\n![\"eicZhoGYCfyYibEO9O47lTicPSYJWgGr8GyjhE8LHBLsaZHqBhyHUJjwScOQjwG5290rxVMcOzaeE8hNwIbxSibbDQ\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/eicZhoGYCfyYibEO9O47lTicPSYJWgGr8GyjhE8LHBLsaZHqBhyHUJjwScOQjwG5290rxVMcOzaeE8hNwIbxSibbDQ.jpg\")
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<\/figure><\/div>\n\n<\/div>\n\u57fa\u56e0\u6167<\/div>\n
GeneClub<\/div>\n
\u57fa\u56e0\u5927\u6570\u636e \u00b7 \u533b\u5b66\u4eba\u5de5\u667a\u80fd<\/div>\n
\u5185\u5bb9\u5a92\u4f53\/\u884c\u7814\u6570\u636e\u5e93\/FA\u54a8\u8be2<\/div>\n
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\u5173\u952e\u8bcd\uff1a\u57fa\u56e0\u6d4b\u5e8f\u6280\u672f \u534e\u5927\u667a\u9020\uff08MGI\uff09<\/div>\n
\u534e\u5927\u57fa\u56e0 \u5e73\u53f0\u89c4\u5212 \u5927\u6c11\u751f<\/div>\n
\u51713819\u5b57 \u5efa\u8bae\u7528\u65f66\u5206\u949f<\/div>\n
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\n\n
\n![\"eicZhoGYCfyao5maAp2VXXHoZvFULrnzjy0RrXWBibRrh4ibQwPpAg6NaF51CgWmsjdjjtZKaJbVFHglgNiaCqA6vA\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/eicZhoGYCfyao5maAp2VXXHoZvFULrnzjy0RrXWBibRrh4ibQwPpAg6NaF51CgWmsjdjjtZKaJbVFHglgNiaCqA6vA.jpeg\")
<\/figure><\/div>\n\n
<\/figure><\/div>\n\n\u5f80\u671f\u76f8\u5173<\/div>\n
\u534e\u5927\u80a1\u4efdCEO-\u5c39\u70e8<\/a>Illumina\u603b\u7ecf\u7406-\u8d75\u745e\u6797<\/a><\/div>\n
\u701a\u6d77\u57fa\u56e0\u8463\u4e8b\u957f-\u8d3a\u5efa\u594e<\/a>\u5317\u4eac\u57fa\u56e0\u7ec4\u6240-\u65b9\u5411\u4e1c<\/a><\/div>\n
Bionano\u521b\u59cb\u4eba-\u66f9\u6db5\u8c08<\/a> \u89e3\u653e\u519b\u603b\u533b\u9662-\u6768\u4e91\u751f<\/a><\/div>\n
\u56fd\u5bb6\u751f\u7269\u533b\u5b66\u5206\u6790\u4e2d\u5fc3-\u6768\u745e\u99a5<\/a><\/div>\n
\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u513f\u79d1\u533b\u9662\u9662\u957f-\u9ec4\u56fd\u82f1<\/a><\/div>\n
\u00a0<\/div>\n
\u4e0e\u60a8\u5206\u4eab\u768453\u671f<\/div>\n
\u8bbf\u8005 | \u848b\u6167<\/div>\n
\u8d23\u7f16 | \u8292\u679c<\/div>\n
\u6821\u5bf9 | \u963f\u7b60\u3001\u5e03\u4e09\u5c11<\/div>\n
\u00a0<\/div>\n
\u57fa\u56e0\u6d4b\u5e8f\u4eea\u6280\u672f\u7684\u53d1\u5c55<\/div>\n
Part 1.<\/div>\n
\u3010\u57fa\u56e0\u6167\u3011\u848b\u9662\u957f\uff0c\u60a8\u5728\u534e\u5927\u5de5\u4f5c\u5341\u4f59\u5e74\uff0c\u4e00\u76f4\u4e13\u6ce8\u57fa\u56e0\u6d4b\u5e8f\u6280\u672f\u3002\u4ece1986\u5e74\u7b2c\u4e00\u53f0\u57fa\u56e0\u6d4b\u5e8f\u4eea\u5f00\u59cb\u5230\u73b0\u572831\u5e74\uff0c\u80fd\u5426\u8bf7\u60a8\u7b80\u77ed\u8c08\u8c08\u57fa\u56e0\u6d4b\u5e8f\u6280\u672f\u7684\u57fa\u672c\u539f\u7406\u548c\u53d1\u5c55\u6f14\u5316\uff1f\u8c22\u8c22\uff01<\/div>\n
\u3010\u848b\u6167\u3011\u8c22\u8c22\uff01\u4e0b\u9762\u6211\u548c\u57fa\u56e0\u6167\u8bfb\u8005\u7b80\u77ed\u5206\u4eab\u4e0bDNA\u6d4b\u5e8f\u4eea\u4ece\u4e00\u4ee3\u5230\u56db\u4ee3\u7684\u53d1\u5c55\u8fc7\u7a0b\u3002<\/div>\n
\u6211\u4eec\u77e5\u9053\uff0c\u7b2c\u4e00\u4ee3\u6d4b\u5e8f\u4eea\u662f\u57fa\u4e8e\u53cc\u8131\u6c27\u7ec8\u6b62\u6cd5\u7684\u81ea\u52a8\u6d4b\u5e8f\u4eea\uff0c\u5b83\u4f7f\u7528\u975e\u653e\u5c04\u6027\u8367\u5149\u6807\u8bb0\u4ee3\u66ff\u540c\u4f4d\u7d20\u6807\u8bb0\uff0c\u901a\u8fc7\u6fc0\u5149\u6fc0\u53d1\u8367\u5149\u53cd\u5e94\u5e76\u901a\u8fc7\u63a2\u6d4b\u5668\u6536\u96c6\u8367\u5149\u4fe1\u606f\uff0c\u901a\u8fc7\u56fe\u50cf\u8bc6\u522b\u548c\u5206\u6790\u81ea\u52a8\u83b7\u5f97DNA\u5e8f\u5217\u30021987\u5e74\u7f8e\u56fdApplied Biosystems(ABI)\u516c\u53f8\u63a8\u51fa\u7b2c\u4e00\u53f0\u81ea\u52a8\u5316\u6d4b\u5e8f\u4eeaABI370\uff0c\u4ea7\u91cf\u8fbe\u5230\u6bcf\u59291000\u4e2a\u78b1\u57fa\u3002\u8fd9\u79cd\u81ea\u52a8\u5316\u6280\u672f\u4e0d\u65ad\u5347\u7ea7\uff0c\u76f4\u52301997\u5e74\u63a8\u51faABI 3700\u80fd\u591f\u4f7f\u752896\u9053\u6bdb\u7ec6\u7ba1\u9635\u5217\u540c\u65f6\u68c0\u6d4b96\u4e2a\u6837\u672c\uff0c\u4ea7\u91cf\u8fbe\u5230\u6bcf\u5929500,000\u52301,000,000\u4e2a\u78b1\u57fa\u30022017\u5e74Thermo Fisher \u63a8\u51fa\u4e86\u6700\u65b0\u7684\u4e00\u4ee3\u6d4b\u5e8f\u4eeaSeqStudio\u4f7f\u7528\u4e00\u4f53\u5316\u5361\u5939\u8bbe\u8ba1\uff0c\u4f7f\u7528\u524d\u7684\u51c6\u5907\u548c\u64cd\u4f5c\u66f4\u7b80\u5355\u3002<\/div>\n
