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\u00a0<\/div>\n
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\u00a0<\/div>\n
5\u3001\u83cc\u7fa4\u79fb\u690d\u6cbb\u7597\u4fbf\u79d8<\/div>\n
\u57fa\u4e8e\u80a0\u9053\u83cc\u7fa4\u548c\u80a0\u52a8\u529b\u4e4b\u95f4\u7684\u5bc6\u5207\u5173\u7cfb\uff0c\u8fd1\u5e74\u6765\u4e0d\u5c11\u7814\u7a76\u8005\u5c1d\u8bd5\u5e94\u7528\u83cc\u7fa4\u79fb\u690d\uff08fecal microbiota transplantation\uff0cFMT\uff09\u6765\u91cd\u5efa\u60a3\u8005\u80a0\u9053\u83cc\u7fa4\uff0c\u4ece\u800c\u8fbe\u5230\u6cbb\u7597\u75be\u75c5\u7684\u76ee\u7684\u3002<\/div>\n
\u83cc\u7fa4\u79fb\u690d\uff08FMT\uff09\uff0c\u5373\u5c06\u5065\u5eb7\u4eba\u7caa\u4fbf\u4e2d\u7684\u529f\u80fd\u83cc\u7fa4\uff0c\u901a\u8fc7\u4e00\u5b9a\u65b9\u5f0f\u79fb\u690d\u5230\u75c5\u4eba\u80a0\u9053\u5185\uff0c\u8c03\u8282\u80a0\u9053\u83cc\u7fa4\u5931\u8861\uff0c\u91cd\u5efa\u5177\u6709\u6b63\u5e38\u529f\u80fd\u7684\u80a0\u9053\u5fae\u751f\u6001\u7cfb\u7edf\uff0c\u4e3a\u6cbb\u7597\u80a0\u9053\u5185\u53ca\u80a0\u9053\u5916\u75be\u75c5\u63d0\u4f9b\u5e2e\u52a9\u30021989\u5e74\uff0c\u6fb3\u5927\u5229\u4e9a\u6089\u5c3c\u6d88\u5316\u533b\u5b66\u4e2d\u5fc3\u7684Borody\u533b\u751f\u53ca\u5176\u540c\u4e8b\uff0c\u7528\u7ed3\u80a0\u955c\u5c06\u7caa\u4fbf\u4e0a\u6e05\u6db2\u6ce8\u5165\u5230\u7ed3\u80a0\uff0c\u4ee5\u6cbb\u7597\u6162\u6027\u4fbf\u79d8\u3002\u8fd1\u5e74\u6765\uff0c\u56fd\u5916\u4e5f\u5f00\u5c55\u6162\u6027\u4fbf\u79d8\u60a3\u8005\u80a0\u9053\u7caa\u4fbf\u53ca\u9ecf\u819c\u83cc\u7fa4\u7684\u57fa\u7ebf\u7814\u7a76\uff0c\u660e\u786e\u53d1\u73b0\u80a0\u9053\u83cc\u7fa4\u8ddf\u7caa\u4fbf\u6027\u72b6\u4e0e\u786c\u5ea6\u6709\u76f8\u5173\u6027\u3002<\/div>\n\n
\n
\"eicZhoGYCfyaia9UXNhMYNO0mibic2ELFQOauCsFiciaZf4bWVEyU5rPfLNqZJQkJY7gXje1adZNaqthoCkWS5gHvRsQ\"\/<\/figure><\/div>\n\n
\u56fe\u7247\u6765\u81ea\u4f5c\u8005\u6388\u6743\u63d0\u4f9b<\/div>\n
