{"id":11563,"date":"2018-01-15T07:50:34","date_gmt":"2018-01-14T23:50:34","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMzE4MzU3NA==&#038;mid=504150374&#038;idx=1&#038;sn=170fc7d2ed9d6a6751802c02b4597aab&#038;chksm=7371995f44061049ca887d16c006fb00534408528f720920b8afddb9e52705d7e8666fbecea4#rd"},"modified":"2026-04-09T09:32:40","modified_gmt":"2026-04-09T01:32:40","slug":"9710052","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2018\/01\/15\/9710052\/","title":{"rendered":"\u4e13\u8bbf\u5965\u7ef4\u68ee\u57fa\u56e0\u8054\u5408\u521b\u59cb\u4eba\u5f20\u65ed\uff1a\u8ba9\u57fa\u56e0\u6280\u672f\u670d\u52a1\u4eba\u4eba\u5065\u5eb7 | \u5927\u5496\u8bba\u506568\u671f"},"content":{"rendered":"<p><!-- wechat_content_hash: ad4b9a93bf0a617b --><\/p>\n<div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/eicZhoGYCfyYibEO9O47lTicPSYJWgGr8GyjhE8LHBLsaZHqBhyHUJjwScOQjwG5290rxVMcOzaeE8hNwIbxSibbDQ.jpg\" alt=\"eicZhoGYCfyYibEO9O47lTicPSYJWgGr8GyjhE8LHBLsaZHqBhyHUJjwScOQjwG5290rxVMcOzaeE8hNwIbxSibbDQ\"\/><\/figure><\/div>\n\n<\/div>\n<div><\/div>\n<div>\u5173\u952e\u8bcd\uff1a\u51dd\u5fc3\u805a\u529b \u878d\u5408\u53d1\u5c55 \u670d\u52a1\u5927\u4f17<\/div>\n<div>\u5927\u7ea6\u7528\u65f6\uff1a10\u5206\u949f<\/div>\n<div><\/div>\n<div>\u5bfc\u8bed<\/div>\n<div>2017\u5e74\u5e95\uff0c\u5965\u7ef4\u68ee\u533b\u5b66\u4e2d\u5fc3\u5728\u5929\u6d25\u7a7a\u6e2f\u5f00\u5e55\uff08<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&amp;mid=2247486628&amp;idx=1&amp;sn=94aa0191533a4bc076f4bc789c7ea5d9&amp;scene=21#wechat_redirect\" 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src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/eicZhoGYCfyZf0Z3uDficqrfyg60nJ3VnKf9YPPMu4IKcBHGXQL6EaOujU0RDhATwjSCcoptH4tTuNKqKetsia3QQ.jpeg\" 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\u4ece\u5357\u5f00\u5927\u5b66\u751f\u79d1\u9662\u5230\u534e\u5927\u57fa\u56e0<\/div>\n<div>\u3010\u57fa\u56e0\u6167\u3011\u5f20\u603b\uff0c\u60a8\u597d\uff01\u6309\u7167\u60ef\u4f8b\uff0c\u54b1\u4eec\u5148\u8c08\u8c08\u60a8\u7684\u80cc\u666f\u3002\u60a82005\u5e74\u6bd5\u4e1a\u4e8e\u5357\u5f00\u5927\u5b66\u751f\u547d\u79d1\u5b66\u5b66\u9662\uff0c\u90a3\u65f6\u5019\u5305\u62ec\u6211\u5728\u5185\u9762\u4e34\u7740\u4e00\u4e2a\u771f\u5b9e\u7684\u201c\u8c0e\u8a00\u201d\uff1a\u201c21\u4e16\u7eaa\u5c06\u662f\u751f\u7269\u5b66\u7684\u4e16\u7eaa\u201d\u3002\u8fd9\u4e2a\u201c\u8c0e\u8a00\u201d\u73b0\u5728\u53d8\u6210\u73b0\u5b9e\u4e86\uff0c\u4f46\u57282007\u5e74\u534e\u5927\u57fa\u56e0\u5357\u4e0b\u6df1\u5733\u6269\u62db\u4e4b\u524d\uff0c\u5bf9\u4e8e\u751f\u7269\u76f8\u5173\u4e13\u4e1a\u9886\u57df\u7684\u6bd5\u4e1a\u751f\uff0c\u5c31\u4e1a\u548c\u804c\u4e1a\u89c4\u5212\u90fd\u662f\u6bd4\u8f83\u6a21\u7cca\u7684\uff0c12\u5e74\u8fc7\u53bb\u4e86\uff0c\u60a8\u5f53\u65f6\u600e\u4e48\u7b03\u5b9a\u8fd9\u884c\u7ee7\u7eed\u5e72\u4e0b\u53bb\u5462\uff1f<\/div>\n<div>\u3010\u5f20\u65ed\u3011\u8fd9\u662f\u4e2a\u975e\u5e38\u6709\u610f\u601d\u7684\u95ee\u9898\u3002\u4e4b\u524d\u5728\u77e5\u4e4e\u4e0a\u6211\u4e5f\u88ab\u95ee\u5230\u7c7b\u4