\u5230\u4e86\u7b2c\u4e8c\u4ee3\u6d4b\u5e8f\uff0c\u7531\u4e8e\u7b2c\u4e00\u4ee3\u6d4b\u5e8f\u4eea\u5b58\u5728\u6210\u672c\u9ad8\u548c\u901a\u91cf\u4f4e\u7b49\u65b9\u9762\u7684\u4e0d\u8db3\uff0c\u5c24\u5176\u662f\u968f\u7740\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u7684\u5b8c\u6210\uff0c\u4f20\u7edf\u7684\u6d4b\u5e8f\u65b9\u6cd5\u5df2\u7ecf\u4e0d\u80fd\u6ee1\u8db3\u6df1\u5ea6\u6d4b\u5e8f\u548c\u91cd\u590d\u6d4b\u5e8f\u7b49\u5927\u89c4\u6a21\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u7684\u9700\u6c42\uff0c\u8fd9\u4fc3\u4f7f\u4e86\u7b2c\u4e8c\u4ee3DNA\u6d4b\u5e8f\u6280\u672f\u7684\u8bde\u751f\u3002\u7b2c\u4e8c\u4ee3\u6d4b\u5e8f\u6280\u672f\u6700\u663e\u8457\u7684\u7279\u5f81\u662f\u901a\u8fc7\u82af\u7247\u5b9e\u73b0\u4e86\u9ad8\u901a\u91cf\u6d4b\u5e8f\uff0c\u4e00\u6b21\u80fd\u5bf9\u4e0a\u4ebf\u6761DNA\u5206\u5b50\u8fdb\u884c\u5e8f\u5217\u6d4b\u5e8f\uff0c\u4f7f\u5f97\u6210\u672c\u964d\u5230\u76f8\u5bf9\u6700\u4f4e\uff0c\u6d4b\u5e8f\u4e3b\u8981\u662f\u805a\u5408\u9176\u6cd5\u548c\u8fde\u63a5\u9176\u6cd5\uff0c\u7ed3\u5408\u5149\u5b66\u68c0\u6d4b\u6216\u7535\u4fe1\u53f7\u68c0\u6d4b\u5b9e\u73b0\u78b1\u57fa\u4fe1\u606f\u8bfb\u53d6\u3002\u76ee\u524d\u4e3b\u6d41\u6d4b\u5e8f\u5e73\u53f0\u5305\u62ecIllumina\u516c\u53f8MiSeq\u3001NextSeq\u3001HiSeq\u548cNovaSeq\u7cfb\u5217\u6d4b\u5e8f\u4eea\uff1bThermo Fisher\u516c\u53f8PGM\uff0cProton\u7b49\u7cfb\u5217\u4eea\u5668\uff1b\u4ee5\u53ca\u534e\u5927 BGISEQ\u7cfb\u5217\u6d4b\u5e8f\u4eea\u3002<\/div>\n
\u73b0\u5728\u5927\u5bb6\u8c08\u5230\u7b2c\u4e09\u4ee3\u6d4b\u5e8f\u548c\u56db\u4ee3\u6d4b\u5e8f\uff0c\u4e00\u822c\u8ba4\u4e3a\u5355\u5206\u5b50\u6d4b\u5e8f\u6280\u672f\u4e3a\u7b2c\u4e09\u4ee3\u6d4b\u5e8f\u6280\u672f\uff0c\u4f46\u662f\u7531\u4e8e\u73b0\u884c\u5355\u5206\u5b50\u6d4b\u5e8f\u6280\u672f\u65b9\u6cd5\u5b58\u5728\u8f83\u5927\u5dee\u5f02\uff0c\u8f83\u4e3a\u5e38\u89c1\u5305\u62ec\u57fa\u4e8e\u7c7b\u4f3c\u4e8c\u4ee3\u7684\u5355\u5206\u5b50\u5149\u5b66\u68c0\u6d4b\u6280\u672f\uff08\u6bd4\u5982PacBio\u548cHelicos\u7b49\uff09\u548c\u7eb3\u7c73\u5b54\u5355\u5206\u5b50\u6d4b\u5e8f\uff08\u6bd4\u5982Oxford Nanopore\u548cGenia\u7b49\uff09\uff0c\u4e5f\u6709\u4e13\u5bb6\u5c06\u524d\u8005\u79f0\u4e3a\u7b2c\u4e09\u4ee3\u6d4b\u5e8f\u6280\u672f\uff0c\u800c\u628a\u540e\u8005\u79f0\u4e3a\u7b2c\u56db\u4ee3\u6d4b\u5e8f\u6280\u672f\u3002<\/div>\n
\u00a0<\/div>\n
Part 2.<\/div>\n
\u3010\u57fa\u56e0\u6167\u3011\u6211\u4eec\u77e5\u9053\uff0c\u4f5c\u4e3a\u57fa\u56e0\u9886\u57df\u7684\u4e0a\u6e38\uff0c\u57fa\u56e0\u6d4b\u5e8f\u5e73\u53f0\u4e00\u65b9\u9762\u662f\u8d8b\u4e8e\u5e73\u53f0\u5316\uff0c\u8054\u5408\u4e86\u81ea\u52a8\u5316\u5efa\u5e93\u3001\u6355\u83b7\u7b49\u81ea\u52a8\u5316\u786c\u4ef6\u8bbe\u5907\u4ee5\u53ca\u4e91\u8ba1\u7b97\u7b49\u8f6f\u4ef6\uff1b\u53e6\u4e00\u65b9\u9762\u662f\u5c0f\u578b\u5316\uff0c\u4ece\u5927\u578b\u673a\u52302011\u5e74\u7684\u684c\u9762\u578b\u5230U\u76d8\u5927\u5c0f\u7684MinION \u6d4b\u5e8f\u4eea<\/a>\u3002\u60a8\u5bf9\u8fd9\u4e24\u65b9\u9762\u662f\u600e\u4e48\u770b\u5f85\u7684\uff1f\u653e\u773c\u672a\u67655-10\u5e74\uff0c\u60a8\u8ba4\u4e3a\u6d4b\u5e8f\u4eea\u4f1a\u671d\u7740\u54ea\u4e9b\u65b9\u5411\u53d1\u5c55\uff1f\u8c22\u8c22\uff01<\/div>\n
\u3010\u848b\u6167\u3011\u6d4b\u5e8f\u4eea\u8981\u53d8\u6210\u6211\u4eec\u5e38\u7528\u7684\u68c0\u6d4b\u548c\u7814\u7a76\u5de5\u5177\uff0c\u5fc5\u7136\u9700\u8981\u5b9e\u73b0\u81ea\u52a8\u5316\u7684\u6837\u672c\u5236\u5907\u548c\u6570\u636e\u5206\u6790\uff0c\u5b9e\u73b0\u7b80\u6613\u64cd\u4f5c\u3002\u76ee\u524d\u81ea\u52a8\u5316\u6837\u672c\u5236\u5907\u90e8\u5206\u4e3b\u8981\u662f\u4ee5\u79fb\u6db2\u7cfb\u7edf\u4e3a\u4e3b\uff0c\u80fd\u591f\u5b9e\u73b0\u4ece\u8840\u6db2\u6837\u672c\u5230\u6700\u540e\u6587\u5e93\u7684\u5927\u90e8\u5206\u6d41\u7a0b\u81ea\u52a8\u5316\u3002\u5728\u6570\u636e\u5206\u6790\u90e8\u5206\uff0c\u65e0\u8bba\u662f\u4e91\u8ba1\u7b97\u8fd8\u662f\u672c\u5730\u5316\u5206\u6790\u90fd\u5df2\u7ecf\u53d6\u5f97\u91cd\u8981\u8fdb\u5c55\uff0c\u9488\u5bf9WGS\u3001WES\u7b49\u5e38\u89c1\u79d1\u7814\u5e94\u7528\u548c\u65e0\u521b\u4ea7\u524d\u548c\u80bf\u7624\u7b49\u4e34\u5e8a\u68c0\u6d4b\u90fd\u5df2\u7ecf\u5728\u5206\u6790\u901f\u5ea6\u548c\u5206\u6790\u6210\u672c\u4e0a\u5b9e\u73b0\u5927\u89c4\u6a21\u3001\u6279\u91cf\u5316\u7684\u5206\u6790\u3002<\/div>\n
