{"id":11593,"date":"2017-07-19T13:14:19","date_gmt":"2017-07-19T05:14:19","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMzE4MzU3NA==&#038;mid=504149879&#038;idx=1&#038;sn=ddac4824162b544c79b279970fc96f6d&#038;chksm=7371974e44061e580e172e7aea2a4b0cda3923fbe06b40d6f4054aeb91cd1d6ddbda739cc92d#rd"},"modified":"2026-04-09T09:46:32","modified_gmt":"2026-04-09T01:46:32","slug":"5710250","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2017\/07\/19\/5710250\/","title":{"rendered":"\u701a\u6d77\u57fa\u56e0\u8d3a\u5efa\u594e\uff1a\u56fd\u4ea7\u4e09\u4ee3\u6d4b\u5e8f\u4eea\u7684\u62d3\u8352\u4e4b\u8def | \u5927\u5496\u8bba\u5065\u7b2c46\u671f"},"content":{"rendered":"<p><!-- wechat_content_hash: 9f2e503e03b415c8 --><\/p>\n<div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/eicZhoGYCfyY95jGYeVicVvCQdrscZSxyxBYHBYRsicTXZ32XbpjDFrr5WdOYMIe0icicg5Xd9ISzEibT9YXRDCfQPDA.gif\" alt=\"eicZhoGYCfyY95jGYeVicVvCQdrscZSxyxBYHBYRsicTXZ32XbpjDFrr5WdOYMIe0icicg5Xd9ISzEibT9YXRDCfQPDA\"\/><\/figure><\/div>\n\n<\/div>\n<div><\/div>\n<div><\/div>\n<div>\u3010\u5927\u5496\u8bba\u5065\u3011\u8c08\u5230\u57fa\u56e0\u6d4b\u5e8f\uff0c\u9664\u4e86Illumina\u3001Thermo 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MiSeq\u6d4b\u5e8f\u4eea\u4e00\u81f4\u6027\u8fbe\u523099.7%\u3002GenoCare\u5df2\u5b8c\u6210\u5c0f\u6279\u91cf\u6837\u673a\u751f\u4ea7\uff0c\u5e76\u5c06\u4e8e7\u670831\u65e5\u4e3e\u529e\u6d4b\u5e8f\u4eea\u4e0a\u5e02\u65b0\u95fb\u53d1\u5e03\u4f1a\u3002\u5c31\u6b64\uff0c\u57fa\u56e0\u6167\u72ec\u5bb6\u4e13\u8bbf\u4e86\u701a\u6d77\u57fa\u56e0\u8463\u4e8b\u957f\u3001\u5357\u65b9\u79d1\u6280\u5927\u5b6680\u540e\u526f\u6559\u6388\u8d3a\u5efa\u594e\u6559\u6388\u3002\u56de\u590d\u201cGenoCare\u201d\u53ef\u83b7\u5f97\u6587\u732e\u5168\u6587pdf\u3002<\/div>\n<div><\/div>\n<div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/eicZhoGYCfyZFTVDCStcfayglSmRHdGzibHl7JykVpA3tS8cqu6jvYn33r6eAEJiajSDs1nkV1HicRNUl88x4Cnic8Q.jpeg\" alt=\"eicZhoGYCfyZFTVDCStcfayglSmRHdGzibHl7JykVpA3tS8cqu6jvYn33r6eAEJiajSDs1nkV1HicRNUl88x4Cnic8Q\"\/><\/figure><\/div>\n\n<\/div>\n<div><\/div>\n<div>\u672c\u671f\u7cbe\u5f69\u5185\u5bb9<\/div>\n<div><\/div>\n\n<div>\u56fd\u4ea7\u4e09\u4ee3\u6d4b\u5e8f\u4eea\u7684\u62d3\u8352\u4e4b\u8def<\/div>\n<div>\u5173\u952e\u8bcd\uff1a\u5355\u5206\u5b50\u4e09\u4ee3\u6d4b\u5e8f\u4eea \u56fd\u4ea7\u5316<\/div>\n<div>\u4e91\u5e73\u53f0 \u701a\u6d77\u57fa\u56e0<\/div>\n<div>\u00a0<\/div>\n<div>Part 1.<\/div>\n<div>\u57fa\u56e0\u6167<\/div>\n<div>\u8d3a\u6559\u6388\uff0c\u60a8\u597d\uff01\u60a8\u66fe\u8bf4\u6d4b\u5e8f\u4eea\u56fd\u4ea7\u5316\u9700\u81f3\u5c11\u4e94\u5e74\uff0c\u4ece\u60a8\u521b\u4e1a\u5230\u73b0\u5728\u521a\u597d\u7b2c\u4e94\u4e2a\u5e74\u5934\uff0c\u701a\u6d77\u57fa\u56e0\u76f8\u7ee7\u53d1\u5e03\u4e86\u539f\u7406\u673a (2015\u5e74)\u3001\u5de5\u7a0b\u673a(2016\u5e74)\uff0c\u83b7\u5f97\u56fd\u5bb6\u533b\u7597\u5668\u68b0\u5907\u6848\u8bb8\u53ef\u8bc1\u7684\u6d4b\u5e8f\u8bd5\u5242\u76d2(2017\u5e74)\u3002\u8fd9\u4e2a\u6708\uff0c\u701a\u6d77\u57fa\u56e0\u6d4b\u5e8f\u4eea\u6700\u65b0\u6d4b\u5e8f\u6210\u679c\u53d1\u8868\uff0c\u795d\u8d3a\uff01\u6839\u636e\u701a\u6d77\u57fa\u56e0\u548c\u4e2d\u7f8e\u79d1\u5b66\u5bb6\u5728BioRxi\u671f\u520a\u4e0a\u8054\u5408\u53d1\u8868\u8bba\u6587\u79f0\uff0c\u701a\u6d77\u57fa\u56e0\u7684GenoCare\u4e09\u4ee3\u6d4b\u5e8f\u4eea\u5bf9\u5927\u80a0\u6746\u83cc\u6d4b\u5e8f\u6570\u636e\u7ed3\u679c\u4e0eillumina MiSeq\u6d4b\u5e8f\u4eea\u7684\u4e00\u81f4\u6027\u8fbe\u523099.7%\uff0c\u8fd9\u4e2a\u6570\u5b57\u610f\u5473\u7740\u4ec0\u4e48\u610f\u4e49\u5462\uff1f\u53ef\u5426\u5411\u57fa\u56e0\u6167\u8bfb\u8005\u7b80\u8981\u8c08\u8c08\u8fd9\u9879\u7814\u7a76\u7684\u80cc\u666f\u3001\u8bbe\u8ba1\u548c\u8de8\u56fd\u56e2\u961f\u7684\u534f\u4f5c\u60c5\u51b5\uff1f<\/div>\n<div>\u8d3a\u5efa\u594e\uff1a\uff08\u57fa\u56e0\uff09\u6570\u636e\u662f\u8bc1\u660e\u4e00\u53f0\u6d4b\u5e8f\u4eea\u7684\u6839\u672c\uff0c\u800c\u6d4b\u5e8f\u7684\u51c6\u786e\u6027\u662f\u6d4b\u5e8f\u6570\u636e\u6700\u91cd\u8981\u7684\u4e5f\u662f\u6700\u57fa\u672c\u7684\u4e00