{"id":11655,"date":"2016-12-27T06:33:18","date_gmt":"2016-12-26T22:33:18","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMzE4MzU3NA==&mid=504148771&idx=1&sn=bdff0f708574bf93def377d9b678be3f&chksm=7371931a44061a0cbbb1f2902b04be4884364bdeae9ebc3f526987c6d3549973bd71e1de9387#rd"},"modified":"2026-04-09T14:16:31","modified_gmt":"2026-04-09T06:16:31","slug":"564853-2","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2016\/12\/27\/564853-2\/","title":{"rendered":"63,000\u540d\u60a3\u8005\u7814\u7a76\u4f7fAJCC\u9996\u6b21\u5c06ER\/PR\/HER2\u4f5c\u4e3a\u4e73\u817a\u764c\u5206\u671f\u4f9d\u636e"},"content":{"rendered":"

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\u5173\u952e\u8bcd\uff1aAJCC \u4e73\u817a\u764c\u5206\u671f \u5206\u5b50\u6807\u8bb0 ER\/PR\/HER2 Genomics Health<\/div>\n
\u9605\u8bfb\u7528\u65f6\uff1a\u7ea63\u5206\u949f<\/div>\n
\u6269\u5c55\u9605\u8bfb\uff1aCancer Panel\u6807\u51c6\u5316<\/a>\uff1b\u80bf\u7624\u7cbe\u51c6\u533b\u7597\u62a5\u544a<\/a>\uff1bGenePanel\u8bbe\u8ba1\u57fa\u56e0\u5217\u8868<\/a><\/div>\n
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\"eicZhoGYCfyaskHys5ibibyfWIWibQv4HIibLkeugPN4sCEP9c8OlpjONW7Pu3ibdUQst5WibjmSibwb1vic8T1PJxDb2Lg\"\/<\/figure><\/div>\n\n

\u56fe\u7247\u6765\u81ea\uff1anews.vanderbilt.edu<\/p>\n

\u7f8e\u56fd\u764c\u75c7\u8054\u5408\u59d4\u5458\u4f1a(AJCC)\u9996\u6b21\u5c06\u5c06\u5206\u5b50\u6807\u8bb0\u6dfb\u52a0\u5230\u5206\u671f\u6807\u51c6\uff0c\u5305\u62ec\u96cc\u6fc0\u7d20\u53d7\u4f53\uff08ER\uff09\uff0c\u5b55\u916e\u53d7\u4f53\uff08PR\uff09\u548cHER2\u7b49<\/div>\n
\u7f8e\u56fd\u764c\u75c7\u8054\u5408\u59d4\u5458\u4f1a\uff08AJCC\uff09\u4eca\u5929\u5ba3\u5e03\uff0c\u57fa\u4e8e\u7fd4\u5b9e\u7684\u4e34\u5e8a\u8bc1\u636e\uff0c\u7f8e\u56fd\u764c\u75c7\u8054\u5408\u59d4\u5458\u4f1a\uff08AJCC\uff09\u628aOncotypeDX\u00ae\u68c0\u6d4b\u8bd5\u5242\u76d2\u7eb3\u5165\u6700\u8fd1\u516c\u5e03\u7684\u7b2c\u516b\u7248AJCC\u764c\u75c7\u5206\u671f\u624b\u518c\u4e2d\u3002\u6839\u636e\u8d85\u8fc763,000\u540d\u60a3\u8005\u7684\u4e34\u5e8a\u8bc1\u636e\uff0c\u66f4\u65b0\u7684\u6807\u51c6\u57fa\u4e8e\u4e25\u683c\u7684\u591a\u5b66\u79d1\u8bc4\u4f30\uff0c\u5c06Oncotype DX\u9009\u5b9a\u4e3a\u552f\u4e00\u786e\u5b9a\u4e73\u817a\u764c\u60a3\u8005\u7684\u6b63\u5f0f\u5206\u671f\u5177\u6709I\u7ea7\u8bc1\u636e\u7684\u591a\u57fa\u56e0\u68c0\u6d4b\u3002<\/div>\n\n
