\n![\"RmFicvQBAkgBqJyMcQxUZibhoFCjLcSCNYDXUEhmz2Zf3jEC87jjYiceTyIaB3JnrFLh5ibjQQBCozYupUkT2icDsTA\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBqJyMcQxUZibhoFCjLcSCNYDXUEhmz2Zf3jEC87jjYiceTyIaB3JnrFLh5ibjQQBCozYupUkT2icDsTA.gif\")
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\u8001\u5fb7\uff0c\u542c\u8bf423andme\u548cGenentech\u4eca\u5929\u5728NG\u4e0a\u53d1\u4e86\u7bc7\u786c\u7a3f\u554a\uff0c\u5e94\u8be5\u662f\u8fd9\u5bb6\u57fa\u56e0\u516c\u53f8\u548c\u836f\u5382\uff0c\u53bb\u5e746000\u4e07\u7f8e\u91d1\u5927\u624b\u7b14\u5408\u4f5c\u6709\u6210\u679c\u4e86\u6492~<\/div>\n\n
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\u53d1\u8868\u57289\u670811\u300aNature Genetics\u300b\u4e0a\u7684\u6700\u65b0\u6210\u679c\uff0c6,476\u540d\u5e15\u91d1\u68ee\u60a3\u8005\u548c302,042\u540d\u6b63\u5e38\u4eba\u7684\u5bf9\u7167\uff0c\u901a\u8fc7\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u5206\u6790\uff08GWAS\uff09\u548c\u835f\u8403\u5206\u6790\uff08\u53c8\u79f0\u201cmeta\u5206\u6790\u201d\uff09\u65b9\u6cd5\uff0c\u53d1\u73b0\u4e8617\u4e2a\u65b0\u7684\u5e15\u91d1\u68ee\u76f8\u5173\u7684\u98ce\u9669\u57fa\u56e0\u4f4d\u70b9\u3002<\/div>\n
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\u8be5\u56e2\u961f\u5305\u62ec23andme\uff0cGenentech\uff0c\u56fd\u5bb6\u8001\u9f84\u5316\u7814\u7a76\u6240\uff08National Institute on Aging\uff09\u548c\u6570\u636e\u79d1\u5b66\u54a8\u8be2\u521d\u521b\u4f01\u4e1aData Tecnica International\u3002<\/div>\n
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\n\n
\n![\"RmFicvQBAkgBbL6XiaiaN4a9yylAv9WNJIwadcJdDAiauZuRffHibTibl1Tl3fqXDNFb7DlcJecEzvwBLib3gRR0IkfYQ\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBbL6XiaiaN4a9yylAv9WNJIwadcJdDAiauZuRffHibTibl1Tl3fqXDNFb7DlcJecEzvwBLib3gRR0IkfYQ.jpeg\")
<\/figure><\/div>\n\n<\/div>\n
<\/figure><\/div>\n\n<\/div>\nRobert Graham, 2007\u8fdb\u5165Genentech<\/div>\n
\u4e13\u6ce8\u4e8e\u7814\u7a76\u963f\u5179\u6d77\u9ed8\u75c7\u548c\u5e15\u91d1\u68ee\u75c5\u7684\u57fa\u56e0\u673a\u5236\u548c\u7f55\u89c1\u53d8\u5f02\u53d1\u73b0<\/div>\n
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Genentech\u7684\u7814\u7a76\u4eba\u5458\u3001\u672c\u6587\u901a\u8baf\u4f5c\u8005Robert Graham\u4ee5\u53ca\u4ed6\u7684\u5408\u4f5c\u4f19\u4f34\u5728\u6587\u4e2d\u5199\u9053\uff1a\u201c\u8fd9\u4e9b\u5019\u9009\u57fa\u56e0\u7684\u9274\u5b9a\u63a8\u52a8\u4e86\u529f\u80fd\u7814\u7a76\uff0c\u4ece\u800c\u66f4\u5feb\u786e\u5b9a\u5e15\u91d1\u68ee\u7684\u81f4\u75c5\u57fa\u56e0\u548c\u53ef\u80fd\u7684\u6cbb\u7597\u9776\u70b9\u3002\u201d<\/div>\n
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\n\n
