5408\u4e0e\u8c03\u63a7\u63a8\u65ad\u65b0\u65b9\u6cd5\u2014\u2014GLUE"},"content":{"rendered":"

<\/p>\n

\u672c\u671f\u79d1\u7814\u5927\u5496 \u00b7 \u5317\u4eac\u5927\u5b66\u9ad8\u6b4c\u8001\u5e08<\/div>\n
<\/div>\n
\u7b14\u8005\u7b2c\u4e00\u6b21\u4e0e\u9ad8\u6b4c\u8001\u5e08\u53d6\u5f97\u8054\u7cfb\u65f6\u63a5\u8fd1\u51cc\u6668\u4e00\u70b9\uff0c\u5f7c\u65f6\u4ed6\u6001\u5ea6\u8c26\u548c\u5730\u89e3\u91ca\u81ea\u5df1\u521a\u521a\u5f00\u5b8c\u4f1a\uff0c\u5fd9\u788c\u2014\u2014\u662f\u7b14\u8005\u5bf9\u9ad8\u6b4c\u8001\u5e08\u7684\u7b2c\u4e00\u5370\u8c61\u3002<\/div>\n
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\"eicZhoGYCfyZiaV509qm6zUovXOPlzWknl8TUH6m4oydTgaGmZQKNeehaGwOeGZSmGoyUaxlichU3ktv8jib1KgQtQ\"\/<\/figure><\/div>\n\n
\u56fe\uff1a\u9ad8\u6b4c\u8001\u5e08\uff08\u6765\u6e90\/\u53d7\u8bbf\u8005\u63d0\u4f9b\uff09<\/div>\n
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\u9ad8\u6b4c\u8001\u5e08\u5bf9\u7b14\u8005\u8bf4\uff1a\u201c \u628a\u95ee\u9898\u60f3\u6e05\u695a\u5f88\u591a\u65f6\u5019\u6bd4\u76f2\u76ee\u7684\u201c\u70bc\u4e39\u201d\u66f4\u6709\u610f\u4e49\u3002\u4f5c\u4e3a\u751f\u7269\u4fe1\u606f\u5b66\u5de5\u4f5c\u8005\uff0c\u5f00\u53d1\u51fa\u5bf9\u5927\u5bb6\u6709\u7528\u7684\u65b9\u6cd5\u662f\u6211\u4eec\u7684\u6838\u5fc3\u4f7f\u547d\u4e4b\u4e00\u3002\u201d<\/div>\n
<\/div>\n
\u4f5c\u4e3a\u751f\u7269\u4fe1\u606f\u5b66\u9886\u57df\u4e13\u5bb6\uff0c\u9ad8\u6b4c\u53ca\u56e2\u961f\u4e00\u76f4\u5173\u6ce8\u7740\u8fc5\u901f\u53d1\u5c55\u7684\u5355\u7ec6\u80de\u6d4b\u5e8f\u6280\u672f\u3002\u5982\u4f55\u901a\u8fc7\u5f00\u53d1\u65b0\u7684\u8ba1\u7b97\u65b9\u6cd5\u5b9e\u73b0\u5bf9\u8fd9\u4e9b\u5b9d\u8d35\u6570\u636e\u7684\u6709\u6548\u5229\u7528\u662f\u5f53\u4eca\u751f\u7269\u4fe1\u606f\u5b66\u9886\u57df\u5173\u6ce8\u7684\u91cd\u70b9\u4e0e\u70ed\u70b9\uff0c\u4e5f\u662f\u9ad8\u6b4c\u56e2\u961f\u4e00\u76f4\u5728\u601d\u8003\u7684\u95ee\u9898\u3002<\/div>\n\n
\n
\"eicZhoGYCfyZiaV509qm6zUovXOPlzWknlE8TTI8HlIhZsaO6RffUeNTKnYqUOCuUdOLLJsp1EuNcaLYRxA9fibpg\"\/<\/figure><\/div>\n\n
\u56fe\uff1aMulti-omics single-cell data integration and regulatory inference with graph-linked embedding\uff08\u6765\u6e90 \/Nature Biotechnology\uff09<\/div>\n
2022\u5e745\u67082\u65e5\uff0c\u5317\u4eac\u5927\u5b66\/\u660c\u5e73\u5b9e\u9a8c\u5ba4\u9ad8\u6b4c\u8bfe\u9898\u7ec4\u4e8eNature Biotechnology\u53d1\u8868\u9898\u4e3aMulti-omics single-cell data integration and regulatory inference with graph-linked embedding\u7684\u7814\u7a76\u8bba\u6587\uff0c\u63d0\u51fa\u4e86\u57fa\u4e8e\u56fe\u8026\u8054\u7b56\u7565\u7684\u6df1\u5ea6\u5b66\u4e60\u65b9\u6cd5GLUE\uff0c\u9996\u6b21\u5b9e\u73b0\u4e86\u5bf9\u767e\u4e07\u7ea7\u5355\u7ec6\u80de\u591a\u7ec4\u5b66\u6570\u636e\u7684\u65e0\u76d1\u7763\u7cbe\u51c6\u6574\u5408\u4e0e\u8c03\u63a7\u63a8\u65ad\u3002<\/div>\n
\u00a0<\/div>\n
\u91cd\u70b9\u6982\u8ff0<\/div>\n
1\u3001GLUE\u662f\u4e00\u79cd\u57fa\u4e8e\u56fe\u8026\u8054\u7b56\u7565\u7684\u6df1\u5ea6\u5b66\u4e60\u65b9\u6cd5\uff0c\u53ef\u5c06\u4e0d\u540c\u7ec4\u5b66\u7684\u4f4e\u7ef4\u9690\u7a7a\u95f4\u8868\u793a\u5173\u8054\u8d77\u6765\u5e76\u786e\u4fdd\u5176\u201c\u8bed\u4e49\u4e00\u81f4\u6027\u201d\uff1b<\/div>\n
2\u3001\u8bbe\u8ba1GLUE\u7684\u76ee\u7684\u65e8\u5728\u5168\u9762\u5730\u523b\u753b\u7ec6\u80de\u5185\u7684\u57fa\u56e0\u8c03\u63a7\u72b6\u6001\u3001\u63ed\u793a\u8c03\u63a7\u673a\u5236\uff0c\u4e3a\u524d\u6cbf\u7cbe\u51c6\u533b\u5b66\u7814\u7a76\u63d0\u4f9b\u7ebf\u7d22\uff1b<\/div>\n
3\u3001\u4e0eSeurat\u7b49\u76ee\u524d\u4e3b\u6d41\u5355\u7ec6\u80de\u8de8\u7ec4\u5b66\u6574\u5408\u7b97\u6cd5\u76f8\u6bd4\uff0cGLUE\u7684\u4e3b\u8981\u4f18\u52bf\u5728\u4e8e\u63d0\u51fa\u4e86\u4e0d\u4f9d\u8d56\u4e8e\u7279\u5f81\u8f6c\u6362\u7684\u6574\u5408\u65b9\u6cd5\uff1b<\/div>\n
4\u3001GLUE\u53ef\u5bb9\u6613\u5730\u6269\u5145\u4ee5\u652f\u6301\u5982\u5355\u7ec6\u80deRibo-seq\u3001\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u7b49\u66f4\u591a\u7ec4\u5b66\u7c7b\u578b\u6570\u636e\u6574\u5408\u3002<\/div>\n
\u2026\u2026\u66f4\u591a\u7cbe\u5f69\uff0c\u8bf7\u9605\u8bfb\u672c\u671f\u6df1\u5ea6\u4e13\u8bbf\uff01<\/div>\n