\u5c31\u6d4b\u5e8f\u4eea\u901a\u91cf\u6765\u8bf4\uff0c\u4e3a\u4e86\u6ee1\u8db3\u79d1\u7814\u5927\u6570\u636e\u4ea7\u51fa\u9700\u6c42\uff0c\u5fc5\u7136\u8d70\u5411\u8d85\u9ad8\u901a\u91cf\u6d4b\u5e8f\u4eea\uff0c\u901a\u8fc7\u96c6\u7ea6\u5f0f\u751f\u4ea7\u6765\u5b9e\u73b0\u8fd0\u884c\u6210\u672c\u7684\u964d\u4f4e\uff0c\u6bd4\u5982NovaSeq\u548cRevolocity\u6d4b\u5e8f\u4eea\uff1b\u53e6\u4e00\u65b9\u9762\uff0c\u4e3a\u4e86\u6ee1\u8db3\u53ca\u65f6\u68c0\u6d4b\u9700\u6c42\uff0c\u5c0f\u578b\u5316\u96c6\u6210\u5f0f\u6d4b\u5e8f\u4eea\u5fc5\u7136\u662f\u53d1\u5c55\u8d8b\u52bf\uff0c\u6bd4\u5982MiniSeq\u3001BGISEQ-50\u3001ONT MinION\u7b49\u3002<\/div>\n
\u00a0<\/div>\n
\u534e\u5927\u667a\u9020\u6d4b\u5e8f\u4eea\u79d1\u7814\u6210\u679c\u53ca\u5e94\u7528\u53c2\u6570<\/div>\n
Part 3.<\/div>\n
\u3010\u57fa\u56e0\u6167\u3011\u534e\u5927\u667a\u9020\uff08MGI\uff09\u57282016\u5e74\u60c5\u4eba\u8282\u5f00\u59cb\u91cf\u4ea7\u63a8\u51fa\u56fd\u4ea7\u6d4b\u5e8f\u4eeaBGISEQ-500\uff0c\u4e0a\u534a\u5e74\u57fa\u4e8eBGISEQ-500\u4e5f\u53d1\u5e03\u4e86\u4e0d\u5c11\u91cd\u91cf\u7ea7\u79d1\u7814\u6587\u732e\u6210\u679c\u3002\u540c\u884c\u90fd\u5f88\u5173\u5fc3\u76ee\u524dBGISEQ-500\u7684\u6838\u5fc3\u6280\u672f\u3001\u53d1\u884c\u60c5\u51b5\u548c\u5e94\u7528\u53c2\u6570\uff0c\u60a8\u80fd\u5c31\u53ef\u4ee5\u516c\u5f00\u7684\u4fe1\u606f\u8be6\u7ec6\u5206\u4eab\u4e0b\u5417\uff1f\u8c22\u8c22\uff01<\/div>\n
\u3010\u848b\u6167\u3011BGISEQ-500\u76ee\u524d\u652f\u6301\u53cc\u82af\u7247\u5e73\u53f0\u540c\u65f6\u4e14\u72ec\u7acb\u8fd0\u4f5c\uff0c\u5355\u5f20\u82af\u7247\u7684\u5e73\u5747reads\u6570\u53ef\u8fbe1300M\uff0c\u76ee\u524d\u5df2\u7ecf\u5bf9\u5916\u7684\u8bfb\u957f\u6a21\u5f0f\u5305\u62ecSE50\u3001PE50\u3001SE100\u3001PE100\u56db\u79cd\uff0c\u66f4\u591a\u7684\u8bfb\u957f\u6a21\u5f0f\u76ee\u524d\u5904\u4e8e\u7814\u53d1\u671f\u95f4\uff0c\u90e8\u5206\u5df2\u7ecf\u5230\u4e86\u8f6c\u4ea7\u524d\u671f\uff0c\u6211\u4eec\u4f1a\u6839\u636e\u8fdb\u5ea6\u5b89\u6392\u6765\u9646\u7eed\u53d1\u5e03\u3002<\/div>\n
\u76ee\u524dBGISEQ-500\u80fd\u591f\u505a\u5230\u6700\u5feb24\u5c0f\u65f6\u5373\u53ef\u4ece\u6837\u672c\u5236\u5907\u5230\u5206\u6790\u62a5\u544a\u7684\u5f97\u51fa\u3002\u5c31\u5efa\u5e93\u6765\u8bf4\uff0c\u548cIllumina\u4ee5\u53caThermo Fisher \u5e73\u53f0\u4e00\u6837\uff0c\u90fd\u9700\u8981200ng-1ug\u6837\u672c\u7247\u6bb5\u5316\u3001\u672b\u7aef\u8865\u5e73\u3001\u52a0\u63a5\u5934\u548c\u6269\u589e\u8fd9\u51e0\u4e2a\u4e3b\u8981\u6b65\u9aa4\u3002\u548c\u5176\u4ed6\u5e73\u53f0\u4e0d\u4e00\u81f4\u7684\u662f\u6211\u4eec\u6709\u5355\u72ec\u7684\u73af\u5316\u73af\u8282\u5f62\u6210DNA\u73af\uff0c\u7528\u4e8e\u751f\u6210DNA\u7eb3\u7c73\u7403\u8fdb\u884c\u6d4b\u5e8f\uff0c\u72ec\u7279\u7684DNA\u7eb3\u7c73\u7403\u6280\u672f\u4e5f\u4f7f\u5f97\u6587\u5e93\u6269\u589e\u65f6\u5448\u73b0\u66f4\u5c11\u9519\u8bef\u548c\u504f\u5411\u6027\u3002<\/div>\n
\u76ee\u524d\u6211\u4eec\u5df2\u7ecf\u63a8\u51fa\u4e86WGS\u3001WES\u3001\u8f6c\u5f55\u7ec4\u548c\u8868\u8fbe\u8c31\u6d4b\u5e8f\u7b49\u6807\u51c6\u5316\u5efa\u5e93\u8bd5\u5242\u76d2\uff0c\u4ee5\u53caSE50\uff0cSE100\uff0cPE50\u548cPE100\u6d4b\u5e8f\u8bd5\u5242\u76d2\uff0cPE100\u6d4b\u5e8fQ30\u53ef\u4ee5\u8fbe\u523085%\u4ee5\u4e0a\uff0c\u4f7f\u7528\u6807\u51c6\u6587\u5e93\u751a\u81f3\u53ef\u4ee5\u8fbe\u523090%\u4ee5\u4e0aQ30\uff0c\u53ef\u4ee5\u6ee1\u8db3\u4e0d\u540c\u7c7b\u578b\u7684\u79d1\u7814\u9700\u6c42\uff0c\u4e5f\u53ef\u4ee5\u57fa\u4e8e\u8fd9\u4e9b\u5f00\u53d1\u4e0d\u540c\u7c7b\u578b\u4e34\u5e8a\u68c0\u6d4b\u5e94\u7528\u3002<\/div>\n\n
\n![\"eicZhoGYCfyao5maAp2VXXHoZvFULrnzjCNz9wVno6xOIoml9x8Cn22RmghCNxbWlYelThl3ibgwIeKdoaqrd4DQ\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/eicZhoGYCfyao5maAp2VXXHoZvFULrnzjCNz9wVno6xOIoml9x8Cn22RmghCNxbWlYelThl3ibgwIeKdoaqrd4DQ.jpeg\")
<\/figure><\/div>\n\n<\/div>\n
<\/figure><\/div>\n\n<\/div>\n<\/div>\n
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\n\n
\n![\"eicZhoGYCfyao5maAp2VXXHoZvFULrnzjtKPotLOQeqGDbWR7ibs8UvhogvglJASkAWkfErqTIKBo9ySZY1l4sdQ\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/eicZhoGYCfyao5maAp2VXXHoZvFULrnzjtKPotLOQeqGDbWR7ibs8UvhogvglJASkAWkfErqTIKBo9ySZY1l4sdQ.jpeg\")
<\/figure><\/div>\n\n<\/div>\n
<\/figure><\/div>\n\n<\/div>\n\n\n
\n![\"eicZhoGYCfyao5maAp2VXXHoZvFULrnzjV1zkOk1zgc2Hnxyract3EQWdRArO4Wa9WupROZibu0qzOLib0TBaXlLQ\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/eicZhoGYCfyao5maAp2VXXHoZvFULrnzjV1zkOk1zgc2Hnxyract3EQWdRArO4Wa9WupROZibu0qzOLib0TBaXlLQ.jpeg\")
<\/figure><\/div>\n\n
<\/figure><\/div>\n\n\uff08\u4ee5\u4e0a\u4e09\u56fe\u4e3aBGISEQ-500\u6d4b\u5e8f\u76f8\u5173\u53c2\u6570\uff0c\u6837\u672c\u7c7b\u578bDNA\uff0c\u6d4b\u5e8f\u7c7b\u578bPE100\uff09<\/div>\n