f3c\u5bf9\u4e8e\u8003\u5927\u5b66\u586b\u62a5\u751f\u7269\u7c7b\u5fd7\u613f\u600e\u4e48\u770b\u3001\u5bf9\u4e8e\u751f\u7269\u4ea7\u4e1a\u7684\u53d1\u5c55\u600e\u4e48\u770b\u7b49\u7b49\u95ee\u9898\u3002\u5bf9\u4e8e\u57fa\u56e0\u6167\u7684\u8fd9\u4e2a\u95ee\u9898\uff0c\u6211\u60f3\u7528\u6211\u5728\u534e\u5927\u76843\u6bb5\u7ecf\u5386\u6765\u56de\u7b54\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u9009\u62e9\u534e\u5927\uff1a2005\u5e74\u6211\u4ece\u5357\u5f00\u6bd5\u4e1a\u540e\u4e00\u76f4\u5728\u5929\u6d25\u4e00\u5bb6\u751f\u7269\u516c\u53f8\u5de5\u4f5c\u3002\u4e8b\u5b9e\u4e0a\u6211\u4ece\u51fa\u751f\u5230\u4e0a\u5927\u5b66\u518d\u5230\u5de5\u4f5c\uff0c\u4ece\u672a\u79bb\u5f00\u8fc7\u5929\u6d25\uff0c\u8fd9\u53ef\u80fd\u662f\u4e00\u4e2a\u6807\u51c6\u5929\u6d25\u4eba\u7684\u751f\u6d3b\u65b9\u5f0f\u3002\u57282006\u5e74\u5143\u65e6\u671f\u95f4\u6211\u8bfb\u4e86\u6768\u7115\u660e\u8001\u5e08\u5173\u4e8e\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u7684\u4e00\u672c\u4e66\uff0c\u91cc\u9762\u7684\u5185\u5bb9\u6df1\u6df1\u7684\u9707\u64bc\u4e86\u6211\u3002\u4e8e\u662f\u6211\u505a\u4e86\u4e2a\u91cd\u8981\u7684\u51b3\u5b9a\uff0c\u4e00\u5b9a\u8981\u8d70\u51fa\u53bb\uff01\u56e0\u4e3a\u5f53\u65f6\u5929\u6d25\u7684\u751f\u7269\u4ea7\u4e1a\u53d1\u5c55\u6b65\u4f10\u76f8\u5bf9\u8f83\u7f13\uff0c\u6211\u5e0c\u671b\u6709\u673a\u4f1a\u80fd\u4e0e\u884c\u4e1a\u9876\u7ea7\u7684\u5927\u4f6c\u4eec\u4e00\u8d77\u5de5\u4f5c\uff0c\u5411\u4ed6\u4eec\u5b66\u4e60\uff0c\u5feb\u901f\u6210\u957f\u3002\u56e0\u6b64\uff0c\u9010\u6e10\u5f00\u59cb\u641c\u5bfb\u5317\u4eac\u7684\u76f8\u5173\u5de5\u4f5c\u673a\u4f1a\u3002\u5728\u6536\u5230\u7684\u51e0\u4efdoffer\u91cc\uff0c\u5317\u4eac\u534e\u5927\u57fa\u56e0\u7814\u7a76\u4e2d\u5fc3\u6700\u4e3a\u5438\u5f15\u6211\uff0c\u56e0\u4e3a\u8fd9\u662f\u6768\u7115\u660e\u8001\u5e08\u5de5\u4f5c\u7684\u5730\u65b9\u3002\u5b66\u751f\u7269\u7684\u540c\u5b66\u90fd\u77e5\u9053\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u4e2d\u56fd\u90e8\u5206\u662f\u7531\u534e\u5927\u57fa\u56e0\u7275\u5934\u627f\u62c5\u5e76\u5408\u4f5c\u5b8c\u6210\u7684\u3002\u56e0\u6b64\uff0c\u6211\u6bc5\u7136\u51b3\u7136\u8f9e\u6389\u5f53\u65f6\u7684\u5de5\u4f5c\uff0c\u5954\u5f80\u5f53\u65f6\u5728\u5730\u56fe\u4e0a\uff08\u5f53\u65f6\u5317\u4eac\u7684\u5730\u56fe\u53ea\u5230\u4e94\u73af\uff09\u90fd\u627e\u4e0d\u5230\u7684\u2014\u2014\u5317\u4eac\u534e\u5927\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u9009\u62e9\u9500\u552e\uff1a\u534e\u5927\u603b\u90e8\u5728\u642c\u53bb\u6df1\u5733\u4e4b\u524d\uff0c\u53ea\u6709\u5317\u4eac\u548c\u676d\u5dde\u4e24\u4e2a\u57fa\u5730\uff08\u676d\u5dde\u534e\u5927\u662f\u505a\u6c34\u7a3b\u57fa\u56e0\u7ec4\u65f6\u5efa\u7acb\u7684\uff09\uff0c\u53e6\u5916\u5728\u4e0a\u6d77\u8fd8\u6709\u4e2a\u534e\u5927\u5929\u6e90\uff08\u73b0\u8f89\u6e90\u751f\u7269\uff09\u505a\u836f\u7269\u7b5b\u9009\u3002\u6211\u662f2006\u5e743\u6708\u52a0\u5165\u5317\u4eac\u534e\u5927\uff0c\u8fdb\u5165\u4e86\u5f53\u65f6\u7684\u201c\u5927\u5e73\u53f0\u5e02\u573a\u90e8\u201d\u3002\u90a3\u65f6\u4efb\u