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Biosciences\uff08\u4ee5\u4e0b\u7b80\u79f0\u201cPacBio\u201d\uff09\u3001Oxford Nanopore Technologies\uff08\u4ee5\u4e0b\u7b80\u79f0\u201cONT\u201d\uff09\uff0c\u4f46\u662f\u5b83\u4eec\u4e0d\u662f\u540c\u6837\u7684\u539f\u7406\uff0c\u6240\u4ee5\u5404\u81ea\u6709\u5404\u81ea\u7684\u4f18\u52bf\u3002\u73b0\u5728\u6211\u4eec\u8fd8\u4e0d\u77e5\u9053\u5728\u672a\u6765\u7ade\u4e89\u4e2d\uff0c\u8fd9\u4e9b\u4eea\u5668\u662f\u5426\u80fd\u5b58\u6d3b10\u5e74\u300120\u5e74\u751a\u81f3\u66f4\u957f\u7684\u65f6\u95f4\uff0c\u4f46\u662f\u4e09\u4ee3\u6d4b\u5e8f\u7684\u4f18\u52bf\u662f\u660e\u786e\u7684\uff0cPacBio\u548cONT\u6d4b\u5e8f\u957f\u5ea6\u6bd4\u4e8c\u4ee3\u6d4b\u5e8f\u957f\uff0c\u610f\u5473\u7740\u4fe1\u606f\u7684\u5b8c\u6574\u6027\uff0c\u73b0\u5728\u4e8c\u4ee3\u6d4b\u5e8f\u4eea\u6d4b\u5927\u7ea6\u53ef\u4ee5\u68c0\u6d4b\u51e0\u767e\u4e2a\u6838\u82f7\u9178\uff0c\u4e09\u4ee3\u6d4b\u5e8f\u53ef\u4ee5\u8fbe\u5230\u51e0\u5343\uff0c\u751a\u81f3\u4e0a\u767e\u4e07\uff1b\u4ece\u51c6\u786e\u5ea6\u4e0a\uff0c\u56e0\u4e3a\u4e09\u4ee3\u6d4b\u5e8f\u901a\u91cf\u4e0d\u591f\uff0c\u6240\u4ee5\u51c6\u786e\u5ea6\u8986\u76d6\u5ea6\u6ca1\u6709\u4e8c\u4ee3\u6d4b\u5e8f\u4eea\u597d\uff0c\u5176\u5b9e\u73b0\u5728\u66f4\u591a\u53ef\u4ee5\u91c7\u53d6\u8054\u5408\u5e94\u7528\u5b9e\u73b0\u53d6\u957f\u8865\u77ed\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u76ee\u524d\u770b\u6765\uff0c\u4e09\u4ee3\u6d4b\u5e8f\u4eea\u4f18\u52bf\u5f88\u660e\u786e\uff0c\u4f46\u662f\u4e0d\u80fd\u8bf4\u5b83\u4f1a\u53d6\u4ee3\u73b0\u6709\u5e02\u573a\uff0c\u73b0\u5728\u7684\u5e02\u573a\u4ecd\u5c5e\u4e8e\u4e8c\u4ee3\u6d4b\u5e8f\u4eea\uff0c\u4e09\u4ee3\u6d4b\u5e8f\u7684\u5e02\u573a\u6b63\u5728\u4e0d\u65ad\u62d3\u5c55\uff0c\u5e94\u7528\u8d8a\u6765\u8d8a\u5e7f\u6cdb\uff0c\u8d77\u5230\u4e86\u8865\u77ed\u677f\u7684\u4f5c\u7528\u3002\u5176\u5b9e\u73b0\u5728\u8fd8\u6709\u7b2c\u56db\u4ee3\u6d4b\u5e8f\u4eea\uff0c\u8fd9\u662f\u4e00\u4e2a\u65b0\u6982\u5ff5\uff0c\u7b2c\u56db\u4ee3\u6d4b\u5e8f\u4eea\u53ef\u4ee5\u76f4\u63a5\u6d4bRNA\u5e8f\u5217\uff0c\u800c\u6211\u4eec\u76ee\u524d\u90fd\u662fDNA\u6d4b\u5e8f\u4eea\u3002RNA\u6d4b\u5e8f\u4eea\u7814\u53d1\u6295\u5165\u5df2\u670910\u5e74\uff0c\u5927\u6982\u5168\u4e16\u754c\u670930\u591a\u4e2a\u7814\u53d1\u56e2\u961f\uff0c\u4e00\u822c\u4ece\u5934\u5f00\u59cb\u7814\u53d1\u9700\u898110\u5e74\uff0c\u5e94\u7528\u8f6c\u5316\u81f3\u5c11\u4e5f\u9700\u8981\u5341\u5e