{"id":11610,"date":"2017-04-20T07:59:34","date_gmt":"2017-04-19T23:59:34","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMzE4MzU3NA==&mid=504149613&idx=1&sn=53d950afbdd768976b35983dbae15805&chksm=7371965444061f420026a4e34ef5d12a81595bbb6c73d87913f865a787826940acc63f771ca9#rd"},"modified":"2026-04-09T10:46:10","modified_gmt":"2026-04-09T02:46:10","slug":"10210299-3","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2017\/04\/20\/10210299-3\/","title":{"rendered":"\u300a\u5927\u5496\u8bba\u5065\u300b\u7b2c31\u671f | \u534e\u897f\u533b\u9662\u9b4f\u4e8e\u5168\u9662\u58eb\uff1a\u751f\u7269\u6cbb\u7597\u4e3a\u764c\u75c7\u6cbb\u7597\u5e26\u6765\u65b0\u5e0c\u671b"},"content":{"rendered":"

<\/p>\n

\u57fa\u56e0\u6167<\/div>\n
\u57fa\u56e0\u5065\u5eb7\u884c\u4e1a\u4fe1\u606f\u5e93<\/div>\n
http:\/\/www.geneclub.net.cn<\/div>\n
\u300a\u5927\u5496\u8bba\u5065\u300b\u603b\u7b2c31\u671f<\/div>\n
\u9b4f\u4e8e\u5168\u9662\u58eb<\/div>\n
<\/div>\n
<\/div>\n
\n\n
\n
\"eicZhoGYCfya9YoqYp1W4ENf1keooceIqohxI14icaDicNcksagENZkhvhuEEHiarW9PsANWETFkH3ZIYzQYZPVueQ\"\/<\/figure><\/div>\n\n
\uff08\u56fe1\uff1a\u9b4f\u4e8e\u5168\u9662\u58eb\uff0c\u7ecf\u4f5c\u8005\u6388\u6743\u53d1\u5e03\uff09<\/div>\n
\u5173\u952e\u8bcd\uff1a\u80bf\u7624\u514d\u75ab\u6cbb\u7597 \u5e72\u7ec6\u80de\u6cbb\u7597<\/div>\n
GLP\/GMP\/GCP<\/div>\n
\u5efa\u8bae\u7528\u65f6\uff1a5\u5206\u949f<\/div>\n
\u968f\u7740\u5168\u7403\u7cbe\u51c6\u533b\u5b66\u7684\u4ea7\u4e1a\u7814\u6d6a\u6f6e\u5230\u6765\uff0c\u201c\u5065\u5eb7\u4e2d\u56fd 2030\u201d \u7eb2\u8981\u843d\u5730\uff0c2017\u5e74\u7cbe\u51c6\u533b\u7597\u8fce\u6765\u9ad8\u901f\u53d1\u5c55\u548c\u884c\u4e1a\u6574\u5408\u3002\u56e0\u6b64\uff0c\u57fa\u56e0\u6167\u4e3b\u529e\u300a\u5927\u5496\u8bba\u5065\u300b\uff0c\u805a\u96c6\u79d1\u7814\u3001\u4e34\u5e8a\u3001\u4ea7\u4e1a\u3001\u8d44\u672c\u3001\u653f\u7b56\u7b49\u9886\u57df\u4ee3\u8868\u4eba\u7269\u53c2\u4e0e\u884c\u4e1a\u5927\u63a2\u8ba8\u3002\u6b22\u8fce\u53c2\u4e0e\u3002\u611f\u8c22\u5065\u5eb7\u754c\u5a92\u4f53\u652f\u6301\u3002<\/div>\n
\u00a0<\/div>\n
\u5f80\u671f\u5185\u5bb9<\/div>\n
1. \u9ec4\u5c1a\u5fd7\u3001\u4e01\u6d01\u3001\u738b\u827a\u3001\u6c88\u4ea6\u5e73\u7b4912\u4f4d\u4e34\u5e8a\u5927\u5496<\/a><\/div>\n
2. \u5c39\u70e8\u3001\u5b59\u6d2a\u4e1a\u3001\u718a\u78ca\u3001\u960e\u6d77\u7b4912\u4f4d\u4ea7\u4e1a\u5927\u5496<\/a><\/div>\n
3.\u5357\u4eac\u603b\u533b\u9662\u674e\u5b81\u4e3b\u4efb\uff1a\u80a0\u9053\u5fae\u751f\u6001\u7597\u6cd5<\/a><\/div>\n