5927\u5e73\u53f0\u7684\u8d1f\u8d23\u4eba\u662f\u738b\u4fca\uff0c\u5e02\u573a\u90e8\u7684\u8d1f\u8d23\u4eba\u662f\u6768\u723d\u3002\u6700\u521d\u53ea\u67094\u540d\u9500\u552e\uff0c\u5176\u4e2d\u5305\u62ec\u6211\u3002\u7531\u4e8e\u5f53\u65f6\u534e\u5927\u5c1a\u672a\u5bf9\u5916\u6b63\u5f0f\u505a\u8fc7\u5e02\u573a\uff0c\u9500\u552e\u7684\u6280\u672f\uff08\u670d\u52a1\uff09\u4e5f\u672a\u6574\u7406\u6e05\u695a\u3002\u56e0\u6b64\uff0c\u6211\u4eec4\u4eba\u6e38\u8d70\u5728\u534e\u5927\u7684\u5404\u4e2a\u90e8\u95e8\uff0c\u641c\u5bfb\u76f8\u5bf9\u6210\u719f\u7684\u4ea7\u54c1\u548c\u670d\u52a1\uff0c\u7136\u540e\u56de\u6765\u81ea\u5df1\u7f16\u5199\u4ea7\u54c1\u76ee\u5f55\u3001\u8bbe\u8ba1\u4ea7\u54c1\u76ee\u5f55\u3001\u8bbe\u8ba1\u53d6\u6837\u5305\u88c5\u3001\u8bbe\u8ba1\u6837\u54c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Next Generation Sequencing\uff09\u7684\uff1a454\u7cfb\u7edf\uff08\u7126\u78f7\u9178\u6d4b\u5e8f\uff09\u3001Solexa\u7cfb\u7edf\uff08\u8fb9\u5408\u6210\u8fb9\u6d4b\u5e8f\uff09\u548cSOLiD\u7cfb\u7edf\uff08\u8fb9\u8fde\u63a5\u8fb9\u6d4b\u5e8f\uff09\u3002\u8fd9\u4e9b\u6280\u672f\u7684\u51fa\u73b0\u5bf9\u4e8e\u4f20\u7edf\u7684\u4f4e\u901a\u91cf\u6d4b\u5e8f\u6280\u672f\u662f\u4e2a\u975e\u5e38\u5927\u7684\u98a0\u8986\u6027\u521b\u65b0\uff0c\u52bf\u5fc5\u4f1a\u52a9\u529b\u4ea7\u4e1a\u5347\u7ea7\u3002\u6b64\u5916\uff0c\u6709\u4e00\u4e2a\u4e0d\u5f97\u4e0d\u53bb\u5173\u6ce8\u7684\u91cd\u70b9\u2014\u2014\u6d4b\u5e8f\u6210\u672c\u3002\u968f\u7740\u6280\u672f\u7684\u53d1\u5c55\uff0c\u6d4b\u5e8f\u6210\u672c\u7684\u4e0b\u964d\u901f\u5ea6\u4e0d\u65ad\u8d85\u8d8a\u6469\u5c14\u5b9a\u5f8b\uff08Moore\u2019s Law\uff09\u3002\u8fd9\u4e24\u4e2a\u8d8b\u52bf\u4f7f\u5f97\u4e4b\u524d\u5355\u4e2a\u5b9e\u9a8c\u5ba4\u65e0\u6cd5\u627f\u63a5\u57fa\u56e0\u7ec4\u5b66\u7814\u7a76\uff0c\u4ee5\u53ca\u5355\u4e2a\u673a\u6784\u6216\u5b9e\u9a8c\u5ba4\u65e0\u6cd5\u8d1f\u62c5\u9ad8\u6602\u7684\u7814\u7a76\u6210\u672c\u53d8\u4e3a\u53ef\u80fd\u30022007\u5e74\uff0c\u4e2d\u56fd\u519c\u79d1\u9662\u852c\u83dc\u82b1\u5349\u7814\u7a76\u6240\u9ec4\u4e09\u6587\u6559\u6388\u8bfe\u9898\u7ec4\u4e0e\u534e\u5927\u57fa\u56e0\u5408\u4f5c\u4e86\u9ec4\u74dc\u57fa\u56e0\u7ec4\uff0c\u540e\u6765\u4e5f\u987a\u5229\u53d1\u8868\u5728\u300aNature Genetics\u300b\u6742\u5fd7\uff0c\u5373\u8bf4\u660e\u4e86\u8fd9\u4e2a\u73b0\u5b9e\u3002\u56e0\u6b64\uff0c\u6211\u5f53\u65f6\u5c31\u89c9\u5f97\u4eba\u7c7b\u57fa\u56e0\u7ec4\u57282003\u5e74\u5b8c\u6210\u540e\u6240\u5e26\u6765\u7684\u53d1\u73b0\uff0c\u5728NGS\u6280\u672f\u6210\u719f\u540e\u5fc5\u5c06\u4f1a\u66f4\u5bb9\u6613\u83b7\u5f97\u5927\u91cf\u63a8\u52a8\u533b\u5b66\u548c\u4eba\u7c7b\u53d1\u5c55\u7684\u6570\u636e\u548c\u6210\u679c\uff0c\u4e5f\u5fc5\u5c06\u60e0\u53ca\u8001\u767e\u59d3\u7684\u533b\u7597\u5065\u5eb7\uff0c\u8fd9\u5e94\u8be5\u624d\u662f\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u7b49\u7684\u521d\u8877\u3002<\/div>\n<div>\u6240\u4ee5\u4f60\u95ee\u6211\u4e3a\u4ec0\u4e48\u90a3\u65f6\u5c31\u7b03\u5b9a\u7684\u5728\u8fd9\u4e2a\u884c\u4e1a\u575a\u6301\u5e72\u4e0b\u53bb\uff0c\u76f8\u4fe1\u4ee5\u4e0a\u8fd9\u51e0\u70b9\u8db3\u4ee5\u8bf4\u660e\u3002<\/div>\n<div>\u00a0<\/div>\n<div>2. 