\u00a0<\/div>\n
PART.1<\/div>\n
\u6211\u56fd\u751f\u7269\u4fe1\u606f\u5b66\u754c\u7684\u65b0\u7a81\u7834<\/div>\n
\u201c<\/div>\n
\u9ad8\u8001\u5e08\uff0c\u795d\u8d3a\u60a8\u7684\u56e2\u961f\u5728Nature Biotechnology\u4e0a\u53d1\u8868\u57fa\u4e8e\u6df1\u5ea6\u5b66\u4e60\u65b9\u6cd5\u89e3\u51b3\u5355\u7ec6\u80de\u591a\u7ec4\u5b66\u65e0\u76d1\u7763\u6574\u5408\u7684\u6210\u679c\u3002\u7528\u6e05\u534e\u5927\u5b66\u5f20\u5b66\u5de5\u6559\u6388\u7684\u8bdd\u8bf4\uff0c\u8fd9\u662f\u6211\u56fd\u751f\u7269\u4fe1\u606f\u5b66\u754c\u7684\u4e00\u4e2a\u65b0\u7a81\u7834\uff01\u8bf7\u60a8\u9996\u5148\u4ecb\u7ecd\u4e0b\u8fd9\u9879\u7814\u7a76\u7684\u80cc\u666f\u3002\u7279\u522b\u662f\u9488\u5bf9\u76ee\u524d\u5c5e\u4e8e\u79d1\u7814\u8f6c\u5316\u9636\u6bb5\u7684\u5355\u7ec6\u80de\u591a\u7ec4\u5b66\uff0c\u8fd9\u9879\u7814\u7a76\u65e8\u5728\u89e3\u51b3\u4ec0\u4e48\u96be\u9898\uff1f<\/div>\n
\u9ad8\u6b4c\u56e2\u961f<\/div>\n
\u6211\u4eec\u77e5\u9053\uff0c\u4f20\u7edf\u7684\u6d4b\u5e8f\u7b49\u751f\u547d\u89e3\u7801\u65b9\u6cd5\u662f\u5bf9\u7fa4\u4f53\u7ec6\u80de\u7279\u5f81\u7684\u5e73\u5747\u503c\u6d4b\u91cf\uff0c\u4f46\u662f\u6bcf\u4e2a\u6210\u5e74\u4eba\u4f53\u5185\u5e73\u5747\u670940\u4e07\u4ebf\u4e2a\u7ec6\u80de\uff0c\u800c\u6bcf\u4e2a\u7ec6\u80de\u5728\u5f62\u6001\u3001\u529f\u80fd\u65b9\u9762\u5404\u6709\u4e0d\u540c\uff0c\u5982\u679c\u80fd\u5728\u5355\u7ec6\u80de\u6c34\u5e73\u6d4b\u91cf\u7ec6\u80de\u7684\u72b6\u6001\uff0c\u53ef\u5728\u4e0d\u540c\u75c5\u4eba\u3001\u4f4d\u7f6e\u3001\u9636\u6bb5\u7684\u7ec4\u7ec7\u6837\u54c1\u5185\u9ad8\u7cbe\u5ea6\u5730\u9274\u5b9a\u7ec6\u80de\u7c7b\u7fa4\uff0c\u7814\u7a76\u4e0d\u540c\u7c7b\u7fa4\u7ec6\u80de\u7684\u5206\u5b50\u7279\u70b9\u3001\u7c7b\u7fa4\u95f4\u76f8\u4e92\u4f5c\u7528\u7b49\uff0c\u6709\u52a9\u4e8e\u5b9e\u73b0\u75be\u75c5\u7684\u7cbe\u51c6\u8bca\u65ad\u548c\u6cbb\u7597\u3002<\/div>\n
\u00a0<\/div>\n
\u4ece2009\u5e74\u4ee5\u6765\uff0c\u9ad8\u901a\u91cf\u5355\u7ec6\u80de\u6d4b\u5e8f\u6280\u672f\u5f97\u4ee5\u5feb\u901f\u53d1\u5c55\uff0c\u9010\u6e10\u4ece\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6d4b\u5e8f\uff0c\u53d1\u5c55\u5230\u67d3\u8272\u8d28\u5f00\u653e\u7ec4\u3001DNA\u7532\u57fa\u5316\u7ec4\u3001\u7ec4\u86cb\u767d\u4fee\u9970\u7ec4\u7b49\u7b49\u5728\u5185\u7684\u591a\u7ec4\u5b66\u5206\u6790\u3002\u4f46\u662f\uff0c\u5927\u90e8\u5206\u5355\u7ec6\u80de\u7ec4\u5b66\u6d4b\u5e8f\u6280\u672f\u5728\u4e00\u4e2a\u5355\u7ec6\u80de\u4e2d\u53ea\u80fd\u68c0\u6d4b\u4e00\u79cd\u7ec4\u5b66\uff0c\u8fd9\u6837\u7684\u6570\u636e\u5bf9\u4e8e\u7ec6\u80de\u72b6\u6001\u7684\u523b\u753b\u662f\u7247\u9762\u7684\uff0c\u65e0\u6cd5\u5b8c\u6574\u5730\u53cd\u5e94\u7ec6\u80de\u5185\u7684\u57fa\u56e0\u8c03\u63a7\u72b6\u6001\uff1b\u800c\u8fd9\u4e9b\u7ec4\u5b66\u6570\u636e\u53c8\u5177\u6709\u975e\u5e38\u9ad8\u7684\u7ef4\u5ea6\u548c\u566a\u97f3\uff0c\u4e14\u7279\u5f81\u7a7a\u95f4\u5b58\u5728\u5dee\u5f02\uff0c\u7ed9\u6570\u636e\u6574\u5408\u9020\u6210\u4e86\u5f88\u5927\u7684\u56f0\u96be\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u5e0c\u671b\u901a\u8fc7\u5f00\u53d1\u5efa\u7acb\u5408\u9002\u7684\u8ba1\u7b97\u65b9\u6cd5\u4e0e\u6a21\u578b\uff0c\u89e3\u51b3\u5f53\u524d\u7684\u8de8\u7ec4\u5b66\u8ba1\u7b97\u6574\u5408\u6311\u6218\uff0c\u63d0\u9ad8\u6570\u636e\u6574\u5408\u7cbe\u5ea6\uff0c\u5145\u5206\u5229\u7528\u8fd9\u4e9b\u5b9d\u8d35\u6570\u636e\u4ee5\u66f4\u5168\u9762\u5730\u523b\u753b\u7ec6\u80de\u5185\u7684\u57fa\u56e0\u8c03\u63a7\u72b6\u6001\u3001\u63ed\u793a\u8c03\u63a7\u673a\u5236\uff0c\u4e3a\u524d\u6cbf\u7cbe\u51c6\u533b\u5b66\u7814\u7a76\u63d0\u4f9b\u7ebf\u7d22\u3002<\/div>\n
\u00a0<\/div>\n
PART.2<\/div>\n
GLUE\u7684\u4f18\u52bf\u603b\u7ed3<\/div>\n
\u201c<\/div>\n
\u8bfb\u8005\u670b\u53cb\u4eec\u5bf9\u4e8e\u60a8\u56e2\u961f\u53d1\u5e03\u7684GLUE\u5de5\u5177\u975e\u5e38\u597d\u5947\u3002\u5b83\u76f8\u5bf9\u76ee\u524d\u5e02\u9762\u4e0a\u5df2\u6709\u5355\u7ec6\u80de\u591a\u7ec4\u5b66\u6570\u636e\u6574\u5408\u65b9\u6cd5\uff08\u6bd4\u5982Seurat\u7b49\uff09\u76f8\u6bd4\uff0c\u6709\u54ea\u4e9b\u660e\u663e\u7684\u4f18\u52bf\uff1f\u7a81\u51fa\u5730\u89e3\u51b3\u4e86\u4ec0\u4e48\u95ee\u9898\u5462\uff1f<\/div>\n