74\uff0c\u6240\u4ee5\u5927\u6982\u4ece\u73b0\u5728\u5f00\u59cb10\u5e74\u4ee5\u540e\uff0c\u7b2c\u56db\u4ee3\u6d4b\u5e8f\u4eea\u6709\u53ef\u80fd\u5e94\u7528\u5230\u4e34\u5e8a\u3002\u4f46\u662f\u7b2c\u56db\u4ee3\u6d4b\u5e8f\u4e5f\u4e0d\u4f1a\u66ff\u4ee3\u7b2c\u4e8c\u4ee3\u3001\u7b2c\u4e09\u4ee3\u6d4b\u5e8f\uff0cDNA\u548cRNA\u7684\u68c0\u6d4b\u90fd\u4f1a\u5b58\u5728\uff0c\u53d1\u6325\u5404\u81ea\u7684\u4f18\u52bf\u548c\u529f\u80fd\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u3010\u57fa\u56e0\u6167\u3011\u4e09\u4ee3\u6d4b\u5e8f\u5982\u679c\u5e94\u7528\u5728\u4e34\u5e8a\uff0c\u9762\u4e34\u7684\u4e3b\u8981\u969c\u788d\u6216\u95ee\u9898\u662f\u4ec0\u4e48\uff1f<\/div>\n<div>\u00a0<\/div>\n<div>\u3010\u4e8e\u519b\u6559\u6388\u3011\u5e94\u7528\u5230\u4e34\u5e8a\u7684\u7279\u5f81\u662f\u8981\u6c42\u6709\u5355\u4e00\u7684\u3001\u72ec\u7acb\u7684\u4e34\u5e8a\u5e94\u7528\u6280\u672f\uff0c\u4f46\u662f\u76ee\u524d\u7684\u4e09\u4ee3\u6d4b\u5e8f\uff0c\u9664\u4e86\u701a\u6d77\u7684\u6d4b\u5e8f\u4eea\u5e94\u7528\u4e8eNIPT\uff0c\u53e6\u5916\u4e24\u5bb6\u673a\u5668\u7684\u5e94\u7528\uff0c\u6bd4\u5982\u6d4b\u5b9aRNA\u75c5\u6bd2\u5177\u6709\u4e00\u5b9a\u7684\u4f18\u52bf\uff0c\u4f46\u76ee\u524d\u770b\u6765\u8fd8\u6ca1\u6709\u4e34\u5e8a\u5e94\u7528\u65b9\u5411\u3002<\/div>\n<div>PacBio\u548cONT\u76ee\u524d\u90fd\u8fd8\u53ea\u662f\u89c4\u6a21\u6bd4\u8f83\u5c0f\u7684\u4e0a\u5e02\u516c\u53f8\uff0c\u4ed6\u4eec\u7684\u5386\u53f2\u6ca1\u6709\u90a3\u4e48\u60a0\u4e45\uff0c\u6b63\u5904\u5728\u79ef\u7d2f\u8fc7\u7a0b\u4e2d\uff0c\u671f\u5f85\u4ed6\u4eec\u80fd\u591f\u8bc1\u660e\u4eea\u5668\u6709\u6548\u6027\uff0c\u62d3\u5c55\u5176\u5e94\u7528\uff0c\u6700\u7ec8\u8fdb\u5165\u4e34\u5e8a\uff0c\u8fd9\u5bf9\u4f01\u4e1a\u81ea\u8eab\u53d1\u5c55\u548c\u516c\u4f17\u6765\u8bf4\u90fd\u662f\u4e00\u4ef6\u597d\u4e8b\u3002<\/div>\n<div>\u00a0<\/div>\n<div>3\u3001\u5eb7\u7199\u96c4 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center;\">\u5eb7\u7199\u96c4<\/div>\n<div>\u4e3b\u4efb\u533b\u5e08\u3001\u6559\u6388\u3001\u535a\u58eb\u751f\u5bfc\u5e08\uff0c\u8457\u540d\u4e34\u5e8a\u68c0\u9a8c\u8bca\u65ad\u5b66\u3001\u4e34\u5e8a\u514d\u75ab\u5b66\u4e13\u5bb6\uff0c\u56fd\u5bb6\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u4e34\u5e8a\u7814\u7a76\u4e2d\u5fc3\u3001\u9996\u90fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5317\u4eac\u5929\u575b\u533b\u9662\u5b9e\u9a8c\u8bca\u65ad\u4e2d\u5fc3\u4e3b\u4efb\u3001\u9662