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Innovation Center \u5341\u56db\u5c42\u79df\u4e86\u4e00\u95f4\u5c0f\u529e\u516c\u5ba4\u4f5c\u4e3aBGI Americas \u7684\u603b\u90e8\uff0c\u4f46\u6211\u4eec\uff08Julia, Paul, Zhuo &amp; Xu\u7b49\uff09\u5e72\u7684\u5f88\u5356\u529b\u4e5f\u5f88\u5f00\u5fc3\u3002\u9009\u62e9\u5728\u8fd9\u91cc\u529e\u516c\u662f\u56e0\u4e3a\u6211\u4eec\u5bf9\u9762\u5c31\u662f\u5f53\u65f6\u5168\u7403\u6700\u5927\u7684\u57fa\u56e0\u7ec4\u5b66\u4e2d\u5fc3\u2014\u2014Broad Institute\u3002\u7ecf\u8fc7\u51e0\u4e2a\u6708\u7684\u4e0d\u65ad\u52aa\u529b\uff0c\u4e8e2010\u5e749\u6708\uff0c\u4fc3\u6210\u534e\u5927\u57fa\u56e0\u4e0eMerck\u5236\u836f\u516c\u53f8\u7f8e\u56fd\u603b\u90e8\u7b7e\u7f72\u4e86\u4e3a\u671f5\u5e74\u7684\u8d85\u8fc7\u5343\u4e07\u7f8e\u5143\u7684\u7814\u53d1\u5927\u5355\u3002\u4e4b\u540e\uff0c\u6211\u4eec\u5728\u8d39\u57ce\u513f\u7ae5\u533b\u9662\uff08CHOP\uff09\u548c\u52a0\u5dde\u5927\u5b66\u6234\u7ef4\u65af\uff08UC Davis\uff09\u5206\u6821\u5404\u5efa\u7acb\u4e86\u672c\u5730\u5b9e\u9a8c\u5ba4\u505a\u79d1\u7814\u548c\u4e34\u5e8a\u7684\u6d4b\u5e8f\u6570\u636e\u4ea4\u4ed8\u30022012\u5e744\u6708\u6211\u56de\u56fd\u5de5\u4f5c\u4e4b\u524d\uff0c\u7f8e\u6d32\u534e\u5927\u5728\u5317\u7f8e\u4e0e\u6392\u540d\u524d20\u7684\u836f\u5382\u4e2d\u768419\u5bb6\u90fd\u7b7e\u7f72\u4e86\u79d1\u7814\u5408\u4f5c\u534f\u8bae\uff0c\u7f8e\u6d32\u534e\u5927\u7684\u9500\u552e\u8d21\u732e\u4e5f\u6210\u4e3a\u5f53\u5e74\u534e\u5927\u57fa\u56e0\u5168\u7403\u6d4b\u5e8f\u5e02\u573a\u4e2d\u4efd\u989d\u4ec5\u6b21\u4e8e\u5927\u4e2d\u534e\u533a\u7684\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u4ece\u7f8e\u6d32\u534e\u5927\u56de\u56fd\u540e\uff0c\u6536\u5230\u5f53\u65f6\u4efb\u534e\u5927\u57fa\u56e0\u5317\u4e2d\u56fd\u533a\u8d1f\u8d23\u4eba\u7530\u57c2\u7684\u9080\u8bf7\uff0c\u53bb\u8d1f\u8d23\u521d\u5efa\u72b6\u6001\u7684\u5929\u6d25\u534e\u5927\u3002\u5728\u534e\u5927\u7684\u8fd9\u51e0\u6b21\u5de5\u4f5c\u8c03\u52a8\u4e2d\uff0c\u90fd\u50cf\u662f\u5728\u5185\u90e8\u521b\u4e1a\u3002\u7d27\u63a5\u7740\uff0c\u6768\u73b2\u3001\u502a\u57f9\u76f8\u3001\u6613\u946b\u7b49\u9646\u7eed\u52a0\u5165\u4e86\u5929\u6d25\u534e\u5927\uff0c\u5728\u6768\u73b2\u8001\u5e08\u7684\u5e26\u9886\u4e0b\u5927\u5bb6\u642d\u73ed\u4e00\u8d77\u628a\u5929\u6d25\u534e\u5927\u4ece2012\u5e74\u6700\u521d\u7684\u5341\u51e0\u4e2a\u4eba\u505a\u52302014\u5e74\u7684\u4e24\u767e\u591a\u4eba\uff0c\u5e74\u6536\u5165\u4ece8\u4e07\u5143\u52303200\u4e07\u5143\u3002\u671f\u95f4\uff0c\u5929\u6d25\u534e\u5927\u5b75\u5316\u6216\u4f18\u5316\u4e86\u5f88\u591a\u534e\u5927\u533b\u5b66\u65e9\u671f\u4ea7\u54c1\uff1aNIFTY\u3001\u8033\u804b\u3001\u65b0\u7b5b\u3001\u8001\u5e74\u75c5\u3001PGD\u3001\u5b55\u524d\u3001\u5973\u60274\u764c\u3001\u9057\u4f20\u6027\u80bf\u7624\u3001\u80bf\u7624O-Seq\u7b49\u3002\u4e5f\u5c31\u662f\u5728\u8fd9\u671f\u95f4\uff0c\u56e0\u4e3a\u8ddd\u79bb\u7814\u53d1\u56e2\u961f\u6bd4\u8f83\u8fd1\uff0c\u6211\u5b66\u4