FMT\u4e8e2013 \u5e74\u88ab\u5217\u5165\u7f8e\u56fd\u4e34\u5e8a\u533b\u5b66\u6307\u5357\uff0c\u63a8\u8350\u7528\u4e8e\u590d\u53d1\u96be\u8fa8\u68ad\u72b6\u82bd\u5b62\u6746\u83cc\u611f\u67d3\u7684\u6cbb\u7597\u3002\u75be\u75c5\u8303\u56f4\u6db5\u76d6\u591a\u79cd\u80a0\u9053\u529f\u80fd\u969c\u788d\u6027\u75be\u75c5\u53ca\u4ee3\u8c22\u6027\u75be\u75c5\u3002\u968f\u540eFMT\u7684\u4e34\u5e8a\u5e94\u7528\u8d8a\u6765\u8d8a\u5e7f\u6cdb\u3002\u622a\u6b62\u76ee\u524d\u5171\u6ce8\u518c\u81f3\u5c11126\u9879FMT \u76f8\u5173\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4e3b\u8981\u96c6\u4e2d\u5728CDI\uff0c\u6162\u6027\u4fbf\u79d8\uff0c\u708e\u75c7\u6027\u80a0\u75c5\u53ca\u80a0\u6613\u6fc0\u7efc\u5408\u75c7\u7b49\u75be\u75c5\u65b9\u9762\uff0c\u7814\u7a76\u8303\u56f4\u6269\u5c55\u5230\u4f9b\u4f53\u9009\u62e9\u3001\u79fb\u690d\u9014\u5f84\u53ca\u79fb\u690d\u5242\u578b\u7b49\u65b9\u6cd5\u5b66\u5c42\u9762\u3002<\/div>\n
\u00a0<\/div>\n
6\u3001\u83cc\u7fa4\u79fb\u690d\u7684\u7406\u8bba\u63a2\u8ba8<\/div>\n
\u6211\u4eec\u56e2\u961f\u7387\u5148\u5728\u56fd\u5185\u5f00\u5c55\u4e86\u57fa\u4e8e16Sr RNA\u548c\u5b8f\u57fa\u56e0\u7ec4\u5c42\u9762\u7684\u4fbf\u79d8\u60a3\u8005\u80a0\u9053\u83cc\u7fa4\u5206\u6790\uff0c\u7cfb\u7edf\u7684\u63ed\u793a\u4e86\u4fbf\u79d8\u60a3\u8005\u80a0\u9053\u83cc\u7fa4\u5b58\u5728\u7684\u7d0a\u4e71\uff0c\u540c\u671f\u548c\u5357\u4eac\u5927\u5b66\u6a21\u5f0f\u52a8\u7269\u7814\u7a76\u6240\u5408\u4f5c\uff0c\u5728\u5c0f\u9f20\u4fbf\u79d8\u6a21\u578b\u7814\u7a76\u4e2d\u53d1\u73b0\u79fb\u690d\u5065\u5eb7\u80a0\u9053\u83cc\u7fa4\u53ef\u6539\u5584\u80a0\u9053\u5e73\u6ed1\u808c\u6536\u7f29\uff0c\u8fdb\u800c\u663e\u8457\u6539\u5584\u4fbf\u79d8\u5c0f\u9f20\u75c7\u72b6\u3002\u4e0a\u8ff0\u7814\u7a76\u53d1\u73b0\u4e3aFMT\u4e34\u5e8a\u5e94\u7528\u63d0\u4f9b\u4e86\u7406\u8bba\u57fa\u7840\u3002\u968f\u540e\u6211\u4eec\u5f00\u5c55\u4e86\u9ad8\u8d28\u91cf\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u6765\u63a2\u7d22\u83cc\u7fa4\u79fb\u690d\uff08FMT\uff09\u6cbb\u7597\u6162\u4f20\u8f93\u578b\u4fbf\u79d8\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u7814\u7a76\u663e\u793a\uff0cFMT\u7ec4\u5728\u4e34\u5e8a\u6539\u5584\u7387\u3001\u4e34\u5e8a\u6cbb\u6108\u7387\u3001\u6bcf\u5468\u5b8c\u5168\u81ea\u4e3b\u6392\u4fbf\u6b21\u6570\u3001\u7caa\u4fbf\u6027\u72b6\u8bc4\u5206\u3001\u7ed3\u80a0\u4f20\u8f93\u65f6\u95f4\u4ee5\u53caWexner\u4fbf\u79d8\u8bc4\u5206\u65b9\u9762\u5747\u4f18\u4e8e\u5bf9\u7167\u7ec4\uff08\u88681\uff09\u3002\u603b\u4f53\u6765\u770b\uff0cFMT\u6cbb\u7597\u6162\u4f20\u8f93\u578b\u4fbf\u79d8\u5b89\u5168\u3001\u6709\u6548\uff0c\u77ed\u671f\u6cbb\u7597\u6548\u679c\u826f\u597d\uff0c\u4f46\u4ecd\u5b58\u5728\u957f\u671f\u7597\u6548\u7ef4\u6301\u4e0d\u4f73\u53ca\u79fb\u690d\u9014\u5f84\u6709\u521b\u7b49\u95ee\u9898\u671f\u5f85\u89e3\u51b3\u3002<\/div>\n
\u00a0<\/div>\n
\u88681 FMT\u6cbb\u7597\u4e0e\u5e38\u89c4\u6cbb\u759712\u5468\u540e\u6cbb\u7597\u6548\u679c\uff08ITT\u5206\u6790\u4e0ePP\u5206\u6790\uff09<\/div>\n
\u610f\u5411\u6027\u5206\u6790<\/div>\n
PP \u5206\u6790<\/div>\n
\u5e38\u89c4\u6cbb\u7597\u7ec4(N=30)<\/div>\n
FMT\u7ec4 (N=30)<\/div>\n
P \u503c<\/div>\n
\u5e38\u89c4\u6cbb\u7597\u7ec4\u7ec4(N=24)<\/div>\n
FMT\u7ec4 (N=25)<\/div>\n
P \u503c<\/div>\n
\u4e34\u5e8a\u6cbb\u6108\u7387(%)<\/div>\n
13.3% (4\/30)<\/div>\n
36.7% (11\/30)<\/div>\n
0.04<\/div>\n
8.3% (2\/24)<\/div>\n
36.0% (9\/25)<\/div>\n
0.03<\/div>\n
\u4e34\u5e8a\u6539\u5584\u7387(%)<\/div>\n
20.0% (6\/30)<\/div>\n
53.3% (16\/30)<\/div>\n
0.009<\/div>\n
20.8% (4\/24)<\/div>\n
56.0% (14\/25)<\/div>\n
0.006<\/div>\n
\u6bcf\u5468CSBMs \u6b21\u6570<\/div>\n
2.1 \u00b1 1.2<\/div>\n
3.2 \u00b1 1.4<\/div>\n
0.001<\/div>\n
2.2 \u00b1 0.5<\/div>\n
3.5 \u00b1 1.7<\/div>\n
0.0003<\/div>\n
\u7caa\u4fbf\u6027\u72b6\u8bc4\u5206<\/div>\n
2.4\u00b11.1<\/div>\n
3.9\u00b11.3<\/div>\n
<0.00001<\/div>\n
2.5\u00b10.8<\/div>\n
4.2\u00b11.9<\/div>\n
<0.0001<\/div>\n
\u7ed3\u80a0\u4f20\u8f93\u65f6\u95f4 (\u65f6)<\/div>\n
73.6\u00b18.7<\/div>\n
58.5\u00b19.8<\/div>\n
<0.00001<\/div>\n
71.5\u00b110.6<\/div>\n
56.4\u00b17.5<\/div>\n
0.01<\/div>\n
Wexner \u4fbf\u79d8\u8bc4\u5206<\/div>\n
12.7\u00b12.5<\/div>\n
8.6\u00b11.5<\/div>\n
<0.00001<\/div>\n
11.3\u00b10.8<\/div>\n
8.4\u00b11.2<\/div>\n
0.0002<\/div>\n
\u00a0<\/div>\n
