{"id":11058,"date":"2017-09-04T20:45:18","date_gmt":"2017-09-04T12:45:18","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&mid=100001549&idx=1&sn=3c310f9431bce64f59be5dedf1e3a28f&chksm=6b72b5ba5c053cacf050c308b8406394bf45c784a1b6f1c68fc2a1ab94b2ab324ad3ff09bf61#rd"},"modified":"2026-04-09T09:43:57","modified_gmt":"2026-04-09T01:43:57","slug":"995097","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2017\/09\/04\/995097\/","title":{"rendered":"\u65b0\u77e5 | CSCO\u6765\u4e86\uff0c\u88c5\u5907\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u6280\u672f\u7a81\u7834\u548c\u4ea7\u4e1a\u8981\u95fb"},"content":{"rendered":"

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\"RmFicvQBAkgBqJyMcQxUZibhoFCjLcSCNYDXUEhmz2Zf3jEC87jjYiceTyIaB3JnrFLh5ibjQQBCozYupUkT2icDsTA\"\/<\/figure><\/div>\n\n<\/div>\n
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\u5173\u952e\u5b57\uff1aCSCO \u80bf\u7624 \u514d\u75ab\u6cbb\u7597<\/div>\n
CAR-T<\/div>\n
\u5927\u7ea6\u7528\u65f6\uff1a5\u5206\u949f<\/div>\n
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CSCO 2017\u5b66\u672f\u5e74\u4f1a\u8981\u6765\u4e86\uff013\u5929\u4f1a\u8bae\uff0c80\u573a\u536b\u661f\u4f1a\uff0c\u6709\u8fd150\u573a\u62a5\u544a\u5173\u4e8e\u80bf\u7624\u514d\u75ab\u3002\u201c\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u201d\u5c06\u6210\u4e3a\u91cd\u5934\u620f\u4e4b\u4e00\uff0c\u5728\u6469\u62f3\u64e6\u638c\u5954\u8d74\u91d1\u7816\u4f1a\u8bae\u4e3b\u529e\u5730\u53a6\u95e8\u4e4b\u524d\uff0c\u6211\u4eec\u6765\u4e00\u8d77\u7ec6\u6570\u514d\u75ab\u6cbb\u7597\u9886\u57df\u91cd\u5927\u6280\u672f\u7a81\u7834\u548c\u70ed\u70b9\u4e8b\u4ef6\uff0c\u88c5\u5907\u5e72\u8d27\u597d\u8d76\u8def\u3002<\/div>\n
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\"RmFicvQBAkgD9Nwd3Gr9fkBnU68LVMB3KwwA6fum2kRwqE6fpGZArKVrcCqWhfYzLRpNgauu3ErPmicSib9J1bcTQ\"\/<\/figure><\/div>\n\n
#1 \u00a09\u67084\u65e5\uff0c\u6b66\u7530\u5236\u836f\u6295\u8d44\u5f00\u53d1\u4e0b\u4e00\u4ee3CAR-T\u4ea7\u54c1<\/div>\n
\u6b66\u7530\u5236\u836f\uff08Takeda\uff09\u548c\u4e1c\u4eac\u7684\u521d\u521b\u516c\u53f8Noile-Immune Biotech\u5408\u4f5c\uff0c\u6295\u8d44\u5f00\u53d1\u4e0b\u4e00\u4ee3CAR-T\u836f\u7269\uff0c\u9776\u5411\u5b9e\u4f53\u80bf\u7624\u6cbb\u7597\u3002<\/div>\n
\u53cc\u65b9\u901a\u8fc7\u5c71\u53e3\u5927\u5b66\uff08Yamaguchi University\uff09\u7814\u7a76\u4eba\u5458\u5f00\u53d1\u7684\u65b0\u6280\u672f\uff0c\u63a2\u7d22\u6269\u5c55CAR-T\u7597\u6cd5\u7684\u8303\u56f4\u3002<\/div>\n
\u8fc7\u53bb\u4e00\u5e74\u6b66\u7530\u5236\u836f\uff08Takeda\uff09\u4e00\u76f4\u5728\u91cd\u7ec4\uff0c\u6b63\u5728\u6536\u8d2d\u4e0a\u8ff0\u516c\u53f8\u80a1\u6743\uff0c\u5e76\u9884\u4ed8\u4e86\u6280\u672f\u8d39\uff0c\u83b7\u5f97\u6280\u672f\u6d41\u7a0b\u7684\u8bb8\u53ef\u6743\u3002\u6b66\u7530\u5236\u836f\u975e\u5e38\u770b\u597d\u4e0b\u4e00\u4ee3CAR-T\u7ec6\u80de\u6cbb\u7597\u6280\u672f\u5de8\u5927\u7684\u6f5c\u529b\uff0c\u7279\u522b\u5728\u80bf\u7624\u65b0\u836f\u7814\u53d1\u4e2d\uff0c\u8fd9\u5c06\u6210\u4e3a\u4ed6\u4eec\u6838\u5fc3\u9886\u57df\u4e4b\u4e00\u3002<\/div>\n