\u9879\u6307\u6807\uff0c\u6211\u4eec\u7684\u76ee\u6807\u4e0d\u4ec5\u662f\u8981\u505a\u5168\u7403\u6700\u51c6\u786e\u7684\u5355\u5206\u5b50\u6d4b\u5e8f\u4eea\uff0c\u540c\u65f6\u8981\u505a\u4e00\u6b3e\u6700\u9002\u7528\u4e8e\u4e34\u5e8a\u5e94\u7528\u7684\u6d4b\u5e8f\u4eea\uff0c\u51c6\u786e\u3001\u7b80\u5355\u3001\u65b9\u4fbf\u3002\u5355\u5206\u5b50\u6d4b\u5e8f\u6280\u672f\u5728\u5355\u5206\u5b50\u6c34\u5e73\u4e0a\u5bf9\u78b1\u57fa\u8fdb\u884c\u6d4b\u5e8f\uff0c\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u5177\u6709\u6bd4\u4e8c\u4ee3\u6d4b\u5e8f\u66f4\u9ad8\u7684\u6280\u672f\u58c1\u5792\u3002\u8fd9\u6b21\u6211\u4eec\u5728\u5bf9\u5927\u80a0\u6746\u83cc\u6d4b\u5e8f\u4e2d\u83b7\u5f97\u7684\u6d4b\u5e8f\u7ed3\u679c\uff0c\u663e\u793a\u51c6\u786e\u6027\u4e0e\u4e8c\u4ee3\u6d4b\u5e8f\u9f99\u5934\u4f01\u4e1aIllumina\u7684\u4e00\u81f4\u6027\u8fbe\u5230\u4e8699.7%\uff0c\u8fd9\u5bf9\u5355\u5206\u5b50\u4e09\u4ee3\u6d4b\u5e8f\u4eea\u7814\u53d1\u6765\u8bf4\u610f\u4e49\u975e\u51e1\u8fd9\u610f\u5473\u7740\u701a\u6d77\u57fa\u56e0Genocare\u7b2c\u4e09\u4ee3\u5355\u5206\u5b50\u6d4b\u5e8f\u4eea\u6210\u4e3a\u76ee\u524d\u5168\u7403\u51c6\u786e\u7387\u6700\u9ad8\u3001\u4e14\u552f\u4e00\u7528\u4e8e\u4e34\u5e8a\u5e94\u7528\u7684\u7b2c\u4e09\u4ee3\u57fa\u56e0\u6d4b\u5e8f\u4eea\u3002\u5b9e\u9645\u4e0a\uff0c\u5927\u80a0\u6746\u83cc\u6570\u636e\u7684\u91ca\u653e\u53ea\u662f\u6211\u4eec\u7684\u7814\u7a76\u9879\u76ee\u7684\u4e00\u5c0f\u90e8\u5206\uff0c\u65e9\u671f\u6211\u4eec\u91ca\u653e\u8fc7\u5408\u6210DNA\u7684\u6d4b\u5e8f\u7ed3\u679c\uff0c\u566c\u83cc\u4f53\u6570\u636e\uff0c\u73b0\u5728\u662f\u6a21\u5f0f\u751f\u7269\u5927\u80a0\u6746\u83cc\uff0c\u63a5\u4e0b\u6765\u8fd8\u6709\u66f4\u91cd\u8981\u7684\u4eba\u7684\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u4ee5\u53ca\u5404\u7c7b\u4e34\u5e8a\u5e94\u7528\u7684\u6d4b\u5e8f\u60c5\u51b5\uff0c\u76f8\u4fe1\u8fd9\u4e9b\u6570\u636e\u4f1a\u8ba9\u6211\u4eec\u79bb\u6211\u4eec\u7684\u76ee\u6807\u8d8a\u6765\u8d8a\u8fd1\u3002\u83b1\u65af\u5927\u5b66\u56e2\u961f\u7684\u7814\u7a76\u4fa7\u91cd\u4e8e\u4e09\u4ee3\u6d4b\u5e8f\u539f\u7406\u7684\u6570\u7406\u6a21\u578b\u5efa\u7acb\u548c\u5206\u6790\uff0c\u5357\u65b9\u79d1\u5927\u548c\u701a\u6d77\u57fa\u56e0\u56e2\u961f\u5b8c\u6210\u6587\u7ae0\u7684\u4e3b\u4f53\u5de5\u4f5c\uff0c\u5305\u62ec\u5b9e\u9a8c\u8bbe\u8ba1\u3001\u6d4b\u5e8f\u7cfb\u7edf\u642d\u5efa\u3001\u5b9e\u9a8c\u5b9e\u65bd\u3001\u6570\u636e\u5904\u7406\u7b49\uff0c\u5317\u4eac\u57fa\u56e0\u7ec4\u7814\u7a76\u6240\u56e2\u961f\u7684\u5206\u5de5\u4fa7\u91cd\u4e8e\u6570\u636e\u7ed3\u679c\u7684\u8ba8\u8bba\u548c\u5206\u6790\u3002<\/div>\n<div>\u00a0<\/div>\n<div>Part 2.<\/div>\n<div>\u57fa\u56e0\u6167<\/div>\n<div>\u4ece\u701a\u6d77\u57fa\u56e0\u5b98\u7f51\u4e86\u89e3\u5230\uff0cGenoCare\u5177\u5907\u4e0d\u7528\u51d1run\u3001\u4e0d\u7528PCR\u6269\u589e\u3001\u8d77\u59cb\u91cf\u4f4e\uff0810ng)\u3001\u4eba\u5de5\u64cd\u4f5c\u4fbf\u6377\u300124\u5c0f\u65f6\u53ef\u53d6\u62a5\u544a\u7b49\u7279\u70b9\uff0c\u53ef\u5426\u8c08\u8c08\u5176\u4e2d\u6838\u5fc3\u4f18\u52bf\u662f\u54ea\u4e9b\uff1f\u540c\u65f6\u4ece\u6d4b\u5e8f\u9519\u8bef\u7387\u3001\u6d4b\u5e8f\u6210\u672c\u7b49\u53c2\u6570\u7efc\u5408\u6765\u770b\uff0c\u8ddd\u79bbGenoCare\u4e09\u4ee3\u6d4b\u5e8f\u4eea\u6295\u5165\u91cf\u4ea7\u4f7f\u7528\u8fd8\u6709\u591a\u8fdc\uff1f\u5176\u4e2d\u4e3b\u8981\u9700\u8981\u89e3\u51b3\u4ec0\u4e48\u95ee\u9898\uff1f<\/div>\n<div>\u8d3a\u5efa\u594e\uff1aGenoCare\u662f\u6211\u4eec\u7684\u7b2c\u4e00\u6b3e\u6d4b\u5e8f\u4eea\u4ea7\u54c1\uff0c\u6211\u4eec\u5bf9\u8fd9\u6b3e\u4ea7\u54c1\u7684\u5b9a\u4f4d\u662f\u4e13\u4e3a\u4e34\u5e8a\u8bbe\u8ba1\u7684\u5355\u5206\u5b50\u6d4b\u5e8f\u4eea\uff0c\u6240\u4ee5\u6211\u4eec\u8981\u5145\u5206\u8003\u8651\u5230\u4e34\u5e8a\u4e0a\u9700\u6c42\u3002\u5355\u5206\u5b50\u8fd9\u4e2a\u6280\u672f\u6700\u91cd\u8981\u7684\u4e00\u70b9\u5c31\u662f\u5b83\u65e0\u8bba\u662f\u5728\u6837\u54c1\u5904\u7406\u8fd8\u662f\u6d4b\u5e8f\u8fc7\u7a0b\u4e2d\u90fd\u4e0d\u9700\u8981\u518d\u8fdb\u884cPCR\uff0c\u8fd9\u5c31\u5e26\u6765\u4e86\u5f88\u591a\u597d\u