e60\u4e86\u5f88\u591a\u533b\u5b66\u8f6c\u5316\u7684\u77e5\u8bc6\u3002\u56e0\u4e3a\u5927\u90fd\u662f\u5728\u5929\u6d25\u7814\u53d1\u5b75\u5316\u7684\u4ea7\u54c1\uff0c\u65e9\u671f\u63a8\u5e7f\u90fd\u662f\u6211\u5e26\u961f\u51fa\u53bb\uff0c\u4e5f\u7ec3\u5c31\u4e86\u6211\u5728\u533b\u5b66\u5e02\u573a\u4e0a\u7684\u4e00\u4e9b\u7ecf\u9a8c\u3002\u8fd9\u4e5f\u4e3a\u6211\u540e\u6765\u521b\u4e1a\u7684\u51b2\u52a8\u4e70\u4e0b\u4e86\u5f88\u6df1\u7684\u4f0f\u7b14\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u3010\u57fa\u56e0\u6167\u3011\u60a8\u5728\u7f8e\u6d32\u534e\u5927\u7684\u8fd9\u6bb5\u7ecf\u5386\u5f88\u4e30\u5bcc\uff0c\u4ece\u90a3\u4e4b\u540e\uff0c\u5bf9\u4e8e\u521b\u4e1a\u4e00\u5b9a\u6709\u4e86\u66f4\u6df1\u7684\u7406\u89e3\u548c\u60f3\u6cd5\uff0c\u90a3\u548c\u6587\u8001\u5e08\u4e00\u8d77\u521b\u529e\u5965\u7ef4\u68ee\u7684\u521d\u5fc3\u662f\u4ec0\u4e48\uff1f<\/div>\n<div>\u3010\u5f20\u65ed\u3011\u5728\u534e\u5927\u5de5\u4f5c10\u5e74\uff0c\u5728\u5404\u4f53\u7cfb\u5404\u5c97\u4f4d\u953b\u70bc\u4e8610\u5e74\u3002\u5728\u8fd9\u671f\u95f4\u840c\u53d1\u4e86\u5f88\u591a\u60f3\u6cd5\u548c\u611f\u609f\uff0c\u800c\u4e14\u6709\u4e9b\u4e8b\u53ea\u80fd\u5728\u534e\u5927\u4f53\u7cfb\u5916\u624d\u597d\u5b9e\u73b0\u3002\u56e0\u6b64\uff0c\u6211\u9009\u62e9\u4e86\u521b\u4e1a\u3002\u800c\u521b\u4e1a\u7684\u4f19\u4f34\u517c\u5bfc\u5e08\u5219\u662f\u5f53\u5e74\u4e00\u8d77\u625b\u8fc7\u67aa\u6253\u8fc7\u4ed7\u7684\u6587\u6d01\u8001\u5e08\u3002\u6587\u8001\u5e08\u4e00\u76f4\u662f\u6211\u7684\u8001\u5e08\uff0c\u777f\u667a\u4e14\u6709\u5927\u667a\u6167\uff0c\u53ef\u4ee5\u975e\u5e38\u8f7b\u677e\u9762\u5bf9\u8bb8\u591a\u8270\u96be\u7684\u6311\u6218\u548c\u56f0\u5883\u3002\u9009\u62e9\u6587\u8001\u5e08\u4f5c\u4e3a\u521b\u4e1a\u4f19\u4f34\uff0c\u662f\u56e0\u4e3a\u5979\u4e0d\u4ec5\u5728\u57fa\u56e0\u7ec4\u5b66\u9886\u57df\u6709\u5353\u8d8a\u6210\u5c31\uff0c\u5728\u8bca\u65ad\u8bd5\u5242\u3001\u75ab\u82d7\u7b49\u65b9\u9762\u4e5f\u662f\u6210\u7ee9\u4e0d\u83f2\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u6211\u4eec\u521b\u7acb\u5965\u7ef4\u68ee\uff0c\u7ec8\u6781\u76ee\u6807\u662f\u8981\u8ba9\u57fa\u56e0\u79d1\u6280\u6240\u5e26\u6765\u7684\u5e94\u7528\u66f4\u591a\u7684\u670d\u52a1\u4e8e\u79d1\u7814\u7528\u6237\u548c\u5927\u4f17\u7684\u533b\u7597\u5065\u5eb7\u3002\u5965\u7ef4\u68ee\uff08allwegene\uff09\u4ece\u57fa\u56e0\uff08gene\uff09\u8fd9\u4e2a\u6982\u5ff5\u51fa\u53d1\uff0c\u89e3\u91ca\u57fa\u56e0\u548c\u4eba\u4eec\uff08we\uff09\u4e4b\u95f4\u7684\u5173\u7cfb\uff0c\u8fdb\u800c\u6765\u89e3\u91ca\u57fa\u56e0\u548c\u6240\u6709\u7269\u79cd\uff08all\uff09\u4e4b\u95f4\u7684\u5173\u7cfb\u3002\u8fd9\u5c31\u662fallwegene\u540d\u5b57\u7684\u7531\u6765\u3002<\/div>\n<div>\u00a0<\/div>\n<div>3. \u751f\u4e8e\u5929\u6d25\uff0c\u6bd5\u4e1a\u5929\u6d25\uff0c\u56de\u5f52\u5929\u6d25<\/div>\n<div>\u3010\u57fa\u56e0\u6167\u3011\u60a8\u66fe\u5728\u5357\u5f00\u8bfb\u4e66\uff0c\u53c8\u8d1f\u8d23\u8fc7\u5929\u6d25\u534e\u5927\u7684\u6574\u4f53\u8fd0\u8425\u5de5\u4f5c\uff0c\u73b0\u5728\u53c8\u518d\u6b21\u56de\u5230\u5929\u6d25\