\u79fb\u690d\u524d\u540e\u83cc\u7fa4\u5206\u6790\u7ed3\u679c\u5927\u4f53\u4e0e\u4e34\u5e8a\u75c7\u72b6\u76f8\u5bf9\u5e94\uff0cFMT\u7ec4\u83cc\u7fa4\u79fb\u690d\u540e\u7b2c4\u5468\u591a\u6837\u6027\u6307\u6570\u8d8b\u4e8e\u5e73\u7a33\uff0c\u968f\u540e\u9010\u6e10\u6062\u590d\u5230\u6cbb\u7597\u524d\u72b6\u6001\uff1b\u5e38\u89c4\u6cbb\u7597\u7ec4\u83cc\u7fa4\u591a\u6837\u6027\u672a\u89c1\u663e\u8457\u53d8\u5316\uff0cFMT\u7ec4\u75c7\u72b6\u6539\u5584\u7684\u60a3\u8005\u80a0\u9053\u83cc\u7fa4\u7ec4\u6210\u7279\u70b9\u8d8b\u8fd1\u4e8e\u4f9b\u4f53\u80a0\u9053\u83cc\u7fa4\u7ec4\u6210\u3002\u9488\u5bf9\u4e34\u5e8a\u7814\u7a76\u4e2d\u53d1\u73b0\u7684\u60a3\u8005\u9700\u591a\u6b21\u91cd\u590d\u79fb\u690d\u6cbb\u7597\u7684\u9700\u8981\u4ee5\u53ca\u79fb\u690d\u9014\u5f84\u7684\u6709\u521b\u6027\uff0c\u6211\u4eec\u56e2\u961f\u63a2\u8ba8\u7814\u53d1\u53ef\u4ee5\u53e3\u670d\u7684\u8010\u9178\u7f9f\u4e19\u7532\u7ea4\u7ef4\u7d20\u5305\u88f9\u7684\u80a0\u9053\u5168\u83cc\u8c31\u5e72\u7c89\u6d3b\u83cc\u80f6\u56ca\uff0c\u5e76\u5229\u7528\u7ec6\u83cc\u6b7b\u6d3b\u7ec6\u80de\u89c2\u5bdf\u548c\u8ba1\u6570\u6280\u672f\uff08\u5e73\u677f\u8ba1\u6570\u6cd5\u3001\u6fc0\u5149\u5171\u805a\u7126\u663e\u5fae\u955c\u53ca\u6d41\u5f0f\u7ec6\u80de\u672f\uff09\u9a8c\u8bc1\u4e86\u6d3b\u83cc\u80f6\u56ca\u7684\u8d28\u91cf\uff0c\u5373\u529f\u6548\u7b49\u540c\u4e8eFMT\u83cc\u6db2\uff08\u88682\uff09\uff0c\u5e76\u968f\u4e4b\u5efa\u7acb\u4e86\u83cc\u7fa4\u79fb\u690d\u7684\u4e34\u5e8a\u6cbb\u7597\u8def\u5f84\uff0c\u79d1\u5b66\u7cfb\u7edf\u7684\u660e\u786e\u4e86\u83cc\u7fa4\u79fb\u690d\u6280\u672f\u6cbb\u7597\u6162\u4f20\u8f93\u578b\u4fbf\u79d8\u7684\u673a\u5236\u53ca\u4e34\u5e8a\u6709\u6548\u6027\u3002<\/div>\n
\u00a0<\/div>\n
\u88682 \u5fae\u751f\u7269\u5e73\u677f\u8ba1\u6570\u7ed3\u679c<\/div>\n
\u83cc\u79cd<\/div>\n
FMT\u80f6\u56ca(log10 cfu\/ml)<\/div>\n
FMT\u83cc\u6db2(log10 cfu\/ml)<\/div>\n
P<\/div>\n
\u53cc\u6b67\u6746\u83cc<\/div>\n
6.18\u00b10.34<\/div>\n
7.06\u00b10.10<\/div>\n
>0.05<\/div>\n
\u4e73\u9178\u6746\u83cc<\/div>\n
6.27\u00b10.30<\/div>\n
6.78\u00b10.51<\/div>\n
>0.05<\/div>\n
\u5927\u80a0\u6746\u83cc<\/div>\n
5.46\u00b10.28<\/div>\n
5.67\u00b10.32<\/div>\n
>0.05<\/div>\n
\u62df\u6746\u83cc<\/div>\n
8.12\u00b10.14<\/div>\n
8.54\u00b10.21<\/div>\n
>0.05<\/div>\n
\u00a0<\/div>\n
7\u3001\u80a0\u9053\u5fae\u751f\u6001\u7597\u6cd5\u521d\u6b65\u4e34\u5e8a\u5e94\u7528<\/div>\n
