\n![\"RmFicvQBAkgB2Wkia2jicswicwcVoFyjgcfgTs7EvkIvaL9iaxH58RWS4hMSua2bpu0OvzUl1zL3EL0yicv2V9Gny66g\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgB2Wkia2jicswicwcVoFyjgcfgTs7EvkIvaL9iaxH58RWS4hMSua2bpu0OvzUl1zL3EL0yicv2V9Gny66g.gif\")
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\n\n
\n![\"RmFicvQBAkgDkon3ksnmibmibKGl4EKgicicJGO71fDUP2Hmtzho2erSSV8LSNLCNTTaeMnca7ibp6CXJiaWdA1OdNkFQ\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDkon3ksnmibmibKGl4EKgicicJGO71fDUP2Hmtzho2erSSV8LSNLCNTTaeMnca7ibp6CXJiaWdA1OdNkFQ.jpeg\")
<\/figure><\/div>\n\n
<\/figure><\/div>\n\n\u4f5c\u8005\uff1a\u7279\u7ea6\u7f16\u8f91Calvintan<\/div>\n
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\u00a0<\/div>\n
1\u3001\u80bf\u7624\u7cbe\u51c6\u514d\u75ab\u6cbb\u7597\u6210\u5173\u6ce8\u70b9<\/div>\n
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\u00a0<\/div>\n
\u9664\u4e86\u516c\u8ba4\u7684\u514d\u75ab\u6cbb\u7597\u5728\u665a\u671f\u9ed1\u8272\u7d20\u7624\u4e0e\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e2d\u6709\u66f4\u597d\u751f\u5b58\u65f6\u95f4\u5916\uff0cFDA\u57282016\u5e74\u6279\u590dPD-L1\u7528\u4e8e\u8180\u80f1\u764c\uff08Atezolizumab\uff09\uff0cPD-1\u7528\u4e8e\u5934\u9888\u764c\uff08Nivolumab\uff09\uff0c\u53e6\u5916\u8fd8\u6709\u591a\u4e2a\u57fa\u4e8ePD-1\u7684\u5375\u5de2\u764c\u4e0e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u663e\u8457\u3002\u867d\u7136\u514d\u75ab\u6cbb\u7597\u5728\u8fd9\u4e9b\u80bf\u7624\u7c7b\u578b\u4e2d\u7597\u6548\u663e\u8457\uff0c\u4f46\u662f\u4e5f\u6709\u67d0\u4e9b\u80bf\u7624\u7c7b\u578b\u7597\u6548\u751a\u5fae\u3002\u5728\u4eca\u5e74AACR\u4e0a\u62a5\u544a\u7684\u5728\u8f6c\u79fb\u6027\u4e09\u9634\u6027\u4e73\u817a\u764c\u60a3\u8005\u4e2d\u4f7f\u7528PD-L1\u53ea\u670910~13%\u7684\u6709\u6548\u7387\uff0c\u4f46\u4e00\u65e6\u6709\u6548\u5219\u7597\u6548\u53ef\u6301\u7eed\u8f83\u957f\u65f6\u95f4[1]\u3002\u514d\u75ab\u6cbb\u7597\u4e34\u5e8a\u8bd5\u9a8c\u8feb\u5207\u9700\u8981\u4e00\u4e2a\u80fd\u5408\u7406\u9884\u6d4b\u60a3\u8005\u83b7\u76ca\u7684\u65b9\u6848\u3002<\/div>\n
\u00a0<\/div>\n
\u9664\u4e86\u76ee\u524dFDA\u6279\u51c6\u7684\u4f34\u968f\u8bca\u65ad\u57fa\u4e8eIHC\u7684PD-L1\u8868\u8fbe\u68c0\u6d4b\u65b9\u6cd5\uff0c\u53e6\u5916\u5404\u516c\u53f8\u8fd8\u6709\u57fa\u4e8e\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\uff08MSI\uff09\uff0c\u57fa\u56e0\u9519\u914d\u4fee\u590d\u7f3a\u9677\uff08MMR\uff09\uff0c\u57fa\u4e8e\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\uff08