\u9ad8\u6b4c\u56e2\u961f<\/div>\n
\u5355\u7ec6\u80de\u591a\u7ec4\u5b66\u6570\u636e\u6574\u5408\u7684\u4e00\u5927\u6311\u6218\u5728\u4e8e\u4e0d\u540c\u7ec4\u5b66\u7684\u7279\u5f81\u7a7a\u95f4\u5b58\u5728\u5dee\u5f02\uff0c\u4f8b\u5982\u8f6c\u5f55\u7ec4\u7684\u7279\u5f81\u662f\u57fa\u56e0\uff0c\u800c\u67d3\u8272\u8d28\u5f00\u653e\u7ec4\u7684\u7279\u5f81\u662f\u67d3\u8272\u8d28\u5f00\u653e\u533a\u6bb5\uff0c\u4e0d\u540c\u7279\u5f81\u7a7a\u95f4\u7684\u7ec6\u80de\u7f3a\u4e4f\u53ef\u6bd4\u6027\u3002<\/div>\n
GLUE\u7684\u5168\u79f0\u662fGraphLinked Unified Embedding\uff0c\u5373\u56fe\u8026\u8054\u7edf\u4e00\u5d4c\u5165\uff0c\u5b83\u7684\u7279\u70b9\u662f\u63d0\u51fa\u4e86\u5168\u65b0\u7684\u56fe\u8026\u8054\uff08graph-linking\uff09\u7b56\u7565\uff0c\u5c06\u4e0d\u540c\u7ec4\u5b66\u7684\u4f4e\u7ef4\u9690\u7a7a\u95f4\u8868\u793a\u5173\u8054\u8d77\u6765\u5e76\u786e\u4fdd\u5176\u201c\u8bed\u4e49\u4e00\u81f4\u6027\u201d\u3002<\/div>\n\n
\n
\"eicZhoGYCfyZiaV509qm6zUovXOPlzWknlQDfgibDtB7pVibeoibufQCh2f6D8NBY22pKWic1Gm58hLcajQCUYsW204g\"\/<\/figure><\/div>\n\n
\u56fe\uff1aGLUE\u6a21\u578b\u7684\u7ed3\u6784\u793a\u610f\u56fe<\/div>\n
\u6765\u6e90\/\u5317\u4eac\u5927\u5b66\u751f\u7269\u533b\u5b66\u524d\u6cbf\u521b\u65b0\u4e2d\u5fc3<\/div>\n
\u4e0eSeurat\u7b49\u76ee\u524d\u4e3b\u6d41\u5355\u7ec6\u80de\u8de8\u7ec4\u5b66\u6574\u5408\u7b97\u6cd5\u76f8\u6bd4\uff0cGLUE\u7684\u4e3b\u8981\u4f18\u52bf\u5728\u4e8e\u63d0\u51fa\u4e86\u4e0d\u4f9d\u8d56\u4e8e\u7279\u5f81\u8f6c\u6362\u7684\u6574\u5408\u65b9\u6cd5\u3002Seurat\u7b49\u65b9\u6cd5\u5728\u8fdb\u884c\u5177\u4f53\u6574\u5408\u5de5\u4f5c\u524d\u9700\u8981\u5c06\u4e0d\u540c\u7ec4\u5b66\u6570\u636e\u8f6c\u6362\u4e3a\u540c\u4e00\u7ec4\u7279\u5f81\uff08\u4e00\u822c\u662f\u57fa\u56e0\u7279\u5f81\uff09\uff0c\u4f1a\u9020\u6210\u663e\u8457\u7684\u4fe1\u606f\u635f\u5931\u3002\u5177\u4f53\u6765\u8bf4\uff1aDrop-ChIP\u7684\u6570\u636e\u4e0eATAC\u76f8\u4f3c\u90fd\u662f\u6bd4\u8f83\u9ad8\u7ef4\u3001\u7a00\u758f\u7684\uff0c\u5982\u679c\u4f7f\u7528Seurat\u7684\u8bdd\u5728\u7279\u5f81\u8f6c\u6362\u8fd9\u4e00\u6b65\u5c31\u4f1a\u635f\u5931\u4e00\u90e8\u5206\u7ec6\u80de\u7c7b\u578b\u5206\u8fa8\u7387\uff1b\u53e6\u5916\uff0c\u53d6\u51b3\u4e8eDrop-ChIP\u68c0\u6d4b\u7684\u7ec4\u86cb\u767d\u4fee\u9970\uff0c\u5982\u679c\u662f\u6291\u5236\u6027\u4fee\u9970\u7684\u8bdd\uff0c\u6570\u636e\u8fd8\u9700\u8981\u8fdb\u884c\u53cd\u8f6c\uff0c\u5bfc\u81f4\u8fdb\u4e00\u6b65\u7684\u4fe1\u606f\u635f\u5931\u540c\u65f6\u63d0\u9ad8\u5185\u5b58\u6d88\u8017\u3002<\/div>\n\n
\n
\"eicZhoGYCfyZiaV509qm6zUovXOPlzWknlPff1BH0kJF0vD187GryaY0U0kwRlrFQjCc4Cp6P5kDCgBfr7I13iang\"\/<\/figure><\/div>\n\n
\u56fe:GLUE\u9996\u6b21\u5b9e\u73b0\u4e86\u56fe\u8c31\u7ea7\u8d85\u5927\u89c4\u6a21\u5355\u7ec6\u80de\u591a\u7ec4\u5b66\u6570\u636e\u7684\u51c6\u786e\u6574\u5408\u3002\u4e0e\u540c\u7c7b\u5de5\u5177\u76f8\u6bd4\uff0cGLUE\u5728\u7ec6\u80de\u5206\u8fa8\u7387\u4e0e\u53e0\u5408\u7cbe\u5ea6\u65b9\u9762\u5747\u5177\u6709\u663e\u8457\u7684\u4f18\u52bf\u3002<\/div>\n
\u6765\u6e90\/\u5317\u4eac\u5927\u5b66\u751f\u7269\u533b\u5b66\u524d\u6cbf\u521b\u65b0\u4e2d\u5fc3<\/div>\n
\u603b\u4f53\u6765\u8bf4\uff0cGLUE\u4f18\u52bf\u5305\u62ec\u4ee5\u4e0b\u56db\u70b9\uff1a<\/div>\n
1. \u591a\u7ec4\u5b66\u6574\u5408\u7684\u7cbe\u5ea6\u9ad8\uff1b<\/div>\n
2. \u53ef\u652f\u6301\u4efb\u610f\u6570\u91cf\u3001\u8c03\u63a7\u65b9\u5411\u7684\u8de8\u7ec4\u5b66\u6570\u636e\u5339\u914d\uff1a\u901a\u8fc7\u5f15\u5165\u7ec4\u5b66\u7279\u5f02\u7684\u53d8\u5206\u81ea\u7f16\u7801\u5668(Variational AutoEncoder, VAE)\u7ec4\u4ef6\u5806\u53e0\uff0c\u652f\u6301\u5bf9\u591a\u7ec4\u5b66\u975e\u914d\u5bf9\u6570\u636e\u7684\u65e0\u76d1\u7763\u6574\u5408\uff1b<\/div>\n
3. \u8ba1\u7b97\u53ef\u6269\u5c55\u6027(Scalability)\u5f3a\uff1a\u8ba1\u7b97\u590d\u6742\u5ea6\u4e0e\u7ec6\u80de\u6570\u4e4b\u95f4\u5448\u4e9a\u7ebf\u6027\u5173\u8054\uff0c\u662f\u540c\u7c7b\u65b9\u6cd5\u4e2d\u552f\u4e00\u53ef\u4ee5\u7cbe\u51c6\u5206\u6790\u4e0a\u767e\u4e07\u5355\u7ec6\u80de\u7684\u65b9\u6cd5\uff1b<\/div>\n
