\n![\"eicZhoGYCfyYibEO9O47lTicPSYJWgGr8GyjhE8LHBLsaZHqBhyHUJjwScOQjwG5290rxVMcOzaeE8hNwIbxSibbDQ\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/eicZhoGYCfyYibEO9O47lTicPSYJWgGr8GyjhE8LHBLsaZHqBhyHUJjwScOQjwG5290rxVMcOzaeE8hNwIbxSibbDQ.jpg\")
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\u00a0<\/div>\n
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\u00a0<\/div>\n
3. \u201c\u57fa\u56e0+\u514d\u75ab\u201d\u7684\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u5929\u68af\u8ba1\u5212<\/div>\n
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\n![\"0?wx_fmt=jpeg\"\/](\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/eicZhoGYCfyZvJ8VnPRp2VZlOLyuunUkic2xx83LVibiba1qiaYsWfBWKEpEib8UAz91YsEDqrkpVpibFLzHU4sqxef8A\/0?wx_fmt=jpeg\")
<\/figure><\/div>\n\n
\u5929\u68af\u8ba1\u5212\u53d1\u5e03\u4f1a<\/div>\n
4. \u201c\u6297\u764c\u7814\u7a76\u201d\u83b7\u5f97\u56fd\u9645\u8054\u76df\u8ba4\u53ef<\/div>\n
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\u3010\u9ad8\u5fd7\u535a\u3011 \u6211\u4eec\u77e5\u9053\uff0c\u4ee5\u6297PD-1\u836f\u7269\u4e3a\u4ee3\u8868\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u836f\u7269\u7684\u6cbb\u7597\u9700\u8981\u4f9d\u8d56\u60a3\u8005\u81ea\u8eab\u7684\u514d\u75ab\u7cfb\u7edf\u53d1\u6325\u4f5c\u7528\uff0c\u514d\u75ab\u7cfb\u7edf\u8bc6\u522b\u80bf\u7624\u9700\u8981\u80fd\u53d1\u73b0\u80bf\u7624\u4e0a\u7684\u7279\u5f02\u6027\u6297\u539f\uff08\u5982\u65b0\u751f\u6297\u539f\uff09\uff0c\u6253\u4e2a\u6bd4\u65b9\u7684\u8bdd\u5c31\u50cf\u662f\u63d2\u5728\u764c\u7ec6\u80de\u4e0a\u7684\u7ea2\u8272\u5c0f\u65d7\u5b50\uff0c\u544a\u8bc9\u514d\u75ab\u7cfb\u7edf\u8fd9\u662f\u764c\u7ec6\u80de\uff0c\u9700\u8981\u88ab\u6e05\u9664\u3002\u6240\u4ee5\u8bf4\uff0c\u65b0\u751f\u6297\u539f\u662f\u76f4\u63a5\u53cd\u6620\u514d\u75ab\u6cbb\u7597\u7597\u6548\u7684\u4e00\u4e2a\u6307\u6807\uff0c\u88d5\u7b56\u751f\u7269\u5728\u80bf\u7624\u65b0\u751f\u6297\u539f\u7684\u7814\u7a76\u4e0a\uff0c\u4e00\u76f4\u8d70\u5728\u884c\u4e1a\u7684\u6700\u524d\u6cbf\uff0c\u5c31\u5728\u4eca\u5e74\uff0c\u6211\u4eec\u6210\u529f\u52a0\u5165\u4e86\u56fd\u9645\u4e0a\u4e13\u6ce8\u4e8e\u63a8\u8fdb\u80bf\u7624\u65b0\u751f\u6297\u539f\uff08neoantigen\uff09\u7814\u7a76\u548c\u5e94\u7528\u7684\u7ec4\u7ec7\u2014\u2014\u80bf\u7624\u65b0\u751f\u6297\u539f\u7b5b\u67e5\u8054\u76df\uff08the Tumor Epitope SeLection