TMB\uff09\uff0c\u65b0\u6297\u539f\u53d1\u73b0\u4ee5\u53ca\u57fa\u56e0\u8868\u8fbe\u8c31\u7b49\u68c0\u6d4b\u6b63\u5728\u5f00\u53d1\u3002\u514d\u75ab\u6cbb\u7597\u548c\u57fa\u56e0\u7b49\u80bf\u7624\u5927\u6570\u636e\u7684\u7ed3\u5408\u6210\u4e3a\u8d8b\u52bf\uff0c\u5176\u4e2d\u6253\u901a\u80bf\u7624\u514d\u75ab\u3001\u57fa\u56e0\u5927\u6570\u636e\u548c\u836f\u7269\u7814\u53d1\u4ea7\u4e1a\u94fe\u7684\u6216\u5c06\u5360\u6709\u4ea7\u4e1a\u5148\u673a\u3002\u805a\u7126\u4e8e\u80bf\u7624\u7cbe\u51c6\u514d\u75ab\u6cbb\u7597\u7684\u7684\u516c\u53f8\u5305\u62ec\u8a89\u8861\u57fa\u56e0<\/a>\u3001\u88d5\u7b56\u751f\u7269\u3001\u57fa\u51c6\u533b\u7597\u7b49\u3002\u5176\u4ed6\u77e5\u540d\u80bf\u7624\u4f01\u4e1a\uff0c\u7c7b\u4f3c\u5b89\u53ef\u6d4e\u3001\u91d1\u57df\u68c0\u9a8c\u3001\u8d1d\u745e\u57fa\u56e0\u3001\u8fc8\u57fa\u8bfa\u3001\u601d\u8def\u8fea\u3001\u5143\u7801\u57fa\u56e0\u3001\u534e\u5927\u57fa\u56e0\u7b49\u3002<\/div>\n
\u00a0<\/div>\n
2\u3001\u6db2\u6001\u6d3b\u68c0\u786e\u5b9a\u4e86\u5728\u80bf\u7624\u68c0\u6d4b\u4e2d\u7684\u5730\u4f4d<\/div>\n
2016\u5e74CSCO\u4f1a\u4e0a\u591a\u5bb6\u516c\u53f8\u90fd\u5728\u8ba8\u8bba\u7ec4\u7ec7\u7c7bNGS\u4e0ectDNA NGS\u7684\u6570\u636e\u4e00\u81f4\u6027\uff0c\u4eca\u5e74CSCO\u5df2\u7ecf\u521d\u6b65\u80af\u5b9a\u4e86\u6db2\u6001\u6d3b\u68c0\u5728\u80bf\u7624\u68c0\u6d4b\u4e2d\u7684\u5730\u4f4d\uff0c\u867d\u7136\u4e34\u5e8a\u4e2d\u4ecd\u65e7\u4ee5\u7ec4\u7ec7\u75c5\u7406\u6d3b\u68c0\u4f5c\u4e3a\u91d1\u6807\u51c6\uff0cctDNA\u6837\u672c\u6709\u7740\u5bb9\u6613\u964d\u89e3\u4ee5\u53ca\u8840\u6d46\u4e2d\u91ca\u653e\u7684\u65e0\u6cd5\u63a7\u5236\u7b49\u7f3a\u70b9\uff0c\u7531\u4e8e\u80bf\u7624\u8fdb\u5c55\u4e2d\u8feb\u5207\u9700\u8981\u52a8\u6001\u76d1\u63a7\uff0c\u4f46\u662f\u5b9e\u9645\u60c5\u51b5\u662f\u75c5\u4eba\u65e0\u6cd5\u63a5\u53d7\u591a\u6b21\u7a7f\u523a\u6d3b\u68c0\uff0c\u800c\u4e14\u5728\u8fd9\u4e00\u5e74\u6765\u884c\u4e1a\u7684\u4f18\u5316\u4e0e\u8fdb\u6b65\uff0c\u968f\u7740\u5404\u5bb6\u516c\u53f8\u516c\u5e03\u7684\u6570\u5b57\uff0c\u7ec4\u7ec7NGS\u4e0e\u6db2\u6001\u6d3b\u68c0\u7684\u4e00\u81f4\u6027\u90fd\u662f\u8d85\u8fc750%\u7684\u3002<\/div>\n
\u00a0<\/div>\n
3\u3001cfDNA\/ctDNA\u7532\u57fa\u5316\u5206\u5b50\u6807\u8bb0\u65e5\u8d8b\u6210\u719f<\/div>\n