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\"eicZhoGYCfyaskHys5ibibyfWIWibQv4HIibLdXAvLesfTa6efTXict1ibuQ4wdvJuqmRqdyl2bIRFu4Kibatzv8k6Sleg\"\/<\/figure><\/div>\n\n
Steven Shak, M.D. Co-Founder, Chief Scientific Officer\uff0cGenomic Health<\/div>\n
Genomic Health\u9996\u5e2d\u79d1\u5b66\u5b98Steven Shak\u535a\u58eb\u8bf4\uff1a\u201cAJCC\u9996\u6b21\u589e\u52a0\u4e86\u5206\u5b50\u6807\u8bb0\u4ee5\u8865\u5145\u8be5\u75be\u75c5\u7684\u4f20\u7edf\u89e3\u5256\u7279\u5f81\uff0c\u5c06\u764c\u75c7\u8bca\u65ad\u548c\u62a4\u7406\u8f6c\u53d8\u4e3a\u771f\u6b63\u7684\u4e2a\u4f53\u5316\u533b\u7597\u3002 \u201c\u901a\u8fc7Oncotype DX \u7684\u591a\u4e2a\u524d\u77bb\u6027\u7814\u7a76\uff0c\u6211\u4eec\u76f8\u4fe1\u8fd9\u4e00\u7a81\u7834\u6027\u7684\u91cc\u7a0b\u7891\u5c06\u5e2e\u52a9\u4e34\u5e8a\u533b\u751f\u63d0\u9ad8\u80fd\u529b\uff0c\u66f4\u597d\u5730\u670d\u52a1\u4e8e\u60a3\u8005\u3002<\/div>\n
\u4ece2018\u5e741\u6708\u8d77\uff0cAJCC\u5c06Oncotype DX Breast Recurrence Score\u2122\uff08Oncology DX\u4e73\u817a\u764c\u590d\u53d1\u8bc4\u5206\uff09\u6dfb\u52a0\u5230\u65b0\u7684\u9884\u540e\u9636\u6bb5\u5206\u671f\uff0c\u5c06ER\uff0cPR\u548cHER2\u7b49\u5206\u5b50\u6807\u8bb0\u7269\u72b6\u6001\uff0c\u8054\u5408\u6dcb\u5df4\u7ed3\u72b6\u6001\uff0c\u80bf\u7624\u5927\u5c0f\uff0c\u80bf\u7624\u7b49\u7ea7\u4f5c\u4e3a\u4e73\u817a\u764c\u5206\u671f\u3002\u5bf9\u4e8e\u6dcb\u5df4\u7ed3\u9634\u6027\u6216\u6dcb\u5df4\u7ed3\u5fae\u8f6c\u79fb\u7684\u60a3\u8005\uff0c\u4f4e\u7684Oncotype DX\u590d\u53d1\u8bc4\u5206\uff08RS <11\uff09\u5c06\u60a3\u8005\u5206\u4e3a\u6700\u6709\u5229\u7684\u9884\u540e\u671f\uff0c\u4e0e\u80bf\u7624\u5206\u7ea7\u6216\u80bf\u7624\u5927\u5c0f\u65e0\u5173\uff08\u9ad8\u8fbe5\u5398\u7c73\uff09\u3002<\/div>\n
\u00a0<\/div>\n
\u4f5c\u4e3a\u5b9e\u65bd\u8fc7\u7a0b\u7684\u4e00\u90e8\u5206\uff0c\u6240\u6709AJCC\u5408\u4f5c\u4f19\u4f34\uff0c\u5305\u62ec\u7f8e\u56fd\u75c5\u7406\u5b66\u5bb6\u5b66\u9662\uff08CAP\uff09\u548c\u56fd\u5bb6\u7efc\u5408\u764c\u75c7\u7f51\u7edc\uff08NCCN\uff09\uff0c\u5c06\u5236\u5b9a\u548c\u66f4\u65b0\u534f\u8bae\u548c\u5de5\u5177\uff0c\u4ee5\u4fc3\u8fdb\u57282018\u5e74\u6210\u529f\u91c7\u7528\u6240\u9700\u7684\u65b0\u5206\u671f\u7cfb\u7edf\u89c4\u5219\u3002\u7b2c\u516b\u7248AJCC\u764c\u75c7\u5206\u671f\u624b\u518c\u7684\u7535\u5b50\u7248\u9884\u8ba1\u5c06\u4e8e2017\u5e74\u7b2c\u4e00\u5b63\u5ea6\u4e0a\u5e02\u3002<\/div>\n