4. \u53ef\u540c\u65f6\u8fdb\u884c\u8c03\u63a7\u63a8\u65ad\uff1a\u5728\u5148\u9a8c\u8c03\u63a7\u56fe\u4e2d\u76f4\u63a5\u5bf9\u8c03\u63a7\u5173\u7cfb\u8fdb\u884c\u4e86\u5efa\u6a21\uff0c\u8fd8\u53ef\u7efc\u5408\u5148\u9a8c\u8c03\u63a7\u4fe1\u606f\u4e0e\u591a\u7ec4\u5b66\u6570\u636e\u7edf\u8ba1\u76f8\u5173\u6027\uff0c\u5b9e\u73b0\u53ef\u9760\u7684\u8f6c\u5f55\u8c03\u63a7\u63a8\u65ad\u3002<\/div>\n
\u00a0<\/div>\n
PART.3<\/div>\n
\u7528\u6b63\u786e\u7684\u65b9\u6cd5\u505a\u5bf9\u7684\u4e8b<\/div>\n
\u201c<\/div>\n
\u542c\u8d77\u6765\u975e\u5e38\u60ca\u8273\uff01\u89e3\u51b3\u4e86\u4f5c\u4e3a\u751f\u7269\u4fe1\u606f\u5de5\u4f5c\u8005\u7684\u8bf8\u591a\u96be\u9898\uff0c\u8bf7\u95ee\u8fd9\u4e2a\u6a21\u578b\u8bbe\u8ba1\u8fc7\u7a0b\u4e2d\u9047\u5230\u4e86\u54ea\u4e9b\u56f0\u96be\uff1f\u4f60\u4e0e\u56e2\u961f\u53c8\u662f\u5982\u4f55\u5c06\u56f0\u96be\u4e00\u6b65\u6b65\u4f18\u5316\u6210\u6700\u7ec8\u8fd9\u6837\u7f8e\u5999\u7684\u7b56\u7565\u7684\u5462\uff1f<\/div>\n
\u9ad8\u6b4c\u56e2\u961f<\/div>\n
\u5728\u6574\u4e2a\u5de5\u4f5c\u8fc7\u7a0b\u4e2d\uff0c\u6211\u4eec\u4e00\u76f4\u7684\u539f\u5219\u662f\u201c\u7528\u6b63\u786e\u7684\u65b9\u6cd5\u505a\u5bf9\u7684\u4e8b\u60c5\u201d\uff0c\u5e0c\u671b\u901a\u8fc7\u7406\u6027\u8bbe\u8ba1(rational design)\u6765\u6784\u5efa\u53ef\u7406\u89e3\u3001\u53ef\u89e3\u91ca\u7684\u6a21\u578b\uff0c\u7528\u4ee5\u89e3\u51b3\u5b9e\u9645\u7684\u751f\u7269\u5b66\u95ee\u9898\u3002<\/div>\n
\u00a0<\/div>\n
\u4f8b\u5982\uff0c\u65e9\u671f\u6211\u4eec\u66fe\u5c1d\u8bd5\u501f\u9274\u56fe\u50cf\u5b66\u4e60\u9886\u57df\u7684CycleGAN\u6a21\u578b\uff0c\u4f7f\u7528\u5faa\u73af\u4e00\u81f4\u6027\u635f\u5931\uff08cycle-consistency loss\uff09\u6765\u4fdd\u8bc1\u975e\u914d\u5bf9\u591a\u6a21\u6001\u6570\u636e\u6574\u5408\u7684\u51c6\u786e\u6027\uff0c\u4f46\u6211\u4eec\u53cd\u590d\u7422\u78e8\u540e\u610f\u8bc6\u5230CycleGAN\u6a21\u578b\u5e76\u4e0d\u662f\u5b8c\u5168\u4f9d\u8d56\u5faa\u73af\u4e00\u81f4\u6027\u635f\u5931\u4fdd\u8bc1\u6574\u5408\u6b63\u786e\u6027\u7684\uff0c\u56fe\u50cf\u9886\u57df\u57fa\u4e8e\u5377\u79ef\u7684\u7279\u6b8a\u7f16\u7801\u3001\u89e3\u7801\u7f51\u7edc\u7ed3\u6784\u7b49\u56fe\u50cf\u9886\u57df\u7684\u5148\u9a8c\u77e5\u8bc6\u5bf9\u4e8e\u7ed3\u679c\u6b63\u786e\u6027\u6709\u7740\u4e0d\u53ef\u66ff\u4ee3\u7684\u91cd\u8981\u4f5c\u7528\uff0c\u8fd9\u8ba9\u6211\u4eec\u610f\u8bc6\u5230\u5728\u6570\u636e\u6574\u5408\u4e2d\u5148\u9a8c\u77e5\u8bc6\u7684\u91cd\u8981\u6027\uff0c\u8fdb\u800c\u63d0\u51fa\u4e86\u57fa\u4e8e\u56fe\u6a21\u578b\u5728\u795e\u7ecf\u7f51\u7edc\u4e2d\u5f15\u5165\u7ec4\u5b66\u6570\u636e\u5148\u9a8c\u4fe1\u606f\u7684\u601d\u8def\uff1b\u4e0e\u6b64\u540c\u65f6\uff0c\u6211\u4eec\u901a\u8fc7\u5728\u6a21\u578b\u8bbe\u8ba1\u4e2d\u521b\u9020\u6027\u5730\u5f15\u5165\u4e86\u975e\u7ebf\u6027\u7f16\u7801\u5668(Encoder)\u4e0e\u7ebf\u6027\u89e3\u7801\u5668(Decoder)\u7ec4\u5408\uff0c\u5728\u63d0\u9ad8\u8ba1\u7b97\u6548\u7387\u7684\u540c\u65f6\u663e\u8457\u6539\u5584\u4e86\u7ed3\u679c\u7684\u53ef\u89e3\u91ca\u6027\uff0c\u8fd9\u4e5f\u6210\u4e3a\u4e86\u6700\u7ec8\u91c7\u53d6\u7684\u56fe\u8026\u8054(Graph-linked)\u7b56\u7565\u7684\u96cf\u5f62\u3002<\/div>\n
\u00a0<\/div>\n
\u5728\u8fd9\u4e2a\u8fc7\u7a0b\u4e2d\u6211\u4eec\u4e5f\u78b0\u5230\u4e86\u82e5\u5e72\u56f0\u96be\uff0c\u5982\u5728\u767e\u4e07\u7ea7\u7ec6\u80de\u56fe\u8c31\u6574\u5408\u7684\u5de5\u4f5c\u4e2d\uff0c\u53d1\u73b0\u6211\u4eec\u7684\u6574\u5408\u7ed3\u679c\u4e0e\u539f\u6587\u4f5c\u8005\u7ed9\u51fa\u7684\u6ce8\u91ca\u5b58\u5728\u4e0d\u4e00\u81f4\u7684\u60c5\u51b5\u3002\u5f88\u957f\u4e00\u6bb5\u65f6\u95f4\u91cc\u8bef\u4ee5\u4e3a\u662f\u6211\u4eec\u641e\u9519\u4e86\uff0c\u7ecf\u8fc7\u53cd\u590d\u68c0\u67e5\u624d\u5f97\u4ee5\u786e\u8ba4\u6211\u4eec\u7684\u7ed3\u679c\u662f\u6b63\u786e\u7684\u7684\uff0c\u6700\u7ec8\u8fd9\u4e9b\u7ed3\u679c\u4e5f\u5f97\u5230\u4e86\u539f\u6587\u4f5c\u8005\u7684\u8ba4\u53ef\u3002<\/div>\n