Alliance\uff0cTESLA\uff09\uff0c\u76ee\u524d\u5df2\u7ecf\u53c2\u4e0e\u5230\u8054\u76df\u5185\u6709\u5173\u65b0\u751f\u6297\u539f\u7684\u9879\u76ee\u5408\u4f5c\u3002\u65b0TESLA\u8054\u76df\u662f\u7531\u7f8e\u56fd\u56fd\u5bb6\u764c\u75c7\u4e2d\u5fc3\uff08NCI\uff09\u548c\u5e15\u514b\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u7814\u7a76\u6240\uff08PICI\uff09\u8054\u5408\u7eaa\u5ff5\u65af\u9686\u51ef\u7279\u7433\u764c\u75c7\u4e2d\u5fc3\uff08MSKCC\uff09\u3001MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\u7b49\u51e0\u5bb6\u9876\u7ea7\u533b\u9662\u5171\u540c\u6210\u7acb\uff0c\u63a8\u52a8\u5efa\u7acb\u65b0\u751f\u6297\u539f\u68c0\u6d4b\u7684\u7b97\u6cd5\u548c\u6807\u51c6\u3002\u8054\u76df\u7684\u6210\u5458\u5305\u62ec\u5168\u740330\u5bf9\u5bb6\u9876\u7ea7\u764c\u75c7\u7814\u7a76\u4e2d\u5fc3\uff0c\u5305\u542b\u6700\u8fd1\u5728\u300aNature\u300b\u4e0a\u53d1\u5e03\u4e24\u7bc7\u4e2a\u4f53\u5316\u80bf\u7624\u75ab\u82d7\u7684\u516c\u53f8\uff1aBioNTech\u548cNeon\u3002\u88d5\u7b56\u751f\u7269\u662f\u4e2d\u56fd\u7b2c\u4e00\u5bb6\u52a0\u5165\u8be5\u8054\u76df\u5e76\u4e14\u901a\u8fc7\u8054\u76df\u8003\u6838\u7684\u516c\u53f8\u3002\u6211\u4eec\u521a\u521a\u8bb2\u7684\u80bf\u7624\u65b0\u751f\u6297\u539f\u7684\u9884\u6d4b\uff0c\u662f\u57fa\u4e8e\u4e8c\u4ee3\u6d4b\u5e8f\u548c\u751f\u7269\u4fe1\u606f\u7684\u65b9\u6cd5\u8fdb\u884c\u7684\uff0c\u9884\u6d4b\u5b8c\u4ee5\u540e\u8fd8\u6709\u4e2a\u9a8c\u8bc1\u51c6\u786e\u6027\u7684\u95ee\u9898\uff0c\u5f88\u9057\u61be\uff0c\u76ee\u524d\u56fd\u9645\u4e0a\u7684\u9884\u6d4b\u51c6\u786e\u6027\u5e76\u4e0d\u662f\u5f88\u9ad8\uff0c\u6240\u4ee5\u624d\u6709TESLA\u8054\u76df\u6765\u7275\u5934\u505a\u8fd9\u4e2a\u4e8b\uff0c\u6211\u4eec\u52a0\u5165\u4e5f\u662f\u4e3a\u4e86\u8fdb\u4e00\u6b65\u5b8c\u5584\u81ea\u5df1\u7684\u7b97\u6cd5\u3002\u56e0\u6b64\uff0c\u76f4\u63a5\u62ff\u65b0\u751f\u6297\u539f\u4f5c\u4e3a\u9884\u6d4b\u514d\u75ab\u6cbb\u7597\u7597\u6548\u7684\u6307\u6807\uff0c\u5728\u4e34\u5e8a\u4e0a\u96be\u5ea6\u6bd4\u8f83\u5927\uff0c\u5c24\u5176\u662f\u4f53\u5916\u9a8c\u8bc1\u8017\u65f6\u66f4\u4e45\uff0c\u75c5\u4eba\u751a\u81f3\u53ef\u80fd\u7b49\u4e0d\u5230\u7ed3\u679c\u51fa\u6765\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u60f3\u5230\u7684\u4e00\u4e2a\u89e3\u51b3\u529e\u6cd5\u5c31\u662f\uff0c\u5728\u80bf\u7624\u65b0\u751f\u6297\u539f\u9884\u6d4b\u7684\u57fa\u7840\u4e0a\uff0c\u6211\u4eec\u5f80\u524d\u63a8\u4e00\u6b65\uff0c\u5bfb\u627e\u4e0e\u9ad8\u8d28\u91cf\u65b0\u751f\u6297\u539f\u76f8\u5173\u6027\u8f83\u9ad8\u7684\u80bf\u7624\u7a81\u53d8\u5165\u624b\uff0c\u8fd9\u4e5f\u76f4\u63a5\u4ea7\u751f\u4e86\u6211\u4eec\u7684811\u57fa\u56e0\u68c0\u6d4bpanel\uff0c\u5176\u4e2d\u4e00\u4e2a\u6700\u6838\u5fc3\u7684\u6307\u6807\u5c31\u662fTMB\uff0c\u5e76\u4e14\u7efc\u5408\u8003\u8651\u4e86HLA\u914d\u578b\uff0cMHC-I\u3001MHC-II\u4eb2\u548c\u529b\u9884\u6d4b\u7b49\uff0c\u4e5f\u5c31\u662f\u6211\u4eec\u7684YuceOne\u2122 