\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u5df2\u7ecf\u5728BGISEQ\u5e73\u53f0\u4e0a\u53d1\u8868\u6587\u7ae0\u5341\u4f59\u7bc7\uff0c\u540e\u7eed\u4f1a\u6709\u66f4\u591a\u9ad8\u6c34\u5e73\u6587\u7ae0\u7684\u4ea7\u51fa\u3002<\/div>\n
\u53d1\u8868\u671f\u520a\uff1a2016\u5e749\u6708\uff0c\u300aInsect Biochemistry and Molecular Viology\u300b<\/div>\n
\u6587\u732e\u6807\u9898\uff1aComparative transcriptome analysis of chemosensory genes in two sister leaf beetles provides insights into chemosensory speciation<\/div>\n
\u7814\u7a76\u6210\u679c\uff1a\u901a\u8fc7BGISEQ-500\u8f6c\u5f55\u7ec4\u6d4b\u5e8f\u9996\u6b21\u7814\u7a76\u5e76\u9274\u5b9a\u4e86\u53f6\u7532\u79d1\u6606\u866bPyrrhalta\u7684\u4e24\u4e2a\u59d0\u59b9\u54c1\u79cd\u7684\u5316\u611f\u57fa\u56e0\u5bb6\u65cf\uff0c\u53d1\u73b0\u5316\u5b66\u611f\u5e94\u57fa\u56e0\u5728\u5316\u5b66\u5f15\u5bfc\u7684\u751f\u6b96\u9694\u79bb\u548c\u751f\u6001\u9694\u79bb\u4e2d\u8d77\u4e86\u5173\u952e\u4f5c\u7528\u3002<\/div>\n
\u00a0<\/div>\n
\u53d1\u8868\u671f\u520a\uff1a2016\u5e7411\u6708\uff0c\u300aClinical Epigenetics\u300b<\/div>\n
\u6587\u732e\u6807\u9898\uff1acPAS-based sequencing on the BGISEQ-500 to explore small non-coding RNAs.<\/div>\n
\u7814\u7a76\u6210\u679c\uff1a\u4f7f\u7528BGISEQ-500\u5e73\u53f0\u5bf9\u4eba\u6837\u54c1\u8fdb\u884cSmall RNA\u9ad8\u901a\u91cf\u6d4b\u5e8f\uff0c\u5e76\u4e0eHiSeq\u5e73\u53f0\u3001\u82af\u7247\u6bd4\u8f83\u3002\u4f18\u5316\u7684\u8054\u5408\u63a2\u9488\u951a\u5b9a\u805a\u5408\u6280\u672f\uff08cPAS\uff09\u4f7f\u5f97\u6d4b\u5e8f\u6570\u636e\u5177\u6709\u5f88\u9ad8\u7684\u6280\u672f\u91cd\u590d\u6027\uff08\u76f8\u5173\u6027\u7cfb\u6570\u9ad8\u8fbe99%\uff09\u3002HiSeq\u3001BGISEQ-500\u3001\u82af\u7247\u7b49\u6d4b\u5e8f\u6570\u636e\u6bd4\u5bf9\u5230miR-451a\u7684reads\u6bd4\u4f8b\u5206\u522b\u4e3a0.8%\u300145.9%\u548c37.2%\u3002BGISEQ-500\u5e73\u53f0\u4e0e\u82af\u7247\u5206\u6790\u7ed3\u679c\u57fa\u672c\u4e00\u81f4\u3002\u8fd9\u4e2a\u7814\u7a76\u8868\u660eBGISEQ-500\u5e73\u53f0\u662f\u5bf9\u73b0\u6709\u6d4b\u5e8f\u5e73\u53f0\u7684\u8865\u5145\uff0c\u662fSmall RNA\u6d4b\u5e8f\u7814\u7a76\u7684\u4f18\u9009\u5e73\u53f0\u3002<\/div>\n
\u00a0<\/div>\n
\u53d1\u8868\u671f\u520a\uff1a2017\u5e744\u6708\uff0c\u300aRice\u300b<\/div>\n
\u6587\u732e\u6807\u9898\uff1aOver expression ofOsHSP18.0-CIEnhances Resistance to Bacterial Leaf Streak in Rice<\/div>\n
\u7814\u7a76\u6210\u679c\uff1a\u4f5c\u8005\u4ece\u5355\u4e00\u57fa\u56e0\u529f\u80fd\u7814\u7a76\u5165\u624b\uff0c\u5728\u505a\u5b8c\u8f6c\u57fa\u56e0\u548cRNAi\u5b9e\u9a8c\u4e4b\u540e\uff0c\u5148\u7528qRT-PCR\u5bf9\u8be5\u57fa\u56e0\u7684\u8868\u8fbe\u8fdb\u884c\u9a8c\u8bc1\uff0c\u5728\u5f97\u5230\u9884\u671f\u7ed3\u679c\u540e\uff0c\u4f7f\u7528BGISEQ-500\u6d4b\u5e8f\u5e73\u53f0\u8fdb\u884c\u4e86RNA-Seq\u5206\u6790\uff0cclean reads\u6bd4\u5bf9\u7387\u8fbe\u523099.98%\u3002RNA-Seq\u7684\u7ed3\u679c\u4e0d\u4ec5\u9a8c\u8bc1\u4e86qRT-PCR\u7684\u7ed3\u679c\uff0c\u8fd8\u53d1\u73b0\u4e86\u8bb8\u591a\u5dee\u5f02\u8868\u8fbe\u7684\u57fa\u56e0\uff0c\u53d1\u73b0OsHSP18.0-CI\u7684\u8d85\u8868\u8fbe\u80fd\u6709\u6548\u7684\u63d0\u9ad8\u6c34\u7a3b\u6297\u75c5\u80fd\u529b\u3002<\/div>\n
\u00a0<\/div>\n
\u53d1\u8868\u671f\u520a\uff1a2017\u5e744\u6708\uff0c\u300aGigaScience\u300b<\/div>\n
\u6587\u732e\u6807\u9898\uff1aA reference human genome dataset of the BGISEQ-500 sequencer<\/div>\n
\u7814\u7a76\u6210\u679c\uff1a\u91c7\u7528\u88ab\u5e7f\u6cdb\u4f7f\u7528\u7684\u201c\u74f6\u4e2d\u57fa\u56e0\u7ec4\u201d\u8054\u76df\u53d1\u5e03\u7684\u4eba\u7c7b\u7ec6\u80de\u7cfbHG001(NA12878)\u5bf9BGISEQ-500\u548cHiSeq 2500\u7684\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u6bd4\u8f83\u3002BGISEQ-500\u6d4b\u5e8f\u4eea\u4ea7\u51fa\u7684PE50\u53caPE100\u6570\u636e\u5206\u522b\u7ea6135.5Gbp\u3001153.6 Gbp\uff0c\u5171\u4e24\u5f20\u82af\u7247\uff0c\u8017\u65f6\u7ea672\u5c0f\u65f6\uff0c\u4e0eHiSeq 2500\u6d4b\u5e8f\u4eea\u5feb\u901f\u6a21\u5f0fv1\uff08persingle flow cell 40\u5c0f\u65f6\u4ea7\u51fa80Gbp\uff09\u901a\u91cf\u76f8\u4f3c\u3002\u5206\u6790\u7ed3\u679c\u8868\u660eBGISEQ-500 PE100\u4e0eHiSeq 2500 PE150\u5177\u6709\u76f8\u4f3c\u7684\u7075\u654f\u5ea6\u3001\u9633\u6027\u68c0\u51fa\u7387\u3001\u5047\u9633\u6027\u7387\u548c\u5047\u9634\u6027\u7387\u3002<\/div>\n