4. Illumina\u603b\u7ecf\u7406\u8d75\u745e\u6797\uff1a\u5efa\u7acb\u66f4\u6210\u719f\u7684\u751f\u6001\u5708<\/a><\/div>\n
\u66f4\u591a\u8be6\u60c5\u89c1\u6587\u672b\u3002<\/div>\n\n
\u751f\u7269\u6cbb\u7597\u4e3a\u764c\u75c7\u6cbb\u7597\u5e26\u6765\u65b0\u5e0c\u671b<\/div>\n
\u4f5c\u8005\uff1a\u9b4f\u4e8e\u5168\u9662\u58eb\/\u56db\u5ddd\u5927\u5b66\u534e\u897f\u533b\u9662<\/div>\n
\u7f16\u8005\uff1a\u57fa\u56e0\u6167<\/div>\n
\u672c\u671f\u7b80\u4ecb<\/div>\n
\u4e34\u5e8a\u80bf\u7624\u4e2d\u5fc3\u4e0e\u751f\u7269\u6cbb\u7597\u56fd\u5bb6\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u4ece\u57fa\u7840\u7814\u7a76\u5230GCP\u7684\u201c\u6280\u672f\u94fe\u201d<\/div>\n
\u514d\u75ab\u6cbb\u7597\u76f8\u5173\u5e94\u7528\u7b80\u4ecb<\/div>\n
\u5e72\u7ec6\u80de\u6cbb\u7597\u7684\u56fd\u5916\u52a8\u6001\u548c\u56fd\u5185\u653f\u7b56\u5bfc\u5411<\/div>\n
\u751f\u7269\u6cbb\u7597\u5728\u836f\u7269\u7814\u53d1\u65b9\u9762\u7684\u673a\u9047\u548c\u6311\u6218<\/div>\n
\u00a0<\/div>\n
1.\u751f\u7269\u6cbb\u7597\u56fd\u5bb6\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u548c\u201c\u6280\u672f\u94fe\u201d<\/div>\n
\u57fa\u56e0\u6167\uff1a\u9b4f\u6559\u6388\uff0c\u60a8\u597d\uff01\u611f\u8c22\u60a8\u63a5\u53d7\u57fa\u56e0\u6167\u7684\u4e13\u8bbf\u3002\u60a880\u5e74\u4ee3\u4ece\u534e\u897f\u533b\u79d1\u5927\u5b66\u6bd5\u4e1a\uff0c90\u5e74\u4ee3\u5728\u65e5\u672c\u4eac\u90fd\u5927\u5b66\u83b7\u5f97\u535a\u58eb\u5b66\u4f4d\uff0c\u56de\u56fd\u540e\u5728\u80bf\u7624\u751f\u7269\u6cbb\u7597\u7684\u57fa\u7840\u7814\u7a76\u3001\u5e94\u7528\u5f00\u53d1\u4e0e\u4e34\u5e8a\u533b\u7597\u65b9\u9762\u505a\u4e86\u5f88\u591a\u5de5\u4f5c\u3002\u8bf7\u60a8\u5411\u57fa\u56e0\u6167\u7684\u8bfb\u8005\u4ecb\u7ecd\u4e0b\u60a8\u81ea\u5df1\u7684\u7ecf\u5386\u4ee5\u53ca\u7814\u7a76\u7684\u9886\u57df\u3002\u8c22\u8c22\uff01<\/div>\n
\u9b4f\u4e8e\u5168\uff1a\u6211\u4e00\u76f4\u4ece\u4e8b\u80bf\u7624\u7684\u751f\u7269\u6cbb\u7597\u7684\u57fa\u7840\u7814\u7a76\u3001\u5173\u952e\u6280\u672f\u5f00\u53d1\u3001\u4ea7\u54c1\u7814\u53d1\u53ca\u4e34\u5e8a\u6cbb\u7597\u7b49\u3002\u73b0\u5728\u56db\u5ddd\u5927\u5b66\u534e\u897f\u533b\u9662\u4e34\u5e8a\u80bf\u7624\u4e2d\u5fc3\u4e0e\u751f\u7269\u6cbb\u7597\u56fd\u5bb6\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u5de5\u4f5c\u4efb\u4e3b\u4efb\uff0c\u5728\u751f\u7269\u836f\u7269\uff0c\u5305\u62ec\u4e86\u57fa\u56e0\u836f\u7269\u3001\u6297