\u7532\u57fa\u5316\u662f\u4e00\u79cd\u975e\u5e38\u7a33\u5b9a\u7684DNA\u4fee\u9970\uff0c\u5404\u7ec6\u80de\u7c7b\u578b\u643a\u5e26\u6709\u5176\u72ec\u7279\u7684\u7532\u57fa\u5316\u72b6\u6001\uff0c\u548c\u7ec6\u80de\u5185\u7684\u57fa\u56e0\u8868\u8fbe\u4e00\u81f4\u3002\u5df2\u6709\u7814\u7a76\u8868\u660e\uff1a\u5728\u4eba\u7c7b\u80da\u80ce\u5e72\u7ec6\u80de\u5411\u591a\u80da\u5c42\u7ec6\u80de\u5206\u5316\uff0c\u4ee5\u53ca\u8bf1\u5bfc\u591a\u529f\u80fd\u5e72\u7ec6\u80de\u518d\u5206\u5316\u548c\u91cd\u7f16\u7a0b\u8fc7\u7a0b\u4e2d\uff0c\u6709\u7532\u57fa\u5316\u72b6\u6001\u7684\u6539\u53d8\u3002\u5728\u4e0d\u540c\u6b63\u5e38\u7ec4\u7ec7\u4e4b\u95f4\uff0c\u65b0\u751f\u513f\u548c\u8001\u5e74\u4eba\u4e4b\u95f4\uff0c\u4ea7\u524d\u662f\u5426\u906d\u53d7\u9965\u8352\uff0c\u80bf\u7624\u7ec4\u7ec7\u548c\u6b63\u5e38\u7ec4\u7ec7\u4e4b\u95f4\uff0c\u6709\u660e\u663e\u7684\u7532\u57fa\u5316\u5dee\u5f02\u3002\u80bf\u7624\u7ec4\u7ec7\u548c\u6b63\u5e38\u7ec4\u7ec7\u76f8\u6bd4\uff0c\u6709\u660e\u663e\u7684\u7532\u57fa\u5316\u6c34\u5e73\u5dee\u5f02\u3002\u5362\u715c\u660e\u6559\u6388\u7684\u56e2\u961f\u68c0\u6d4b\u4e86\u809d\u764c\u60a3\u8005\u548c\u5065\u5eb7\u4ebacfDNA\u7684\u5168\u57fa\u56e0\u7ec4\u7532\u57fa\u5316\u72b6\u6001\uff0c\u4ee51.1%\u7684\u4f4e\u7532\u57fa\u5316bins\uff081Mb\uff09\u4e3a\u4e34\u754c\u503c\uff0c\u809d\u764c\u60a3\u8005\u7684\u68c0\u6d4b\u7075\u654f\u5ea6\u4e3a81%\uff0c\u7279\u5f02\u6027\u4e3a94%\u3002\u8fdb\u4e00\u6b65\u7684\u80bf\u7624\u7ec4\u7ec7\u548c\u6b63\u5e38\u7ec4\u7ec7\u7684\u7532\u57fa\u5316\u68c0\u6d4b\u9a8c\u8bc1\u4e86\u8be5\u65b9\u6cd5\u7684\u53ef\u9760\u6027[2]\u3002<\/div>\n
\u4eca\u5e74\u591a\u5bb6\u516c\u53f8\u90fd\u63a8\u51fa\u57fa\u4e8ectDNA\u7684\u7532\u57fa\u5316\u68c0\u6d4b\u7684\u6280\u672f\u65b9\u6848\u4e0e\u521d\u671f\u6570\u636e\uff0c\u5305\u62ec\u57fa\u51c6\u533b\u7597\uff0c\u9e4d\u8fdc\u751f\u7269\uff0c\u4f2f\u8c6a\u751f\u7269\u3001\u9e4d\u8fdc\u57fa\u56e0\u3001\u8d1d\u745e\u57fa\u56e0\u7b49\u3002\u6700\u8fd1\u5f20\u9e4d\u6559\u6388\u56e2\u961f\u5229\u7528\u7532\u57fa\u5316\u5355\u500d\u4f53\u578b\u6a21\u5757\uff0c\u9884\u6d4b\u80ba\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u548c\u5065\u5eb7\u4eba\u7684\u51c6\u786e\u6027\u5206\u522b\u8fbe\u523082.8%\u300188.5%\u548c91.2%[3]\u3002<\/div>\n
\u00a0<\/div>\n
4\u3001\u771f\u5b9e\u4e16\u754c\u5927\u6570\u636e\u7814\u7a76<\/div>\n