u521b\u7acb\u5965\u7ef4\u68ee\u533b\u5b66\u4e2d\u5fc3\uff0c\u6709\u8863\u9526\u8fd8\u4e61\u7684\u611f\u89c9\u5417\uff1f\u8fd8\u662f\u767e\u6298\u5343\u56de\uff1f\u4ece\u4ece\u4e1a\u548c\u521b\u4e1a\u89d2\u5ea6\u3002<\/div>\n<div>\u3010\u5f20\u65ed\u3011\u867d\u7136\u4ece\u5357\u5f00\u6bd5\u4e1a\uff0c\u4e4b\u524d\u4e5f\u5728\u5929\u6d25\u534e\u5927\u5de5\u4f5c\u8fc7\uff0c\u4f46\u76ee\u524d\u5728\u4e8b\u4e1a\u4e0a\u8fd8\u672a\u505a\u5230\u8ba9\u81ea\u5df1\u8ba4\u53ef\u7684\u6210\u5c31\u3002\u6b64\u6b21\u56de\u5230\u5929\u6d25\u521b\u7acb\u5965\u7ef4\u68ee\u533b\u5b66\u4e2d\u5fc3\u5176\u5b9e\u662f\u4f5c\u4e3a\u6d77\u6cb3\u513f\u5973\u501f\u6545\u4e61\u5929\u6d25\u8fd9\u65b9\u5b9d\u5730\u5b9e\u73b0\u81ea\u5df1\u7684\u521b\u4e1a\u76ee\u6807\uff0c\u8c08\u4e0d\u4e0a\u8863\u9526\u8fd8\u4e61\u3002<\/div>\n<div>\u9009\u62e9\u5929\u6d25\u4f5c\u4e3a\u5965\u7ef4\u68ee\u7684\u533b\u5b66\u4e2d\u5fc3\uff0c\u4e00\u65b9\u9762\u662f\u987a\u5e94\u4e86\u56fd\u5bb6\u5bf9\u4e8e\u4eac\u6d25\u5180\u4e00\u4f53\u5316\u5927\u601d\u8def\u5927\u53d1\u5c55\u5927\u6218\u7565\u7684\u91cd\u8981\u6307\u793a\u3002\u6211\u4eec\u8ba4\u4e3a\u4eac\u6d25\u5180\u4e00\u4f53\u5316\u4f7f\u5f97\u5929\u6d25\u653f\u5e9c\u5bf9\u751f\u7269\u533b\u836f\u884c\u4e1a\u751f\u6001\u7684\u53d1\u5c55\u653f\u7b56\u3001\u4eba\u624d\u7684\u805a\u96c6\u653f\u7b56\u3001\u7814\u53d1\u7684\u4fc3\u8fdb\u653f\u7b56\u7b49\u90fd\u8d77\u7740\u975e\u5e38\u91cd\u8981\u7684\u63a8\u52a8\u4f5c\u7528\u3002\u53e6\u4e00\u65b9\u9762\u5929\u6d25\u7684\u533b\u7597\u8d44\u6e90\u6709\u81ea\u5df1\u7684\u4f18\u52bf\uff1a\u5929\u6d25\u7684\u5987\u5e7c\u7cfb\u7edf\u662f\u5168\u56fd\u6700\u5065\u5168\u7684\u5987\u5e7c\u7f51\u7edc\u3001\u5929\u6d25\u80bf\u7624\u533b\u9662\u662f\u5168\u56fd\u6392\u540d\u524d\u4e09\u7684\u5927\u578b\u53ca\u5b66\u672f\u578b\u80bf\u7624\u533b\u9662\u3001\u5929\u6d25\u6cf0\u8fbe\u5fc3\u8840\u7ba1\u533b\u9662\u662f\u5168\u56fd\u8f83\u597d\u7684\u4e13\u79d1\u533b\u9662\u3001\u5929\u6d25\u4e2d\u5fc3\u5987\u4ea7\u79d1\u533b\u9662\u662f\u5168\u56fd\u6392\u540d\u9760\u524d\u7684\u8f85\u52a9\u751f\u6b96\u4e13\u79d1\u533b\u9662\u3001\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u8840\u6db2\u75c5\u7814\u7a76\u6240\u53c8\u662f\u767d\u8840\u75c5\u53caCAR-T\u505a\u7684\u975e\u5e38\u597d\u7684\u533b\u9662\u3002\u968f\u7740\u4eba\u53e3\u8001\u9f84\u5316\u548c\u4e8c\u80ce\u653f\u7b56\u7684\u5f00\u653e\uff0c\u5929\u6d25\u5bf9\u4e8e\u7cbe\u51c6\u533b\u5b66\u548c\u4eba\u4eba\u5065\u5eb7\u7684\u9700\u6c42\u4f1a\u9010\u6b65\u52a0\u5f3a\u3002\u6b64\u5916\uff0c\u4f5c\u4e3a\u5929\u6d25\u4eba\u6211\u70ed\u7231\u8fd9\u65b9\u571f\u5730\uff0c\u66f4\u70ed\u7231\u8fd9\u91cc\u7684\u4eba\u4eec\u3002\u9009\u62e9\u5728\u5929\u6d25\u521b\u7acb\u533b\u5b66\u4e2d\u5fc3\uff0c\u4e0d\u4ec5\u8981\u5bf9\u5929\u6d25\u533b\u836f\u884c\u4e1a\u7684\u57fa\u56e0\u6280\u672f\u5e94\u7528\u8f6c\u5316\u8d77\u5230\u5f15\u9886\u548c\u5e26\u52a8\u7684\u4f5c\u7528\uff0c\u66f4\u91cd\u8981\u7684\u662f\u4e3a\u5929\u6d25\u4eba\u6c11\u505a\u597d\u670d\u52a1\uff0c\u8ba9\u5929\u6d25\u771f\u6b63\