\u00a0<\/div>\n
\u53d1\u8868\u671f\u520a\uff1a2017\u5e747\u6708\uff0c\u300aGigaScience\u300b<\/div>\n
\u6587\u732e\u6807\u9898\uff1aComparative performance of the BGISEQ-500 versus Illumina HiSeq 2500 sequencing platforms for palaeogenomic sequencing<\/div>\n
\u7814\u7a76\u6210\u679c\uff1a\u5206\u522b\u91c7\u7528BGISEQ-500\u548cIllumina HiSeq 2500\u5e73\u53f0\uff0c\u5bf991-14000\u5e74\u524d\u76848\u4e2a\u53e4\u8001\u5927\u578b\u72ac\u79d1\u52a8\u7269\u7684DNA \u6837\u672c\u8fdb\u884c\u6d4b\u5e8f\uff0c\u5e76\u5bf9\u6d4b\u5e8f\u6027\u80fd\u548c\u6570\u636e\u8d28\u91cf\u8fdb\u884c\u6bd4\u8f83\u3002\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u6570\u636e\u8868\u73b0\u5728\u4e24\u4e2a\u6d4b\u5e8f\u5e73\u53f0\u4e0a\u6574\u4f53\u57fa\u672c\u76f8\u5f53\uff0cBGISEQ-500\u5e73\u53f0\u4ea7\u751f\u76848\u4e2a\u6587\u5e93\u4e2d\u67097\u4e2a\u7684\u6587\u5e93\u590d\u6742\u5ea6\u90fd\u663e\u8457\u7684\u9ad8\u4e8eHiSeq\u5e73\u53f0\u3002\u5176\u4e2d\u5dee\u5f02\u6700\u5927\u7684\uff0c\u6b63\u662f\u8ddd\u4eca14,000\u5e74\u524d\u7684\u6700\u53e4\u8001\u6837\u672c\u4e4b\u4e00\u3002<\/div>\n\n
\n![\"eicZhoGYCfyao5maAp2VXXHoZvFULrnzjXqRHR94iaQQFPia7iaLEOIVoO0QgbdbQPiaziaYiaXibqpwsSUUiaNE1Bka90g\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/eicZhoGYCfyao5maAp2VXXHoZvFULrnzjXqRHR94iaQQFPia7iaLEOIVoO0QgbdbQPiaziaYiaXibqpwsSUUiaNE1Bka90g.jpeg\")
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<\/figure><\/div>\n\n<\/div>\n<\/div>\n
\n\n
\n![\"eicZhoGYCfyao5maAp2VXXHoZvFULrnzjWnn1iaJs0YNgBjicLtkOENBvvq33SB8Hnue0DMmHDvUforaUicFMAz1rg\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/eicZhoGYCfyao5maAp2VXXHoZvFULrnzjWnn1iaJs0YNgBjicLtkOENBvvq33SB8Hnue0DMmHDvUforaUicFMAz1rg.png\")
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<\/figure><\/div>\n\n\uff08\u4ee5\u4e0a\u4e24\u56fe\u4e3aBGISEQ-500\u6d4b\u5e8f\u53c2\u6570\u548cHiSeq 2500\u7684\u6bd4\u8f83\u3002PE150\u7684\u6570\u636e\u5c1a\u672a\u53d1\u8868\uff0c\u8fd1\u671f\u5373\u5c06\u516c\u5f00\uff09<\/div>\n
\u534e\u5927\u667a\u9020\uff08MGI\uff09\u54c1\u724c\u548c\u5e73\u53f0\u6218\u7565<\/div>\n
Part 4.<\/div>\n
\u3010\u57fa\u56e0\u6167\u3011MGI\u4f5c\u4e3a\u534e\u5927\u96c6\u56e2\u7684\u5341\u5927\u4f53\u7cfb\u4e4b\u4e00\uff0c\u4ee5\u72ec\u2f74\u7acb\u54c1\u724c\u8fd0\u4f5c\uff0c\u627f\u8f7d\u4e86\u201c\u56fd\u4e4b\u91cd\u5668\u201d\u7684\u4f7f\u547d\u3002\u8bf7\u60a8\u5411\u5e7f\u5927\u540c\u884c\u4ecb\u7ecd\u4e0b\u534e\u5927\u667a\u9020\uff08MGI\uff09\u7684\u54c1\u724c\u5b9a\u4f4d\u3001\u73b0\u72b6\u53ca\u53d1\u5c55\u7b49\u3002<\/div>\n
\u3010\u848b\u6167\u3011\u534e\u5927\u667a\u9020\u79c9\u627f\u96c6\u56e2\u201c\u57fa\u56e0\u79d1\u6280\u9020\u798f\u4eba\u7c7b\u201d\u7684\u7406\u5ff5\uff0c\u81f4\u529b\u4e8e\u57fa\u56e0\u79d1\u6280\u7684\u521b\u65b0\uff0c\u63d0\u4f9b\u5b9e\u65f6\uff08Real Time\uff09\u3001\u5168\u666f\uff08Whole Picture\uff09\u3001\u5168\u751f\u547d\u5468\u671f\uff08Life Long\uff09\u7684\u751f\u547d\u6570\u5b57\u5316\u5168\u5957\u8bbe\u5907\uff0c\u4e3a\u7cbe\u51c6\u533b\u7597\u3001\u7cbe\u51c6\u519c\u4e1a\u548c\u7cbe\u51c6\u5065\u5eb7\u7b49\u5173\u7cfb\u56fd\u8ba1\u6c11\u751f\u7684\u5b9e\u9645\u9700\u6c42\u63d0\u4f9b\u5148\u8fdb\u8bbe\u5907\u3001\u6280\u672f\u4fdd\u969c\u548c\u89e3\u51b3\u65b9\u6848\u3002<\/div>\n
\u73b0\u9636\u6bb5\uff0c\u6211\u4eec\u5df2\u7ecf\u9646\u7eed\u542f\u52a8\u591a\u4e2a\u5e73\u53f0\u6280\u672f\u7814\u53d1\uff0c\u843d\u5b9e\u96c6\u56e2\u5927\u79d1\u5b66\u3001\u5927\u4ea7\u4e1a\u3001\u5927\u6c11\u751f\u8d2f\u7a7f\u7684\u6574\u4f53\u65b9\u9488\uff0c\u6b66\u88c5\u5168\u7ebf\u7684\u540c\u65f6\u670d\u52a1\u5168\u793e\u4f1a\uff0c\u6253\u9020\u4e2d\u56fd\u65b0\u5174\u4ea7\u4e1a\u7684\u6807\u6746\u3002\u5e76\u5df2\u5728\u6d77\u5916\u6210\u7acb\u5206\u516c\u53f8\uff0c\u5f62\u6210\u4e86\u5168\u7403\u5316\u7684\u5236\u9020\u3001\u8425\u9500\u548c\u670d\u52a1\u7f51\u7edc\u3002\u76ee\u524d\u6211\u4eec\u5df2\u7ecf\u7ec4\u5efa\u4e86\u7814\u53d1\u3001\u751f\u4ea7\u3001\u8d28\u91cf\u3001\u4f9b\u5e94\u94fe\u548c\u8425\u9500\u591a\u4e2a\u4e2d\u5fc3\uff0c\u5b9e\u73b0\u4e86\u5168\u9762\u80fd\u529b\u5efa\u8bbe\uff0c\u56e2\u961f\u89c4\u6a21\u5df2\u7ecf\u8d85\u8fc7500\u4eba\u3002\u5728\u4ea7\u54c1\u7ebf\u65b9\u9762\uff0c\u4e0d\u4ec5\u4ec5\u63a8\u51fa\u4e86BGISEQ-500RS\u548cBGISEQ-50RS\u4e24\u6b3e\u6d4b\u5e8f\u4eea\uff0c\u8fd8\u63a8\u51fa\u4e86\u81ea\u52a8\u5316\u5efa\u5e93\u7cfb\u7edfBGISP-100\uff0c\u4ee5\u53ca10\u4f59\u79cd\u5efa\u5e93\u548c\u6d4b\u5e8f\u8bd5\u5242\u76d2\uff0c\u53ef\u4ee5\u7528\u4e8e\u8fdb\u884cWGS\u3001WES\u3001\u8f6c\u5f55\u7ec4\u3001\u8868\u8fbe\u8c31\u3001ChIP-seq\u3001small