\u00a0<\/div>\n
#2 \u00a08\u670830\u65e5\uff0cFDA\u6279\u51c6\u9996\u4e2aCAR-T\u7ec6\u80de\u7597\u6cd5\u4e0a\u5e02<\/div>\n
\u8fd9\u662f\u4eba\u7c7b\u5386\u53f2\u9996\u6b21\u88abFDA\u6279\u51c6\u4e0a\u5e02\u7684CAR-T\u7597\u6cd5\uff0c\u4e5f\u662f\u7f8e\u56fd\u5883\u5185\u9996\u6b21\u6279\u51c6\u7684\u57fa\u56e0\u7597\u6cd5<\/div>\n
\u88ab\u6279\u51c6\u7684CAR-T\u7597\u6cd5\u7684\u5546\u54c1\u540d\u4e3aKymriah\uff08tisagenlecleucel\uff0c\u66fe\u7528\u540dCTL019\uff09\uff0c\u7528\u4e8e\u6cbb\u7597\u7f79\u60a3\u96be\u6cbb\u6027B-\u7ec6\u80de\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08ALL\uff09\u6216\u590d\u53d1\u6027\u768425\u5c81\u4ee5\u4e0b\u60a3\u8005\u3002<\/div>\n
Kymriah\u7597\u6cd5\u6cbb\u7597\u4e00\u6b21\u82b1\u8d39\u7ea647.5\u4e07\u7f8e\u5143\uff0c\u5148\u4ece\u4e2a\u4f53\u60a3\u8005\u7684\u4f53\u5185\u63d0\u53d6\u51fa\u514d\u75ab\u7ec6\u80deT\u7ec6\u80de\uff0c\u5e76\u901a\u8fc7\u57fa\u56e0\u5de5\u7a0b\u6539\u4f7fT\u7ec6\u80de\u5f15\u5165\u5168\u65b0\u7684\u5d4c\u5408\u6297\u539f\u53d7\u4f53\uff08CAR\uff09\uff0c\u4f7f\u5176\u76f4\u63a5\u9776\u5411\u5e76\u6740\u4f24\u5e26\u6709CD19\u6297\u539f\u7684\u767d\u8840\u75c5\u7ec6\u80de\uff0c\u6539\u9020\u540e\u7684T\u7ec6\u80de\u91cd\u65b0\u8f93\u6ce8\u56de\u60a3\u8005\u4f53\u5185\u5171\u8ba1\u764c\u7ec6\u80de\u3002<\/div>\n
\u5728\u6cbb\u7597\u76843\u4e2a\u6708\u5185\uff0cCAR-T\u7597\u6cd5\u603b\u4f53\u7f13\u89e3\u7387\u8fbe\u523083%\u3002\u540c\u65f6FDA\u5c06\u7ec6\u80de\u56e0\u5b50\u7a81\u91ca\u7efc\u5408\u5f81\uff08CRS\uff09\u5217\u4e3a Kymriah\u7684\u9ed1\u6846\u8b66\u544a\uff0c\u6765\u81ea\u7f57\u6c0f\u7684Actemra\u5355\u6297\uff08Tocilizumab\uff09\u53ef\u5bf9\u6297CRS\u3002<\/div>\n
\u00a0<\/div>\n
#3 \u00a08\u670829\u65e5\uff0cGilead \u5ba3\u5e03\u5c06\u4ee5119\u4ebf\u7f8e\u5143\u6536\u8d2d Kite Pharma\u00a0<\/div>\n
\u8fd9\u4e0d\u4ec5\u662f Gilead \u516c\u53f8\u5386\u53f2\u4e0a\u89c4\u6a21\u6700\u5927\u7684\u6536\u8d2d\u4e4b\u4e00\uff0c\u4e5f\u53ef\u80fd\u4f5c\u4e3a\u5178\u578b\u6536\u8d2d\u6848\u4f8b\u4e4b\u4e00\u3002\u672c\u6b21\u6536\u8d2d\u5c06\u4e8e\u4eca\u5e74\u7b2c\u56db\u5b63\u5ea6\u5b8c\u6210\u3002<\/div>\n
Kite\u65d7\u4e0b\u9996\u6b3eCAR-T\u7597\u6cd5axicabtagene ciloleucel\uff08axi-cel\uff09\u5728\u96be\u6cbb\u6027\u4fb5\u88ad\u6027\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u7684\u6cbb\u7597\u4e0a\uff0c\u6709\u9ad8\u8fbe82%\u7684\u60a3\u8005\u63a5\u53d7\u5355\u6b21\u6ce8\u5c04\u540e\u51fa\u73b0\u4e86\u7f13\u89e3\uff0c\u4eca\u5e745\u6708\u83b7\u5f97\u7f8e\u56fdFDA\u9881\u53d1\u7684\u4f18\u5148\u5ba1\u8bc4\u8d44\u683c\uff1b\u65d7\u4e0b\u4e0b\u4e00\u4ee3CAR-T\u7597\u6cd5KITE-585\u00a0\u9776\u5411\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7ec6\u80de\u8868\u9762\u5e38\u89c1\u7684BCMA\u6297\u539f\uff0c\u5176IND\u7533\u8bf7\u5df2\u7ecf\u5f97\u5230\u4e86\u7f8e\u56fdFDA\u7684\u6279\u51c6\uff0c\u5373\u5c06\u542f\u52a81\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/div>\n