ICIs\u5728\u8fd9\u4e00\u70b9\u4e0a\uff0c\u56fd\u5185\u80fd\u505a\u5230\u7684\u516c\u53f8\u5f88\u5c11\u3002<\/div>\n\n
\n![\"eicZhoGYCfyZvJ8VnPRp2VZlOLyuunUkicYY5zqoZib9Sw6jpRAmdhN3j0wNWnIMibgUJp2sOE6opb2XbSwUZZQI5w\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/eicZhoGYCfyZvJ8VnPRp2VZlOLyuunUkicYY5zqoZib9Sw6jpRAmdhN3j0wNWnIMibgUJp2sOE6opb2XbSwUZZQI5w.jpeg\")
<\/figure><\/div>\n\n
<\/figure><\/div>\n\n\u80bf\u7624\u65b0\u751f\u6297\u539f\u7b5b\u67e5\u8054\u76df<\/div>\n
5. \u7cbe\u51c6\u533b\u7597\u672a\u6765\u5c55\u671b<\/div>\n
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1\uff09\u56fd\u5185\u7cbe\u51c6\u533b\u7597\u9886\u57df\u53d1\u5c55\u8fc5\u731b\uff0c\u4f46\u662f\u5728\u7cbe\u51c6\u7528\u836f\u65b9\u9762\u8fd8\u662f\u76f8\u5bf9\u6ede\u540e\uff0c\u540c\u56fd\u5916\u8bb8\u591a\u6210\u719f\u4ea7\u54c1\u76f8\u6bd4\u5728\u65f6\u95f4\u4e0a\u5df2\u5f62\u6210\u5dee\u8ddd\u3002\u7cbe\u51c6\u533b\u7597\u5230\u6700\u540e\u8fd8\u662f\u56de\u5230\u6709\u836f\u53ef\u7528\uff0c\u76ee\u524d\u7684\u60c5\u51b5\u662f\u6709\u4e86\u6cbb\u7597\u65b9\u6848\u4ee5\u540e\uff0c\u5374\u6ca1\u6709\u5bf9\u5e94\u7684\u836f\u7269\uff0c\u6211\u8ba4\u4e3a\u8fd9\u662f\u963b\u788d\u7cbe\u51c6\u533b\u7597\u53d1\u5c55\u7684\u5173\u952e\u56e0\u7d20\u4e4b\u4e00\u3002<\/div>\n
2\uff09\u76ee\u524d\u4e2d\u56fd\u7684\u65b0\u836f\u7814\u53d1\u4ee5\u53ca\u514d\u75ab\u6cbb\u7597\u65b9\u9762\u4e0e\u897f\u65b9\u56fd\u5bb6\u76f8\u6bd4\u8fd8\u6709\u4e00\u5b9a\u5dee\u8ddd\uff0c\u8fd9\u4e5f\u7ed9\u56fd\u5185\u4f01\u4e1a\u63d0\u4f9b\u4e86\u975e\u5e38\u5927\u7684\u673a\u4f1a\uff0c\u56e0\u6b64\u5728\u4e00\u4e9b\u65b0\u5174\u673a\u4f1a\u51fa\u73b0\u7684\u65f6\u5019\uff0c\u4f1a\u6709\u4e00\u4e9b\u4f01\u4e1a\u4f1a\u4e3a\u4e3a\u4e86\u77ed\u6682\u7684\u5229\u76ca\u800c\u505a\u51fa\u4e00\u4e9b\u7834\u574f\u5e02\u573a\u7684\u884c\u4e3a\uff0c\u8fd9\u662f\u4e0d\u79d1\u5b66\u4e0d\u5408\u7406\u4e5f\u4e0d\u5b89\u5168\u7684\uff0c\u6240\u4ee5\u5728\u6b64\uff0c\u6211\u4e5f\u5e0c\u671b\u884c\u4e1a\u4ece\u4e1a\u8005\u90fd\u80fd\u79c9\u6301\u521d\u5fc3\uff0c\u5171\u540c\u63a8\u52a8\u884c\u4e1a\u53d1\u5c55\uff0c\u5171\u540c\u62b5\u5236\u548c\u907f\u514d\u4e00\u4e9b\u8fdd\u80cc\u6cd5\u5f8b\u548c\u9053\u5fb7\u7684\u4ea7\u54c1\u51fa\u73b0\uff0c\u5e76\u505a\u51fa\u865a\u5047\u5ba3\u4f20\uff0c\u5bf9\u884c\u4e1a\u53d1\u5c55\u9020\u6210\u963b\u788d\u3002<\/div>\n