\u5982AJCC\u51fa\u7248\u7269\u4e2d\u6240\u8ff0\uff0c\u201c\u4e13\u5bb6\u7ec4\u786e\u5b9a\uff0c\u6839\u636e\u76ee\u524d\u6700\u597d\u7684\u8bc1\u636e\uff0c\u5408\u5e76\u591a\u57fa\u56e0\u5206\u5b50\u8c31\u4ee5\u5c06Oncotype DX Breast Recurrence Score\u2122\uff08Oncology DX\u4e73\u817a\u764c\u590d\u53d1\u8bc4\u5206\uff09\u7eb3\u5165TAILORx\u7814\u7a76\u4e2d\u7684Arm A\u5b9a\u4e49\u7684\u5c0f\u7ec4\u5206\u671f\uff0c\u8fd9\u4e9b\u60a3\u8005\u5e94\u6839\u636eAJCC\u9884\u540e\u9636\u6bb5\u7ec4\u8fdb\u884c\u5206\u671f\uff0cOncotype DX\u68c0\u67e5\u7684\u7ed3\u679c\u7531I\u7ea7\u8bc1\u636e\uff08\u5927\u89c4\u6a21\u524d\u77bb\u6027\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\uff09\u652f\u6301\u3002<\/div>\n
\u00a0<\/div>\n
\u6269\u5c55\u9605\u8bfb<\/div>\n
1. \u5173\u4e8eOncotypeDX\u00ae<\/div>\n
\u4e73\u817a\u764c\uff0c\u7ed3\u80a0\u764c\u548c\u524d\u5217\u817a\u764c\u68c0\u6d4b\u7684OncotypeDX\u00ae\u7cfb\u5217\u5e94\u7528\u5148\u8fdb\u7684\u57fa\u56e0\u7ec4\u79d1\u5b66\u6765\u63ed\u793a\u80bf\u7624\u7684\u72ec\u7279\u751f\u7269\u5b66\uff0c\u4ee5\u4f18\u5316\u764c\u75c7\u6cbb\u7597\u51b3\u7b56\u3002\u8be5\u516c\u53f8\u7684\u65d7\u8230\u4ea7\u54c1Oncotype DX\u4e73\u817a\u764c\u68c0\u6d4b\u5df2\u88ab\u8bc1\u660e\u53ef\u9884\u6d4b\u5316\u7597\u7597\u6548\u548c\u6d78\u6da6\u6027\u4e73\u817a\u764c\u590d\u53d1\u7684\u53ef\u80fd\u6027\u3002\u6b64\u5916\uff0c\u8be5\u8bd5\u9a8c\u9884\u6d4b\u79f0\u4e3aDCIS\u7684\u4e73\u817a\u764c\u7684\u9884\u4fb5\u88ad\u5f62\u5f0f\u7684\u590d\u53d1\u7684\u53ef\u80fd\u6027\u3002\u8d85\u8fc770\u4e07\u60a3\u8005\u572890\u591a\u4e2a\u56fd\u5bb6\u8fdb\u884c\u8bd5\u9a8c\uff0cOncotype DX test\u91cd\u65b0\u5b9a\u4e49\u4e2a\u6027\u5316\u7684\u836f\u7269\uff0c\u4f7f\u57fa\u56e0\u7ec4\u5b66\u6210\u4e3a\u764c\u75c7\u8bca\u65ad\u548c\u6cbb\u7597\u7684\u5173\u952e\u90e8\u5206\u3002<\/div>\n
\u00a0<\/div>\n
Oncotype DX\u4e73\u817a\u764c\u68c0\u6d4b\uff0c\u68c0\u67e5\u60a3\u8005\u4e73\u817a\u80bf\u7624\u7ec4\u7ec7\u4e2d21\u4e2a\u57fa\u56e0\u7684\u6d3b\u6027\uff0c\u4ee5\u57fa\u4e8e\u5176\u4e2a\u4f53\u75be\u75c5\u7684\u751f\u7269\u5b66\u7279\u5f81\u4e3a\u5b9a\u5236\u6cbb\u7597\u63d0\u4f9b\u4e2a\u6027\u5316\u4fe1\u606f\u3002\u8be5\u8bd5\u9a8c\u7531\u591a\u4e2a\u4e25\u683c\u7684\u4e34\u5e8a\u9a8c\u8bc1\u7814\u7a76\u652f\u6301\uff0c\u8bc1\u5b9e\u8be5\u8bd5\u9a8c\u9884\u6d4b\u5316\u7597\u7597\u6548\u7684\u53ef\u80fd\u6027\u4ee5\u53ca\u65e9\u671f\u4e73\u817a\u764c\u4e2d\u764c\u75c7\u590d\u53d1\u7684\u53ef\u80fd\u6027\u3002\u8be5\u8bd5\u9a8c\u65e8\u5728\u7528\u4e8e\u6240\u6709\u65b0\u8bca\u65ad\u7684\u60a3\u6709\u65e9\u671f\uff08\u9636\u6bb5I\uff0cII\u6216IIIa\uff09\uff0c\u5177\u6709\u6dcb\u5df4\u7ed3\u9634\u6027\u6216\u6dcb\u5df4\u7ed3\u9633\u6027\uff081-3\uff09\uff0c\u96cc\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\uff08ER +\uff09\uff0cHER2 – \u9634\u6027\u75be\u75c5\u3002<\/div>\n
\u7f51\u7ad9\uff1awww.OncotypeDX.com\uff1b www.MyBreastCancerTreatment.org\u3002<\/div>\n
\u00a0<\/div>\n
2. \u5173\u4e8eGenomic Health<\/div>\n
Genomic Health\uff0cInc.\uff08\u7eb3\u65af\u8fbe\u514b\u80a1\u7968\u4ee3\u7801\uff1aGHDX\uff09\u662f\u4e16\u754c\u9886\u5148\u7684\u57fa\u4e8e\u57fa\u56e0\u7ec4\u7684\u8bca\u65ad\u6d4b\u5e8f\u63d0\u4f9b\u5546\uff0c\u901a\u8fc7\u89e3\u51b3\u75be\u75c5\u7684\u8fc7\u5ea6\u6cbb\u7597\u5e2e\u52a9\u4f18\u5316\u764c\u75c7\u62a4\u7406\uff0c\u8fd9\u662f\u5f53\u4eca\u533b\u7597\u4fdd\u5065\u4e2d\u6700\u5927\u7684\u95ee\u9898\u4e4b\u4e00\u3002\u51ed\u501f\u5176Oncotype IQ\u2122\u57fa\u56e0\u7ec4\u667a\u80fd\u5e73\u53f0\uff0c\u8be5\u516c\u53f8\u6b63\u5728\u5e94\u7528\u5176\u4e16\u754c\u7ea7\u7684\u79d1\u5b66\u548c\u5546\u4e1a\u4e13\u4e1a\u77e5\u8bc6\u548c\u57fa\u7840\u8bbe\u65bd\uff0c\u5c06\u4e34\u5e8a\u548c\u57fa\u56e0\u7ec4\u5927\u6570\u636e\u8f6c\u5316\u4e3a\u53ef\u884c\u7684\u7ed3\u679c\uff0c\u7528\u4e8e\u60a3\u8005\u6574\u4e2a\u764c\u75c7\u6cbb\u7597\u8ba1\u5212\uff0c\u4ece\u8bca\u65ad\u5230\u6cbb\u7597\u9009\u62e9\u548c\u76d1\u6d4b\u3002 Oncotype IQ\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u548c\u670d\u52a1\u7ec4\u5408\u76ee\u524d\u5305\u62ec\u8be5\u516c\u53f8\u65d7\u8230\u7cfb\u5217\u7684Oncotype DX\u57fa\u56e0\u8868\u8fbe\u6d4b\u5e8f\uff0c\u5df2\u88ab\u7528\u4e8e\u6307\u5bfc\u5168\u7403\u8d85\u8fc7700,000\u540d\u764c\u75c7\u60a3\u8005\u7684\u6cbb\u7597\u51b3\u7b56\u3002 Genomic Health\u6b63\u5728\u6269\u5927\u5176\u8bd5\u9a8c\u7ec4\u5408\uff0c\u4ee5\u5305\u62ec\u989d\u5916\u7684\u57fa\u4e8e\u6db2\u4f53\u548c\u7ec4\u7ec7\u7684\u68c0\u6d4b\uff0c\u5305\u62ec\u6700\u8fd1\u63a8\u51fa\u7684OncotypeSEQ\u00ae\u3002\u516c\u53f8\u603b\u90e8\u4f4d\u4e8e\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u7ea2\u6728\u57ce\uff0c\u56fd\u9645\u603b\u90e8\u8bbe\u5728\u745e\u58eb\u65e5\u5185\u74e6\u3002<\/div>\n