5904\u3002\u7b2c\u4e00\uff0c\u5927\u5927\u7b80\u5316\u6b65\u9aa4\uff0c\u73b0\u5728\u6211\u4eec\u7684\u6837\u54c1\u5904\u7406\u53ea\u9700\u8981\u4e0d\u5230\u534a\u4e2a\u5c0f\u65f6\u7684\u65f6\u95f4\uff0c\u975e\u5e38\u7b80\u5355\uff0c\u533b\u9662\u4e0d\u9700\u8981\u518d\u8058\u8bf7\u4e13\u95e8\u7684\u5efa\u5e93\u5b9e\u9a8c\u5458\uff0c\u81ea\u5df1\u5c31\u53ef\u4ee5\u64cd\u4f5c\uff1b\u7b2c\u4e8c\uff0c\u89c4\u907f\u4e86PCR\u5f15\u5165\u7684\u9519\u8bef\uff0c\u4e00\u65b9\u9762PCR\u672c\u8eab\u4f1a\u5e26\u6765\u9519\u8bef\uff0c\u5f71\u54cd\u6d4b\u5e8f\u7ed3\u679c\uff0c\u53e6\u4e00\u65b9\u9762PCR\u610f\u5473\u7740\u66f4\u957f\u7684\u624b\u52a8\u64cd\u4f5c\u65f6\u95f4\uff0c\u8fd9\u540c\u6837\u4e5f\u4f1a\u5e26\u6765\u9519\u8bef\u3002\u7b2c\u4e09\uff0c\u7075\u654f\u5ea6\u4e5f\u66f4\u9ad8\u4e86\uff0c\u5355\u5206\u5b50\u7684\u5206\u8fa8\u7387\uff0c\u6211\u4eec\u80fd\u505a\u7684\u66f4\u591a\uff0c\u5c31\u62ff\u6700\u5e38\u89c4\u7684NIPT\u6765\u8bf4\uff0c\u76ee\u524d\u56fd\u5185\u80fd\u505a\u5230\u7684\u6700\u65e9\u5b55\u5468\u662f12\u5468\uff0c\u8fd9\u4e3b\u8981\u53d7\u9650\u4e86\u8fc7\u4f4e\u7684\u80ce\u513fDNA\u6d53\u5ea6\uff0c\u6211\u4eec\u76ee\u524d\u6b63\u5728\u8bd5\u56fe\u6536\u96c6\u6570\u636e\uff0c\u5bf9\u66f4\u65e9\u671f\u7684\u5b55\u5987\u8fdb\u884cNIPT\u3002\u7b2c\u56db\uff0c\u5c31\u662f\u5b83\u7684\u5feb\u6377\u6027\uff0c\u66f4\u5feb\u7684\u6837\u54c1\u5904\u7406\u548c\u6d4b\u5e8f\u65f6\u95f4\uff0c\u5bf9\u4e8e\u4e00\u4e9b\u5982\u75c5\u539f\u4f53\u9274\u5b9a\u8fd9\u7c7b\u5e94\u7528\u662f\u975e\u5e38\u91cd\u8981\u7684\u3002\u7b2c\u4e94\uff0c\u5c31\u662f\u6d4b\u5e8f\u6210\u672c\uff0c\u7b80\u5316\u7684\u6b65\u9aa4\u610f\u5473\u7740\u66f4\u5c11\u7684\u8bd5\u5242\u6d88\u8017\uff0c\u76f8\u5e94\u7684\u6210\u672c\u5c31\u4f4e\uff0c\u52a0\u4e0a\u6211\u4eec\u7684\u82af\u7247\u4e0d\u9700\u8981\u51d1\u6837\uff0c\u4e0a\u6837\u91cf\u4e0d\u4f1a\u660e\u663e\u7684\u5f71\u54cd\u6d4b\u5e8f\u6210\u672c\u3002100\u7f8e\u5143\u6d4b\u5e8f\uff0c\u6211\u4eec\u5e0c\u671b\u53ef\u4ee5\u5c3d\u5feb\u8fbe\u5230\u8fd9\u4e2a\u76ee\u6807\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u73b0\u5728\u6211\u4eec\u4e5f\u6b63\u5728\u4e3a\u4ea7\u54c1\u4e0a\u5e02\u505a\u4e00\u7cfb\u5217\u7684\u51c6\u5907\uff0c\u9664\u4e86\u6570\u636e\u7684\u91ca\u653e\uff0c\u4ea7\u54c1\u7684\u91cf\u4ea7\u4e5f\u5728\u8fdb\u884c\u5f53\u4e2d\u3002\u8ddf\u6240\u6709\u521d\u6b65\u8e0f\u5165\u5e02\u573a\u7684\u4ea7\u54c1\u4e00\u6837\uff0c\u5e02\u573a\u603b\u662f\u514d\u4e0d\u4e86\u6709\u4e00\u4e9b\u7591\u95ee\uff0c\u6bd4\u5982\u5f88\u591a\u5ba2\u6237\u60f3\u4e86\u89e3\u6211\u4eec\u5e73\u53f0\u7684\u6d4b\u5e8f\u6570\u636e\u548c\u4e8c\u4ee3\u6570\u636e\u7684\u517c\u5bb9\u6027\u95ee\u9898\uff0c\u6211\u4eec\u4e5f\u6b63\u5728\u5f00\u53d1\u5404\u79cd\u89e3\u51b3\u65b9\u6848\uff0c\u8b6c\u5982\uff0c\u5728\u6570\u636e\u683c\u5f0f\u548c\u63a5\u53e3\u4e0a\u53ef\u4ee5\u548c\u4e8c\u4ee3\u505a\u5230\u517c\u5bb9\uff0c\u4f46\u6839\u636e\u4e09\u4ee3\u6570\u636e\u72ec\u6709\u7684\u7279\u70b9\uff0c\u5728\u5177\u4f53\u7684\u6570\u636e\u5206\u6790\u65b9\u5f0f\u3001\u6570\u636e\u8d28\u91cf\u8bc4\u4ef7\u7b49\u65b9\u9762\u548c\u4e8c\u4ee3\u53c8\u6709\u6240\u533a\u522b\u3002\u76ee\u524d\u6211\u4eec\u7684\u6d4b\u5e8f\u51c6\u786e\u7387\u5df2\u7ecf\u8d85\u8d8a\u5176\u4ed6\u4e09\u4ee3\u6d4b\u5e8f\u6280\u672f\u7684\u516c\u5f00\u7ed3\u679c\uff0c\u5728\u6210\u672c\u4e0a\u66f4\u662f\u5177\u6709\u663e\u8457\u7684\u4f18\u52bf\u3002\u5728\u8fd9\u4e2a\u8fc7\u7a0b\u4e2d\uff0c\u6211\u4eec\u4f1a\u4e0d\u65ad\u53bb\u8ddf\u5ba2\u6237\u8ddf\u5408\u4f5c\u4f19\u4f34\u8c08\uff0c\u8ba9\u4ed6\u4eec\u53c2\u4e0e\u5230\u4ea7\u54c1\u7684\u6539\u8fdb\u8fc7\u7a0b\u4e2d\u3002<\/div>\n<div>\u00a0<\/div>\n<div>Part 3.