{"id":11665,"date":"2016-12-14T23:16:21","date_gmt":"2016-12-14T15:16:21","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMzE4MzU3NA==&mid=504148437&idx=1&sn=081eb462a4adc19e2fc23d6a91277051&chksm=737191ec440618fa4cb9bf4495645ef54cebfd6b0dbc06f9b842c23a1bf34a445fc7633a73b6#rd"},"modified":"2026-04-09T14:17:34","modified_gmt":"2026-04-09T06:17:34","slug":"4810049","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2016\/12\/14\/4810049\/","title":{"rendered":"DNAnexus\u5b8c\u6210\u4e16\u754c\u4e0a\u6700\u5927\u7684\u6cdb\u764c\u75c7\u6570\u636e\u7684\u91cd\u5206\u6790(\u9644\u6570\u636e\u4e0b\u8f7d\uff09"},"content":{"rendered":"

<\/p>\n

\u5173\u952e\u8bcd\uff1aPan Cancer 10487\u60a3\u8005 33\u79cd\u764c\u75c7 \u7a81\u53d8\u68c0\u6d4b TCGA DNAnexus<\/div>\n
\u9605\u8bfb\u7528\u65f6\uff1a1843\u5b57\uff0c\u7ea6\u97004.5\u5206\u949f<\/div>\n
\u5185\u5bb9\u7b80\u4ecb\uff1aDNAnexus \u572812\u67089\u65e5\u5ba3\u5e03\u5b83\u5df2\u5b8c\u6210\u5728\u4e16\u754c\u4e0a\u6700\u5927\u7684\u6cdb\u764c\u75c7\u6570\u636e\u96c6\u4e0a\u7684\u7edf\u4e00\u91cd\u5206\u6790\u548c\u7a81\u53d8\u68c0\u6d4b\uff0c\u6570\u636e\u6765\u81eaTCGA\uff08\u764c\u75c7\u57fa\u56e0\u7ec4\u56fe\u8c31\uff09\u768410,487\u4e2a\u60a3\u8005\uff0c\u6db5\u76d633\u79cd\u764c\u75c7\u7c7b\u3002<\/div>\n
\u00a0<\/div>\n
2016 \u5e7412 \u6708 9 \u65e5 | DNAnexus \u4eca\u5929\u5ba3\u5e03\u5b83\u5df2\u5b8c\u6210\u5728\u4e16\u754c\u4e0a\u6700\u5927\u7684\u6cdb\u764c\u75c7\u6570\u636e\u96c6\u4e0a\u7684\u6807\u51c6\u5316\u7684\u91cd\u5206\u6790\u548c\u7a81\u53d8\u68c0\u6d4b\uff0c\u6570\u636e\u6765\u81eaTCGA\uff08\u764c\u75c7\u57fa\u56e0\u7ec4\u56fe\u8c31\uff09\u768410,487\u4e2a\u60a3\u8005\uff0c\u6db5\u76d633\u79cd\u764c\u75c7\u7c7b\u578b\u3002\u7a81\u53d8\u6570\u636e\u7ecf\u8fc7\u4e86\u989d\u5916\u7684\u8d28\u91cf\u63a7\u5236\u548c\u8fc7\u6ee4\uff0c\u73b0\u4f5c\u4e3a\u5f00\u653e\u9605\u8bfb\u6570\u636e\u96c6\u53ef\u5728 NCI Genomic Data Commons \u548cSynapse\u4e0b\u8f7d\u3002\u4e5f\u53ef\u4ee5\u901a\u8fc7 DNAnexus\u6216 GitHub\u5e93\u91cd\u73b0\u8fd9\u4e2aTCGA \u7a81\u53d8\u7ed3\u679c\u3002<\/div>\n\n
\n
\"eicZhoGYCfyZWXc4V7CwJIsNicqicPCVrPbBcmCXaJXRr82lP846arib2rSxjQ2g9CfmOZMcXI173Im57ibKnkyVBLg\"\/<\/figure><\/div>\n\n
TCGA \u56fe\u7247\u6765\u81ea\uff1aocg.cancer.gov<\/div>\n