2016\u5e74\u7f8e\u56fd\u201c21\u4e16\u7eaa\u6cbb\u6108\u6cd5\u6848\u201d\u2014\u5229\u7528\u771f\u5b9e\u4e16\u754c\u8bc1\u636e\uff0c\u8fdb\u884c\u65b0\u9002\u5e94\u75c7\u7684\u6279\u51c6\uff0c\u6ee1\u8db3\u4e0a\u5e02\u540e\u7684\u7814\u7a76\u9700\u6c42\u3002\u540c\u65f6\uff0c\u5bf9\u4e8e\u771f\u5b9e\u4e16\u754c\u7684\u6570\u636e\u63d0\u51fa\u975e\u5e38\u5927\u7684\u8981\u6c42\u3002\u4e00\u4e2a\u5408\u7406\u7684\u4e34\u5e8aRWS\u7684\u65b9\u6848\uff0c\u771f\u5b9e\u6570\u636e\u9700\u8981\u63d0\u70bc\u5230\u771f\u5b9e\u8bc1\u636e\uff0c\u9700\u8981\u6ee1\u8db3\u4e24\u5927\u539f\u5219\uff1a1. \u76f8\u5173\u6027\uff08\u8db3\u591f\u7684\u7ec6\u8282\u53cd\u6620\u836f\u68b0\u7684\u4f7f\u7528\uff0c\u6570\u636e\u7684\u7814\u7a76\u8981\u7528\u6709\u6548\u7684\u7edf\u8ba1\u5b66\u7684\u65b9\u6cd5\u6765\u5206\u6790\uff0c\u63d0\u4f9b\u7684\u6570\u636e\u9700\u8981\u662f\u5df2\u77e5\u7684\u4e34\u5e8a\/\u79d1\u5b66\u5224\u65ad\u53ef\u4ee5\u89e3\u91ca\u7684\uff09\uff1b2. \u771f\u5b9e\u6027\uff08\u771f\u5b9e\u4e16\u754c\u6570\u636e\u9700\u8981\u9884\u5148\u5b9a\u4e49\u6570\u636e\u7c7b\u578b\u4e0e\u641c\u96c6\u7684\u6570\u636e\u6846\u67b6\u534f\u8bae\uff0c\u6570\u636e\u6c47\u805a\u548c\u786e\u5b9a\u7684\u65b9\u6cd5\u9700\u8981\u660e\u786e\uff0c\u6570\u636e\u6536\u96c6\u7684\u65f6\u6548\u6027\uff09\u3002\u4ee5\u4e0a\u4e24\u4e2a\u539f\u5219\u9020\u6210\u4e86\u771f\u5b9e\u4e16\u754c\u5927\u6570\u636e\u7814\u7a76\u6709\u7740\u6570\u636e\u91cf\u4e0e\u6570\u636e\u7ef4\u5ea6\u90fd\u662f\u4f20\u7edf\u968f\u673a\u5bf9\u7167\u7814\u7a76\u6570\u636e\u7684\u6570\u767e\u751a\u81f3\u4e0a\u5343\u500d\uff0c\u7279\u522b\u662f\u5404\u4e2a\u6570\u636e\u70b9\u4e4b\u95f4\u662f\u6709\u7740\u660e\u786e\u7684\u5173\u7cfb\u5b9a\u4e49\uff0c\u4e0d\u518d\u662f\u4e92\u76f8\u5206\u79bb\uff0c\u8fd9\u4e9b\u53c8\u9020\u6210\u4e86\u76ee\u524d\u771f\u5b9e\u4e16\u754c\u5927\u6570\u636e\u7814\u7a76\u7684\u5c55\u5f00\u56f0\u96be\uff0c\u4e5f\u662f\u76ee\u524d\u7cbe\u51c6\u533b\u7597\u62e5\u62b1\u6df1\u5ea6\u5b66\u4e60\u4e0e\u4eba\u5de5\u667a\u80fd\u7684\u6f5c\u5728\u5e94\u7528\u573a\u666f\u3002\uff08\u6574\u7406\u81ea\u5434\u4e00\u9f99\u6559\u6388\u57282017\u5e74CSCO\u80bf\u7624\u533b\u751f\u4e0e\u5927\u6570\u636e\u4e13\u573a\u4f1a\u8bae\u4e13\u9898\u53d1\u8a00\uff09<\/div>\n
\u00a0<\/div>\n
5\u3001Nanopore\u4e09\u4ee3\u6d4b\u5e8f\u4eea\u8fdb\u5165\u79d1\u7814\u5e02\u573a<\/div>\n
\u6700\u8fd1\u6765\u6e90\u4e8e\u4f26\u6566\u7684Nanopore\u7b2c\u4e09\u4ee3\u6d4b\u5e8f\u4eea\u5df2\u7ecf\u8fdb\u5165\u56fd\u5185\u5f00\u59cb\u53c2\u4e0e\u79d1\u7814\u9886\u57df\u3002\u9664\u4e86\u4e09\u4ee3\u6d4b\u5e8f\u7684\u6807\u5fd7\u957f\u5ea6\u957f\u5e26\u6765\u9ad8\u8d28\u91cf\u7684\u7ed3\u6784\u53d8\u5f02\u4fe1\u53f7\u4e0e\u5355\u500d\u578b\u4fe1\u53f7\uff0cNanopore\u6709\u7740\u8bb8\u591a\u4ee4\u4eba\u5174\u594b\u7684\u7279\u70b9\uff0c\u6bd4\u5982\u4f53\u79ef\u5c0f\u5de7\u53ea