\u56de\u5934\u6765\u770b\uff0c\u8fd9\u6bb5\u7ecf\u5386\u4e0d\u4ec5\u8ba9\u6211\u4eec\u6709\u673a\u4f1a\u7cfb\u7edf\u6027\u5730\u68c0\u9a8c\u4e86\u6574\u4e2a\u5de5\u4f5c\uff0c\u4e5f\u8fdb\u4e00\u6b65\u575a\u5b9a\u4e86\u6211\u4eec\u5bf9\u6240\u91c7\u7528\u7684\u4ece\u57fa\u7840\u51fa\u53d1\u3001\u7406\u6027\u8bbe\u8ba1\u6a21\u578b\u800c\u975e\u7b80\u5355\u4fee\u8865\u4ee5\u201c\u70bc\u4e39\u201d(Making it right before making it better)\u8fd9\u4e00\u57fa\u672c\u7406\u5ff5\u7684\u4fe1\u5fc3\u3002<\/div>\n
\u00a0<\/div>\n
PART.4<\/div>\n
\u6a21\u578b\u7684\u8bbe\u8ba1\u662f\u975e\u5e38\u91cd\u8981\u7684<\/div>\n
\u201c<\/div>\n
\u8bf7\u95ee\u54b1\u4eec\u8fd9\u9879\u7814\u7a76\u7684\u6574\u4f53\u5468\u671f\u591a\u957f\uff0c\u5728\u54ea\u4e2a\u9636\u6bb5\u82b1\u8d39\u7684\u65f6\u95f4\u6700\u957f\u5462\uff1f<\/div>\n
\u9ad8\u6b4c\u56e2\u961f<\/div>\n
GLUE\u4ece\u5f00\u59cb\u6784\u601d\u5230\u5b8c\u6210\u5de5\u4f5c\u5f00\u59cb\u5199\u7a3f\u82b1\u4e86\u4e24\u5e74\u534a\u7684\u65f6\u95f4\uff0c2\/3\u4ee5\u4e0a\u7684\u65f6\u95f4\uff08\u7ea620\u4e2a\u6708\uff09\u90fd\u662f\u82b1\u5728\u524d\u671f\u6a21\u578b\u8bbe\u8ba1\u3001\u8bd5\u9519\u548c\u6027\u80fd\u8bc4\u6d4b\u4e0a\uff1b\u8fd9\u4e9b\u5de5\u4f5c\u6253\u4e86\u975e\u5e38\u597d\u7684\u57fa\u7840\uff0c\u540e\u7eed\u7684\u8fd9\u4e9b\u5e94\u7528\u5b9e\u4f8b\u82b1\u7684\u65f6\u95f4\u53cd\u800c\u76f8\u5bf9\u8f83\u5c11\u3002<\/div>\n
\u4e8b\u5b9e\u4e0a\uff0c\u6211\u4eec\u8ba4\u4e3a\u6a21\u578b\u7684\u8bbe\u8ba1\u662f\u975e\u5e38\u91cd\u8981\u7684\uff1b\u5982\u679c\u6a21\u578b\u5bf9\u4e86\uff0c\u90a3\u4e48\u5e94\u7528\u5b9e\u4f8b\u5e94\u8be5\u82b1\u4e0d\u4e86\u592a\u591a\u65f6\u95f4\uff0c\u800c\u5982\u679c\u57fa\u7840\u6a21\u578b\u6709\u7f3a\u9677\uff0c\u5728\u5e94\u7528\u5b9e\u4f8b\u4e0a\u82b1\u518d\u591a\u7684\u65f6\u95f4\u610f\u4e49\u4e5f\u4e0d\u5927\u3002<\/div>\n
\u00a0<\/div>\n
PART.5<\/div>\n
\u628a\u95ee\u9898\u60f3\u6e05\u695a\u6709\u65f6\u6bd4\u76f2\u76ee\u201c\u70bc\u4e39\u201d\u66f4\u6709\u610f\u4e49<\/div>\n
\u201c<\/div>\n
\u8bfb\u8005\u8fd8\u6bd4\u8f83\u5173\u5fc3\u76ee\u524dGLUE\u6846\u67b6\u80fd\u591f\u5e94\u7528\u5230\u54ea\u4e9b\u5b9e\u9645\u7684\u5206\u6790\u4e2d\uff1f\u672a\u6765\u4f18\u5316\u65b9\u5411\u662f\u4ec0\u4e48\uff1f<\/div>\n
\u9ad8\u6b4c\u56e2\u961f<\/div>\n
\u5bf9\u4e8e\u8de8\u6a21\u6001\u6570\u636e\u6574\u5408\uff0c\u5982\u679c\u4e0d\u540c\u6a21\u6001\u7684\u7279\u5f81\u5173\u7cfb\u5b58\u5728\u5148\u9a8c\u77e5\u8bc6\uff0c\u7406\u8bba\u4e0a\u90fd\u53ef\u4ee5\u5e94\u7528GLUE\u6765\u5b8c\u6210\u6574\u5408\u3002GLUE\u5728\u8bbe\u8ba1\u4e0a\u5f15\u5165\u4e86\u6a21\u5757\u5316\u601d\u60f3\uff0c\u53ef\u5bb9\u6613\u5730\u6269\u5145\u4ee5\u652f\u6301\u5982\u5355\u7ec6\u80deRibo-seq\u3001\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u7b49\u66f4\u591a\u7ec4\u5b66\u7c7b\u578b\u6570\u636e\u6574\u5408\u3002<\/div>\n
\u00a0<\/div>\n
\u76ee\u524d\uff0cGLUE\u6240\u6709\u4ee3\u7801\u5747\u5df2\u5f00\u6e90\u53d1\u5e03\uff0c\u53ef\u4ee5\u4f5c\u4e3a\u4e00\u4e2a\u901a\u7528\u7684\u6846\u67b6\u652f\u6301\u8fdb\u4e00\u6b65\u7684\u5f00\u53d1\u4e0e\u4f18\u5316(https:\/\/github.com\/gao-lab\/GLUE)\u3002<\/div>\n
\u6211\u4eec\u9f13\u52b1\u5e76\u671f\u5f85\u6765\u81ea\u751f\u7269\u4fe1\u606f\u5b66\u3001\u57fa\u56e0\u7ec4\u5b66\u3001\u6570\u636e\u79d1\u5b66\u548cAI\u7814\u7a76\u7b49\u9886\u57df\u7684\u4e13\u5bb6\u548c\u4eba\u624d\u5145\u5206\u78b0\u649e\u4e0e\u5408\u4f5c\uff0c\u5728GLUE\u7684\u57fa\u7840\u4e0a\u8fdb\u4e00\u6b65\u5f15\u5165\u3001\u6539\u8fdb\u6216\u8bbe\u8ba1\u5168\u65b0\u7684\u8ba1\u7b97\u6a21\u578b\uff0c\u6765\u5145\u5206\u5730\u6316\u6398\u6d77\u91cf\u5355\u7ec6\u80de\u6570\u636e\u4e2d\u9690\u85cf\u7684\u751f\u547d\u79d1\u5b66\u65b0\u73b0\u8c61\u3001\u65b0\u89c4\u5f8b\u4e0e\u65b0\u6cd5\u5219\u3002<\/div>\n
\u00a0<\/div>\n
PART.6<\/div>\n
\u7406\u89e3\u751f\u547d\u7684\u89c4\u5f8b<\/div>\n
\u201c<\/div>\n
\u4ece\u53d1\u8868\u7684\u8bba\u6587\u4e2d\u53ef\u4ee5\u770b\u51fa\u56e2\u961f\u7684\u4e25\u8c28\u3001\u7528\u5fc3\u4ee5\u53ca\u5bf9\u4e8e\u751f\u547d\u79d1\u5b66\u9886\u57df\u7684\u4f7f\u547d\u611f\uff0c\u8bf7\u95ee\u60a8\u6709\u4ec0\u4e48\u60f3\u8981\u5bf9\u5728\u8fd9\u4e00\u9886\u57df\u6216\u8005\u60f3\u8981\u4ece\u4e8b\u5355\u7ec6\u80de\u9886\u57df\u7684\u7814\u7a76\u8005\u8bf4\u7684\u5462\uff1f<\/div>\n
\u9ad8\u6b4c\u56e2\u961f<\/div>\n