3\uff09\u540c\u65f6\u4e2d\u56fd\u80bf\u7624\u75c5\u4eba\u6570\u91cf\u57fa\u6570\u5927\uff0c\u968f\u7740\u7ecf\u6d4e\u7684\u53d1\u5c55\uff0c\u5bf9\u65b0\u578b\u6cbb\u7597\u7684\u63a5\u53d7\u5ea6\u4e5f\u8d8a\u6765\u8d8a\u9ad8\uff0c\u5728\u5065\u5eb7\u533b\u7597\u5927\u7684\u80cc\u666f\u4e4b\u4e0b\uff0c\u968f\u7740\u66f4\u591a\u7684\u4eba\u624d\u548c\u5176\u4ed6\u8d44\u6e90\u7684\u8fdb\u5165\uff0c\u524d\u666f\u975e\u5e38\u597d\uff0c\u671f\u5f85\u80bf\u7624\u80fd\u65e9\u65e5\u6210\u4e3a\u4e00\u79cd\u6162\u6027\u75c5\uff0c\u901a\u8fc7\u836f\u7269\u6216\u8005\u5176\u4ed6\u6cbb\u7597\u65b9\u5f0f\u80fd\u5ef6\u957f\u75c5\u4eba\u7684\u751f\u5b58\u671f\u548c\u63d0\u5347\u75c5\u4eba\u7684\u751f\u5b58\u8d28\u91cf\uff0c\u8fd9\u662f\u5927\u5bb6\u6240\u671f\u5f85\u7684\u7406\u60f3\u72b6\u6001\uff0c\u540c\u65f6\u56fd\u5bb6\u4e5f\u5728\u5236\u5b9a\u66f4\u591a\u7684\u653f\u7b56\u6765\u652f\u6301\u5e02\u573a\u53d1\u5c55\uff0c\u5e02\u573a\u63a8\u8fdb\u653f\u7b56\u7684\u6a21\u5f0f\uff0c\u56e0\u6b64\u662f\u673a\u9047\u4e5f\u662f\u6311\u6218\u3002<\/div>\n
4\uff09\u884c\u4e1a\u5feb\u901f\u53d1\u5c55\u4f34\u968f\u6d4b\u5e8f\u884c\u4e1a\u800c\u53d1\u5c55\u8d77\u6765\u7684\uff0c\u6d4b\u5e8f\u884c\u4e1a\u7684\u4e0a\u6e38\u6d4b\u5e8f\u548c\u8bd5\u5242\u90fd\u638c\u63a7\u5728\u5916\u56fd\u624b\u4e0a\uff0c\u6ca1\u6709\u592a\u591a\u8bae\u4ef7\u80fd\u529b\uff0c\u5bfc\u81f4\u6210\u672c\u8fc7\u9ad8\uff0c\u540c\u65f6\u56e0\u4e3a\u75c5\u4eba\u63a5\u53d7\u80fd\u529b\u7684\u9650\u5236\uff0c\u6309\u7167\u5408\u89c4\u7684\u6d41\u7a0b\u6765\u8fdb\u884c\u64cd\u4f5c\uff0c\u4ea7\u54c1\u5f88\u96be\u6709\u7a7a\u95f4\u6765\u8fdb\u884c\u76c8\u5229\uff0c\u5982\u679c\u6709\u4e00\u4e2a\u5f3a\u52b2\u7684\u7ade\u4e89\u5bf9\u624b\u7684\u51fa\u73b0\u53ef\u80fd\u4f1a\u6253\u7834\u73b0\u5728\u7684\u50f5\u5c40\uff0c\u4ece\u800c\u4ea7\u751f\u964d\u4ef7\u673a\u4f1a<\/div>\n
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\u00a0<\/div>\n
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\u8bb0\u8005\uff1a\u4e01\u6167 |\u7f16\u8005\uff1a\u5c18\u7070<\/div>\n
\u6821\u5bf9\uff1aCindy |\u5ba1\u6838\uff1a\u8292\u679c<\/div>\n
———- END———-<\/div>\n
\u00a0<\/div>\n
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