\u9700\u8981USB\u63a5\u53e3\u63d0\u4f9b\u7535\u6e90\uff0c\u6837\u672c\u4e0d\u9700\u8981\u6269\u589e\u4e0e\u5efa\u5e93\uff0c\u53ea\u7b80\u5355\u52a0\u5165\u67d3\u6599\u6df7\u5300\u5c31\u53ef\u4ee5\u4e0a\u673a\u6d4b\u5e8f\uff0c\u53ef\u4ee5\u7528\u4e8e\u76f4\u63a5\u7684\u7532\u57fa\u5316\u6d4b\u5e8f\u4e0eRNA\u6d4b\u5e8f\u3002\u4f46\u662fNanopore\u4e5f\u6709\u7740\u4e00\u4e9b\u4e0d\u8db3\uff0c\u6bd4\u59822014\u5e74\u4ee5\u6765\u6d4b\u5e8f\u9519\u8bef\u7387\u4ee5\u53ca\u6570\u636e\u4ea7\u51fa\u4e0d\u7a33\u5b9a\u4e00\u76f4\u5236\u7ea6\u7740\u5176\u66f4\u5e7f\u9614\u7684\u5e94\u7528\uff0c\u56e0\u6b64\u5176\u6bcd\u516c\u53f8\u7ecf\u8fc7\u4e24\u5e74\u6765\u7684\u505a\u9176\u7684\u4fee\u9970\u5de5\u4f5c\uff0c\u5e76\u57282016\u5e74\u53d1\u5e03\u4e86R7\u8bd5\u5242\u83b7\u5f97\u4e86\u975e\u5e38\u5927\u7684\u8fdb\u6b65\uff08\u5176\u5ba3\u79f0\u6700\u5927\u5355flow cell\u4ea7\u51fa20G\uff0c\u76ee\u524d\u5168\u7403\u7528\u6237\u516c\u5e03\u7684\u5e73\u5747\u771f\u5b9e\u4ea7\u51fa\u57284~10G\uff0c\u6700\u9ad8\u6709\u7528\u6237\u62a5\u544a\u4ea7\u51fa15G\uff0c\u5e76\u4e14\u7edd\u5927\u90e8\u5206\u90fd\u662f\u957f\u8bfb\u5e8f\uff09\uff0c\u5e76\u57282017\u5e74\u9884\u544a\u4e86R9\u4e0eR94\u8bd5\u5242\u6027\u80fd\u8fdb\u4e00\u6b65\u4f18\u5316\u3002[4]<\/div>\n
\u00a0<\/div>\n
6\u3001CTC\u6280\u672f\u7684\u9010\u6e10\u5b8c\u5584<\/div>\n
CTC\u5728\u80bf\u7624\u65e9\u7b5b\u4e2d\u5730\u4f4d\u975e\u5e38\u91cd\u8981\uff0c\u80fd\u4fdd\u6301\u5b8c\u6574\u7684\u7ec6\u80de\u5f62\u6001\u80fd\u8fdb\u884c\u5f62\u6001\u5b66\u4e0a\u5224\u5b9a\u4e0e\u75c5\u7406\u5b66\u4e0a\u91d1\u6807\u51c6\u5bf9\u5e94\uff0c\u800c\u4e14\u5305\u62ec\u5b8c\u6574\u7684\u8f6c\u5f55\u7ec4\uff0c\u57fa\u56e0\u7ec4\uff0c\u86cb\u767d\u8d28\u7ec4\u7684\u4fe1\u606f\u3002\u4f46\u662fCTC\u4e00\u76f4\u6709\u7740\u5176\u5e94\u7528\u573a\u666f\u53d7\u9650\uff0c\u4f8b\u5982\u80bf\u7624\u8868\u9762\u6297\u4f53\u7684\u9009\u62e9\uff08EpCAM\uff0cEGFR\uff0c\u53f6\u9178\uff0c\u8f6c\u94c1\u86cb\u767d\uff0cEGF\uff0cHer-2\u7b49\uff09\uff0c\u80bf\u7624\u7ec6\u80de\u6355\u83b7\u7684\u6548\u7387\u4e0e\u7279\u5f02\u6027\u7b49\uff0c\u76ee\u524d\u4e3b\u6d41\u6280\u672f\u4ecd\u9700\u8981\u5bf9\u7b5b\u9009\u7684\u7ec6\u80de\u505a\u514d\u75ab\u7ec4\u5316\u4e8c\u6b21\u786e\u8ba4\uff0c\u52a0\u5927\u4e86\u68c0\u6d4b\u7684\u5468\u671f\u4e0e\u4e0d\u540c\u5b9e\u9a8c\u5ba4\u95f4\u7684\u6f5c\u5728\u5dee\u5f02\u3002CTC\u5728\u80bf\u7624\u4e2d\u4e3b\u8981\u7528\u4e8e\u65e9\u671f\u7b5b\u67e5\uff0c\u9884\u540e\uff0c\u590d\u53d1\u76d1\u63a7\u7b49\u3002<\/div>\n