RNA\u3001\u5355\u7ec6\u80de\u6d4b\u5e8f\u7b49\uff0c\u6b64\u5916\u4e3a\u4e86\u652f\u6301\u548c\u9f13\u52b1\u5408\u4f5c\u65b9\u5728\u6211\u4eec\u5e73\u53f0\u4e0a\u5f00\u53d1\u6d4b\u5e8f\u5e94\u7528\uff0c\u6211\u4eec\u4e5f\u63d0\u4f9b\u4e86\u5355\u72ec\u7684\u73af\u5316\u8bd5\u5242\u76d2\uff0c\u5728\u672a\u6765\u6211\u4eec\u5c06\u63a8\u51fa\u66f4\u591a\u4e0d\u540c\u9886\u57df\u7684\u5e94\u7528\uff0c\u6bd4\u5982\u8054\u5408\u63a8\u51fa\u519c\u4e1a\u548c\u68c0\u9a8c\u68c0\u75ab\u65b9\u9762\u7684\u8bd5\u5242\u76d2\u3002<\/div>\n
\u534e\u5927\u667a\u9020\u4ee5\u6253\u9020\u751f\u547d\u6570\u5b57\u5316\u5168\u666f\u672a\u6765\u4e3a\u4f7f\u547d\uff0c\u7528\u521b\u65b0\u529b\u91cf\u5f15\u9886\u751f\u547d\u79d1\u6280\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u5c06\u4e0d\u4f1a\u4ec5\u4ec5\u505c\u7559\u5728\u6d4b\u5e8f\u4eea\u7814\u53d1\u548c\u751f\u4ea7\u4e0a\uff0c\u5c06\u8fdb\u4e00\u6b65\u62d3\u5c55\u5b9e\u73b0\u4e0d\u540c\u5c3a\u5ea6\u548c\u4e0d\u540c\u7c7b\u578b\u7684\u751f\u547d\u76f8\u5173\u6570\u5b57\u5316\u667a\u80fd\u5e73\u53f0\u7814\u5236\uff0c\u4eceDNA\u3001RNA\u3001\u86cb\u767d\u3001\u4ee3\u8c22\u5c0f\u5206\u5b50\u3001\u7ec6\u80de\u3001\u5668\u5b98\u5230\u4e2a\u4f53\uff0c\u771f\u6b63\u8fbe\u5230\u4eba\u4eba\u5b9e\u65f6\u7ec8\u751f\u5927\u6570\u636e\u91c7\u96c6\u548c\u5206\u6790\uff0c\u5b9e\u73b0\u201cYour Life in Your Hands\u201d\u3002<\/div>\n
\u00a0<\/div>\n
Part 5.<\/div>\n
\u3010\u57fa\u56e0\u6167\u3011\u57fa\u56e0\u4ea7\u4e1a\u4ece\u672c\u8d28\u4e0a\u770b\u5c5e\u4e8e\u533b\u7597\u5927\u5065\u5eb7\u548c\u5de5\u519c\u4e1a\u80fd\u6e90\uff0c\u57fa\u56e0\u6167\u4ece\u4e13\u4e1a\u5a92\u4f53\u548c\u54a8\u8be2\u89d2\u5ea6\u53bb\u770b\uff0c\u8d44\u6e90\u5411\u653f\u7b56\u65b9\u548c\u8d44\u672c\u65b9\u805a\u5408\u3002\u90a3\u4e48\u5bf9\u4e8e\u4e2d\u5c0f\u4f01\u4e1a\u751f\u5b58\u548c\u53d1\u5c55\u7a7a\u95f4\u60a8\u600e\u4e48\u770b\uff1f\u5728\u5168\u4ea7\u4e1a\u94fe\u6574\u5408\u7684\u7a97\u53e3\uff0c\u6211\u4eec\u770b\u5230MGI\u548c\u827e\u5409\u6cf0\u5eb7\u3001\u8054\u5ddd\u751f\u7269<\/a>\u3001WeGene\u7b49\u4e0b\u6e38\u516c\u53f8\u5747\u6210\u4e3a\u5408\u4f5c\u4f19\u4f34\uff0c\u90a3\u4e48MGI\u5728\u6b64\u662f\u626e\u6f14\u4e0a\u6e38\u4f9b\u5e94\u5546\u89d2\u8272\u8fd8\u662f\u53ef\u80fd\u7c7b\u4f3cillumina+Helix\u4e00\u6837\u4f5c\u4e3a\u5e73\u53f0\u63a5\u5165\u53e3\u5462\uff1f<\/div>\n
\u3010\u848b\u6167\u3011\u76ee\u524d\u6211\u56fd\u56f4\u7ed5\u8fd9\u57fa\u56e0\u6d4b\u5e8f\u4e0a\u4e2d\u4e0b\u6e38\u5df2\u7ecf\u6709\u6570\u5343\u5bb6\u4f01\u4e1a\uff0c\u5e76\u4e14\u4f9d\u7136\u4fdd\u6301\u4e86\u8f83\u5feb\u901f\u7684\u589e\u957f\u3002\u5bf9\u4e8e\u884c\u4e1a\u6765\u8bf4\uff0c\u4f9d\u7136\u5177\u6709\u8f83\u5927\u7684\u53d1\u5c55\u6f5c\u529b\uff0c\u6211\u4eec\u53ef\u4ee5\u770b\u5230\u5927\u90e8\u5206\u4f01\u4e1a\u90fd\u96c6\u4e2d\u5728\u51e0\u4e2a\u70ed\u95e8\u9886\u57df\uff0c\u5bf9\u4e8e\u4e2d\u5c0f\u4f01\u4e1a\u6765\u8bf4\uff0c\u6700\u4e3a\u91cd\u8981\u7684\u57fa\u4e8e\u6838\u5fc3\u6280\u672f\u6216\u7ade\u4e89\u529b\u7684\u7ec6\u5206\u9886\u57df\u5b9a\u4f4d\u3002\u73b0\u5728\u5927\u90e8\u5206\u6d4b\u5e8f\u4eea\u96c6\u4e2d\u5728\u5c11\u6570\u5341\u51e0\u4e2a\u4f01\u4e1a\u4e2d\uff0c\u8fd9\u4e2a\u5bf9\u4e8e\u7814\u5236\u5177\u6709\u5dee\u5f02\u5316\u548c\u7ade\u4e89\u529b\u7684\u4ea7\u54c1\uff0c\u5feb\u901f\u62d3\u5c55\u6d4b\u5e8f\u6280\u672f\u5e94\u7528\u662f\u6bd4\u8f83\u4e0d\u5229\u7684\u3002<\/div>\n
\u5bf9\u4e8e\u534e\u5927\u667a\u9020\u6765\u8bf4\uff0c\u6211\u4eec\u5e0c\u671b\u80fd\u591f\u4e3a\u6211\u56fd\u57fa\u56e0\u884c\u4e1a\u4e2d\u7684\u4f01\u4e1a\u63d0\u4f9b\u5177\u6709\u7ade\u4e89\u529b\u7684\u5e73\u53f0\uff0c\u5e2e\u52a9\u4f01\u4e1a\u5efa\u7acb\u81ea\u4e3b\u7814\u53d1\u548c\u751f\u4ea7\u5e73\u53f0\uff0c\u534f\u52a9\u5f00\u53d1\u65b0\u6280\u672f\u65b0\u4ea7\u54c1\uff0c\u5e2e\u52a9\u52a0\u5feb\u4ece\u7814\u53d1\u5b9e\u9a8c\u5ba4\u5230\u5927\u89c4\u6a21\u4ea7\u4e1a\u5316\u7684\u8f6c\u5316\u3002\u5c24\u5176\u662f\u7ed3\u5408\u56fd\u5185\u540c\u6837\u4e0a\u6e38\u7684\u4f01\u4e1a\u63d0\u4f9b\u66f4\u52a0\u672c\u5730\u5316\u7684\u89e3\u51b3\u65b9\u6848\u3002\u5305\u62ec\u4ece\u5b9e\u9a8c\u5ba4\u8bbe\u8ba1\u5230\u8ba4\u8bc1\u3001\u4ece\u6d4b\u5e8f\u4eea\u786c\u4ef6\u5230\u5b9e\u9a8c\u5ba4\u751f\u4ea7\u7ba1\u7406\u7cfb\u7edf\u3001\u4ece\u63d0\u4f9b\u539f\u8f85\u6750\u6599\u5230\u6210\u54c1\u8bd5\u5242\u76d2\u3001\u4ece\u524d\u671f\u57f9\u8bad\u5230\u540e\u671f\u5347\u7ea7\uff0c\u6700\u540e\u7684\u76ee\u6807\u90fd\u662f\u5e2e\u52a9\u66f4\u591a\u4f01\u4e1a\u5feb\u901f\u53d1\u5c55\u3002<\/div>\n
