{"id":11072,"date":"2017-10-03T20:02:38","date_gmt":"2017-10-03T12:02:38","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&mid=100001870&idx=1&sn=35054fe19cc780394b585eec3c5beb67&chksm=6b72baf95c0533efabdf1ac086c2300f1f44460d69b25ba516fd8adc2d5ed8cfb96422400cca#rd"},"modified":"2026-04-09T09:41:45","modified_gmt":"2026-04-09T01:41:45","slug":"495754","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2017\/10\/03\/495754\/","title":{"rendered":"\u600e\u4e48\u901a\u4fd7\u5730\u89e3\u91ca2017\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\uff1a\u751f\u7269\u949f\u6216\u7531\u57fa\u56e0\u51b3\u5b9a\u7684"},"content":{"rendered":"

<\/p>\n

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\"RmFicvQBAkgB2Wkia2jicswicwcVoFyjgcfgTs7EvkIvaL9iaxH58RWS4hMSua2bpu0OvzUl1zL3EL0yicv2V9Gny66g\"\/<\/figure><\/div>\n\n
\u5173\u952e\u5b57\uff1a\u751f\u7269\u949f \u8bfa\u8d1d\u5c14\u59562017<\/div>\n
\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956 \u751f\u7269\u8282\u5f8b\u57fa\u56e0<\/div>\n
\u7528\u65f6\uff1a\u7ea65\u5206\u949f<\/div>\n
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\u6821 \u00a0 \u00a0\u5bf9\uff1a\u5341\u4e00\u90ce<\/div>\n
2017\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u5df2\u4e8e\u745e\u5178\u5f53\u5730\u65f6\u95f410\u67082\u65e511:30\uff08\u5317\u4eac\u65f6\u95f410\u67082\u65e517:30\uff09\u6b63\u5f0f\u63ed\u6653\uff0c\u8be5\u5956\u9879\u6388\u4e88\u7f8e\u56fd\u79d1\u5b66\u5bb6\u6770\u5f17\u91cc\u00b7\u970d\u5c14\u3001\u8fc8\u514b\u5c14\u00b7\u7f57\u65af\u5df4\u4ec0\u548c\u8fc8\u514b\u5c14\u00b7\u626c\uff0c\u4ee5\u8868\u5f70\u4ed6\u4eec\u5728\u7814\u7a76\u751f\u7269\u949f\u8fd0\u884c\u7684\u5206\u5b50\u673a\u5236\u65b9\u9762\u7684\u6210\u5c31\u3002<\/div>\n
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1\u3001\u83b7\u5956\u4eba\u4ecb\u7ecd<\/div>\n\n
\n
\"5aXUrW9MfZCPeqDa9SF2NuReZOVWf3QS9a3BXWXAoUoZRQR0ibrxnra4smrNtBAGOK37ibyMiap8o6LVvLRiaWz23w\"\/<\/figure><\/div>\n\n
JEFFREY C. HALL US<\/div>\n
\uff08\u6770\u5f17\u91cc\u00b7\u970d\u5c14 \u7f8e\u56fd\uff09<\/div>\n
\u7f8e\u56fd\u9057\u4f20\u5b66\u5bb6\u30021945\u5e74\u751f\u4e8e\u7f8e\u56fd\u7ebd\u7ea6\uff0c1971\u5e74\u83b7\u5f97\u897f\u96c5\u56fe\u534e\u76db\u987f\u5927\u5b66\u9057\u4f20\u5b66\u535a\u58eb\u5b66\u4f4d\uff0c\u4e8e1974\u5e74\u6210\u4e3a\u5e03\u5170\u4ee3\u65af\u5927\u5b66\u6559\u5458\u3002\u4e8e2013\u5e74\u83b7\u5f97\u90b5\u9038\u592b\u751f\u547d\u79d1\u5b66\u53ca\u533b\u5b66\u5956\u30021984\u5e74\u4ed6\u548c\u8fc8\u514b\u5c14\u00b7\u7f57\u65af\u5df4\u4ec0\u7684\u7814\u7a76\u5c0f\u7ec4\u514b\u9686\u4e86\u679c\u8747\u7684\u5468\u671f\u57fa\u56e0\uff0c\u8fd9\u4e2a\u57fa\u56e0\u80fd\u591f\u8c03\u8282\u679c\u8747\u7684\u751f\u7269\u949f\u3002<\/div>\n\n