\u00a0<\/div>\n
7\u3001NCCN\u6307\u5357\u4e0e\u4e2d\u56fd\u60a3\u8005\u5e94\u7528\u7684\u5dee\u522b<\/div>\n
\u5317\u5927\u80bf\u7624\u533b\u9662\u7684\u8d3e\u6dd1\u82b9\u5728\u8d1d\u745e\u57fa\u56e0\u7684\u536b\u661f\u4f1a\u4e0a\u8c08\u5230\uff0c\u5bf92000\u4f8b\u4e2d\u56fd\u80c3\u764c\u6837\u672c\u7814\u7a76\u7ed3\u679c\uff0c\u7ed3\u8bba\u5bf9\u6bd4NCCN\u6307\u5357\uff0c\u53d1\u73b0\u6307\u5357\u5bf9\u6307\u5bfc\u4e2d\u56fd\u60a3\u8005\u6709\u4e00\u5b9a\u7684\u5dee\u8ddd\u3002\u4e2d\u56fd\u80c3\u764c\u60a3\u8005\u9057\u4f20\u57fa\u56e0\u7a81\u53d8\u7387\u9ad8\u8fbe5%\uff0c\u9057\u4f20\u57fa\u56e0\u9ad8\u8fbe28\u4e2a\uff08\u539f\u9ad8\u4e8eNCCN\u6307\u5357\u4e2d\u768410\u4e2a\uff09\uff0c\u7a81\u53d8\u9891\u7387\u6700\u9ad8\u4e0d\u8d85\u8fc71%\uff0c\u4e73\u817a\u764c\u53ea\u6709BRCA1\/2\u8d85\u8fc71%\u3002\u9996\u6b21\u53d1\u73b0\u56db\u4e2a\u57fa\u56e0\u4e0e\u80bf\u7624\u7efc\u5408\u5f81\u76f8\u5173\uff1aATM\u3001MLH1\u3001CDH1\u3001RAD51D\uff0c\u6307\u5357\u63a8\u8350\u7684\u57fa\u56e0\u68c0\u6d4b\u5230\u7684\u57fa\u56e0\u53ea\u670920%\u3002\u540c\u65f6\u53d1\u73b0\uff0cLauren\u5206\u578b\u5e76\u975e\u7a81\u53d8\u6709\u6548\u9884\u6d4b\u56e0\u7d20\u3002\u6839\u636e\u4ee5\u4e0a\u7ed3\u679c\uff0c\u5efa\u8baeNCCN\u6307\u5357\u7b5b\u67e5\u7684\u57fa\u56e0\u9700\u8981\u8865\u5145\uff0c\u80c3\u764c\u5bb6\u65cf\u53f2\u4f5c\u4e3a\u57fa\u56e0\u7b5b\u67e5\u7684\u4f9d\u636e\u9700\u8981\u8865\u5145\u3002<\/div>\n
\u00a0<\/div>\n
8\u3001\u6570\u5b57PCR\u4f5c\u4e3a\u4e34\u5e8a\u68c0\u6d4b\u8bd5\u5242\u76d2\u7684\u7533\u62a5<\/div>\n
\u5728\u8fd9\u6b21\u5927\u4f1a\u4e2d\u8bb8\u591a\u516c\u53f8\u90fd\u516c\u5e03\u4e86\u6db2\u6001\u6d3b\u68c0\u7684\u9a8c\u8bc1\u6570\u636e\uff0c\u7edd\u5927\u90e8\u5206\u90fd\u662f\u4f7f\u7528\u6570\u5b57PCR\u4f5c\u4e3aNGS\u7ed3\u679c\u7684\u9a8c\u8bc1\u3002\u53e6\u5916\u8fd8\u6709\u6570\u5bb6\u516c\u53f8\u4e13\u95e8\u4f7f\u7528\u6570\u5b57PCR\u4f5c\u4e3a\u4e34\u5e8a\u68c0\u6d4b\u8bd5\u5242\u76d2\u7684\u7533\u62a5\uff0c\u5176\u4e2d\u9996\u6279\u7533\u62a5\u7684\u5305\u62ec\u4e86EGFR T790M TKI\u7684\u8010\u836f\u53d8\u5f02\u4ee5\u53caHER-2\u62f7\u8d1d\u6570\u53d8\u5f02\u3002\u5bf9\u4e8e\u6db2\u6001\u6d3b\u68c0\u4e2d\u7684\u4e34\u5e8a\u9633\u6027cutoff\u7684\u8bbe\u5b9a\uff0c\u6765\u81ea\u6cb3\u5357\u7701\u80bf\u7624\u533b\u9662\u7684\u9a6c\u6770\u6559\u6388\u5206\u4eab\u4e86\u5bf9\u4e8eEGFR T790M\u7684\u68c0\u6d4b\u4e0b\u9650\uff0cctDNA\u7a81\u53d8\u8d1f\u8377\u57281%\u4ee5\u4e0a\u4e09\u4ee3TKI\u9776\u5411\u836f\u6cbb\u7597\u6548\u679c\u975e\u5e38\u543b\u5408\uff0c0.1%\u751a\u81f3\u662f\u52300.04%\u5bf9\u4e00\u4ee3TKI\u9776\u5411\u836f\u8010\u836f\u6709\u5f88\u5927\u7684\u9884\u793a\u5f71\u50cf\u5b66\u8fdb\u5c55\u7684\u63d0\u793a\u4f5c\u7528\u3002<\/div>\n