\u4f5c\u4e3a\u751f\u547d\u79d1\u5b66\u5de5\u4f5c\u8005\uff0c\u6211\u4eec\u7684\u6700\u7ec8\u76ee\u6807\u662f\u7406\u89e3\u751f\u547d\u7684\u89c4\u5f8b\u4ece\u800c\u4e3a\u4eba\u7c7b\u670d\u52a1\u3002\u968f\u7740\u4ee5\u6df1\u5ea6\u6d4b\u5e8f\u4e3a\u4ee3\u8868\u7684\u9ad8\u901a\u91cf\u6d4b\u91cf\u6280\u672f\u8fc5\u731b\u53d1\u5c55\uff0c\u5f53\u4eca\u751f\u547d\u79d1\u5b66\u7814\u7a76\u6b63\u5728\u5feb\u901f\u8fdb\u5165\u201c\u5927\u6570\u636e\u65f6\u4ee3\u201d\uff0c\u4e3a\u6b64\u6211\u4eec\u9700\u8981\u53d1\u5c55\u65b0\u8ba1\u7b97\u6a21\u578b\u65b9\u6cd5\u4ee5\u66f4\u597d\u5730\u89e3\u8bfb\u8fd9\u4e9b\u5b9d\u8d35\u7684\u751f\u547d\u4fe1\u606f\u3002<\/div>\n
\u5728\u6b64\u8fc7\u7a0b\u4e2d\u7684\u5173\u952e\u662f\u8981\u201c\u7528\u6b63\u786e\u7684\u65b9\u6cd5\u505a\u5bf9\u7684\u4e8b\u60c5\u201d\u2014\u2014\u8ba1\u7b97\u624b\u6cd5\u53ef\u4ee5\u590d\u6742\u3001\u4f46\u6a21\u578b\u5e94\u8be5\u662f\u53ef\u4ee5\u7406\u89e3\u7684(understandable)\uff1b\u8ba1\u7b97\u8fc7\u7a0b\u53ef\u80fd\u7e41\u590d\u3001\u4f46\u7ed3\u679c\u9700\u8981\u662f\u53ef\u4ee5\u89e3\u91ca\u7684(interpretable)\uff0c\u628a\u95ee\u9898\u60f3\u6e05\u695a\u5f88\u591a\u65f6\u5019\u6bd4\u76f2\u76ee\u7684\u201c\u70bc\u4e39\u201d\u66f4\u6709\u610f\u4e49\u3002<\/div>\n
\u00a0<\/div>\n
PART.7<\/div>\n
\u5de5\u4f5c\u7684\u987a\u5229\u63a8\u8fdb\u9700\u8981\u591a\u9762\u652f\u6301<\/div>\n
\u201c<\/div>\n
\u672c\u6b21\u7684\u7814\u7a76\u662f\u7531\u56fd\u5bb6\u91cd\u70b9\u7814\u53d1\u8ba1\u5212\u3001\u86cb\u767d\u8d28\u4e0e\u690d\u7269\u57fa\u56e0\u7814\u7a76\u56fd\u5bb6\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u3001\u5317\u4eac\u672a\u6765\u57fa\u56e0\u8bca\u65ad\u9ad8\u7cbe\u5c16\u521b\u65b0\u4e2d\u5fc3\u548c\u660c\u5e73\u5b9e\u9a8c\u5ba4\u8d44\u52a9\uff0c\u5927\u89c4\u6a21\u8ba1\u7b97\u5206\u6790\u5de5\u4f5c\u5728\u5317\u4eac\u5927\u5b66\u9ad8\u6027\u80fd\u8ba1\u7b97\u6821\u7ea7\u516c\u5171\u5e73\u53f0\u548c\u5317\u4eac\u5927\u5b66\u592a\u5e73\u6d0b\u9ad8\u6027\u80fd\u8ba1\u7b97\u5e73\u53f0\u5b8c\u6210\u3002\u9488\u5bf9\u653f\u3001\u4ea7\u3001\u5b66\u3001\u7814\u7684\u5408\u4f5c\uff0c\u60a8\u6709\u4ec0\u4e48\u60f3\u8981\u5206\u4eab\u7684\u4f53\u4f1a\u548c\u5bf9\u672a\u6765\u7684\u5408\u4f5c\u671f\u5f85\uff1f<\/div>\n
\u9ad8\u6b4c\u56e2\u961f<\/div>\n
\u4e00\u4e2a\u5de5\u4f5c\u7684\u987a\u5229\u63a8\u8fdb\u9700\u8981\u591a\u9762\u7684\u652f\u6301\u3002<\/div>\n
\u5728GLUE\u5f00\u53d1\u7684\u8fc7\u7a0b\u4e2d\uff0c\u6211\u4eec\u4e0d\u4ec5\u5f97\u5230\u4e86\u6765\u81ea\u5404\u4e2a\u65b9\u9762\u7ecf\u8d39\u7684\u652f\u6301\uff0c\u66f4\u91cd\u8981\u7684\u662f\u4e0e\u5404\u4f4d\u540c\u4ec1\u7684\u8ba8\u8bba\uff0c\u5982\u5f20\u6cfd\u6c11\u3001\u9676\u4e50\u5929\u3001\u9093\u660e\u534e\u3001\u5f20\u5f3a\u950b\u7b49\u5404\u4f4d\u8001\u5e08\u5728\u8ba1\u7b97\u65b9\u6cd5\u4e0a\u7684\u5b9d\u8d35\u610f\u89c1\uff0c\u8c22\u6653\u4eae\u3001\u6c64\u5bcc\u916c\u3001\u674e\u7a0b\u3001\u9ec4\u5ca9\u8c0a\u7b49\u8001\u5e08\u5728\u5355\u7ec6\u80de\u591a\u7ec4\u5b66\u6280\u672f\u4e0e\u5e94\u7528\u65b9\u9762\u7684\u5173\u952e\u542f\u53d1\u90fd\u4ee4\u6211\u4eec\u53d7\u76ca\u532a\u6d45\u3002\u540c\u65f6\u9ad8\u6548\u7a33\u5b9a\u7684\u9ad8\u6027\u80fd\u8ba1\u7b97\u5e73\u53f0\u5bf9\u4e8e\u786e\u4fdd\u5927\u89c4\u6a21\u9a8c\u8bc1\u5de5\u4f5c\u7684\u5feb\u901f\u63a8\u8fdb\u4e5f\u81f3\u5173\u91cd\u8981\u3002<\/div>\n
\u800c\u8fd9\u4e00\u5207\u90fd\u79bb\u4e0d\u5f00\u4e00\u4e2a\u5f00\u653e\u3001\u4ea4\u53c9\u3001\u5305\u5bb9\u7684\u667a\u529b\u73af\u5883\u4e0e\u6280\u672f\u9a71\u52a8\u3001\u9762\u5411\u524d\u6cbf\u3001\u8ffd\u6c42\u5353\u8d8a\u7684\u5b66\u672f\u7cbe\u795e\u3002<\/div>\n
\u00a0<\/div>\n
PART.8<\/div>\n
\u6b22\u8fce\u591a\u9886\u57df\u4e13\u5bb6\u7684\u5408\u4f5c<\/div>\n
\u201c<\/div>\n