\n
\"5aXUrW9MfZCPeqDa9SF2NuReZOVWf3QSJvv7kXmR9uSrjAcNGO9Jp9oZEOUxCiaIKeDeeP6cm73LswcsKtQmYkQ\"\/<\/figure><\/div>\n\n
MICHAEL ROSBASH US\u00a0<\/div>\n
\uff08\u8fc8\u514b\u5c14\u00b7\u7f57\u65af\u5df4\u4ec0 \u7f8e\u56fd\uff09<\/div>\n
\u7f8e\u56fd\u9057\u4f20\u5b66\u5bb6\u30021944 \u5e74\u751f\u4e8e\u5bc6\u82cf\u91cc\u5dde\u3002\u7f57\u65af\u5df4\u4ec0\u662f\u5e03\u5170\u4ee3\u65af\u5927\u5b66\u6559\u6388\u548c\u970d\u534e\u5fb7\u00b7\u4f11\u65af\u533b\u5b66\u7814\u7a76\u6240\u7684\u7814\u7a76\u5458\u30021984\u5e74\u4ed6\u548c\u6770\u5f17\u91cc\u00b7\u970d\u5c14\u7684\u7814\u7a76\u5c0f\u7ec4\u514b\u9686\u4e86\u679c\u8747\u7684\u5468\u671f\u57fa\u56e0\uff0c1990\u5e74\u63d0\u51fa\u4e86\u751f\u7269\u949f\u7684\u8f6c\u5f55\u7ffb\u8bd1\u8d1f\u53cd\u9988\u56de\u8def\u7684\u6982\u5ff5\u3002 1998\u5e74\uff0c\u5728\u679c\u8747\u4e2d\uff0c\u4ed6\u4eec\u53d1\u73b0\u4e86\u5468\u671f\u57fa\u56e0\u548c\u65f6\u949f\u57fa\u56e0\u3002 2003\u5e74\u5f53\u9009\u4e3a\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u58eb\u3002<\/div>\n\n
\n
\"5aXUrW9MfZCPeqDa9SF2NuReZOVWf3QSSqytluicce444dhYibdaM4HwDRbAPpkibbPU35QsWOZZRuLSrg873iaPdA\"\/<\/figure><\/div>\n\n
MICHAEL W. YOUNG US<\/div>\n
\uff08\u8fc8\u514b\u5c14\u00b7\u626c \u7f8e\u56fd\uff09<\/div>\n
\u7f8e\u56fd\u9057\u4f20\u5b66\u5bb6\u3001\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u58eb\u30021949 \u5e74\u751f\u4e8e\u4f5b\u7f57\u91cc\u8fbe\u5dde\u30021975\u5e74\u83b7\u5f97\u514b\u8428\u65af\u5927\u5b66\u5965\u65af\u6c40\u5206\u6821\u535a\u58eb\u5b66\u4f4d\uff0c1978\u5e74\u8d77\u4efb\u6d1b\u514b\u83f2\u52d2\u5927\u5b66\u6559\u5458\uff0c\u540e\u6210\u4e3a\u8be5\u6821\u526f\u6821\u957f\u30022013\u5e74\u83b7\u5f97\u90b5\u9038\u592b\u751f\u547d\u79d1\u5b66\u53ca\u533b\u5b66\u5956\u30021984\u5e74\u4ed6\u7684\u56e2\u961f\u514b\u9686\u51fa\u679c\u8747\u7684\u5468\u671f\u57fa\u56e0\uff0c\u8fd9\u4e2a\u57fa\u56e0\u80fd\u591f\u8c03\u8282\u679c\u8747\u7684\u751f\u7269\u949f\u3002<\/div>\n
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2\u3001\u83b7\u5956\u9879\u76ee\u4ecb\u7ecd<\/div>\n
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\n
\"5aXUrW9MfZCPeqDa9SF2NuReZOVWf3QSZ6zm0V57EbLwCzOTQzBaO8Qn7mialWliciaVnicsYGXJMWUXtZiclIePFzw\"\/<\/figure><\/div>\n\n