\n![\"RmFicvQBAkgBbL6XiaiaN4a9yylAv9WNJIwxlVUaJY8QbqfgDJ7LDECgY76ic5p68aQN4b2zUrv7MdIvuaah4LNcYg\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBbL6XiaiaN4a9yylAv9WNJIwxlVUaJY8QbqfgDJ7LDECgY76ic5p68aQN4b2zUrv7MdIvuaah4LNcYg.png\")
<\/figure><\/div>\n\n<\/div>\n
<\/figure><\/div>\n\n<\/div>\n<\/div>\n
\u6211\u4eec\u77e5\u9053\uff0c2015\u5e741\u6708\uff0c\u57fa\u56e0\u6cf0\u514b\u548c23andme\u8fbe\u62106000\u4e07\u7f8e\u5143\u7684\u5408\u4f5c\uff0c\u4e3b\u8981\u5173\u4e8e3000\u540d\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u76f8\u5173\u7684\u5168\u57fa\u56e0\u7ec4\u4fe1\u606f\u5171\u4eab\u3002\u5728\u4e0d\u5c11\u4eba\u63d0\u5230\u6570\u636e\u4ea4\u6613\u7684\u5229\u5f0a\u65f6\uff0c\u6211\u4eec\u4e5f\u770b\u5230\u79d1\u5b66\u548c\u5e02\u573a\u7684\u4e92\u8865\u7ed3\u5408\uff0c\u5171\u540c\u8fbe\u6210\u5b9e\u8d28\u6027\u5e76\u516c\u5e03\u4e0e\u4f17\u7684\u79d1\u7814\u6210\u679c\u7528\u4e8e\u672a\u6765\u75c5\u60a3\u7684\u4e34\u5e8a\u5e94\u7528\u3002<\/div>\n
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\n\n
\n![\"RmFicvQBAkgBbL6XiaiaN4a9yylAv9WNJIwhbH0fmp4YbWoRodX6Fv0uib4cgS0SdJI5RWfBsMLGMFobEJboqAZGZA\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBbL6XiaiaN4a9yylAv9WNJIwhbH0fmp4YbWoRodX6Fv0uib4cgS0SdJI5RWfBsMLGMFobEJboqAZGZA.png\")
<\/figure><\/div>\n\n<\/div>\n
<\/figure><\/div>\n\n<\/div>\n\u56fe\uff1ameta\u5206\u6790\u6d41\u7a0b<\/div>\n
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\u4e3b\u8981\u5206\u6790\u65b9\u6cd5\u662f\u57fa\u4e8e\u4ee5\u4e0a\u6570\u636e\u7684\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u5206\u6790\uff08PDWBS\uff09\uff0c\u4ee5\u53ca\u5305\u542b13,708 PD\u6837\u672c\u548c 95,282\u5bf9\u7167\u7684\u835f\u8403\u5206\u6790\uff08PDGene\uff09\uff0c\u6570\u636e\u7f3a\u5931\u7684impute\u91c7\u7528Minimac2\u5de5\u5177\u548c1000 Genomes phase 1 haplotypes\u6570\u636e\u3002<\/div>\n
<\/div>\n
PDWBS\u548cPDGene\u7814\u7a76\u53d1\u73b0\u67099,830\u91cd\u53e0\u7684SNPs\uff0c\u901a\u8fc7P\u503c\u6821\u6b63\u7b49\u65b9\u6cd5\u53d1\u73b0<\/div>\n
P\u503c\u5c0f\u4e8e10\u7684-6\u6b21\u65b9\u60c5\u51b5\u4e0b\u53d1\u73b035 loci\uff0cP\u503c\u5c0f\u4e8e10\u7684-8\u6b21\u65b9\u60c5\u51b5\u4e0b\u53d1\u73b015 loci\u3002 \u7136\u540e\u5bf9\u4e8e\u8fd935\u4e2a\u4f4d\u70b9\uff0c\u901a\u8fc7NeuroX Illumina \u82af\u7247\u7684\u00a0\u6b27\u6d32\u7956\u6e90\u76845,851cases\u548c5,866 \u5bf9\u7167\u6837\u672c\u9a8c\u8bc1\uff0c\u8fc7\u6ee4\u621029\u4e2a\uff0c\u7136\u540e\u8054\u5408PDGene, PDWBS\u548cNeuroX\u7684meta\u5206\u6790\uff0c\u5f97\u523016\u4e2a\u5019\u9009\u7684\u76f8\u5173\u57fa\u56e0\u4f4d\u70b9\uff08P\u503c\u5c0f\u4e8e10\u7684-6\u6b21\u65b9\uff09\u3002\u52a0\u4e0a\u4e4b\u524d\u62a5\u9053\u7684\u4e00\u4e2a\u4f4d\u70b9\uff0c\u53d1\u73b0\u53ef\u4ee5\u9884\u6d4b\u5e15\u91d1\u68ee\u98ce\u9669\u3002\u4e00\u517117\u4e2a\u65b0\u53d1\u73b0\u7684\u5e15\u91d1\u68ee\u76f8\u5173\u7684\u57fa\u56e0\u4f4d\u70b9\u3002<\/div>\n