\u201c\u5728\u8fc7\u53bb\uff0cTCGA \u6837\u54c1\u7684\u7a81\u53d8\u68c0\u6d4b\u4e3b\u8981\u662f\u5bf9\u4e8e\u4e2a\u4f53\u7684\u80bf\u7624\u7c7b\u578b\uff0c\u9879\u76ee\u4f7f\u7528\u4e0d\u540c\u7684\u53d8\u5f02\u68c0\u6d4b\u5de5\u5177\u6216\u4e0d\u540c\u7248\u672c\u7684\u53d8\u5f02\u68c0\u6d4b\u5de5\u5177\uff0c\u8fd9\u610f\u5473\u7740\u6570\u636e\u4e0d\u7edf\u4e00\u201d\uff0c\u9879\u76ee\u4e3b\u4efbCarolyn Hutter\u535a\u58eb\u5728NHGRI\u7684\u57fa\u56e0\u7ec4\u533b\u5b66\u90e8\u95e8\u7684\u58f0\u660e\u4e2d\u8bf4\uff0c\u201c\u6211\u4eec\u73b0\u5728\u8ba4\u4e3a\u6700\u597d\u7684\uff08\u764c\u75c7\u6570\u636e\uff09\u5206\u6790\u5bf9\u8c61\u901a\u8fc7\u591a\u4e2a\u53d8\u5f02\u68c0\u6d4b\u5de5\u5177\u5206\u6790\uff0c\u7136\u540e\u7ecf\u8fc7\u8d28\u91cf\u63a7\u5236\u548c\u8fc7\u6ee4\uff0c\u6db5\u76d6\u591a\u79cd\u764c\u75c7\u7c7b\u578b\u5f97\u5230\u7684\u6570\u636e\u3002\u8fd9\u5c31\u662f\u4e3a\u4ec0\u4e48 TCGA \u56e2\u961f\u51b3\u5b9a\u56de\u8fc7\u5934\u91cd\u65b0\u5206\u6790TCGA\u4e2d10,000 \u591a\u4e2a\u5916\u663e\u5b50\uff0c\u5e76\u4e14\u5206\u6790\u5f97\u5230\u8fd9\u79cd\u591a\u4e2a\u53d8\u5f02\u68c0\u6d4b\u5de5\u5177\u5f97\u5230\u7684\u4f53\u7ec6\u80de\u7a81\u53d8\uff08somatic mutation)\u6570\u636e\u96c6\u3002\u201d<\/div>\n
TCGA\u6210\u5458\u673a\u6784\u4e0d\u5177\u5907\u8de8\u8d8a\u591a\u79cd\u764c\u75c7\u7c7b\u578b\u7684\u7a81\u53d8\u5206\u6790\u6240\u9700\u7684\u8ba1\u7b97\u8d44\u6e90\u3002\u7a81\u53d8\u68c0\u6d4b\u5305\u62ec\u75c5\u4eba\u4fe1\u606f\u7684\u5b89\u5168\u3001\u53ef\u4ee5\u5904\u7406\u6570\u4ee5\u4e07\u8ba1\u7684\u5916\u663e\u5b50\uff0c\u53ef\u6269\u5c55\u7684\u73af\u5883\uff0c\u548c\u53ef\u91cd\u590d\u7684\u7ed3\u679c\uff0c\u8fd9\u91cc\u91c7\u7528\u4e86DNAnexus \u5e73\u53f0\u3002<\/div>\n\n
\n
\"eicZhoGYCfyZWXc4V7CwJIsNicqicPCVrPbRSIZFUticacBeVldU3vCQABTCNXTbia5nkI5ZX9sgiaMeHNjqTlZfgdCA\"\/<\/figure><\/div>\n\n
DNAnexus\u5de5\u4f5c\u539f\u7406 \u56fe\u7247\u6765\u6e90\uff1asmartplanet.com<\/div>\n