2012\u5e74\uff0cGilead\u66fe\u4ee5\u7c7b\u4f3c\u7684\u6570\u5b57\uff08112\u4ebf\u7f8e\u5143\uff09\u6536\u8d2d Pharmasset\u3002CEO Milligan\u535a\u58eb\u6307\u51fa\uff0c\u6b64\u6b21\u6536\u8d2d\u4e0d\u6b62\u662f\u4e3a\u4e86axi-cel\u4e00\u6b3e\u4ea7\u54c1\uff0c\u800c\u662f\u4e3a\u4e86\u6574\u4e2a\u5f00\u53d1\u6297\u764c\u7ec6\u80de\u7597\u6cd5\u7684\u6280\u672f\u5e73\u53f0\uff0c\u5efa\u7acb\u4e00\u4e2a\u53ef\u6301\u7eed\u7684\u51fa\u8272\u80bf\u7624\u5b66\u5e73\u53f0\u3002<\/div>\n
\u00a0<\/div>\n
\u4eca\u5e745\u6708\uff0cPD-1\u6297\u4f53Keytruda \u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u643a\u5e26\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\u9ad8\uff08microsatellite instability-high\uff0cMSI-H\uff09\u6216\u9519\u914d\u4fee\u590d\u7f3a\u9677\uff08mismatch repair deficient\uff0cdMMR\uff09\u7684\u6210\u4eba\u548c\u513f\u7ae5\u5b9e\u4f53\u7624\u60a3\u8005\u3002DNA\u4fee\u590d\u673a\u5236\u7684\u7f3a\u9677\u5176\u5b9e\u5c31\u662f\u4e00\u79cd\u5bfc\u81f4\u80bf\u7624\u51fa\u73b0\u9ad8\u6c34\u5e73\u7684\u7a81\u53d8\u8d1f\u8377\uff0c\u4ea7\u751f\u65b0\u6297\u539f\u7684\u539f\u56e0\u4e4b\u4e00\u3002<\/div>\n
\u9648\u7afa<\/div>\n
\u00a0<\/div>\n
GeneMail<\/div>\n
\u60a8\u53ef\u80fd\u8fd8\u4f1a\u611f\u5174\u8da3\u7684<\/div>\n
\u2606\u00a0<\/a>\u9b4f\u4e8e\u5168\u9662\u58eb\uff1a\u751f\u7269\u6cbb\u7597\u4e3a\u764c\u75c7\u6cbb\u7597\u5e26\u6765\u65b0\u5e0c\u671b<\/a><\/div>\n
\u2606<\/a>\u00a0Sidney <\/a>Kimmerl\u764c\u75c7\u4e2d\u5fc3\u6768\u864e\u5c71\uff1acfDNA\u5927\u6570\u636e<\/a><\/div>\n
\u2606<\/a>\u00a0\u5317\u5927\u5f20\u6cfd\u6c11\uff1a\u9996\u6b21\u53d1\u5e03\u5927\u89c4\u6a21\u80bf\u7624\u5355\u7ec6\u80de\u514d\u75ab\u56fe\u8c31<\/a><\/div>\n
\u2606<\/a>\u00a0\u80bf\u7624\u7cbe\u51c6\u533b\u7597\u6280\u672f\u8c03\u7814\u62a5\u544a(130\u9875PPT)<\/a><\/div>\n
\u2606<\/a>\u00a0NGS Cancer Panel\u6807\u51c6\u5316\u4f53\u7cfb\u7814\u8ba8\u4f1aPPT<\/a><\/div>\n
\u2606<\/a>\u00a0\u56fd\u5185\u591650\u4f59\u4e2a\u7cbe\u51c6\u533b\u5b66\u961f\u5217\u9879\u76ee\u7565\u89c8<\/a><\/div>\n
\u2606<\/a>\u00a0\u80bf\u7624\u9776\u5411\u6cbb\u7597\u53ca\u5176FDA\u6279\u51c6\u9776\u5411\u836f\u6e05\u5355<\/a><\/div>\n
\u2606<\/a>\u00a0\u764c\u75c7\u5e8f\u5217\u53d8\u5f02\u89e3\u91ca\u548c\u62a5\u544a\u7684\u6807\u51c6\u548c\u6307\u5357<\/a><\/div>\n
\u2606<\/a>\u00a0ASCO2017\u5e74\u770b\u70b9<\/a><\/div>\n\n
\n
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