\u901a\u8fc7\u5927\u91cf\u57fa\u7840\u7814\u7a76\u53ca\u4e34\u5e8a\u63a2\u7d22\uff0c\u5728\u9ece\u4ecb\u5bff\u9662\u58eb\u6307\u5bfc\u4e0b\uff0c\u5357\u4eac\u603b\u533b\u9662\u80a0\u9053\u5fae\u751f\u6001\u6cbb\u7597\u4e2d\u5fc3\u674e\u5b81\u6559\u6388\u6784\u5efa\u4e86\u4ee5FMT\u6280\u672f\u4e3a\u57fa\u7840\uff0c\u8054\u5408\u76ca\u751f\u83cc\u3001\u76ca\u751f\u5143\u53ca\u8425\u517b\u652f\u6301\u7b49\u624b\u6bb5\u7684\u80a0\u9053\u5fae\u751f\u6001\u7efc\u5408\u6cbb\u7597\u7406\u5ff5\u3002\u5728\u53d6\u5f97\u533b\u9662\u4f26\u7406\u59d4\u5458\u4f1a\u6279\u51c6\u4ee5\u53ca\u6c5f\u82cf\u7701\u536b\u8ba1\u59d4\u65b0\u6280\u672f\u8bc4\u5b9a\u540e\uff0c\u83cc\u7fa4\u79fb\u690d\u6280\u672f\u6b63\u5f0f\u5728\u6211\u79d1\u5e94\u7528\u3002<\/div>\n\n
\n
\"eicZhoGYCfybkcoUpsFqxuOomAib8123L2fgIMm0k4uG37fG4AYk8jRtmictsGjqHewR0ibxoyjynmxn79s6C2e2FQ\"\/<\/figure><\/div>\n\n
\u56fe\u7247\u6765\u81ea\u4f5c\u8005\u6388\u6743\u63d0\u4f9b<\/div>\n
\u5728\u8be5\u6cbb\u7597\u7406\u5ff5\u6307\u5bfc\u4e0b\uff0c\u5357\u4eac\u603b\u533b\u9662\u666e\u901a\u5916\u79d1\u80a0\u9053\u5fae\u751f\u6001\u6cbb\u7597\u4e2d\u5fc3\u81ea2014\u5e74\u7cfb\u7edf\u5f00\u5c55FMT\u6cbb\u7597\u4fbf\u79d8\u3001\u8270\u96be\u68ad\u83cc\u611f\u67d3\u53ca\u708e\u75c7\u6027\u80a0\u75c5\u7b49\u75be\u75c5\u7684\u6cbb\u7597\uff0c\u5171\u6cbb\u7597\u60a3\u8005\u8d85\u8fc7600\u4eba\u6b21\uff0c\u5176\u4e2d\u4e00\u534a\u60a3\u8005\u4e3a\u5404\u5927\u578b\u77e5\u540d\u533b\u9662\u4e45\u6cbb\u4e0d\u6108\u8f6c\u9662\u800c\u6765\u60a3\u8005\uff0c\u53d6\u5f97\u826f\u597d\u7684\u4e34\u5e8a\u6cbb\u7597\u6548\u679c\u548c\u793e\u4f1a\u8d5e\u8a89\u5ea6\u3002\u80a0\u9053\u5fae\u751f\u6001\u6cbb\u7597\u7406\u5ff5\u7684\u63d0\u51fa\uff0c\u662f\u4e00\u79cd\u5f00\u521b\u6027\u7684\u6cbb\u7597\u601d\u8def\uff0c\u8be5\u6cbb\u7597\u624b\u6bb5\u5177\u6709\u4e34\u5e8a\u6cbb\u6108\u6548\u679c\u597d\u3001\u65e0\u660e\u663e\u4e0d\u826f\u53cd\u5e94\u53ca\u6cbb\u7597\u8d39\u7528\u4f4e\u7b49\u4f18\u70b9 2016\u5e74\u4e2d\u592e\u7535\u89c6\u53f0\u300a\u65b0\u95fb\u8054\u64ad\u300b\u53ca\u300a\u79d1\u6280\u4e4b\u5149\u300b\u4e13\u9898\u62a5\u9053\u8be5\u9879\u6280\u672f\u5728\u4fbf\u79d8\u4e2d\u7684\u6210\u529f\u5e94\u7528\uff08http:\/\/www.haodf.com\/zhuanjiaguandian\/njzylining_3929584431.htm\uff09\u3002<\/div>\n\n