u610f\u4e49\u4e0a\u5b9e\u73b0\u67d0\u4e9b\u75c5\u79cd\u7684\u7edd\u8ff9\uff0c\u63d0\u5347\u67d0\u4e9b\u75be\u75c5\u7684\u8bca\u65ad\u548c\u6cbb\u6108\u6982\u7387\uff0c\u4ece\u800c\u63d0\u5347\u4eba\u6c11\u7684\u6574\u4f53\u751f\u6d3b\u6c34\u5e73\u3002\u653f\u5e9c\u5f15\u9886\u793e\u4f1a\u5b9e\u73b0\u4eba\u4eba\u5c0f\u5eb7\uff0c\u5965\u7ef4\u68ee\u670d\u52a1\u767e\u59d3\u5b9e\u73b0\u4eba\u4eba\u5065\u5eb7\u3002<\/div>\n<div>\u00a0<\/div>\n<div>4. \u4ee5\u5fae\u751f\u7269\u4e3a\u521b\u4e1a\u5207\u5165\u70b9\u7684\u6838\u5fc3\u7ade\u4e89\u529b<\/div>\n<div>\u3010\u57fa\u56e0\u6167\u3011\u5965\u7ef4\u68ee\u6210\u7acb4\u5e74\u6765\uff0c\u4ece\u5317\u4eac\u603b\u90e8\u5230\u6210\u7acb\u5357\u4eac\u79d1\u6280\u516c\u53f8\u3001\u5929\u6d25\u533b\u5b66\u4e2d\u5fc3\uff0c\u76ee\u524d\u4e5f\u662f\u201c\u56fd\u5bb6\u9ad8\u65b0\u6280\u672f\u4f01\u4e1a\u201d\u3001\u201c\u4e2d\u5173\u6751\u9ad8\u65b0\u6280\u672f\u4f01\u4e1a\u201d\u3001\u201c\u79d1\u521b\u578b\u4f01\u4e1a\u201d\u548c\u201c\u4e2d\u5173\u6751\u77aa\u7f9a\u4f01\u4e1a\u201d\uff0c\u6700\u5f00\u59cb\u9009\u62e9\u5fae\u751f\u7269\u7ec4\u8fd9\u4e2a\u8d5b\u9053\u7684\u8003\u8651\u662f\u4ec0\u4e48\u5462\uff1f<\/div>\n<div>\u3010\u5f20\u65ed\u3011\u5965\u7ef4\u68ee\u4ece2015\u5e74\u4ee5\u6765\u53d1\u5c55\u8282\u594f\u786e\u5b9e\u6bd4\u8f83\u5feb\uff0c\u4e0d\u4f46\u662f\u56fd\u5bb6\u9ad8\u65b0\u4f01\u4e1a\u3001\u77aa\u7f9a\u4f01\u4e1a\u3001\u4e13\u5229\u8bd5\u70b9\u5355\u4f4d\uff0c\u53c8\u83b7\u5f97\u201c\u5317\u4eac\u5e02\u65b0\u6280\u672f\u65b0\u4ea7\u54c1\uff08\u670d\u52a1\uff09\u8ba4\u5b9a\u201d\u3001ISO 9001:2015\u8d28\u91cf\u7ba1\u7406\u4f53\u7cfb\u8ba4\u8bc1\uff0c\u540c\u65f6\u8fd8\u83b7\u5f97\u8fd130\u9879\u8f6f\u4ef6\u8457\u4f5c\u6743\u548c4\u9879\u53d1\u660e\u4e13\u5229\u3002\u76ee\u524d\u5728\u5317\u4eac\u6709\u79d1\u6280\u670d\u52a1\u677f\u5757\u7684\u5168\u56fd\u6570\u636e\u4ea4\u4ed8\u4e2d\u5fc3\u3001\u5065\u5eb7\u677f\u5757\u7684\u5168\u56fd\u8fd0\u8425\u4e2d\u5fc3\uff0c\u5728\u5357\u4eac\u6709\u79d1\u6280\u670d\u52a1\u677f\u5757\u7684\u5357\u4eac\u4e2d\u5fc3\uff0c\u5728\u5929\u6d25\u6709\u533b\u5b66\u4e2d\u5fc3\uff0c\u5728\u7f8e\u56fdNew Jersey\u7684Rutgus Univeristy\u6709\u8054\u5408\u5b9e\u9a8c\u5ba4\u3002<\/div>\n<div>\u6211\u4eec\u5f53\u521d\u9009\u62e9\u4ee5\u5fae\u751f\u7269\u4f5c\u4e3a\u521b\u4e1a\u7684\u8d77\u70b9\u548c\u6838\u5fc3\u7ade\u4e89\u529b\uff0c\u4e00\u65b9\u9762\u662f\u56e0\u4e3a\u6211\u4eec\u4ece2010\u5e74MetaHIT\u5f00\u59cb\u5c31\u4e00\u76f4\u5173\u6ce8\u5fae\u751f\u7269\u7ec4\u5b66\u7684\u53d1\u5c55\u3002\u968f\u7740\u4e8c\u4ee3\u3001\u4e09\u4ee3\u6d4b\u5e8f\u6280\u672f\u7684\u53d1\u5c55\uff0c\u6309\u7167\u6280\u672f\u9769\u65b0\u5fc5\u5c06\u5e26\u6765\u4ea7\u4e1a\u53d1\u5c55\u7684\u5b9a\u7406\uff0c\u5b8f\u57fa\u56e0\u7ec4\u4e0e\u6574\u4f53\u5fae\u751f\u7269\u7ec4\u7684\u7814\u7a76\u4ece2010\u5e74\u5f00\u59cb\u6bcf\u5e74\u5448\u73b0\u8d85\u8d8a\u4eba\u7c7b\u57fa\u56e0\u7ec4\u7814\u7a76\u6210\u5c31\u7684\u901f\u5ea6\u5728\u8de8\u8d8a\u53d1\u5c55\u3002\u80a0\u9053\u5fae\u751f\u7269\u57fa\u56e0\u7ec4\u4f5c\u4e3