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\n\n
\n![\"RmFicvQBAkgBbL6XiaiaN4a9yylAv9WNJIwZF54fEgHwCLeKL54yYBvSSFtYibasrFHRI4a492eWENC3tC7c5LTAbg\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBbL6XiaiaN4a9yylAv9WNJIwZF54fEgHwCLeKL54yYBvSSFtYibasrFHRI4a492eWENC3tC7c5LTAbg.png\")
<\/figure><\/div>\n\n<\/div>\n
<\/figure><\/div>\n\n<\/div>\n\u56fe\uff1a\u672c\u6b21\u7814\u7a76\u53d1\u73b017\u4e2a\u5e15\u91d1\u68ee\u5019\u9009\u98ce\u9669\u57fa\u56e0\u4f4d\u70b9<\/div>\n
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\u540c\u65f6\uff0c\u7814\u7a76\u8005\u6ce8\u610f\u5230\u5e15\u91d1\u68ee\u4e0eHLA\u533a\u57df\u5173\u8054\u6bd4\u8f83\u590d\u6742\u3002 HLA\u533a\u57df\u7684\u4e24\u4e2a\u57fa\u56e0\u4e5f\u4f5c\u4e3a\u5019\u9009\u57fa\u56e0\uff0c \u8fd9\u4e0e\u4ee5\u524d\u7684\u7814\u7a76\u7ed3\u679c\u4e00\u81f4\uff0c\u8868\u660eHLA\u533a\u57df\u7684\u5e15\u91d1\u68ee\u5173\u8054\u53ef\u80fd\u6307\u5411\u591a\u79cd\u56e0\u5b50\uff0c\u4e4b\u524d\u6709\u7814\u7a76\u8868\u660e\u7cbe\u795e\u5206\u88c2\u75c7\u4e2d\u89c2\u5bdf\u5230HLA\u76f8\u5173\u6027\u4ee5\u53caC4\u62f7\u8d1d\u6570\u3002<\/div>\n
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\n\n
\n![\"RmFicvQBAkgBbL6XiaiaN4a9yylAv9WNJIwRiabgShwib4tBCNHa3eQJbJdJBzH5aFhaLCbfzSzicHlaSMgAkeIEgdgw\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBbL6XiaiaN4a9yylAv9WNJIwRiabgShwib4tBCNHa3eQJbJdJBzH5aFhaLCbfzSzicHlaSMgAkeIEgdgw.png\")
<\/figure><\/div>\n\n
<\/figure><\/div>\n\n\u56fe\uff1a\u4e0e\u5e15\u91d1\u68ee\u75c5\u76f8\u5173\u7684\u5730\u533a\u7684\u5019\u9009\u57fa\u56e0\u3002<\/div>\n
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\u56fd\u5185\u7c7b\u4f3c\u6807\u7684\u4f01\u4e1a\uff0cWeGene<\/a>\u3001\u57fa\u4e91\u60e0\u5eb7<\/a>\u300123\u9b54\u65b9<\/a>\u3001\u5955\u771f\u751f\u7269<\/a>\u7b49\u4e0e\u76f8\u5173\u79d1\u7814\u673a\u6784\u90fd\u6709\u7c7b\u4f3c\u5408\u4f5c\uff0c\u671f\u5f85\u66f4\u591a\u6210\u679c\u3002\u5305\u62ec\u521d\u521b\u4f01\u4e1a\u7684\u4f18\u79c0\u6280\u672f\u548c\u4ea7\u4e1a\u6210\u679c\uff0c\u57fa\u56e0\u6167\u7684\u201c\u660e\u65e5\u4e4b\u661f\u201d\u4e13\u680f\uff08\u6b22\u8fce\u8054\u7cfbinfo@genonet.cn\uff09\u53ef\u4ee5\u63d0\u4f9b\u62a5\u9053\u652f\u6301\u3002<\/div>\n
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\u00a0<\/div>\n
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