\u58eb\u4f53\u68c0\u4e13\u5bb6\u3001\u9996\u90fd\u533b\u79d1\u5927\u5b66\u4e34\u5e8a\u68c0\u9a8c\u8bca\u65ad\u5b66\u7cfb\u4e3b\u4efb\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u3010\u57fa\u56e0\u6167\u3011\u5eb7\u6559\u6388\u60a8\u597d\uff0c\u8bf7\u60a8\u4ecb\u7ecd\u4e00\u4e0b\u76ee\u524d\u6d4b\u5e8f\u4eea\u5728\u4e34\u5e8a\u5e94\u7528\u7684\u60c5\u51b5\uff0c\u6bd4\u8f83\u6210\u719f\u7684\u5e94\u7528\u5728\u54ea\u4e9b\u65b9\u9762\uff1f<\/div>\n<div>\u00a0<\/div>\n<div>\u3010\u5eb7\u7199\u96c4\u6559\u6388\u3011\u73b0\u5728\u6d4b\u5e8f\u4eea\u7684\u4e34\u5e8a\u5e94\u7528\u8d8a\u6765\u8d8a\u5e7f\u6cdb\uff0c\u800c\u4e14\u8fd8\u5728\u4e0d\u65ad\u5730\u5f00\u62d3\u65b0\u9886\u57df\uff0c\u76ee\u524d\u76f8\u5bf9\u6210\u719f\u7684\u5e94\u7528\u4e3b\u8981\u662f\u5728\u4e24\u4e2a\u9886\u57df\uff0c\u75be\u75c5\u8bca\u65ad\u9886\u57df\u548c\u5065\u5eb7\u9886\u57df\u3002\u8fd8\u6709\u7b2c\u4e09\u4e2a\u9886\u57df\uff0c\u6211\u81ea\u5df1\u5efa\u7acb\u4e86\u4e00\u4e2a\u65b0\u7684\u5b66\u79d1\u53eb\u533b\u5b66\u9884\u6d4b\u5b66\uff0c\u8fd9\u4e09\u4e2a\u9886\u57df\u90fd\u662f\u7528\u6d4b\u5e8f\u5e73\u53f0\u53bb\u505a\u7684\u3002<\/div>\n<div>\u9996\u5148\uff0c\u5728\u75be\u75c5\u8bca\u65ad\u9886\u57df\uff0c\u6bd4\u5982\u80ce\u513f\u8bca\u65ad\uff0c\u8fd9\u662f\u4e34\u5e8a\u5e94\u7528\u6bd4\u8f83\u591a\u7684\uff0c\u800c\u4e14\u662f\u5e02\u573a\u5360\u6709\u7387\u6bd4\u8f83\u9ad8\u7684\u4e00\u4e2a\u9886\u57df\u3002\u518d\u5982\u80bf\u7624\u8bca\u65ad\u9886\u57df\uff0c\u56e0\u4e3a\u591a\u57fa\u56e0\u548c\u591a\u56e0\u7d20\uff0c\u5b83\u7684\u8bca\u65ad\u76f8\u5bf9\u590d\u6742\uff0c\u4f46\u662f\u76ee\u524d\u4e5f\u5728\u8fc5\u901f\u5411\u524d\u63a8\u8fdb\u3002\u8fd8\u6709\u6cbb\u7597\u8bc4\u4ef7\u4f53\u7cfb\uff0c\u5373\u4f34\u968f\u8bca\u65ad\u4f53\u7cfb\uff0c\u5229\u7528\u9057\u4f20\u53d8\u5316\u60c5\u51b5\u6765\u9009\u62e9\u6cbb\u7597\u65b9\u6848\u3002\u5176\u6b21\u662f\u4ee3\u8c22\u8bc4\u4ef7\u4f53\u7cfb\uff0c\u56e0\u4e3a\u6bcf\u4e2a\u4eba\u7684\u4ee3\u8c22\u6c34\u5e73\u90fd\u4e0d\u4e00\u6837\uff0c\u57fa\u4e8e\u4e2a\u4f53\u5316\u8bca\u65ad\uff0c\u60a3\u8005\u53ef\u4ee5\u4e86\u89e3\u81ea\u8eab\u5bf9\u836f\u7684\u4ee3\u8c22\u80fd\u529b\uff0c\u5bf9\u7528\u836f\u8fdb\u884c\u6307\u5bfc\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u7b2c\u4e8c\u4e2a\u65b9\u9762\uff0c\u57fa\u56e0\u68c0\u6d4b\u5728\u5065\u5eb7\u9886\u57df\u4ea7\u751f\u5e7f\u6cdb\u7684\u5e94\u7528\uff0c\u5168\u56fd\u5065