\u201c\u8fd9\u662f\u4e00\u4e2a\u5de8\u5927\u7684\u6311\u6218\uff0c\u4e5f\u662fDNAnexus\u5e73\u53f0\u7684\u4f18\u52bf\u4f53\u73b0\u7684\u4e00\u4e2a\u5178\u578b\u4f8b\u5b50\uff0c\u201dDNAnexus \u7684\u9996\u5e2d\u6267\u884c\u5b98Richard Daly\u8bf4\u5230\uff0c\u201c\u5728\u56db\u4e2a\u661f\u671f\u5185\u5927\u7ea6 180 \u4e07\u5355\u4f4dCPU\uff08core-hours\uff09\u7684\u8ba1\u7b97\u65f6\u95f4\u7528\u4e8e\u5904\u7406400 TB \u7684\u6570\u636e\uff0c\u4ee5\u4ea7\u751f\u53ef\u91cd\u590d\u7684\u7ed3\u679c\u3002\u76ee\u524d\u5f97\u5230\u7684\u4e00\u81f4\u6027\u7684\u6570\u636e\u53ef\u8ba9\u5168\u7403\u7684\u7814\u7a76\u4eba\u5458\u7528\u6765\u89e3\u91ca\u591a\u79cd\u7c7b\u578b\u764c\u75c7\u5171\u4eab\u7684\u57fa\u56e0\u7ec4\u7279\u5f81\u3001\u81f4\u764c\u6807\u5fd7\u7269\u548c\u6f5c\u5728\u6cbb\u7597\u76ee\u6807\u201d\u3002<\/div>\n
\u201c\u7528\u4e00\u79cd\u5355\u4e00\u7684\u65b9\u6cd5\u5728\u65b0\u7684\u6807\u51c6\u7a81\u53d8\u68c0\u6d4b\u4e0a\u91cd\u65b0\u4fee\u6b63 TCGA \u6570\u636e\u5c06\u4f7f\u80bf\u7624\u6570\u636e\u66f4\u52a0\u65b9\u4fbf\u7814\u7a76\u4eba\u5458\u4f7f\u7528\u3002DNAnexus \u901a\u8fc7\u7248\u672c\u63a7\u5236\u7684\u5206\u6790\u53ca\u5de5\u5177\u521b\u5efa\u7edf\u4e00\u7684\uff0c\u654f\u611f\u5ea6\u9ad8\u7684\u5206\u6790\u5904\u7406\uff0c\u8fd9\u5bf9\u5728\u4e00\u5b9a\u7684\u65f6\u95f4\u8303\u56f4\u5185\u5728\u5355\u4e00\u7684\u8bbe\u65bd\u4e0a\u91cd\u590d\u5f88\u5177\u6709\u6311\u6218\u6027\uff0c\u201d\u8d1d\u52d2\u533b\u5b66\u9662\u7684\u5206\u5b50\u548c\u4eba\u7c7b\u9057\u4f20\u5b66\u90e8\u95e8\u7684\u6559\u6388David Wheeler\u535a\u58eb\u8bf4\uff0c\u201c\u6709\u8fd9\u5957\u901a\u8fc7\u51e0\u4e2a\u53d8\u5f02\u68c0\u6d4b\u5de5\u5177\u83b7\u5f97\u7684\u6807\u51c6\u5316\u7a81\u53d8\u68c0\u6d4b\u96c6\uff0c\u6211\u4eec\u5c06\u80fd\u591f\u8bc6\u522b\u975e\u7ec4\u7ec7\u6765\u6e90\u591a\u79cd\u80bf\u7624\u4e4b\u95f4\u5171\u4eab\u7684\u764c\u75c7\u7684\u9057\u4f20\u53d8\u5f02\u56e0\u7d20\u3002\u6211\u4eec\u4e50\u89c2\u5730\u8ba4\u4e3a\uff0c\u83b7\u5f97\u8fd9\u4e9b\u4fe1\u606f\u5c06\u63a8\u52a8\u7cbe\u5bc6\u533b\u5b66\u7684\u8fdb\u6b65\u3002\u201d<\/div>\n
\u73b0\u5728\u7814\u7a76\u4eba\u5458\u9664\u4e86 GitHub\u5e93\u4e5f\u53ef\u4ee5\u901a\u8fc7DNAnexus \u5e73\u53f0\u9014\u5f84\u8bbf\u95ee TCGA\u3002DNAnexus \u5de5\u4f5c\u4ee5\u786e\u4fdd\u6570\u636e\u8bbf\u95ee\u8bf7\u6c42\u7684\u673a\u5236,\u548c\u5f53\u8bf7\u6c42\u8005\u7b26\u5408\u4e91\u7aef dbGaP\u548cTCGA\u6570\u636e\u7684\u5b89\u5168\u6807\u51c6\u65f6\u6279\u51c6\u51fa\u552e\u6570\u636e\u3002<\/div>\n
\u00a0<\/div>\n
\u6570\u636e\u4e0b\u8f7d\u5730\u5740\uff08\u9700\u8981\u5148\u514d\u8d39\u6ce8\u518csynase\uff09<\/div>\n