<\/div>\n<div>\u57fa\u56e0\u6167<\/div>\n<div>\u8fd9\u91cc\u628aGenoCare\u548cMiSeq\u8fdb\u884c\u5bf9\u6bd4\uff0c\u540e\u8005\u662fIllumina\u516c\u53f8\u4e3b\u6253\u4e34\u5e8a\u5e94\u7528\u7684\u673a\u578b\uff0c\u8fd9\u662f\u5426\u610f\u5473\u7740GenoCare\u5b9a\u4f4d\u662f\u4e34\u5e8a\u5e94\u7528\uff0c\u5177\u4f53\u9488\u5bf9\u54ea\u4e9b\u4e34\u5e8a\u5e94\u7528\u573a\u666f\u5462\uff1f\u8bf7\u60a8\u5411\u57fa\u56e0\u6167\u8bfb\u8005\u4e2d\u670b\u53cb\u4eec\u8c08\u8c08\u3002<\/div>\n<div>\u8d3a\u5efa\u594e\uff1a\u662f\u7684\uff0cGenoCare\u8fd9\u6b3e\u4eea\u5668\u4e3b\u6253\u4e34\u5e8a\u5e94\u7528\uff0c\u8fd9\u4e5f\u662f\u6211\u4e00\u76f4\u5728\u5f3a\u8c03\u7684\u3002\u73b0\u5728\u57fa\u4e8e\u9ad8\u901a\u91cf\u6d4b\u5e8f\u7684\u4e34\u5e8a\u5e94\u7528\u5df2\u7ecf\u8d8a\u6765\u8d8a\u591a\uff0c\u4e5f\u8d8a\u6765\u8d8a\u88ab\u533b\u751f\u6240\u63a5\u53d7\uff0c\u6211\u4eec\u7684\u76ee\u6807\u662f\u5728\u5404\u7c7b\u4e34\u5e8a\u5e94\u7528\u4e2d\u5efa\u7acb\u6211\u4eec\u7684\u5e73\u53f0\u4f18\u52bf\u3002\u6bd4\u5982\u5728NIPT\u4e2d\u6211\u4eec\u63d0\u4f9b\u66f4\u9ad8\u7684\u7075\u654f\u5ea6\u3001\u66f4\u65e9\u7684\u68c0\u6d4b\u65f6\u95f4\u3001\u66f4\u5feb\u7684\u68c0\u6d4b\u65f6\u95f4\u3001\u66f4\u7b80\u5355\u7684\u64cd\u4f5c\u3002\u533b\u751f\u53ea\u9700\u8981\u6536\u96c6\u5230\u5b55\u5987\u7684\u8840\u6db2\u6837\u672c\uff0c\u7ecf\u8fc7\u7b80\u5355\u7684\u5904\u7406\u5c31\u53ef\u4ee5\u4e0a\u673a\u6d4b\u5e8f\u5e76\u53ef\u4ee5\u76f4\u63a5\u62ff\u5230\u68c0\u6d4b\u62a5\u544a\uff0c\u5176\u4ed6\u7684\u5e94\u7528\u5f88\u591a\u4e5f\u662f\u5982\u6b64\u3002\u518d\u6bd4\u5982\u80bf\u7624\u57fa\u56e0\u68c0\u6d4b\uff0c\u73b0\u5728\u5f88\u591a\u6837\u54c1\u5904\u7406\u7684\u505a\u6cd5\u90fd\u662f\u91c7\u7528\u63a2\u9488\u6355\u83b7\u7684\u65b9\u6cd5\u8fdb\u884c\u5efa\u5e93\uff0c\u800c\u6211\u4eec\u6709\u5b9a\u5236\u5316\u7684\u9776\u5411\u6355\u83b7\u6d4b\u5e8f\u82af\u7247\uff0c\u6837\u54c1\u65e0\u9700\u7ecf\u8fc7\u57fa\u56e0\u5206\u79bb\u3001\u6355\u83b7\u3001\u6269\u589e\u3001\u7eaf\u5316\u5404\u4e2a\u6b65\u9aa4\uff0c\u5c24\u5176\u662fctDNA\uff0c\u53ef\u4ee5\u76f4\u63a5\u6d4b\u5e8f\u3002\u76ee\u524d\u6211\u4eec\u5728NIPT\u3001PGS\u3001\u80bf\u7624\u57fa\u56e0\u68c0\u6d4b\u3001\u9057\u4f20\u75c5\u68c0\u6d4b\u3001\u75c5\u539f\u4f53\u68c0\u6d4b\u7b49\u65b9\u5411\uff0c\u90fd\u627e\u5230\u4e86\u4e00\u4e9b\u5408\u4f5c\u4f19\u4f34\uff0c\u6211\u4eec\u4e5f\u671f\u5f85\u66f4\u591a\u7684\u5408\u4f5c\u4f19\u4f34\u52a0\u5165\u3002GenoCare\u672c\u8eab\u4f5c\u4e3a\u4e00\u4e2a\u4eea\u5668\u5e73\u53f0\uff0c\u53ef\u4ee5\u8986\u76d6\u76ee\u524d\u4e3b\u6d41\u7684\u4e34\u5e8a\u6d4b\u5e8f\u9886\u57df\uff0c\u4f46\u9488\u5bf9\u4e0d\u540c\u7684\u4e34\u5e8a\u5e94\u7528\uff0c\u9700\u8981\u91c7\u7528\u6211\u4eec\u6240\u7814\u53d1\u7684\u76f8\u5e94\u89c4\u683c\u7684\u6d4b\u5e8f\u82af\u7247\u548c\u8bd5\u5242\u76d2\u3002<\/div>\n<div>\u00a0<\/div>\n<div>Part 4.<\/div>\n<div>\u57fa\u56e0\u6167<\/div>\n<div>\u60a8\u5728\u53bb\u5e74\u4e03\u6708\u8c08\u5230\u701a\u6d77\u57fa\u56e0\u6b63\u5728\u7b79\u5907\u4e91\u8ba1\u7b97\u5e73\u53f0\uff0c\u76ee\u524d\u51c6\u5907\u5230\u54ea\u4e2a\u9636\u6bb5\u5462\uff1f\u636e\u57fa\u56e0\u6167\u7edf\u8ba1\uff0c\u56fd\u5185\u6709\u8d85\u8fc7\uff08\u5728\u7814\uff0915\u5bb6\u57fa\u56e0\u4e91\u5e73\u53f0\uff0c\u5df2\u5b58\u5728\u540c\u8d28\u5316\u3002\u6211\u4eec\u77e5\u9053\u4e91\u8ba1\u7b97\u5e73\u53f0\u548c\u6d4b\u5e8f\u7b49\u6280\u672f\u5e73\u53f0\u662f\u57fa\u56e0\u884c\u4e1a\u7684\u57fa\u7840\u8bbe\u65bd\uff0c\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u662f\u5426\u610f\u5473\u7740\u701a\u6d77\u57fa\u56e0\u7684\u5b9a\u4f4d\u662f\u5168\u529b\u6253\u9020\u4e0a\u6e38\u5e73\u53f0\u548c\u751f\u6001\uff1f<\/div>\n<div>\u8d3a\u5efa\u594e\uff1a\u4ece\u5b9e\u9a8c\u79d1\u5b66\u3001\u7406\u8bba\u79d1\u5b66\u3001\u8ba1\u7b97\u79d1\u5b66\u5230\u5bc6\u96c6\u6570\u636e\u5206\u6790\uff0c\u8fd9\u662f\u4e00\u4e2a\u81ea\u7136\u79d1\u5b66\u7814\u7a76\u65b9\u5f0f\u7684\u53d1\u5c55\u8fc7\u7a0b\u3002\u7b2c\u4e00\u4e2a\u4eba\u7684\u57fa\u56e0\u7ec4\uff0c\u5168\u4e16\u754c\u505a\u4e8613\u5e74\uff0c\u82b1\u8d39\u4e86\u8fd130\u4ebf\u7f8e\u91d1\u3002\u800c\u4eca\u5929\uff0c\u4e2a\u4eba\u7684\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u6210\u672c\u5df2\u7ecf\u903c\u8fd1\u4e861000\u7f8e\u91d1\u5927\u5173\u3002\u4f46\u5728\u4e34\u5e8a1000\u7f8e\u5143\u7684\u4ef7\u683c\u4e5f\u8fd8\u662f\u592a\u9ad8\uff0c\u6700\u597d\u662f100\u7f8e\u5143\u3002\u8