\u00a0<\/div>\n
9\u3001NGS\u80bf\u7624\u68c0\u6d4b\u751f\u6001\u5708\u5df2\u521d\u5177\u89c4\u6a21<\/div>\n
\u76ee\u524d\u6709\u591a\u5bb6\u516c\u53f8\u5728\u5bf9NGS\u68c0\u6d4b\u8bd5\u5242\u76d2\u8fdb\u884c\u6ce8\u518c\u7533\u62a5\uff0c\u800c\u4e14\u90fd\u662f\u9488\u5bf9\u80ba\u764c\u9776\u5411\u836f\u7684\u70ed\u70b9\u68c0\u6d4b\u3002\u53e6\u5916\u4e1a\u5185\u8fd8\u6709\u66f4\u591a\u516c\u53f8\u63d0\u4f9b\u79d1\u7814\u8bd5\u5242\u76d2\u6216\u8005NGS\u6355\u83b7\u65b9\u6848\u7684\u5b9a\u5236\u670d\u52a1\uff0c\u4ea7\u4e1a\u94fe\u4e5f\u8d8a\u53d1\u7684\u6210\u719f\u3002\u56fd\u5185\u57fa\u4e8eNGS\u7684\u80bf\u7624\u68c0\u6d4b\u884c\u4e1a\u751f\u6001\u5708\u5df2\u7ecf\u521d\u5177\u89c4\u6a21\uff0c\u6700\u4e0a\u6e38\u7684\u6d4b\u5e8f\u4eea\u6709\u591a\u5bb6\u6d4b\u5e8f\u4eea\u53d1\u5e03\uff0c\u4e2d\u6e38\u7684\u6355\u83b7\u8bd5\u5242\u4e0e\u5efa\u5e93\u8bd5\u5242\u4e5f\u6709\u8bb8\u591a\u516c\u53f8\u53c2\u4e0e\uff0c\u57fa\u4e8e\u6570\u636e\u5206\u6790\u9886\u57df\u4e5f\u6709\u57fa\u4e8e\u4e91\u8ba1\u7b97\u7b49\u89e3\u51b3\u65b9\u6848\u4f9b\u5e94\u5546\uff0c\u8fd9\u4e9b\u884c\u4e1a\u5185\u7684\u4f9b\u5e94\u94fe\u914d\u5957\u7684\u6210\u719f\u9884\u8ba1\u4f1a\u66f4\u597d\u7684\u4fc3\u8fdb\u884c\u4e1a\u7684\u5171\u540c\u8fdb\u6b65\u4e0e\u53d1\u5c55\u3002<\/div>\n
\u00a0<\/div>\n
10\u3001CFDA\u52a0\u5febNGS\u80bf\u7624\u68c0\u6d4b\u4ea7\u54c1\u5ba1\u6279<\/div>\n
9\u670828\u65e5\u5706\u684c\u8ba8\u8bba\u4f1a\u4e0a\uff0c\u5609\u5bbe\u8521\u4e09\u519b\u6559\u6388\u3001\u5b8b\u52c7\u6559\u6388\uff0c\u4ee5\u53ca\u4e3b\u6301\u5434\u4e00\u9f99\u6559\u6388\u4e0e\u738b\u601d\u777f\u6559\u6388\uff0c\u516d\u4f4d\u4e34\u5e8a\u4e13\u5bb6\u5c55\u5f00\u4e86\u6fc0\u70c8\u7684\u8ba8\u8bba\u3002\u5176\u4e2d\u5404\u4f4d\u4e13\u5bb6\u80af\u5b9a\u4e86NGS\u5728\u76ee\u524d\u5bf9\u80bf\u7624\u4e34\u5e8a\u8bca\u65ad\u7684\u79ef\u6781\u4f5c\u7528\uff0c\u5e76\u4e14\u90fd\u5bf9NGS\u5728\u4eca\u540e\u66f4\u7d27\u5bc6\u53c2\u4e0e\u4e34\u5e8a\u4e0a\u7684\u51b3\u7b56\u6709\u5f88\u597d\u7684\u524d\u666f\uff0c\u540c\u65f6\u5404\u4f4d\u4e13\u5bb6\u4e5f\u63d0\u51fa\u62c5\u5fe7\uff0c\u76ee\u524d\u56fd\u5185\u4f17\u591a\u8fdb\u884c\u57fa\u56e0\u68c0\u6d4b\u7684\u6d4b\u5e8f\u516c\u53f8\u4e0e\u7b2c\u4e09\u65b9\u4e34\u5e8a\u