\u4eca\u5e74\u7684\u8bfa\u8d1d\u5c14\u751f\u7269\u5b66\u5956\u83b7\u5f97\u8005\u4eec\u4ece\u679c\u8747\u8eab\u4e0a\u5206\u79bb\u51fa\u4e86\u4e00\u79cd\u57fa\u56e0\uff0c\u8fd9\u79cd\u57fa\u56e0\u7528\u6765\u63a7\u5236\u679c\u8747\u7684\u65e5\u5e38\u751f\u7269\u8282\u5f8b\u30021984 \u5e74\uff0cJeffrey Hall \u548c Michael Robash\uff08\u5f53\u65f6\u4e24\u4eba\u5728\u6ce2\u58eb\u987f\u7684\u5e03\u5170\u8fea\u65af\u5927\u5b66\uff09\u548c\u6d1b\u514b\u83f2\u6d1b\u5927\u5b66\u7684 Michael Young \u7d27\u5bc6\u5408\u4f5c\uff0c\u6210\u529f\u5730\u5206\u79bb\u51fa\u4e86 period \u57fa\u56e0\u3002\u4ed6\u4eec\u628a\u8fd9\u4e2a\u57fa\u56e0\u7f16\u7801\u7684\u86cb\u767d\u5176\u540d\u4e3a\u201cPER\u201d\u3002\u4ed6\u4eec\u53d1\u73b0\uff0c\u8fd9\u79cd\u57fa\u56e0\u53ef\u4ee5\u4f7f\u5f97\u679c\u8747\u5728\u767d\u5929\u65f6\u5bf9\u4f53\u5185\u7684\u4e00\u79cd\u86cb\u767d\u8d28\u8fdb\u884c\u7f16\u7801\uff0c\u5728\u665a\u4e0a PER \u4f1a\u5728\u679c\u8747\u4f53\u5185\u805a\u96c6\uff0c\u5230\u4e86\u767d\u5929\u53c8\u4f1a\u81ea\u52a8\u5206\u89e3\u3002\u6240\u4ee5 PER \u7684\u6d53\u5ea6\u4f1a\u5faa\u73af\u9707\u8361\uff0c\u5468\u671f\u4e3a 24 \u5c0f\u65f6\uff0c\u548c\u663c\u591c\u8282\u5f8b\u76f8\u540c\u3002\u968f\u540e\uff0c\u7814\u7a76\u4eba\u5458\u53c8\u53d1\u73b0\u4e86\u8fd9\u79cd\u673a\u5236\u7684\u5176\u4ed6\u86cb\u767d\u8d28\u7ec4\u5206\uff0c\u4ece\u800c\u63ed\u793a\u4e86\u5230\u5e95\u662f\u4e00\u79cd\u600e\u6837\u7684\u673a\u5236\u4f7f\u5f97\u7ec6\u80de\u5185\u7684\u751f\u7269\u949f\u6301\u7eed\u5de5\u4f5c\u3002\u800c\u8fd9\u79cd\u7ec6\u80de\u5185\u673a\u5236\u540c\u6837\u4f5c\u7528\u4e8e\u5176\u4ed6\u591a\u7ec6\u80de\u751f\u7269\uff0c\u5305\u62ec\u4eba\u7c7b\u672c\u8eab\u3002<\/div>\n
\u00a0<\/div>\n
\u690d\u7269\u4f53\u5185\u6216\u4e5f\u5b58\u5728\u751f\u7269\u949f<\/div>\n
\u5927\u591a\u6570\u7684\u751f\u7269\u53ef\u4ee5\u9884\u6d4b\u5e76\u9002\u5e94\u73af\u5883\u4e2d\u7684\u65e5\u5e38\u53d8\u5316\u3002\u572818 \u4e16\u7eaa\u65f6\u671f\uff0c\u6cd5\u56fd\u79d1\u5b66\u5bb6 Jean-Jacques d’Ortous de Mairan \u5c06\u542b\u7f9e\u8349\u7f6e\u4e8e\u6052\u5b9a\u9ed1\u6697\u7684\u73af\u5883\u4e0b\u3002\u4ed6\u53d1\u73b0\uff0c\u542b\u7f9e\u8349\u53f6\u7247\u7684\u6d3b\u52a8\u4ecd\u80fd\u4fdd\u6301 24 \u5c0f\u65f6\u7684\u6ce2\u52a8\u6027\u53d8\u5316\u3002\u690d\u7269\u4f3c\u4e4e\u90fd\u6709\u81ea\u5df1\u7684\u751f\u7269\u949f\uff0c\u90a3\u6b21\u53d1\u73b0\u4e5f\u88ab\u8ba4\u4e3a\u662f\u751f\u7269\u5177\u6709\u5185\u6e90\u751f\u7269\u8282\u5f8b\u7684\u6700\u65e9\u8bc1\u636e\u3002<\/div>\n\n
\n
\"LicTqho3hYIScxnUibE5u7rhlZOzfaWFSazHahWTMuoibgvziaCZviceotO2nI45EHWHQsickEGO7YLEwkT9RuqaGjnA\"\/<\/figure><\/div>\n\n
\u56fe\u4e28\u542b\u7f9e\u8349\u7684\u751f\u7269\u949f\u73b0\u8c61<\/div>\n
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\u00a0<\/div>\n
PER\u86cb\u767d\u81ea\u6211\u8c03\u8282\u7684\u5468\u671f\u8282\u5f8b<\/div>\n