fd9\u6837\u6bcf\u4e2a\u4eba\u90fd\u53ef\u4ee5\u505a\uff0c\u666e\u901a\u4eba\u4e5f\u80fd\u63a5\u53d7\u5f97\u4e86\u8fd9\u4ef7\u683c\u3002\u5f53\u7136\uff0c\u8fd9\u4e0d\u662f\u73b0\u5728\u80fd\u5b9e\u73b0\u7684\uff0c\u9884\u8ba1\u4e94\u5e74\u4e4b\u540e\u624d\u80fd\u5b9e\u73b0\u3002100\u7f8e\u5143\u6d4b\u5e8f\uff0c\u5c06\u6210\u4e3a\u6bcf\u4e2a\u4eba\u90fd\u53ef\u4ee5\u505a\u7684\u4e8b\uff0c\u8fd9\u5c31\u662f\u672a\u6765\u3002\u5982\u679c\u4e2a\u4eba\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u6210\u672c\u53ef\u4ee5\u964d\u4f4e\u5230100\u7f8e\u5143\uff0c\u90a3\u4e48\u76f8\u4fe1\u4ece\u5e94\u7528\u7aef\u53cd\u9988\u56de\u6765\u7684\u57fa\u56e0\u6570\u636e\u5c06\u4f1a\u50cf\u6838\u5f39\u7206\u70b8\u4e00\u6837\u6539\u5199\u76ee\u524d\u6211\u4eec\u5bf9\u4eba\u7c7b\u9057\u4f20\u4fe1\u606f\u7684\u8ba4\u77e5\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u6211\u4eec\u751f\u6d3b\u4e2d\u5df2\u7ecf\u62e5\u6709\u5229\u7528\u5927\u6570\u636e\u5206\u6790\u57fa\u56e0\u8f85\u52a9\u8bca\u65ad\u7684\u6848\u4f8b\u3002\u6bd4\u5982\u56e0\u4e3a\u5bb6\u65cf\u62e5\u6709\u4e73\u817a\u764c\u9057\u4f20\u53f2\uff0c\u7f8e\u56fd\u67d0\u77e5\u540d\u5f71\u661f\u68c0\u67e5\u57fa\u56e0\u7ec4\u65f6\u53d1\u73b0\u81ea\u5df1\u4e5f\u643a\u5e26\u6709\u7f3a\u9677\u57fa\u56e0\uff0c\u6839\u636e\u533b\u751f\u8bc4\u4f30\u6709\u8fd180%\u7684\u53ef\u80fd\u60a3\u4e73\u817a\u764c\uff0c\u56e0\u6b64\u5979\u9884\u9632\u6027\u5730\u5207\u9664\u4e73\u623f\u7ec4\u7ec7\u3002\u6211\u56fd\u4e5f\u6709\u533b\u9662\u5efa\u7acb\u4e34\u5e8a\u6570\u636e\u4e2d\u5fc3\uff0c\u5982\u679c\u5c06\u5404\u5bb6\u533b\u9662\u7684\u6240\u6709\u75c5\u4f8b\u7684\u75c7\u72b6\u3001\u8bca\u7597\u60c5\u51b5\u3001\u533b\u5631\u4fe1\u606f\u3001\u7528\u836f\u6548\u679c\u7b49\u6536\u5165\u5176\u4e2d\uff0c\u5f53\u6211\u4eec\u5728\u5168\u56fd\u641c\u7d22\u67d0\u4e2a\u75be\u75c5\u65f6\uff0c\u4f1a\u6709\u8fd1\u767e\u4e07\u4f8b\u76f8\u5173\u75be\u75c5\u8bb0\u5f55\uff0c\u8f85\u52a9\u533b\u751f\u5206\u6790\u51b3\u7b56\u3002\u4f46\u662f\u8fd9\u4e9b\u53ea\u662f\u5229\u7528\u5927\u6570\u636e\u201c\u770b\u75c5\u201d\u7684\u7b80\u5355\u6848\u4f8b\u3002\u82e5\u60f3\u5229\u7528\u5927\u6570\u636e\u6280\u672f\u5b9e\u73b0\u5168\u9762\u4e86\u89e3\u6bcf\u4e2a\u4eba\u7684\u8eab\u4f53\u60c5\u51b5\uff0c\u8fd8\u8981\u4ece\u4eba\u7684\u9057\u4f20\u57fa\u56e0\u5165\u624b\u3002\u771f\u6b63\u7684\u96be\u9898\u662f\u6211\u4eec\u62e5\u6709\u4e86\u8fd9\u672c\u4e66\uff0c\u5168\u4e16\u754c\u7684\u79d1\u5b66\u5bb6\u5f53\u524d\u5374\u53ea\u80fd\u8bfb\u61c2\u8fd9\u672c\u4e66\u76843%\uff0c\u5269\u4f59\u768497%\u8fd8\u5728\u7814\u7a76\u7834\u8bd1\u9636\u6bb5\uff0c\u7834\u8bd1\u7684\u5173\u952e\u5728\u4e8e\u5c06\u4eba\u7c7b\u7684\u5404\u79cd\u8868\u578b\u548c\u5176\u5f53\u65f6\u5f53\u5730\u7684\u57fa\u56e0\u4fe1\u606f\u5bf9\u5e94\u8d77\u6765\uff0c\u901a\u8fc7\u6d77\u91cf\u7684\u57fa\u56e0\u6570\u636e\u5206\u6790\uff0c\u7a77\u4e3e\u51fa\u6240\u6709\u7684\u53ef\u80fd\uff0c\u5e76\u4ece\u4e2d\u627e\u51fa\u8be5\u9879\u8868\u578b\u5bf9\u5e94\u7684\u57fa\u56e0\u6539\u53d8\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u56e0\u4e3a\u4f7f\u7528\u5355\u5206\u5b50\u6d4b\u5e8f\u6280\u672f\u65e0\u9700\u6269\u589e\uff0c\u5e94\u7528\u7aef\u5728\u4f7f\u7528\u8fc7\u7a0b\u4e2d\u53ef\u4ee5\u8f83\u4ee5\u5f80\u5feb\u901f\u7684\u5b8c\u6210\u6837\u672c\u5236\u5907\u4e0e\u6d4b\u5e8f\u8fc7\u7a0b\uff0c\u540c\u65f6\u5355\u4e2a\u6d4b\u5e8f\u6210\u672c\u6709\u671b\u5927\u5e45\u964d\u4f4e\uff0c\u7531\u6b64\u701a\u6d77\u57fa\u56e0\u6d4b\u5e8f\u7cfb\u7edf\u7684\u5ba2\u6237\u53ef\u4ee5\u5feb\u901f\u79ef\u7d2f\u5404\u79cd\u4e0d\u540c\u573a\u666f\u4e0b\u7684\u6d77\u91cf\u6570\u636e\u3002\u4f5c\u4e3a\u6d4b\u5e8f\u884c\u4e1a\u7684\u57fa\u7840\u8bbe\u65bd\uff0c\u701a\u6d77\u57fa\u56e0\u53ef\u4ee5\u6839\u636e\u4e0d\u540c\u5408\u4f5c\u4f19\u4f34\u7684\u9700\u6c42\uff0c\u5171\u540c\u5f00\u53d1\u9002\u5408\u7684\u68c0\u6d4b\u5e94\u7528\uff0c\u4ece\u591a\u4e2a\u65b9\u9762\u548c\u7ef4\u5ea6\u6536\u96c6\u8868\u578b\u4e0e\u57fa\u56e0\u4e4b\u95f4\u7684\u4fe1\u606f\uff0c\u5e76\u671f\u671b\u6700\u7ec8\u6c47\u603