https:\/\/www.synapse.org\/#!Synapse:syn7214402\/files\/<\/div>\n
\u6570\u636e\u96c6\uff08syn5917256\uff09WiKi\u7f51\u5740\uff1a<\/div>\n
https:\/\/www.synapse.org\/#!Synapse:syn7214402\/wiki\/405297<\/div>\n
\u53c2\u8003\u6587\u732e\uff1a<\/div>\n
http:\/\/www.bio-itworld.com\/2016\/12\/9\/dnanexus-reanalyzes-cancer-genome-atlas-data.aspx<\/div>\n
\u00a0<\/div>\n
\u9080\u8bf7 & \u9884\u544a<\/div>\n
\u300a\u6e29\u65452016\u300b\u7cfb\u5217\u8282\u76ee\u5728\u672a\u6765\u4e00\u4e2a\u6708\u5185\u5c06\u8ba1\u5212\u63a8\u51fa\u80bf\u7624\u57fa\u56e0\u68c0\u6d4b\u3001\u5fae\u751f\u7269\u7ec4\u3001\u4e2a\u4eba\u57fa\u56e0\u7ec4\u3001\u751f\u7269\u4e91\u5e73\u53f0\u7b49\u4e13\u9898\u7684\u4e09\u4eba\u8bbf\u8c08\u8282\u76ee\u300a\u57fa\u56e0\u4e09\u4eba\u884c\u300b\u3002\u656c\u8bf7\u5173\u6ce8\uff0c\u6b22\u8fce\u63d0\u51fa\u60a8\u5b9d\u8d35\u7684\u5efa\u8bae\u3002<\/div>\n
\u57fa\u56e0\u6167\u56e2\u961f\u5c06\u79c9\u6301\u201c\u4f7f\u8fde\u63a5\u4ea7\u751f\u4ef7\u503c\uff0c\u8ba9\u77e5\u8bc6\u83b7\u5f97\u5c0a\u91cd\u201d\u7684\u521d\u5fc3\uff0c\u8fde\u63a5\u884c\u4e1a\uff0c\u670d\u52a1\u5927\u5bb6\uff08010-56527551\uff0cinfo@genonet.cn)\u3002<\/div>\n
\u7cbe\u534e\u6587\u7ae0<\/div>\n
\u70b9\u51fb\u4e0b\u5217\u94fe\u63a5\uff0c\u53ef\u89c1\u66f4\u591a\u63a8\u8350\u6587\u7ae0\uff1a<\/div>\n
64 \u3010\u57fa\u56e0\u4e09\u4eba\u884c01\u3011\u300a\u57fa\u56e0\u4e09\u4eba\u884c\u300b\uff1a\u9ec4\u5c1a\u5fd7\uff0c\u987e\u536b\u7ea2\uff0c\u738b\u5955\u9e25\u8c08\u57fa\u56e0\u68c0\u6d4b\u4e34\u5e8a\u5e94\u7528\uff08\u4e0a\uff09<\/a><\/div>\n
63 \u3010\u6e29\u65452016\u301112\u5f20\u56fe\u56de\u987e\u57fa\u56e0\u884c\u4e1a2016\u6295\u878d\u8d44\u7bc7<\/a><\/div>\n
62 \u3010\u7f55\u89c1\u75c5\u5206\u4f1a\u3011\u7814\u7a76\u578b\u533b\u9662\u5b66\u4f1a\u7f55\u89c1\u75c5\u5206\u4f1aPPT<\/a><\/div>\n
61 \u3010\u6e29\u65452016\u301112\u5f20\u56fe\u56de\u987e\u57fa\u56e0\u884c\u4e1a2016\u6280\u672f\u7bc7<\/a><\/div>\n
59 \u3010ACMG\u3011ACMG \u66f4\u65b0\u89e3\u8bfb\uff0835\u9875PPT)<\/a><\/div>\n
57 \u3010\u8f85\u52a9\u8bca\u65ad\u3011\u4e34\u5e8a\u57fa\u56e0\u68c0\u6d4b\u7684\u75db\u70b9\u548c\u65b9\u6848<\/a><\/div>\n
56 \u3010GeneMail\u3011\u7cbe\u51c6\u533b\u7597\u6bcf\u65e5\u8d44\u8baf<\/a><\/div>\n