\u4f53\u836f\u7269\u3001\u75ab\u82d7\u3001\u91cd\u7ec4\u86cb\u767d\u8d28\u836f\u7269\u4e0e\u5c0f\u5206\u5b50\u9776\u5411\u836f\u7269\u7684\u7814\u53d1\u4ee5\u53ca\u4e34\u5e8a\u7814\u7a76\u7b49\u65b9\u9762\u53d6\u5f97\u4e86\u4e00\u7cfb\u5217\u7684\u7814\u7a76\u8fdb\u5c55\uff0c\u5e76\u5728\u4ea7\u5b66\u7814\u5408\u4f5c\u4e0e\u6210\u679c\u8f6c\u8ba9\u65b9\u9762\uff0c\u4f5c\u4e3a\u8d1f\u8d23\u4eba\u6216\u53c2\u4e0e\u4eba\u7814\u53d1\u7684\u751f\u7269\u836f\u4ee5\u53ca\u5c0f\u5206\u5b50\u9776\u5411\u836f\u7269\u7b49\u4e00\u6279\u521b\u65b0\u836f\uff0c\u5df2\u8f6c\u8ba9\u7ed9\u56fd\u5185\u591a\u5bb6\u533b\u836f\u4f01\u4e1a\u7b49\u3002\u540c\u65f6\u7533\u8bf7\u4e13\u522970\u4f59\u9879\uff0c\u6709\u5173\u7814\u7a76\u7ed3\u679c\u5728\u56fd\u9645\u6742\u5fd7\u4e0a\u53d1\u8868SCI\u8bba\u6587300\u4f59\u7bc7\u3002\u521b\u529eSignal Transduction and Targeted Therapy\u3001\u88ab\u8058\u4e3aHuman Gene Therapy \u526f\u4e3b\u7f16\u3001Current Molecular Medicine\u526f\u4e3b\u7f16\u3001Current Cancer Drug Targets \u8d1f\u8d23\u4e9a\u6d32\u5730\u533a\u7684\u7f16\u59d4\uff0cScientific Reports\u7f16\u59d4\u7b49\u3002<\/div>\n
\u00a0<\/div>\n
\u57fa\u5730\u5efa\u8bbe\u65b9\u9762\uff0c\u6211\u7275\u5934\u5efa\u7acb\u4e86\u751f\u7269\u6cbb\u7597\u56fd\u5bb6\u91cd\u70b9\u5b9e\u9a8c\u5ba4\uff0c\u5efa\u7acb\u4e86\u4ece\u57fa\u56e0\u53d1\u73b0\u5230\u836f\u7269\u7814\u53d1\u53ca\u4e34\u5e8a\u6cbb\u7597\u7b49\u4e00\u6574\u5957\u836f\u7269\u7814\u53d1\u7684\u5173\u952e\u6280\u672f\u5e73\u53f0\uff0c\u5305\u62ec\u57fa\u56e0\u7ec4\u3001\u86cb\u767d\u8d28\u7ec4\u3001\u57fa\u56e0\u5de5\u7a0b\u5c0f\u9f20\u3001\u6591\u9a6c\u9c7c\u7814\u7a76\u3001\u57fa\u56e0\u6cbb\u7597\u3001\u514d\u75ab\u6cbb\u7597\u3001\u751f\u7269\u6280\u672f\u836f\u7269\u3001\u5e72\u7ec6\u80de\u53ca\u7ec4\u7ec7\u5de5\u7a0b\u3001\u5316\u5b66\u751f\u7269\u5b66\u3001\u8ba1\u7b97\u673a\u8f85\u52a9\u836f\u7269\u8bbe\u8ba1\u3001\u5c0f\u5206\u5b50\u9776\u5411\u6cbb\u7597\u836f\u7269\u5408\u6210\u3001\u7eb3\u7c73\u751f\u7269\u6280\u672f\u3001\u65b0\u836f\u4e34\u5e8a\u524d\u5b89\u5168\u6027\u8bc4\u4ef7\uff08GLP\uff09\u3001\u4e2d\u8bd5\u751f\u4ea7\uff08GMP\uff09\u3001\u751f\u7269\u6cbb\u7597\u65b0\u836f\u4e34\u5e8a\u8bd5\u9a8c\uff08GCP\uff09\u7b49\u5355\u5143\u548c\u5173\u952e\u6280\u672f\u5e73\u53f0, \u5f62\u6210\u4e86\u9ad8\u5ea6\u6574\u5408\u53ca\u76f8\u4e92\u5173\u8054\u7684\u201c\u6280\u672f\u94fe\u201d\uff0c\u53d7\u5230\u4e86\u56fd\u5bb6\u836f\u7269\u7814\u53