b\u4e0d\u540c\u7684\u5e94\u7528\u573a\u666f\u4fe1\u606f\uff0c\u5c06\u6240\u6709\u4fe1\u606f\u6253\u901a\u5f62\u6210\u4e00\u4e2a\u5b8c\u6574\u7684\u8868\u578b-\u57fa\u56e0\u7f51\u7edc\uff0c\u66f4\u52a0\u5168\u9762\u7684\u7834\u89e3\u4eba\u7c7b\u57fa\u56e0\u5929\u4e66\u7684\u5bc6\u7801\u3002<\/div>\n<div>\u701a\u6d77\u6240\u5efa\u8bbe\u7684\u4e91\u5e73\u53f0\u4e0d\u662f\u4e00\u4e2a\u7b80\u5355\u7684\u6570\u636e\u96c6\u6563\u5730\u6216\u8ba1\u7b97\u67a2\u7ebd\u3002\u77ed\u671f\u7684\u76ee\u6807\u800c\u8a00\uff0c\u5b83\u662f\u57fa\u4e8e\u4e09\u4ee3\u6d4b\u5e8f\u4eea\u8fd9\u4e00\u57fa\u7840\u8bbe\u65bd\u7684\u5e94\u7528\u5f00\u53d1\u548c\u6570\u636e\u5206\u6790\u5e73\u53f0\uff0c\u800c\u957f\u8fdc\u6765\u770b\uff0c\u5b83\u7684\u76ee\u6807\u662f\u5efa\u8bbe\u4ee5\u57fa\u56e0\u4fe1\u606f\u4e3a\u6838\u5fc3\u7684\u751f\u547d\u5065\u5eb7\u4ea7\u4e1a\u751f\u6001\u3002<\/div>\n<div>\u00a0<\/div>\n<div>Part 5.<\/div>\n<div>\u57fa\u56e0\u6167<\/div>\n<div>\u701a\u6d77\u57fa\u56e0\u53ea\u67095\u5c81\uff0c\u4f46\u53d1\u5c55\u5f88\u5feb\uff0c\u4e0e\u7f8e\u56fdPacBio\u3001\u82f1\u56fd\u7684NanoPore\u5e76\u5217\u4e3a\u4e3a\u6570\u4e0d\u591a\u7684\u4e09\u4ee3\u6d4b\u5e8f\u4eea\u7684\u5f00\u53d1\u5e73\u53f0\u3002\u548c\u60a8\u6838\u5b9e\u4e00\u7ec4\u6570\u5b57\uff0c\u636e\u8bf4\u701a\u6d77\u57fa\u56e0\u5171\u7533\u8bf7\u4e8650\u591a\u9879\u4e13\u5229\uff0c\u5168\u7403\u4e13\u5229\u6388\u67436\u9879\uff0c\u62db\u6536\u4e8620\u4e2a\u987e\u95ee\uff0c\u6bcf\u6708\u7684\u987e\u95ee\u8d39\u51e0\u5341\u4e07\uff0c\u572850\u4eba\u7684\u65f6\u5019\u62db\u6536\u4e86\u5341\u51e0\u4e2a\u535a\u58eb\u548c\u6d77\u5f52\u3002\u662f\u4ec0\u4e48\u4fc3\u4f7f\u60a8\u4e0b\u5b9a\u8fd9\u4e48\u5927\u7684\u51b3\u5fc3\u653b\u514b\u4e09\u4ee3\u6d4b\u5e8f\u4eea\u56fd\u4ea7\u5316\uff1f\u662f\u9762\u5bf9NGS\u5784\u65ad\u4f01\u4e1a70%\u7684\u6bdb\u5229\u7387\u3001\u5b9e\u73b0\u767e\u5143\u57fa\u56e0\u7ec4\u7684\u68a6\u60f3\u8fd8\u662f\u66f4\u5927\u7684\u613f\u666f\u5462\uff1f<\/div>\n<div>\u8d3a\u5efa\u594e\uff1a\u4e2d\u56fd\u5df2\u7ecf\u5230\u4e86\u4e00\u4e2a\u521b\u65b0\u7ecf\u6d4e\u65f6\u4ee3\uff0c\u6211\u4eec\u4f5c\u4e3a\u79d1\u5b66\u5bb6\u4f01\u4e1a\u5bb6\u4e0d\u80fd\u4ec5\u4ec5\u6ee1\u8db3\u4e8e\u8fdb\u53e3\u66ff\u4ee3\uff0c\u6ee1\u8db3\u4e8e\u56fd\u5185\u5e02\u573a\u3002\u6700\u91cd\u8981\u662f\uff0c\u6211\u4eec\u5e94\u8be5\u628a\u57fa\u56e0\u7ec4\u5b66\u4e34\u5e8a\u5e94\u7528\uff0c\u5e26\u9886\u5168\u7403\u63a8\u5230\u5168\u65b0\u7684\u9886\u57df\u548c\u9ad8\u5ea6\u3002\u5728\u8fd9\u8fc7\u7a0b\u4e2d\uff0c\u6700\u6839\u672c\u5c31\u662f\u628a\u6210\u672c\u5927\u5e45\u5ea6\u4e0b\u964d\uff0c\u5b9e\u73b0100\u7f8e\u5143\u57fa\u56e0\u7ec4\uff0c\u8ba9\u57fa\u56e0\u6d4b\u5e8f\u4e3a\u4eba\u4eba\u670d\u52a1\u3002\u8fd9\u8981\u6c42\u6211\u4eec\u6e90\u5934\u51fa\u53d1\uff0c\u4ece\u6d4b\u5e8f\u4eea\u65b9\u9762\uff0c\u5bfb\u627e\u964d\u4f4e\u6210\u672c\u7684\u65b9\u6848\u3002\u6211\u8ba4\u4e3a\u5355\u5206\u5b50\u6d4b\u5e8f\u662f\u89e3\u51b3\u65b9\u6848\uff0c\u6240\u4ee5\u8fd9\u4fc3\u4f7f\u6211\u7814\u53d1\u7b2c\u4e09\u4ee3\u57fa\u56e0\u6d4b\u5e8f\u3002<\/div>\n<div>\u6211\u5e0c\u671b\u4ece\u6e90\u5934\u4e0a\u7684\u6280\u672f\u5e26\u52a8\u5168\u4e16\u754c\uff0c\u5b9e\u73b0\u6bcf\u4e2a\u4eba\u90fd\u80fd\u505a\u57fa\u56e0\u68c0\u6d4b\u3002\u968f\u4e4b\u800c\u6765\uff0c\u7cbe\u51c6\u533b\u5b66\u3001\u57fa\u56e0\u6cbb\u7597\u7b49\uff0c\u53ef\u80fd\u80fd\u8ba9\u4eba\u7c7b\u5bff\u547d\u5e73\u5747\u5ef6\u957f20\u5c81\u3002\u8fd9\u5c31\u662f\u6211\u6700\u7ec8\u76ee\u7684\u2014\u2014\u4ece\u6e90\u5934\u6280\u672f\u4e0a\u63a8\u52a8\u751f\u547d\u4ef7\u503c\u7684\u63d0\u5347\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u57fa\u56e0\u6d4b\u5e8f\u4eea\u5c24\u5176\u662f\u4e09\u4ee3\u57fa\u56e0\u6d4b\u5e8f\u4eea\u7684\u7814\u53d1\u4e4b\u524d\u5728\u56fd\u5185\u51e0\u4e4e\u662f\u4e00\u5f20\u767d\u7eb8\uff0c\u627e\u4e0d\u5230\u6709\u76f8\u5173\u7ecf\u9a8c\u7684\u4eba\u3002\u800c\u6b27\u7f8e\u5728\u8fd9\u4e2a\u9886\u57df\u53d1\u5c55\u7684\u6bd4\u8f83\u65e9\uff0c\u6709\u4e00\u5b9a\u7684\u4ece\u4e1a\u4eba\u5458\u89c4\u6a21\u3002\u