a\u4eba\u4f53\u7684\u7b2c\u4e8c\u57fa\u56e0\u7ec4\u662f\u5bf9\u7b2c\u4e00\u57fa\u56e0\u7ec4\u4fe1\u606f\u7684\u8865\u5145\u3002\u5373\u4e0d\u80fd\u5355\u7eaf\u7684\u770b\u4eba\u4f53\u672c\u8eab\u7684\u57fa\u56e0\u53ca\u8868\u8fbe\u60c5\u51b5\u6765\u8bca\u65ad\u75c5\u56e0\uff0c\u8fd8\u5e94\u5728\u4e00\u4e9b\u75be\u75c5\u9886\u57df\u52a0\u5f3a\u5fae\u751f\u7269\u7ec4\u7684\u5206\u6790\u6765\u5171\u540c\u786e\u8bca\u3002\u4eba\u4f53\u80a0\u9053\u5fae\u751f\u7269\u4e0e\u6d88\u5316\u9053\u75be\u75c5\u3001\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\u3001\u795e\u7ecf\u7cbe\u795e\u7c7b\u75be\u75c5\u3001\u4ee3\u8c22\u7d0a\u4e71\u75be\u75c5\u3001\u5404\u79cd\u80bf\u7624\u7684\u53d1\u751f\u4e0e\u6cbb\u7597\uff08\u6700\u65b0\u7684\u5173\u4e8ePDL1\u7684\u7597\u6548\u5f71\u54cd\uff09\u7b49\u7684\u5173\u7cfb\u968f\u7740\u6280\u672f\u7684\u53d1\u5c55\u65e5\u76ca\u6e05\u6670\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u6211\u4eec\u81ea\u8eab\u6709\u5f88\u5f3a\u7684\u5fae\u751f\u7269\u7ec4\u5b9e\u9a8c\u6280\u672f\u548c\u4fe1\u606f\u6280\u672f\u7684\u4f18\u52bf\u3002\u4f17\u6240\u5468\u77e5\uff0c\u5bf9\u5fae\u751f\u7269\u7fa4\u843d\u768416S\u4fdd\u5b88\u533a\u6d4b\u5e8f\u4e2d\u6700\u5e38\u7528\u7684\u662f16S rRNA\u57fa\u56e0\u7684V3-V4\u533a\uff0c\u800c\u8fd9\u4e2a\u533a\u57df\u7684\u957f\u5ea6\u5728580bp\u5de6\u53f3\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u76ee\u524d\u5e02\u573a\u4e0a\u53ea\u6709Illumina\u7684MiSeq\u6d4b\u5e8f\u7cfb\u7edf\u7684PE300\u6d4b\u5e8f\u65b9\u5f0f\u53ef\u4ee5\u5c06\u5176\u6d4b\u901a\u3002\u8fd9\u4e2a\u6d4b\u5e8f\u6280\u672f\u7684\u96be\u70b9\u5728\u4e8e\u5efa\u5e93\u7684\u7a33\u5b9a\u6027\u3001\u78b1\u57fa\u4e0d\u5e73\u8861\u6587\u5e93\u6df7\u5e93\u7684\u5b9a\u91cf\u7684\u7a33\u5b9a\u6027\u3001\u6574\u4f53\u6587\u5e93\u4e0a\u673a\u6d4b\u5e8f\u524d\u7684\u5b9a\u91cf\u7684\u7a33\u5b9a\u6027\u7b49\u7b49\u3002\u5f53\u65f6\u51e0\u4e4e\u6240\u6709\u6d4b\u5e8f\u516c\u53f8\u90fd\u53ef\u4ee5\u63d0\u4f9b\u8fd9\u79cd\u670d\u52a1\uff0c\u4f46\u5f53\u5965\u7ef4\u68ee\u7684\u5fae\u751f\u7269\u6d4b\u5e8f\u670d\u52a1\u63a8\u51fa\u5e76\u9010\u6e10\u88ab\u79d1\u7814\u5de5\u4f5c\u8005\u4eec\u8ba4\u53ef\u540e\uff0c\u73b0\u5728\u9664\u6211\u4eec\u4e4b\u5916\u6574\u4e2a\u5317\u65b9\u7684\u6d4b\u5e8f\u516c\u53f8\u90fd\u5df2\u7ecf\u4e0d\u518d\u63d0\u4f9bMiSeq 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Nature Genetics\u300b \u7ea7\u522b\u6587\u7ae0\u7684\u5408\u4f5c\uff0c\u8d85\u8fc710\u4e2aPNAS\u7ea7\u522b\u6587\u7ae0\u7684\u5408\u4f5c\u3002\u6574\u4f53\u79d1\u6280\u677f\u5757\u627f\u63a5\u7684\u8d85\u8fc7\u767e\u4e07\u7ea7\u7684\u5355\u4e2a\u9879\u76ee\u5c31\u4e0d\u4e0b5\u4e2a\u3002\u56e0\u6b64\uff0c\u5965\u7ef4\u68ee\u57fa\u56e0\u7684\u201c\u57fa\u56e0\u201d\u603b\u7ed3\u8d77\u6765\u53ef\u4ee5\u662f\uff1a\u51dd\u5fc3\u805a\u529b\uff0c\u878d\u5408\u53d1\u5c55\uff0c\u670d\u52a1\u5927\u4f17\uff01<\/div>\n<div>\u00a0<\/div>\n<div>7. 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Information Management 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