54 \u3010\u5341\u5e74\u3011\u5168\u56fd500\u4f59\u5bb6\u80bf\u7624\u7cbe\u51c6\u533b\u7597\u4f01\u4e1a<\/a><\/div>\n
52 \u3010NGS\u5e94\u7528\u3011NGS\u5728\u9057\u4f20\u75c5\u8bca\u65ad\u4e2d\u7684\u5e94\u7528<\/a><\/div>\n
51 \u3010\u9057\u4f20\u5927\u4f1a\u3011\u7b2c\u5341\u5c4a\u5168\u56fd\u9057\u4f20\u75c5\u8bca\u65ad\u548c\u4ea7\u524d\u8bca\u65ad\u5b66\u672f\u4ea4\u6d41\u4f1a\u4f1a\u8bae\u7b14\u8bb0<\/a><\/div>\n
50 \u3010\u80bf\u7624\u62a5\u544a\u3011\u80bf\u7624\u7cbe\u51c6\u533b\u7597\u8c03\u7814\u62a5\u544a\uff08130\u9875\uff09<\/a><\/div>\n
49 \u3010\u6db2\u4f53\u6d3b\u68c0\u301115\u5bb6\u80bf\u7624\u4f01\u4e1a\u5927\u5496\u89e3\u8bfb\u5171\u8bc6<\/a><\/div>\n
46 \u3010\u7f55\u89c1\u75c5\u3011\u79d1\u5b66\u8ba4\u8bc6\u7f55\u89c1\u75c5\uff0870\u9875PPT)<\/a><\/div>\n
45 \u3010\u5fae\u751f\u7269\u3011\u80a0\u9053\u5fae\u751f\u7269\u7ec4<\/a><\/div>\n
43 \u3010\u961f\u5217\u3011\u56fd\u5185\u591650\u4f59\u4e2a\u7cbe\u51c6\u533b\u5b66\u961f\u5217\u9879\u76ee<\/a><\/div>\n
40 \u3010Panel \u8bbe\u8ba1\u3011Cancer Panel\u6807\u51c6\u5316\u7814\u8ba8\u4f1aPPT\u7cbe\u534e<\/a><\/div>\n
39 \u3010\u9776\u5411\u836f\u3011\u80bf\u7624\u9776\u5411\u6cbb\u7597\u548c\u9776\u5411\u836f<\/a><\/div>\n
28\u3010\u57fa\u56e0\u8bca\u65ad\u3011\u54c8\u4f5b\u6c88\u4ea6\u5e73\u8c08\u57fa\u56e0\u8bca\u65ad<\/a><\/div>\n
20\u3010\u751f\u7269\u4fe1\u606f\u3011\u751f\u7269\u4fe1\u606f\u57f9\u8bad\u8d44\u6599\u63a8\u8350 <\/a><\/div>\n
19 \u3010\u4e91\u5e73\u53f0\u3011\u9996\u5c4a\u57fa\u56e0\u7ec4\u4e91\u5927\u4f1aPPT\u7cbe\u534e<\/a><\/div>\n
17 \u3010\u6db2\u4f53\u6d3b\u68c0\u3011\u4e00\u5957PPT\u8bfb\u61c2\u6db2\u4f53\u6d3b\u68c0<\/a><\/div>\n
15\u3010\u57fa\u56e0\u7f16\u8f91\u3011 \u57fa\u56e0\u7f16\u8f91\u7684\u6280\u672f\u548c\u539f\u7406<\/a><\/div>\n
8 \u3010\u4eba\u5de5\u667a\u80fd\u3011 \u4eba\u5de5\u667a\u80fd+\u57fa\u56e0\u5065\u5eb7<\/a><\/div>\n\n
\n
\"eicZhoGYCfya8d9amvCQUkI0swluE5cc4aG2icPmTGzUl3kEO47YOwcHWGRriboGhvLRFUXUYYOOicTBUNibHD5ialoQ\"\/<\/figure><\/div>\n\n<\/div>\n
<\/div>\n
\u66f4\u591a\u5e72\u8d27\uff0c\u6b22\u8fce\u8fdb\u5165\u57fa\u56e0\u6167\u77e5\u8bc6\u94fa<\/div>\n
\n\n
\n
\"eicZhoGYCfyYA27eSceibibXTibxiaeuRAfCnd76p08wYk4ibYr98uPpPPnH9w9ibClibBpopw4Equib1UQ4IRCf5IMkkgA\"\/<\/figure><\/div>\n\n<\/div>\n
\u58f0\u660e<\/div>\n
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