d1\u7efc\u5408\u5927\u5e73\u53f0\u7684\u91cd\u70b9\u652f\u6301\uff0c\u8be5\u5e73\u53f0\u5df2\u6709\u8fd11000\u4eba\uff0c\u5176\u4e2d\u8fd1\u5e74\u5f15\u8fdb\u56fd\u5bb6\u5343\u4eba\u8ba1\u5212\u5b66\u8005\u5305\u62ec\u9752\u5e74\u5343\u4eba\u8ba1\u521245\u4eba\uff0c\u5df2\u670960\u4f59\u4e2a\u4e00\u7c7b\u65b0\u836f\u8f6c\u8ba9\u7ed9\u4f01\u4e1a\uff0c\u6bcf\u5e74\u8fd8\u53d1\u8868SCI\u6536\u5f55\u8bba\u6587600\u7bc7\u4ee5\u4e0a\u3002<\/div>\n\n
\n
\"eicZhoGYCfya9YoqYp1W4ENf1keooceIqiaSAYic6I1J9ffkh2x8rao8jjrAfhzOiaYL1kbOhVv05huL9xFQACs3Cg\"\/<\/figure><\/div>\n\n
\uff08\u56fe2\uff0c\u751f\u7269\u6cbb\u7597\u56fd\u5bb6\u91cd\u70b9\u5b9e\u9a8c\u5ba4\uff0c\u7ecf\u4f5c\u8005\u6388\u6743\u53d1\u5e03\uff09<\/div>\n
2. \u80bf\u7624\u514d\u75ab\u6cbb\u7597\u8fdb\u5c55<\/div>\n
\u57fa\u56e0\u6167\uff1a\u8c08\u5230\u80bf\u7624\u751f\u7269\u6cbb\u7597\uff0c\u751f\u7269\u884c\u4e1a\u8a00\u5fc5\u8c08PD-1\/PD-L1\u3001CAR-T\u7b49\uff0c\u8fd9\u5176\u5b9e\u5c5e\u4e8e\u514d\u75ab\u6cbb\u7597\u7684\u4e24\u79cd\u65b9\u6cd5\uff0c\u524d\u8005\u5c5e\u4e8e\u514d\u75ab\u68c0\u9a8c\u5355\u6297\uff0c\u7c7b\u4f3c\u7684\u8fd8\u6709CDLA-4\uff1b\u540e\u8005\u5c5e\u4e8e\u8fc7\u7ee7T\u7ec6\u80de\u7597\u6cd5\uff0c\u7c7b\u4f3c\u7684\u8fd8\u6709TCR\u7b49\uff1b\u9664\u4e86\u8fd9\u4e24\u79cd\u6cbb\u7597\u65b9\u6cd5\uff0c\u6211\u4eec\u77e5\u9053\u8fd8\u6709\u80bf\u7624\u75ab\u82d7\u7b49\u7b49\u3002\u60a8\u80fd\u591f\u5728\u8fd9\u91cc\u548c\u5927\u5bb6\u7cfb\u7edf\u3001\u7b80\u6d01\u5730\u5206\u4eab\u4e0b\u80bf\u7624\u751f\u7269\u6cbb\u7597\u5f53\u524d\u7684\u73b0\u72b6\uff0c\u5305\u62ec\u6280\u672f\u65b9\u6cd5\u548c\u4e34\u5e8a\u5e94\u7528\uff0c\u8c22\u8c22\uff01<\/div>\n
\u9b4f\u4e8e\u5168\uff1a\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u8fd1\u5e74\u6765\u53d6\u5f97\u4e86\u91cd\u8981\u8fdb\u5c55\u5e76\u83b7\u5f97\u91cd\u5927\u7a81\u7834\uff0c\u5728\u80bf\u7624\u7684\u751f\u7269\u6cbb\u7597\u9886\u57df\u5341\u5206\u5f15\u4eba\u6ce8\u76ee\u3002\u9776\u5411\u514d\u75ab\u68c0\u67e5\u70b9\u7684\u5355\u6297\u7597\u6cd5\u5df2\u7ecf\u83b7\u5f97\u4e0a\u5e02\u6279\u51c6\uff0c\u751a\u81f3\u6210\u4e3a\u4e86\u80ba\u764c\u80bf\u7624\u7684\u4e00\u7ebf\u6cbb\u7597\u65b9\u6848\uff1b\u57fa\u56e0\u4fee\u9970\u7684T\u7ec6\u80de\uff08\u542bCAR-T, TCR-T\uff09\u8fc7\u7ee7\u7ec6\u80de\u7597\u6cd5\u4e5f\u5728\u6cbb\u7597\u8840\u6db2\u7cfb\u7edf\u80bf\u7624\u4e2d\u7597\u6548\u663e\u8457\uff0c\u9884\u8ba1\u672c\u5e74\u5ea6\u5185\u76f8\u5173