\u7f51\u7ad9\uff1awww.GenomicHealth.com<\/div>\n
\u00a0<\/div>\n
3. AJCC Cancer Staging Manual, 8th Edition, 2016<\/div>\n
http:\/\/www.prnewswire.com\/news-releases\/genomic-health-announces-inclusion-of-oncotype-dx-in-the-8th-edition-of-american-joint-committee-on-cancer-ajcc-criteria-for-breast-cancer-staging-300382899.html<\/div>\n
\u00a0<\/div>\n
\u53c2\u8003\u8d44\u6599\uff1a<\/div>\n
1. http:\/\/investor.genomichealth.com\/releasedetail.cfm?releaseid=1005324<\/div>\n
2. http:\/\/www.genomichealth.com\/en-US\/oncotype_iq_products\/oncotype_dx\/oncotype_dx_breast_cancer<\/div>\n
\u00a0<\/div>\n
\u58f0\u660e<\/div>\n
1. \u4ee5\u4e0a\u5185\u5bb9\u662f\u57fa\u56e0\u6167\u539f\u521b\u6574\u7406\u548c\u7f16\u8bd1\u800c\u6210\uff0c\u7248\u6743\u5c5e\u4e8e\u57fa\u56e0\u6167\uff08\u5317\u4eac\u57fa\u56e0\u754c\u79d1\u6280\u4fe1\u606f\u54a8\u8be2\u6709\u9650\u516c\u53f8\uff09\u3002\u8f6c\u8f7d\u8bf7\u6ce8\u660e\uff1a\u6765\u81ea\u57fa\u56e0\u6167\u3002<\/div>\n
2.\u6211\u4eec\u79c9\u6301\u5ba2\u89c2\u3001\u4e25\u8c28\u3001\u4e2d\u7acb\u7684\u6001\u5ea6\uff0c\u4ece\u591a\u65b9\u6e20\u9053\u6536\u96c6\uff0c\u52a0\u5de5\u5e76\u53d1\u5e03\u4fe1\u606f\uff0c\u4f9b\u884c\u4e1a\u53c2\u8003\u3002\u4f46\u53d7\u6536\u96c6\u5f53\u65f6\u4fe1\u606f\u516c\u5f00\u7684\u65f6\u6548\u6027\uff0c\u4e0d\u540c\u6e20\u9053\u5b58\u5728\u4e0d\u540c\u89c1\u89e3\uff0c\u4e0d\u80fd\u5b8c\u5168\u4fdd\u8bc1\u4fe1\u606f\u7684\u5b8c\u6574\u6027\u548c\u51c6\u786e\u6027\uff0c\u5982\u6709\u9519\u6f0f\u4e4b\u5904\uff0c\u6b22\u8fce\u6307\u6b63\u3002<\/div>\n
\u00a0<\/div>\n
\u7cbe\u534e\u63a8\u8350<\/div>\n
\u3010\u5927\u5496\u3011\u9ad8\u798f\u9662\u58eb<\/a>| \u674e\u7ee7\u627f<\/a>|\u5c39\u70e8<\/a> | \u5b59\u6d2a\u4e1a<\/a>|\u9ec4\u5c1a\u5fd7\u987e\u5927\u592b\u738b\u5955\u9e25\u300a\u57fa\u56e0\u4e09\u4eba\u884c\u300b<\/a>| \u54c8\u4f5b\u6c88\u4ea6\u5e73<\/a>| \u795e\u7ecf\u9057\u4f20\u4e13\u5bb6\u987e\u5927\u592b<\/a>|\u534e\u5927\u57fa\u56e0\u738b\u5a01<\/a>|\u81ea\u95ed\u75c7\u4e13\u5bb6\u738b\u660e\u5e2e<\/a>|\u8bb8\u660e\u708e<\/a>|15\u4f4dCEO\u89e3\u8bfb\u6db2\u4f53\u6d3b\u68c0<\/a>|\u738b\u5955\u9e25<\/a>|\u7cbe\u51c6\u533b\u5b66\u4e13\u9879\u4e13\u5bb6<\/a><\/div>\n
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