673a\u6784\uff0c\u76ee\u524d\u7f3a\u4e4f\u76d1\u7ba1\u4e0e\u7edf\u4e00\u6807\u51c6\uff0c\u5404\u673a\u6784\u6c34\u5e73\u826f\u83a0\u4e0d\u9f50\u3002\u76ee\u524d\u7f8e\u56fd\u6709CLIA\u548cCAP\u7684\u8ba4\u8bc1\u76d1\u7ba1\u4f53\u7cfb\uff0c\u800c\u6765\u81eaCFDA\u7684\u9093\u521a\u4e3b\u4efb\u548c\u5415\u5141\u51e4\u90e8\u957f\u63d0\u51fa\uff0c\u76ee\u524d\u56fd\u5185\u8fd8\u6ca1\u6709\u80bf\u7624\u76f8\u5173NGS\u68c0\u6d4b\u8bd5\u5242\u76d2\u901a\u8fc7CFDA\u5ba1\u6279\uff0cCFDA\u5bf9\u4e8e\u4f01\u4e1a\u7533\u62a5NGS\u68c0\u6d4b\u9879\u76ee\u662f\u9f13\u52b1\u7684\uff0c\u5e76\u4e14\u63d0\u51fa\u4e3a\u4e86\u52a0\u5febNGS\u80bf\u7624\u68c0\u6d4b\u76f8\u5173\u4ea7\u54c1\u7684\u5ba1\u6279\uff0c\u5728\u836f\u7269\u7533\u8bf7\u7684\u6570\u636e\u53ef\u4ee5\u7528\u4e8eNGS\u68c0\u6d4b\u8bd5\u5242\u548c\u4ea7\u54c1\u7533\u8bf7\u7684\u6570\u636e[5]\u3002<\/div>\n
\u00a0<\/div>\n
\u53c2\u8003\u6587\u732e\uff1a<\/div>\n
[1] \u00a0http:\/\/www.medscape.com\/viewarticle\/878125#vp_1<\/div>\n
[2] \u00a0https:\/\/bookdown.org\/youcai\/Liquid_biopsy_PocketBook\/methylation-technology.html#dna<\/div>\n
[3] \u00a0https:\/\/kknews.cc\/zh-hk\/health\/j2aooq.html<\/div>\n
[4] \u00a0CAP Cancer Biomarker Reporting Templates\uff0cLungBiomarkers 1.3.0.1\uff0c2016<\/div>\n
[5] \u00a0http:\/\/www.geneclub.net.cn\/info\/industry\/5305.html?appinstall=0&from=timeline<\/div>\n
\u00a0<\/div>\n
\u60a8\u53ef\u80fd\u8fd8\u4f1a\u611f\u5174\u8da3\u7684<\/div>\n
\u2606\u00a0<\/a>CSCO 2017\u00a0<\/a>9\u670827\u65e5\u4e94\u4e2a\u4e13\u573a\u901f\u8bb0<\/a><\/div>\n
\u2606\u00a0<\/a>\u57fa\u56e0\u6167\u4e13\u8bbf\uff1a\u5317\u5927\u56fd\u9645\u533b\u9662\u6881\u519b\u526f\u9662\u957f<\/a><\/div>\n
\u2606\u00a0<\/a>\u6881\u519b\uff1a\u6211\u4eec\u5df2\u8fdb\u5165\u514d\u75ab\u6cbb\u7597\u65f6\u4ee3<\/a><\/div>\n
\u2606\u00a0<\/a>C<\/a>SCO 2017 \u4e13\u5bb6\u53ca\u536b\u661f\u4f1a\u76ee\u5f55<\/a><\/div>\n
\u2606\u00a0<\/a>\u8fd9\u5bb6\u57fa\u56e0\u68c0\u6d4b\u516c\u53f8\uff0c\u8981\u505a10000\u4f8b\u80bf\u7624\u7cbe\u51c6\u514d\u75ab\u68c0\u6d4b\u8ba1\u5212<\/a><\/div>\n
\u2606\u00a0<\/a>\u536b<\/a>\u661f\u4f1a\u901f\u8bb0 | \u767e\u6d0b\u667a\u80fd\u3001\u62d3\u666e\u3001\u9f0e\u6676\u3001\u777f\u601d<\/a><\/div>\n
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<\/figure><\/div>\n\n<\/div>\n
<\/figure><\/div>\n\n<\/div>\n<\/div>\n
<\/div>\n
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<\/figure><\/div>\n\n<\/div>\n
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