\u5eb7\u5927\u4f1a\u4e0a\u4e3b\u5e2d\u5f3a\u8c03\u4e86\u5065\u5eb7\u5f3a\u56fd\u7684\u5efa\u8bbe\uff0c\u5982\u4f55\u505a\u5230\u751f\u547d\u5168\u7a0b\u7684\u5065\u5eb7\u4fdd\u969c\u5462\uff1f\u9996\u5148\u5728\u751f\u547d\u7684\u5f00\u7aef\uff0c\u8981\u80fd\u591f\u5224\u65ad\u5375\u6bcd\u7ec6\u80de\u662f\u5426\u5065\u5eb7\u3002\u6211\u4eec\u73b0\u5728\u5df2\u7ecf\u6709\u4e86\u89e3\u51b3\u65b9\u6cd5\uff0c\u5373\u5355\u7ec6\u80de\u6d4b\u5e8f\uff0c\u6216\u5355\u5206\u5b50\u6d4b\u5e8f\uff0c\u8fd9\u4e5f\u662f\u8d3a\u5efa\u594e\u535a\u58eb\u6240\u8bf4\u7684\u7b2c\u4e09\u4ee3\u6d4b\u5e8f\u4eea\u4f53\u7cfb\u3002\u57fa\u56e0\u6d4b\u5e8f\u80fd\u8bc4\u4ef7\u751f\u547d\u6bcf\u4e2a\u9636\u6bb5\u7684\u7279\u5f81\u6027\u610f\u4e49\uff0c\u8d2f\u7a7f\u751f\u547d\u5168\u5468\u671f\u7684\u5065\u5eb7\u8bc4\u4ef7\u4f53\u7cfb\uff0c\u53ef\u4ee5\u5206\u6790\u548c\u8bc4\u4ef7\u5065\u5eb7\u72b6\u6001\u3002<\/div>\n<div>\u7b2c\u4e09\u4e2a\u65b9\u9762\uff0c\u5728\u75be\u75c5\u9884\u8b66\u7684\u89d2\u5ea6\u4e0a\uff0c\u6211\u4eec\u4e5f\u53ef\u4ee5\u901a\u8fc7\u57fa\u56e0\u68c0\u6d4b\uff0c\u63d0\u65e9\u53d1\u73b0\u7f3a\u9677\uff0c\u8fdb\u800c\u9884\u6d4b\u5c06\u8981\u53d1\u751f\u7684\u75be\u75c5\u6216\u8005\u75c7\u72b6\u3002\u73b0\u5728\u7684\u6280\u672f\u53ef\u4ee5\u5c06\u57fa\u56e0\u68c0\u6d4b\u548c\u4eba\u5de5\u667a\u80fd\u7ed3\u5408\uff0c\u5efa\u7acb\u8d77\u9884\u6d4b\u533b\u5b66\u4f53\u7cfb\uff0c\u8fd9\u4e2a\u8bfe\u7a0b\u6211\u5df2\u7ecf\u7ed9\u7814\u7a76\u751f\u6388\u8bfe\u4e09\u5e74\u591a\u3002<\/div>\n<div>\u6240\u4ee5\u5728\u6211\u770b\u6765\uff0c\u57fa\u56e0\u6d4b\u5e8f\u662f\u4ece\u4ee5\u4e0a\u4e09\u4e2a\u65b9\u9762\u5e2e\u52a9\u4e0d\u540c\u9636\u6bb5\u7684\u4eba\u89e3\u51b3\u4e0d\u540c\u7684\u95ee\u9898\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u3010\u57fa\u56e0\u6167\u3011\u60a8\u5982\u4f55\u770b\u5f85\u6df1\u5733\u5728\u5168\u56fd\u57fa\u56e0\u6d4b\u5e8f\u9886\u57df\u4e2d\u626e\u6f14\u7684\u89d2\u8272\uff1f<\/div>\n<div>\u00a0<\/div>\n<div>\u3010\u5eb7\u7199\u96c4\u6559\u6388\u3011\u5168\u56fd\u57fa\u56e0\u6d4b\u5e8f\u53d1\u5c55\u6700\u9886\u5148\u7684\u533a\u57df\u5e94\u8be5\u662f\u5e7f\u4e1c\u7701\uff0c\u5c24\u5176\u662f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src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/eicZhoGYCfyawibqkvVKsqvkEibicoY0gEjoSH47Ugf6p1W0ReCgcoRTa6UH0ofP9wRHkic4yBn1bV5IH3xov6vyuDQ.jpeg\" 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