2009\u5e74\u4ee5\u6765\uff0c\u9ad8\u901a\u91cf\u5355\u7ec6\u80de\u6d4b\u5e8f\u53d1\u5c55\u4e8613\u5e74\uff0c\u8fd1\u5e74\u4e5f\u5728\u5355\u7ec6\u80de\u591a\u7ec4\u5b66\u3001\u65f6\u7a7a\u7ec4\u5b66\u65b9\u9762\u6709\u957f\u8db3\u53d1\u5c55\u3002\u90e8\u5206\u4f01\u4e1a\u4e5f\u5728\u5c06\u5355\u7ec6\u80de\u6280\u672f\u8f6c\u5316\u5230\u8f85\u52a9\u751f\u6b96\u3001\u764c\u75c7CTC\u65e9\u7b5b\u65b9\u9762\uff0c\u5bf9\u4e8e\u672a\u6765\u5355\u7ec6\u80de\u9886\u57df\u5728\u4e34\u5e8a\u7684\u5e94\u7528\u5c55\u671b\uff0c\u60a8\u8ba4\u4e3a\u6700\u6709\u53ef\u80fd\u843d\u5730\u662f\u54ea\u4e9b\u573a\u666f\uff1f\u5bf9\u6b64\uff0c\u54b1\u4eec\u751f\u7269\u4fe1\u606f\u65b9\u6cd5\u53ef\u4ee5\u4ece\u54ea\u4e9b\u65b9\u9762\u7740\u624b\u89e3\u51b3\u5e94\u7528\u8f6c\u5316\u7684\u95ee\u9898\uff1f<\/div>\n
\u9ad8\u6b4c\u56e2\u961f<\/div>\n
\u7ec6\u80de\u662f\u6784\u6210\u751f\u547d\u7684\u57fa\u672c\u5355\u5143\uff0c\u7ec6\u80de\u4e2d\u591a\u79cd\u8c03\u63a7\u673a\u5236\u9020\u5c31\u4e86\u673a\u4f53\u4e2d\u529f\u80fd\u5f62\u6001\u4e30\u5bcc\u591a\u6837\u7684\u7ec6\u80de\u7fa4\u4f53\uff0c\u5e76\u8fdb\u800c\u6784\u6210\u4e86\u65e9\u671f\u53d1\u80b2\u3001\u80bf\u7624\u53d1\u5c55\u7b49\u591a\u79cd\u5173\u952e\u751f\u7406\u75c5\u7406\u73b0\u8c61\u7684\u751f\u7269\u5b66\u57fa\u7840\u3002\u968f\u7740\u5355\u7ec6\u80de\u591a\u7ec4\u5b66\u6280\u672f\u7684\u8fc5\u731b\u53d1\u5c55\uff0c\u4eba\u4eec\u5728\u5386\u53f2\u4e0a\u9996\u6b21\u6709\u53ef\u80fd\u4ece\u6574\u4f53\u4e0a\u6784\u5efa\u89e3\u6790\u7ec6\u80de\u8c03\u63a7\u56fe\u8c31\u3001\u5728\u8ba1\u7b97\u673a\u4e2d\u5efa\u7acb\u7ec6\u80de\u8c03\u63a7\u7684\u9ad8\u7cbe\u5ea6\u6a21\u578b\uff0c\u4ece\u800c\u5168\u9762\u7406\u89e3\u7ec6\u80de\u5728\u75c5\u7406\u72b6\u6001\u548c\u751f\u7406\u72b6\u6001\u4e4b\u95f4\u7684\u5dee\u5f02\uff0c\u5e76\u7cbe\u51c6\u9501\u5b9a\u8bca\u65ad\u6807\u5fd7\u7269\u548c\u6cbb\u7597\u6027\u9776\u70b9\u3002<\/div>\n
\u5982\u6211\u4eec\u901a\u8fc7\u5bf9\u8fd1\u4e94\u5343\u4e07\u4e2a\u5355\u7ec6\u80de\u6570\u636e\u7684\u6574\u5408\u6784\u5efa\u4e86\u57fa\u4e8e\u5927\u6570\u636e\u7684\u7ec6\u80de-\u8868\u578b\u5173\u8054\u9274\u5b9aCWAS (Cell-Wide Association Study)\uff0c\u53ef\u4ee5\u9488\u5bf9\u6570\u767e\u4e2a\u7ec6\u80de\u7c7b\u578b\u53ca\u5176\u7ec4\u5408\u7cfb\u7edf\u5bfb\u627e\u9274\u5b9a\u5176\u4e0e\u7279\u5b9a\u751f\u7406\/\u75c5\u7406\u8868\u578b\u4e4b\u95f4\u7684\u5b9a\u91cf\u5173\u8054\uff0c\u8fdb\u800c\u5b9e\u73b0\u57fa\u4e8e\u7ec6\u80de\u8c03\u63a7\u56fe\u8c31\u7684\u75be\u75c5\u65e9\u7b5b\/\u65e9\u8bca\u3002<\/div>\n
\u4f5c\u4e3a\u751f\u7269\u4fe1\u606f\u5b66\u5de5\u4f5c\u8005\uff0c\u6211\u4eec\u5b9e\u9a8c\u5ba4\u5728\u6301\u7eed\u5f00\u5c55\u4e16\u754c\u4e00\u6d41\u7684\u751f\u7269\u4fe1\u606f\u5b66\u65b9\u6cd5\u4e0e\u6280\u672f\u5f00\u53d1\u7814\u7a76\u7684\u540c\u65f6\uff0c\u5341\u5206\u6b22\u8fce\u6765\u81ea\u5404\u4e2a\u9886\u57df\u7684\u4e13\u5bb6\u5b66\u8005\u4e0e\u6211\u4eec\u5171\u540c\u5408\u4f5c\u5c06\u57fa\u7840\u65b9\u6cd5\u7814\u7a76\u7684\u6210\u679c\u52a0\u901f\u8f6c\u5316\u4e3a\u540e\u7eed\u751f\u7269\u533b\u5b66\u7684\u5e94\u7528\uff0c\u4e3a\u6539\u5584\u4eba\u6c11\u7684\u751f\u547d\u5065\u5eb7\u505a\u51fa\u81ea\u5df1\u7684\u8d21\u732e\u3002<\/div>\n
\u00a0<\/div>\n
PART.9<\/div>\n
\u8bba\u6587\u4f5c\u8005\u4ecb\u7ecd<\/div>\n\n
\n
\"RmFicvQBAkgCtZENVriaQyO2B0tPibRLSxR1joogp6NUe9MdKB8BncP8zNdziasoIyyKJ1fIVFaE0GULiaHGWtgictLA\"\/<\/figure><\/div>\n\n<\/div>\n
<\/div>\n
\n\n
\n
\"RmFicvQBAkgCtZENVriaQyO2B0tPibRLSxRRpIGlxPe2dznIBDOKSTe0kVESeHDpMrkicPujHqkGtFmGVdLPNBO9MQ\"\/<\/figure><\/div>\n\n
\u67e5\u770b\u8bba\u6587>><\/div>\n
https:\/\/www.nature.com\/articles\/s41587-022-01284-4<\/div>\n
GLUE\u4ee3\u7801\u83b7\u53d6>><\/div>\n
https:\/\/github.com\/gao-lab\/GLUE<\/div>\n
\u00a0<\/div>\n
\u4f5c\u8005\u4e28\u5f20\u742a \u5ba1\u6838| \u9ad8\u6b4c<\/div>\n
\u9996\u53d1\u4e28\u57fa\u56e0\u6167\u5173\u952e\u8bcd |\u5355\u7ec6\u80de\u591a\u7ec4\u5b66\uff1b\u751f\u547d\u79d1\u5b66\uff1b<\/div>\n
\u5f80\u671f\u63a8\u8350<\/div>\n
\u4e34\u5e8a\u7bc7 27\u4f4d\u4e34\u5e8a\u5927\u5496\u8bbf\u8c08<\/a>|\u9646\u56fd\u8f89\/\u5f20\u5b66<\/a>\/\u738b\u82e5\u5149|\u9ec4\u5c1a\u5fd7<\/a>|<\/a>\u6881\u519b<\/a> |\u9646\u821c<\/a>|\u4e01\u6d01<\/a>|\u4e8e\u4e16\u8f89<\/a>|\u9ec4\u56fd\u82f1<\/a>|\u6c88\u4ea6\u5e73<\/a>|<\/a>\u987e\u5927\u592b<\/a>|\u738b\u6770\u519b<\/a>|\u9ec4\u6d9b\u751f<\/a>|\u6768\u4e91\u751f<\/a>|\u7941\u9e23<\/a>|\u59dc\u8273\u82b3<\/a>|\u6881\u5fd7\u6e05<\/a><\/div>\n