6240\u4ee5\uff0c\u65e9\u671f\u6211\u4eec\u4e0b\u51b3\u5fc3\u4ece\u6d77\u5916\u62db\u6750\u5f15\u667a\uff0c\u5bfb\u627e\u56fd\u9645\u4e0a\u7684\u8d44\u6df1\u884c\u4e1a\u5927\u5496\uff0c\u540c\u65f6\u4ece\u56fd\u5185\u5916\u6316\u6398\u975e\u5e38\u6709\u6f5c\u529b\u7684\u9752\u5e74\u4e13\u5bb6\uff0c\u8ba9\u4ed6\u4eec\u7ad9\u5728\u5de8\u4eba\u7684\u80a9\u8180\u4e0a\u8fc5\u901f\u6210\u957f\u4e3a\u4e00\u652f\u6781\u5177\u6218\u6597\u529b\u7684\u4e13\u4e1a\u56e2\u961f\u3002\u6b63\u662f\u8fd9\u6837\u7684\u80cc\u666f\u4e0b\uff0c\u6211\u4eec\u7684\u6838\u5fc3\u56e2\u961f\u6210\u5458\u53bb\u5e74\u4ee5\u6392\u540d\u7b2c\u4e00\u83b7\u5f97\u4e86\u6df1\u5733\u5e02\u7684\u5b54\u96c0\u56e2\u961f\u8d44\u52a9\u3002<\/div>\n<div>\u00a0<\/div>\n<div>Part 6.<\/div>\n<div>\u57fa\u56e0\u6167<\/div>\n<div>\u60a8\u4ece\u65af\u5766\u798f\u5927\u5b66\u6bd5\u4e1a\u540e\uff0c\u56de\u56fd\u572828\u5c81\u65f6\u5df2\u662f\u5357\u65b9\u79d1\u6280\u5927\u5b66\u7684\u526f\u6559\u6388\uff0c\u4e0d\u4ec5\u5728\u5355\u5206\u5b50\u6d4b\u5e8f\u4e0a\u5f00\u53d1\u4e86SMTS\uff08Single Molecule Targeted Sequencing\uff09\uff0c\u800c\u4e14\u60a8\u7684\u5b9e\u9a8c\u5ba4\u4e5f\u6d89\u730e\u57fa\u56e0\u7ec4\u7f16\u8f91\u3001\u514d\u75ab\u3001\u5355\u7ec6\u80de\u6d4b\u5e8f\u7b49\u591a\u4e2a\u9886\u57df\u3002\u572828\u5c81\u65f6\u53d6\u5f97\u8fd9\u6837\u4f18\u5f02\u7684\u6210\u7ee9\uff1f\u53ef\u5426\u5206\u4eab\u4e0b\u60a8\u7684\u4e2a\u4eba\u7ecf\u5386\uff0c\u4ee5\u53ca\u5982\u4f55\u4fdd\u6301\u5e7f\u800c\u6df1\u7684\u7814\u7a76\u6fc0\u60c5\u548c\u4e13\u4e1a\u5ea6\uff1f<\/div>\n<div>\u8d3a\u5efa\u594e\uff1a\u80fd\u591f\u53d6\u7684\u73b0\u9636\u6bb5\u6210\u7ee9\u7684\u539f\u56e0\uff0c\u9996\u5148\u662f\u56e0\u4e3a\u6211\u6709\u53d1\u81ea\u5185\u5fc3\u7684\u597d\u5947\u5fc3\uff0c\u5373\u6211\u4e00\u76f4\u5bf9\u4e8e\u65b0\u4e8b\u7269\u5145\u6ee1\u70ed\u60c5\u548c\u8ffd\u6c42\u3002\u5176\u6b21\uff0c\u6211\u7684\u5b9a\u4f4d\u8fd8\u662f\u79d1\u5b66\u5bb6\uff0c\u6211\u4f1a\u5728\u524d\u6cbf\u9886\u57df\u5148\u505a\u51fa\u6210\u679c\uff0c\u7136\u540e\u6210\u7acb\u516c\u53f8\uff0c\u5e76\u627e\u4e13\u95e8\u4eba\u624d\u8fdb\u884c\u5546\u4e1a\u5316\u548c\u4ea7\u4e1a\u5316\u3002\u8fd9\u6837\u80fd\u8ba9\u6211\u6709\u66f4\u591a\u65f6\u95f4\u601d\u8003\u65b0\u7684\u6311\u6218\u4e0e\u673a\u9047\u3002\u6211\u6700\u64c5\u957f\uff0c\u4ece\u6e90\u5934\u4e0a\u9762\u53d1\u73b0\u95ee\u9898\uff0c\u627e\u5230\u89e3\u51b3\u65b9\u6848\uff0c\u8fdb\u884c\u6700\u65e9\u671f\u63a2\u7d22\uff0c\u505a\u51fa\u539f\u578b\u6280\u672f\u3002\u5230\u4e86\u4ea7\u4e1a\u5316\u63a8\u5e7f\uff0c\u6211\u5c31\u4f1a\u627e\u4e00\u4e2a\u4e13\u4e1a\u56e2\u961f\u6210\u7acb\u516c\u53f8\u53bb\u505a\u8fd9\u4e2a\u4e8b\u60c5\u3002\u6211\u5c31\u559c\u6b22\u505a\u6211\u6700\u64c5\u957f\u7684\u4e8b\u60c5\uff0c\u6211\u89c9\u5f97\u8fd9\u6837\u6548\u7387\u6700\u9ad8\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u5bf9\u4e8e\u5408\u4f19\u4eba\u548c\u65e9\u671f\u6838\u5fc3\u6210\u5458\uff0c\u6211\u6700\u770b\u91cd\u4ed6\u4eec\u6709\u548c\u6211\u4e92\u8865\u7684\u8ba4\u77e5\u548c\u80fd\u529b\uff0c\u80fd\u591f\u4ece\u4e0d\u4e00\u6837\u7684\u89d2\u5ea6\u601d\u8003\u95ee\u9898\uff0c\u80fd\u591f\u80dc\u4efb\u6211\u6709\u6240\u6b20\u7f3a\u7684\u89d2\u8272\u3002\u8fd9\u65b9\u9762\u548c\u79d1\u7814\u5408\u4f19\u4eba\u7684\u9009\u62e9\u662f\u76f8\u4f3c\u7684\uff0c\u90fd\u9700\u8981\u5bf9\u65b9\u72ec\u7acb\u601d\u8003\u3001\u72ec\u5f53\u4e00\u9762\u3002\u4e0d\u540c\u70b9\u5728\u4e8e\uff0c\u4f01\u4e1a\u7684\u76ee\u6807\u5728\u4e8e\u505a\u51fa\u6700\u597d\u7684\u4ea7\u54c1\uff0c\u5f3a\u8c03\u56e2\u961f\u4e4b\u95f4\u7684\u4e92\u8865\u548c\u534f\u540c\uff0c\u800c\u79d1\u7814\u7684\u76ee\u7684\u662f\u63a2\u7d22\u672a\u77e5\uff0c\u66f4\u559c\u6b22\u4e0d\u540c\u89c2\u70b9\u4e4b\u95f4\u7684\u78b0\u649e\u548c\u706b\u82b1\u3002<\/div>\n<div>\u00a0<\/div>\n<div>Part 7.