\u00a0<\/div>\n
\u4ece\u7eb3\u7c73\u7ea7\u5230\u6beb\u7c73\u7ea7\uff0c\u591a\u7ec4\u5b66\u751f\u547d\u6570\u636e\u7814\u7a76<\/div>\n
Part 6.<\/div>\n
\u3010\u57fa\u56e0\u6167\u3011\u5728\u56fd\u5bb6\u57fa\u56e0\u5e93\uff0c\u6211\u4eec\u770b\u5230\u4e86\u9664\u4e86\u58ee\u89c2\u7684BGISEQ\u6d4b\u5e8f\u4eea\u9635\u5217\uff0c\u8fd8\u5f15\u8fdb\u4e86\u897f\u95e8\u5b50\u7684\u78c1\u5171\u632f\u8bbe\u5907\u3001\u4ee5\u53ca\u5065\u5eb7\u68c0\u6d4b\u4f53\u9a8c\u7684\u201c\u592a\u7a7a\u8231\u201d\uff0c\u4ece\u7eb3\u7c73\u7ea7\u5230\u6beb\u7c73\u7ea7\uff0c\u662f\u5426\u610f\u5473\u7740MGI\u5173\u6ce8\u70b9\u9664\u4e86\u57fa\u56e0\uff0c\u4e5f\u5c06\u751f\u7406\u3001\u751f\u5316\u548c\u5f71\u50cf\u7b49\u7eb3\u5165\u5927\u5065\u5eb7\u7684\u4ea7\u4e1a\u4f53\u7cfb\uff1f\u5176\u4e2d\u7684\u8fde\u63a5\u70b9\u548c\u843d\u5730\u70b9\u4e3b\u8981\u5728\u54ea\u4e9b\u65b9\u9762\u5462\uff1f<\/div>\n
\u3010\u848b\u6167\u3011\u6211\u4eec\u5728\u6301\u7eed\u8fdb\u884c\u79d1\u7814\u7a81\u7834\u548c\u6280\u672f\u521b\u65b0\u540c\u65f6\u4e5f\u5728\u601d\u7d22\uff0c\u662f\u5426\u6d4b\u5e8f\u6570\u636e\u5df2\u7ecf\u8db3\u591f\u63ed\u79d8\u751f\u547d\u5965\u79d8\uff1f\u7b54\u6848\u5f53\u7136\u662f\u5426\u5b9a\u7684\u3002\u5c3d\u7ba1\u6211\u4eec\u73b0\u5728\u5df2\u7ecf\u5bf9\u57fa\u56e0\u7ec4\u8fdb\u884c\u4e86\u5927\u91cf\u7814\u7a76\uff0c\u4f46\u662f\u6211\u4eec\u4e5f\u4f1a\u53d1\u73b0\u4ec5\u4ec5\u4ece\u4e00\u4e2a\u5c42\u9762\u89e3\u91ca\u751f\u547d\u6570\u636e\u8fdc\u8fdc\u4e0d\u591f\uff0c\u6211\u4eec\u8feb\u5207\u9700\u8981\u6574\u5408\u5176\u4ed6\u7ec4\u5b66\u6570\u636e\uff0c\u4ece\u8de8\u5c3a\u5ea6\u3001\u5927\u573a\u666f\u3001\u591a\u7ef4\u5ea6\u5206\u6790\u624d\u6709\u53ef\u80fd\u8fdb\u4e00\u6b65\u4e86\u89e3\u75be\u75c5\u548c\u5065\u5eb7\u7684\u4fe1\u606f\u3002\u8fd9\u5c31\u662f\u4e3a\u4ec0\u4e48\u6211\u4eec\u9700\u8981\u8865\u5145\u5176\u4ed6\u6570\u636e\u5b9e\u73b0\u7cfb\u7edf\u5316\u5206\u6790\u3002\u4ee5\u57fa\u56e0\u68c0\u6d4b\u548c\u5f71\u50cf\u4e3a\u4f8b\uff0c\u5728\u4ea7\u524d\u68c0\u6d4b\u4e2d\u901a\u8fc7\u57fa\u56e0\u7ec4\u5b66\u68c0\u6d4b\u5df2\u7ecf\u80fd\u591f\u5b9e\u73b0\u5bf9\u4e8e\u67d3\u8272\u4f53\u75be\u75c5\uff0c\u6bd4\u598221-\u4e09\u4f53\u7efc\u5408\u5f81\u7684\u51c6\u786e\u68c0\u6d4b\u3002\u4f46\u662f\u5bf9\u4e8e\u53d1\u75c5\u7387\u7b2c\u4e00\u4f4d\u7684\u5148\u5929\u6027\u5fc3\u810f\u75c5\uff0c\u5c31\u9700\u8981\u57fa\u56e0\u52a0\u5f71\u50cf\u624d\u53ef\u80fd\u8fbe\u5230\u8f83\u597d\u7684\u9632\u6cbb\u76ee\u7684\uff0c\u5982\u4f55\u5c06\u4e24\u8005\u4fe1\u606f\u6709\u6548\u7ed3\u5408\u5b9e\u73b0\u51c6\u786e\u8bca\u65ad\uff0c\u9700\u8981\u5927\u91cf\u4e34\u5e8a\u6570\u636e\u79ef\u7d2f\u548c\u5927\u6570\u636e\u667a\u80fd\u5206\u6790\u65b9\u6cd5\u5f00\u53d1\u3002<\/div>\n
\u00a0<\/div>\n
\u57fa\u56e0\u4ea7\u4e1a\u8fb9\u754c\u5ef6\u4f38\u7684\u5408\u4f5c\u70b9<\/div>\n
Part 7.<\/div>\n
\u3010\u57fa\u56e0\u6167\u3011\u8df3\u51fa\u6765\u770b\uff0c\u57fa\u56e0\u6570\u636e\u4ecd\u662f\u5927\u5065\u5eb7\u6570\u636e\u7684\u4e00\u90e8\u5206\u3002\u4ece\u57fa\u56e0\u4ea7\u4e1a\u7684\u8fb9\u754c\u5916\u5ef6\u6765\u770b\uff0c\u5982\u679c\u6574\u5408\u5176\u4ed6\u5f62\u5f0f\u7684\u533b\u7597\u548c\u5065\u5eb7\u8d44\u6e90\u6216\u6280\u672f\u6210\u4e3a\u591a\u7ef4\u5e94\u7528\u5927\u6570\u636e\uff0c\u4e3a\u533b\u7597\u5065\u5eb7\u4ee5\u53ca\u5de5\u519c\u4e1a\u80fd\u6e90\u8d4b\u80fd\u9769\u65b0\u7684\u8bdd\uff0c\u90a3\u4e48\u60a8\u8ba4\u4e3a\u76f8\u5bf9\u53ef\u843d\u5730\u7684\u9886\u57df\u5408\u4f5c\u70b9\u6709\u54ea\u4e9b\u5462\uff1f<\/div>\n
\u3010\u848b\u6167\u3011\u6211\u4eec\u6b22\u8fce\u56f4\u7ed5\u7740\u6d4b\u5e8f\u4eea\u7684\u4e0d\u540c\u9886\u57df\u5e94\u7528\u5f00\u53d1\uff0c\u5305\u62ec\u79d1\u7814\u3001\u533b\u5b66\u3001\u519c\u4e1a\u7b49\u9886\u57df\u3002\u6bd4\u5982\u79d1\u7814\u9879\u76ee\u4e2d\u5e38\u7528\u7684\u6355\u83b7\u5efa\u5e93\u6280\u672f\uff0c\u6211\u4eec\u548c\u827e\u5409\u6cf0\u5eb7\u5efa\u7acb\u4e86\u5408\u4f5c\uff0c\u9664\u6b64\u4e4b\u5916\u6211\u4eec\u73b0\u5728\u4e5f\u5728\u65b0\u578b\u7684Hi-C\u6280\u672f\u548c\u5355\u7ec6\u80de\u6d4b\u5e8f\u6280\u672f\u7b49\u65b9\u9762\u5f00\u5c55\u4e86\u5408\u4f5c\u3002<\/div>\n