\u53e6\u5916\u4e00\u4e2a\u4e9f\u5f85\u89e3\u51b3\u7684\u91cd\u5927\u8bfe\u9898\uff0c\u5c31\u662f PER \u8fd9\u4e2a\u86cb\u767d\u5982\u4f55\u4fdd\u6301\u7a33\u5b9a\u7684\u9707\u8361\u5468\u671f\u3002Jeffery Hall \u548c Michael Rosbash \u63d0\u51fa\u4e86\u4e00\u4e2a\u5047\u8bf4\uff1aPER \u86cb\u767d\u53ef\u4ee5\u8ba9 period \u57fa\u56e0\u5931\u53bb\u6d3b\u6027\u3002\u6362\u53e5\u8bdd\u8bf4\uff0cPER \u548c period \u5f62\u6210\u4e86\u4e00\u4e2a\u6291\u5236\u53cd\u9988\u7684\u73af\u8def\uff0cPER \u53ef\u4ee5\u6291\u5236\u57fa\u56e0\u5408\u6210\u81ea\u5df1\uff0c\u8fd9\u6837\u5c31\u5f62\u6210\u4e86\u4e00\u4e2a\u8fde\u7eed\uff0c\u5faa\u73af\u7684\u8282\u5f8b\uff08\u5982\u4e0b\u56fe\uff09\u3002<\/div>\n\n
\n
\"LicTqho3hYIScxnUibE5u7rhlZOzfaWFSa5MFvwicayGcm56DYmpZc11oF6d7qrHw5w9gyCebtWpMIjYE2DXeggzA\"\/<\/figure><\/div>\n\n
\u56fe\u4e28 period \u57fa\u56e0\u53cd\u9988\u6761\u4ef6\u7684\u7b80\u5355\u793a\u610f\u56fe\u3002<\/div>\n
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PER \u86cb\u767d\u8d28\u53ea\u6709\u4ece\u7ec6\u80de\u8d28\u8fdb\u5165\u7ec6\u80de\u6838\uff0c\u624d\u80fd\u6291\u5236 period \u57fa\u56e0\u3002Jeffery Hall \u548c Robash \u7684\u7814\u7a76\u8868\u660e\uff0c\u6bcf\u5f53\u665a\u4e0a\u7684\u65f6\u5019\uff0cPER \u86cb\u767d\u4f1a\u5728\u7ec6\u80de\u6838\u91cc\u79ef\u7d2f\uff0c\u4f46\u662f\u5b83\u662f\u5982\u4f55\u8fdb\u5165\u7ec6\u80de\u6838\u7684\uff1f1994 \u5e74\uff0cMichael Young \u53d1\u73b0\u4e86\u7b2c\u4e8c\u4e2a\u8282\u5f8b\u57fa\u56e0\uff1atimeless\u3002Timeless \u53ef\u4ee5\u7f16\u7801 TIM \u86cb\u767d\uff0c\u540c\u6837\u4e3a\u6b63\u5e38\u8282\u5f8b\u6240\u9700\u3002Young \u505a\u4e86\u4e00\u4e2a\u6f02\u4eae\u7684\u5b9e\u9a8c\uff0c\u53d1\u73b0 TIM \u4f1a\u7ed3\u5408\u5230 PER \u4e0a\uff0c\u7136\u540e\u4e24\u4e2a\u86cb\u767d\u53ef\u4ee5\u4e00\u8d77\u8fdb\u5165\u7ec6\u80de\u6838\uff0c\u5e76\u4e14\u5728\u90a3\u91cc\u6291\u5236 period \u57fa\u56e0\u7684\u6d3b\u6027\uff08\u5982\u4e0b\u56fe\uff09\u3002<\/div>\n\n
\n
\"LicTqho3hYIScxnUibE5u7rhlZOzfaWFSaf8qAIZj06IKUEib3uSyvBJgWhH7VnjXzTmQHArjYYD7I2A4OSsuWmxw\"\/<\/figure><\/div>\n\n
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\"xWYL70wczZopDvicUJRxftCIsDIrmWbjcrAcP3jLKibu01xPsxErH8bvCmeHQibwX4fkTf6bHbaKZXdO9SnE0mVTw\"\/<\/figure><\/div>\n\n<\/div>\n
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2. Scientific Background Discoveries of Molecular Mechanisms Controlling the Circadian Rhythm\uff08\u5728\u5fae\u4fe1\u516c\u4f17\u53f7\u524d\u53f0\u56de\u590d\u201c2017\u8bfa\u5956\u201d\u5373\u53ef\u83b7\u5f97\u8bba\u6587\u539f\u6587\u4e0b\u8f7d\u65b9\u5f0f\uff09<\/div>\n
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