<\/div>\n<div>\u57fa\u56e0\u6167<\/div>\n<div>\u60a8\u5e08\u4ece\u7f8e\u56fd\u79d1\u5b66\u9662\u3001\u5de5\u7a0b\u9662\u548c\u533b\u5b66\u79d1\u5b66\u9662\u4e09\u9662\u9662\u58ebStephen Quake\uff0c\u4ed6\u4e5f\u662f\u701a\u6d77\u57fa\u56e0\u7684\u9996\u5e2d\u79d1\u5b66\u987e\u95ee\u3002\u540c\u65f6\uff0c\u6211\u4eec\u77e5\u9053\uff0cStephen Quake\u4e5f\u662fHelicos Biosciences\u516b\u5e74\u7684\u521b\u4e1a\u8005\u3002\u4eceQuake\u5230\u60a8\u5230\u51e0\u4e4e\u6bcf\u2f00\u4e00\u4e2a\u8e0f\u5b9e\u7684\u521b\u4e1a\u8005\uff0c\u90fd\u4f1a\u9047\u5230\u8003\u9a8c\u7684\u5173\u53e3\u548c\u7a81\u7834\u540e\u7684\u67f3\u6697\u82b1\u660e\uff0c\u4ece\u79d1\u5b66\u5bb6\u5230\u521b\u4e1a\uff0c\u8fd9\u4e94\u5e74\u6765\u60a8\u6709\u4ec0\u4e48\u6837\u7684\u611f\u53d7\u548c\u4f53\u4f1a\u4e3a\u65b0\u7684\u521b\u4e1a\u8005\u5206\u4eab\u5462\uff1f<\/div>\n<div>\u8d3a\u5efa\u594e\uff1a\u8fd9\u8ba9\u6211\u60f3\u8d77\u521b\u4e1a\u521d\u5fc3\uff0c\u5c31\u662f\u6302\u5728\u701a\u6d77\u5899\u4e0a\u7684\u4e00\u53e5\u8bdd\uff0c\u8fd9\u4e5f\u662f\u516c\u53f8\u7684\u5b97\u65e8\u548c\u4f7f\u547d\u201c\u4e3a\u75c5\u4eba\u3001\u80a1\u4e1c\u548c\u5458\u5de5\u521b\u9020\u4ef7\u503c\u201d\u3002\u6211\u8ba4\u4e3a\uff0c\u505a\u4efb\u4f55\u4e8b\u90fd\u662f\u8981\u6709\u610f\u4e49\u7684\uff0c\u5982\u4e3a\u75c5\u4eba\u521b\u9020\u4ef7\u503c\uff0c\u662f\u56e0\u4e3a\u6d4b\u5e8f\u4eea\u80fd\u591f\u5e94\u7528\u4e8e\u80bf\u7624\u7b49\u5404\u79cd\u75be\u75c5\uff0c\u4e0a\u5e02\u5f97\u5230\u56de\u62a5\uff0c\u80fd\u8ba9\u5458\u5de5\u5f97\u5230\u63d0\u5347\u4e5f\u662f\u5982\u6b64\u3002\u6211\u4e00\u76f4\u575a\u6301\u4e09\u70b9\u539f\u5219\u53bb\u505a\u8fd9\u4e9b\u4e8b\u60c5\uff0c\u521b\u4e1a\u8fc7\u7a0b\u4e2d\u9047\u5230\u95ee\u9898\uff0c\u5404\u65b9\u90fd\u4f1a\u652f\u6301\u6211\u4eec\uff0c\u5c31\u662f\u56e0\u4e3a\u6211\u4e00\u76f4\u6ca1\u6709\u5fd8\u8bb0\u6211\u4e3a\u4ec0\u4e48\u8981\u521b\u4e1a\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u4ece\u6211\u7684\u7ecf\u5386\u6765\u8bf4\uff0c\u6211\u8ba4\u4e3a\u521b\u4e1a\u8fc7\u7a0b\u4e2d\u6700\u91cd\u8981\u7684\u662f\u4e0d\u80fd\u505c\u6b62\u601d\u8003\uff0c\u5bf9\u4e8e\u4f60\u7684\u65b9\u5411\u8981\u59cb\u7ec8\u5177\u5907\u6e05\u6670\u7684\u5224\u65ad\uff0c\u8fd9\u6837\u5728\u9047\u5230\u5173\u53e3\u7684\u65f6\u5019\u624d\u6709\u8db3\u591f\u7684\u4fe1\u5ff5\u548c\u4fe1\u5fc3\u5f80\u524d\u8d9f\u3002\u5728\u8fd9\u4e2a\u8fc7\u7a0b\u4e2d\uff0c\u8981\u548c\u4f60\u7684\u6838\u5fc3\u56e2\u961f\u3001\u6295\u8d44\u4eba\u3001\u987e\u95ee\u3001\u7528\u6237\u4fdd\u6301\u8db3\u591f\u7684\u6c9f\u901a\uff0c\u786e\u4fdd\u6240\u6709\u4eba\u671d\u7740\u4e00\u4e2a\u6700\u7ec8\u88ab\u5171\u540c\u8ba4\u53ef\u7684\u65b9\u5411\u53bb\u653b\u5173\u3001\u53bb\u7a81\u7834\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u60a8\u53ef\u80fd\u8fd8\u4f1a\u611f\u5174\u8da3\u7684<\/div>\n<div><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzIzMzE4MzU3NA==&amp;mid=2651632650&amp;idx=2&amp;sn=50d4b4db1261f8885c3bb4ffd724e2c2&amp;chksm=f3719433c4061d25bd603d896df4b05c36cc24f3bf38136ba0656d9a7070898fcb418e5311ea&amp;mpshare=1&amp;scene=1&amp;srcid=06093tcYFcu8YFsPWzm9d7XL&amp;pass_ticket=qVUxaO7n%2B8ByONkQcKWh040g7LFFrKS%2BVH9vrtnhLUO2Zh0xMKG%2BnfNpiwZQ6FfC#rd\">\u2606<\/a><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMzE4MzU3NA==&amp;mid=2651633145&amp;idx=1&amp;sn=ec65fa3796b679c27f94431fe5568385&amp;scene=21#wechat_redirect\">\u57fa\u56e0\u6167\u5728NGS\u521b\u65b0\u5f00\u53d1\u8005\u5927\u4f1a\u4e0a\u62a5\u544a<\/a><\/div>\n<div><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzIzMzE4MzU3NA==&amp;mid=2651632650&amp;idx=2&amp;sn=50d4b4db1261f8885c3bb4ffd724e2c2&amp;chksm=f3719433c4061d25bd603d896df4b05c36cc24f3bf38136ba0656d9a7070898fcb418e5311ea&amp;mpshare=1&amp;scene=1&amp;srcid=06093tcYFcu8YFsPWzm9d7XL&amp;pass_ticket=qVUxaO7n%2B8ByONkQcKWh040g7LFFrKS%2BVH9vrtnhLUO2Zh0xMKG%2BnfNpiwZQ6FfC#rd\">\u2606<\/a><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&amp;mid=2247484657&amp;idx=1&amp;sn=06414a02e7fb79cfc283b1c02d1050f7&amp;chksm=eb72b646dc053f5046408f649f66fd897c9a75d520abbfe3957868249b31a471b95b6cdb43e9&amp;scene=21#wechat_redirect\">\u57fa\u56e0\u884c\u4e1a36\u4f4dCEO2017\u5e74\u4e2d\u603b\u7ed3<\/a><\/div>\n<div><a 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