\u00a0<\/div>\n
\u5728\u533b\u5b66\u9886\u57df\uff0c\u6211\u4eec\u548c\u8054\u5ddd\u751f\u7269\u8054\u5408\u8fdb\u884c\u80ba\u764c\u76f8\u5173\u57fa\u56e0\u5c0f\u533a\u57df\u9776\u5411\u5bcc\u96c6\u5f00\u53d1\uff0c\u5e0c\u671b\u540e\u7eed\u80fd\u591f\u4e3a\u4e13\u6ce8\u533b\u5b66\u68c0\u6d4b\u7684\u4f01\u4e1a\u63d0\u4f9b\u66f4\u591a\u66f4\u597d\u7684\u65b9\u6848\u9009\u62e9\u3002<\/div>\n
\u5728\u519c\u4e1a\u9886\u57df\uff0c\u76ee\u524d\u4e3b\u8981\u662f\u5728\u52a8\u690d\u7269\u80b2\u79cd\u548c\u52a8\u690d\u7269\u75ab\u75c5\u68c0\u6d4b\u7b49\u9886\u57df\u5f00\u5c55\u5408\u4f5c\u3002\u603b\u4f53\u4e0a\u6765\u8bf4\uff0c\u9664\u4e86\u5e38\u89c4\u6d4b\u5e8f\u4e1a\u52a1\u4e4b\u5916\uff0c\u6211\u4eec\u4e5f\u5e0c\u671b\u80fd\u901a\u8fc7\u5408\u4f5c\u5728\u6d4b\u5e8f\u6280\u672f\u5e94\u7528\u4e0a\u5f00\u5c55\u66f4\u591a\u62d3\u5c55\u3002\u6b64\u5916\uff0c\u9488\u5bf9\u7cfb\u7edf\u5316\u89e3\u51b3\u65b9\u6848\u90e8\u5206\uff0c\u5305\u62ec\u6837\u672c\u5236\u5907\u548c\u6570\u636e\u5206\u6790\u7b49\u4e5f\u662f\u53ef\u4ee5\u5f00\u5c55\u6df1\u5165\u5408\u4f5c\u3002<\/div>\n
\u6709\u4eba\u8bf4\u534e\u5927\u662f\u201c\u4e2d\u56fd\u57fa\u56e0\u4ea7\u4e1a\u7684\u9ec4\u57d4\u519b\u6821\u201d\uff0c\u57f9\u517b\u4e86\u4e00\u5927\u6279\u884c\u4e1a\u7cbe\u82f1\uff0c\u884c\u4e1a\u53d1\u5c55\u4e0d\u4ec5\u4ec5\u9700\u8981\u4eba\uff0c\u4e5f\u9700\u8981\u5e73\u53f0\u548c\u6280\u672f\uff0c\u73b0\u5728\u5e0c\u671b\u534e\u5927\u7684\u5e73\u53f0\u548c\u6280\u672f\u80fd\u591f\u8fdb\u4e00\u6b65\u52a9\u529b\u884c\u4e1a\u7684\u53d1\u5c55\uff0c\u751a\u81f3\u662f\u63d0\u4f9b\u5728\u534e\u5927\u5e73\u53f0\u4e0a\u7684\u57f9\u8bad\u3002\u9664\u6b64\u4e4b\u5916\uff0c\u6211\u4eec\u4e5f\u5c06\u5f00\u5c55\u591a\u7ef4\u5ea6\u7684\u5408\u4f5c\uff0c\u5c06\u8054\u5408\u84dd\u8272\u5f69\u8679\u7b49\u57fa\u91d1\uff0c\u4e3a\u4f01\u4e1a\u53d1\u5c55\u63d0\u4f9b\u521b\u4e1a\u521d\u671f\u8f85\u5bfc\u548c\u91d1\u878d\u652f\u6301\uff0c\u52a9\u529b\u4f01\u4e1a\u53d1\u5c55\u3002<\/div>\n
\uff08\u5168\u6587\u7ecf\u8fc7\u53d7\u8bbf\u8005\u5ba1\u6838\uff0c\u4ec5\u4ee3\u8868\u4e2a\u4eba\u89c2\u70b9\uff1b\u8f6c\u8f7d\u8bf7\u8054\u7cfb\u6388\u6743\uff0c\u4fb5\u6743\u5fc5\u7a76\u3002\uff09<\/div>\n
\u00a0<\/div>\n
\u60a8\u53ef\u80fd\u8fd8\u4f1a\u611f\u5174\u8da3\u7684<\/div>\n
\u2606<\/a>\u534e\u5927\u80a1\u4efdCEO\u5c39\u70e8<\/a><\/div>\n
\u2606<\/a>Illumina\u4e2d\u56fd\u533a\u603b\u7ecf\u7406\u8d75\u745e\u6797<\/a><\/div>\n
\u2606<\/a>\u701a\u6d77\u57fa\u56e0\u8d3a\u5efa\u594e\u8c08\u56fd\u4ea7\u4e09\u4ee3\u6d4b\u5e8f\u4eea<\/a><\/div>\n
\u2606<\/a>\u5317\u4eac\u57fa\u56e0\u7ec4\u6240\u65b9\u5411\u4e1c\u6559\u6388<\/a><\/div>\n
\u2606<\/a>Bionano\u521b\u59cb\u4eba\u66f9\u6db5\u8c08\u5355\u5206\u5b50\u56fe\u8c31\u6280\u672f<\/a><\/div>\n
\u2606<\/a>\u89e3\u653e\u519b\u603b\u533b\u9662\u6768\u4e91\u751f\u6559\u6388\u8c08\u5fae\u751f\u7269<\/a><\/div>\n
\u2606<\/a>\u56fd\u5bb6\u751f\u7269\u533b\u5b66\u5206\u6790\u4e2d\u5fc3\u6768\u745e\u99a5<\/a><\/div>\n
![\"eicZhoGYCfyZlnUvUakqSgyricQ72H2b0qFTh9Rkkg81ZSBo8X3pyp6zavJ3EvODmDvfOKFibK76gpm72ONLKhaXQ\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/eicZhoGYCfyZlnUvUakqSgyricQ72H2b0qFTh9Rkkg81ZSBo8X3pyp6zavJ3EvODmDvfOKFibK76gpm72ONLKhaXQ.gif\")
<\/figure><\/div>\n\n![\"eicZhoGYCfyao5maAp2VXXHoZvFULrnzjT5MUibBWtreq003ry2j3cf0ocv7ZbdZD1k20fMCqj88EOBibgjJSmQ5Q\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/eicZhoGYCfyao5maAp2VXXHoZvFULrnzjT5MUibBWtreq003ry2j3cf0ocv7ZbdZD1k20fMCqj88EOBibgjJSmQ5Q.png\")
<\/figure><\/div>\n\n![\"fgnkxfGnnkR81iaOnJJia1zFc2NdhJfk3tqapGF7fiaFzyuAsRsbcdZYzPLsicOaRxGXpTCGrDy6gMw047o5xfaicQg\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/fgnkxfGnnkR81iaOnJJia1zFc2NdhJfk3tqapGF7fiaFzyuAsRsbcdZYzPLsicOaRxGXpTCGrDy6gMw047o5xfaicQg.jpg\")
<\/figure><\/div>\n\n![\"RmFicvQBAkgDibFpXLmDUiayOs0bRyXN9FaL3SCzoc0mM9YSLFMLmKgac4Q3eFzWEGS3xgW3LMOUicf9cJStdlwYhQ\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDibFpXLmDUiayOs0bRyXN9FaL3SCzoc0mM9YSLFMLmKgac4Q3eFzWEGS3xgW3LMOUicf9cJStdlwYhQ.jpeg\")
<\/figure><\/div>\n\n<\/div>\n