\u4ea7\u4e1a\u7bc734\u4f4d\u4ea7\u4e1a\u5927\u5496\u8bbf\u8c08<\/a>|\u9648\u4e91\u5f1f&\u67f4\u6620\u723d<\/a>\u4e28\u6c6a\u5efa<\/a>|<\/a>\u6768\u4e91\u971e<\/a>|\u5b59\u6d2a\u4e1a<\/a>|\u725f\u5cf0<\/a> |\u8d75\u745e\u6797<\/a>|\u5c39\u70e8<\/a>|\u960e\u6d77<\/a>|\u79e6\u6960<\/a>|\u6587\u6d01<\/a>|\u718a\u78ca<\/a>|\u67f4\u6620\u723d<\/a>|\u8305\u77db<\/a>|<\/a>\u63e3\u5c11\u5764<\/a> |\u7530\u6656<\/a>\u4e28\u5e73\u8d28<\/a>\u4e28\u5468\u6d0b<\/a><\/div>\n
\u79d1\u7814\u7bc7 15\u4f4d\u79d1\u7814\u5927\u5496\u8bbf\u8c08<\/a>|\u9ad8\u798f\u9662\u58eb<\/a>|\u9648\u6da6\u751f\/\u4e8e\u519b\/\u5eb7\u7199\u96c4<\/a>|\u674e\u7ee7\u627f |<\/a>\u8d75\u7acb\u5e73<\/a>|\u6768<\/a>\u745e\u99a5<\/a>|\u65b9\u5411\u4e1c<\/a>|\u5f20\u5f64<\/a>|\u83e0\u841d<\/a>|\u6234\u4fca\u5f6a<\/a>|\u9a6c\u7aef<\/a>|\u5b59\u7acb\u82f1<\/a>|<\/a>\u8881\u6167\u519b<\/a><\/div>\n
\u00a0<\/div>\n
\u3010\u58f0\u660e\u3011\u4e3a\u4e86\u63a8\u52a8\u57fa\u56e0\u53ca\u6570\u5b57\u751f\u547d\u5065\u5eb7\u79d1\u6280\u63a8\u5e7f\u3001\u4ea7\u4e1a\u53d1\u5c55\u53ca\u653f\u4ea7\u5b66\u7814\u7528\u8fde\u63a5\uff0c\u57fa\u56e0\u6167\u79c9\u6301\u4e13\u4e1a\u3001\u8d4b\u80fd\u3001\u4e2d\u7acb\u7684\u7acb\u573a\u6536\u96c6\u3001\u5206\u6790\u53ca\u53d1\u5e03\u76f8\u5173\u4fe1\u606f\u3002\u4f46\u7531\u4e8e\u65f6\u6548\u6027\u53ca\u884c\u4e1a\u7279\u6b8a\u6027\uff0c\u6240\u520a\u767b\u5185\u5bb9\u4ec5\u4f9b\u7814\u7a76\u53c2\u8003\uff0c\u672a\u7ecf\u8bf4\u660e\u4e0d\u4f5c\u4e3a\u51b3\u7b56\u4f9d\u636e\uff1b\u672c\u6587\u76f8\u5173\u4fe1\u606f\u4e0d\u4ee3\u8868\u57fa\u56e0\u6167\u7684\u89c2\u70b9\uff1b\u57fa\u56e0\u6167\u5e73\u53f0\u520a\u767b\u7684\u539f\u521b\u5185\u5bb9\u7684\u77e5\u8bc6\u4ea7\u6743\u4e3a\u201c\u57fa\u56e0\u6167\u201d\u5546\u6807\u62e5\u6709\u8005\u53ca\u76f8\u5173\u6743\u5229\u4eba\u6240\u6709\uff1b\u6b22\u8fce\u8f6c\u8f7d\uff0c\u8f6c\u8f7d\u8bf7\u7533\u8bf7\u5e76\u6ce8\u660e\u6765\u6e90\u3002\u6b22\u8fce\u4e2a\u4eba\u53ca\u673a\u6784\u6295\u7a3f\u53ca\u5408\u4f5c\u3002<\/div>\n
\u5173\u4e8e\u57fa\u56e0\u6167<\/div>\n
\u57fa\u56e0\u6167\u4e13\u6ce8\u6570\u5b57\u751f\u547d\u5065\u5eb7\u4ea7\u4e1a\u77e5\u8bc6\u670d\u52a1\u3002\u521b\u59cb\u56e2\u961f\u6df1\u8015\u884c\u4e1a\u4e00\u7ebf\u5341\u4f59\u5e74\uff0c\u79c9\u6301\u201c\u4f7f\u8fde\u63a5\u4ea7\u751f\u4ef7\u503c\uff0c\u7528\u6570\u636e\u770b\u89c1\u672a\u6765\u201d\u7684\u7406\u5ff5\uff0c\u57fa\u4e8e\u4ea7\u4e1a\u667a\u5e93\u548c\u4e13\u4e1a\u5185\u5bb9\uff0c\u63d0\u4f9b\u4ea7\u4e1a\u89c4\u5212\u3001\u884c\u7814\u54a8\u8be2\u3001\u79d1\u6280\u63a8\u5e7f\u7b49\u670d\u52a1\u3002\u8fde\u7eed\u4e94\u5e74\u53d1\u5e03\u884c\u4e1a\u84dd\u76ae\u4e66\uff0c\u88ab\u56fd\u5bb6\u53ca\u7701\u5e02\u7ea7\u4ea7\u4e1a\u62a5\u544a\u6536\u5f55\uff0c\u7ec4\u7ec7\u591a\u5bb6\u5355\u4f4d\u53d1\u5e03\u884c\u4e1a\u5171\u8bc6\u548c\u56e2\u6807\uff0c\u63a8\u52a8\u751f\u547d\u79d1\u6280\u666e\u60e0\u548c\u4ea7\u4e1a\u878d\u5408\u53d1\u5c55\u3002<\/div>\n
\u2606\u56fd\u53d1\u6539\u300a\u6218\u7565\u6027\u65b0\u5174\u4ea7\u4e1a\u53d1\u5c55\u5c55\u671b\u300b\u767d\u76ae\u4e66\u6267\u7b14<\/a><\/div>\n
\u2606\u8fde\u7eed\u4e94\u5e74\u53d1\u5e03\u57fa\u56e0\u884c\u4e1a\u84dd\u76ae\u4e66<\/div>\n
\u2606\u4e2d\u56fd\u6297\u764c\u534f\u4f1a\u80bf\u7624\u6807\u5fd7\u4e13\u4e1a\u59d4\u5458\u4f1a\u6218\u7565\u5408\u4f5c\u5355\u4f4d<\/a><\/div>\n
\u2606\u4e2d\u56fd\u9057\u4f20\u5b66\u4f1a\u751f\u7269\u4ea7\u4e1a\u4fc3\u8fdb\u59d4\u5458\u4f1a\u59d4\u5458<\/div>\n
\u2606\u5e7f\u4e1c\u7701\u7cbe\u51c6\u533b\u5b66\u5e94\u7528\u5b66\u4f1a\u653f\u7b56\u7814\u7a76\u5e94\u7528\u5206\u4f1a\u5e38\u59d4<\/div>\n
\u2606\u6df1\u5733\u5e02\u5065\u5eb7\u4ea7\u4e1a\u53d1\u5c55\u4fc3\u8fdb\u4f1a\u526f\u4f1a\u957f\u5355\u4f4d<\/div>\n
\u2606\u53c2\u4e0e\u7ec4\u7ec7\u673a\u6784\u53d1\u5e03\u591a\u9879\u884c\u4e1a\u5171\u8bc6<\/a>\u548c\u56e2\u4f53\u6807\u51c6<\/a><\/div>\n
\u2606\u7ec4\u7ec7\u57fa\u56e0\u68c0\u6d4b\u8054\u76df\uff08\u7b79\uff09\u9996\u5c4a<\/a>\u3001\u7b2c\u4e8c\u5c4a<\/a>\u4f1a\u8bae<\/a><\/div>\n
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