\u4ea7\u54c1\u53ef\u80fd\u83b7\u5f97\u4e0a\u5e02\u8bb8\u53ef\u3002\u6211\u4eec\u56fd\u5bb6\u5728\u76f8\u5173\u9886\u57df\u7684\u57fa\u7840\u7814\u7a76\u3001\u4e34\u5e8a\u7814\u7a76\u4ee5\u53ca\u4ea7\u4e1a\u5316\u65b9\u9762\u8fdb\u5c55\u4e5f\u975e\u5e38\u5feb\u968f\u7740\u56fd\u5bb6\u76f8\u5173\u5236\u5ea6\u4e0e\u89c4\u8303\u7684\u4e0d\u65ad\u5b8c\u5584\uff0c\u6211\u56fd\u7684\u76f8\u5173\u4ea7\u54c1\u5e7f\u6cdb\u60e0\u53ca\u4e34\u5e8a\u75c5\u4eba\u4e5f\u6307\u65e5\u53ef\u5f85\u3002\u5176\u4ed6\u7684\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u5982\u80bf\u7624\u75ab\u82d7\u3001\u65b0\u578b\u7ec6\u80de\u56e0\u5b50\u3001\u5229\u7528\u57fa\u56e0\u7f16\u8f91\u5de5\u5177\u8fdb\u884c\u7684\u80bf\u7624\u57fa\u56e0\u514d\u75ab\u6cbb\u7597\u4e5f\u503c\u5f97\u91cd\u70b9\u5173\u6ce8\u3002<\/div>\n\n
\n
\"eicZhoGYCfya9YoqYp1W4ENf1keooceIqW4qpz2SvicKpmnIWJCXpsBFmibd60NcMyyCKjS1HBIHUib9mfah7bQLQQ\"\/<\/figure><\/div>\n\n
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3. \u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u8054\u5408\u6cbb\u7597\u548c\u8f85\u52a9\u6cbb\u7597<\/div>\n
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\u9b4f\u4e8e\u5168\uff1a\u8fd1\u5e74\u6765\uff0cScience\u6742\u5fd7\u8fde\u7eed\u4e24\u6b21\u5c06\u5e72\u7ec6\u80de\u7814\u7a76\u5217\u4e3a\u4e16\u754c\u5341\u5927\u79d1\u5b66\u95ee\u9898\u4e4b\u9996\uff0c2007\u5e74\u548c2011\u5e74\u5e72\u7ec6\u80de\u7814\u7a76\u4e24\u6b21\u83b7\u5f97\u8bfa\u8d1d\u5c14\u751f\u7406\u533b\u5b66\u5956\u3002\u7f8e\u56fd\u3001\u65e5\u672c\u3001\u97e9\u56fd\u3001\u82f1\u56fd\u7b49\u56fd\u5bb6\u5bf9\u5e72\u7ec6\u80de\u7814\u7a76\u548c\u5e72\u7ec6\u80de\u7684\u4e34\u5e8a\u8f6c\u5316\u975e\u5e38\u91cd\u89c6\uff0c\u76f8\u7ee7\u542f\u52a8\u4e86\u591a\u4e2a\u56fd\u5bb6\u5c42\u9762\u91cd\u5927\u7684\u5e72\u7ec6\u80de\u7814\u7a76\u8ba1\u5212\uff0c\u7528\u4e8e\u5e72\u7ec6\u80de\u7684\u7814\u7a76\u53ca\u4e34\u5e8a\u8f6c\u5316\u3002\u76ee\u524d\uff0c\u56fd\u9645\u5e72\u7ec6\u80de\u7814\u7a76\u53ca\u4e34\u5e8a\u8f6c\u5316\u975e\u5e38\u6d3b\u8dc3\uff0c\u622a\u6b62\u52302017\u5e744\u670811\u65e5\uff0c\u5728Clinical Trials.gov\u7f51\u7ad9\u4e0a\u767b\u8bb0\u6ce8\u518c\u7684\u5e72\u7ec6\u80de\u4e34\u5e8a\u8bd5\u9a8c\u9879\u76ee\u67096012\u9879\uff0c\u5927\u90e8\u5206\u662f\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u548c\u9020\u8840\u5e72\u7ec6\u80de\u4ea7\u54c1\u3002<\/div>\n
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