\n
\"eicZhoGYCfyaia9UXNhMYNO0mibic2ELFQOaLBDDaIuF7QyicnNLOFLlGHGUHIDV6KRBXQf7qKoGDyMibHJ7bogO59Zg\"\/<\/figure><\/div>\n\n
\u56fe\u7247\uff1a\u65b0\u95fb\u622a\u56fe<\/div>\n
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1. Ge X, Zhao W, Ding C et al. Potential role of fecal microbiota from patients with slow transit constipation in the regulation ofgastrointestinal motility,Sci Rep. 2017 Mar 27;7(1):441. doi: 10.1038\/s41598-017-00612-y.<\/div>\n
2. Tian H, Ge X, Nie Y et al. Fecal microbiota transplantation in patients with slow-transit constipation: A randomized, clinical trial. PLoS One. 2017 Feb 3;12(2):e0171308. doi: 10.1371\/journal.pone.0171308. eCollection 2017.<\/div>\n
3. Tian HL, Ding C, Gong J, et al. Treatment of slow transit constipation with fecal microbiota transplantation: a pilot study. J Clin Gastroenterol. 2016 Jan 8. \uff08IF\uff1a3.186\uff09<\/div>\n
4. Ge X, Tian H, Ding C, et al. Fecal Microbiota Transplantation in Combination with Soluble Dietary Fiber for Treatment of Slow Transit Constipation: A Pilot Study. Arch Med Res. 2016 Jul 4. pii: S0188-4409(16)30053-4. doi: 10.1016\/j.arcmed.2016.06.005.<\/div>\n
5. Tian H, Ding C, Gong J, Wei Y, McFarland LV, Li N. Freeze-dried, Capsulized Fecal Microbiota Transplantation for Relapsing Clostridium difficile Infection.J Clin Gastroenterol. 2015 Apr 28. [Epub ahead of print]<\/div>\n
6. \u674e\u5b81\uff0c\u7530\u5b8f\u4eae\uff0c\u4e01\u8d85\uff0c\u7b49.\u83cc\u7fa4\u79fb\u690d\u6cbb\u7597\u80a0\u9053\u75be\u75c5406\u4f8b\u7597\u6548\u5206\u6790.\u4e2d\u534e\u80c3\u80a0\u5916\u79d1\u6742\u5fd7.2017:20 (1):10-16.<\/div>\n
7. \u7530\u5b8f\u4eae\uff0c\u4e01\u8d85\uff0c\u9a6c\u6625\u8054\uff0c\u7b49. \u7caa\u83cc\u80f6\u56ca\u6cbb\u7597\u6162\u4f20\u8f93\u578b\u4fbf\u79d815\u4f8b\u4e34\u5e8a\u7597\u6548\u5206\u6790.\u4e2d\u56fd\u5b9e\u7528\u5916\u79d1\u6742\u5fd7. 2016 Vol. 36 (04): 430-432.<\/div>\n
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