{"id":11024,"date":"2016-12-06T08:21:04","date_gmt":"2016-12-06T00:21:04","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&mid=100000003&idx=1&sn=a3182dc5a226d58606cf421ebbaa4f23&chksm=6b72b3b45c053aa22bf5b8aee235e98797a2930779b72af269714bddbf2da02231e31634c7c9#rd"},"modified":"2026-04-09T14:17:58","modified_gmt":"2026-04-09T06:17:58","slug":"525748","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2016\/12\/06\/525748\/","title":{"rendered":"\u201c\u8c6a\u534e\u7248\u8bfa\u8d1d\u5c14\u5956\u201d\u63ed\u6653\uff1a\u5206\u5b50\u751f\u7269\u5b66\u5907\u53d7\u5173\u6ce8\uff08\u9644\u6587\u732e\u4e0b\u8f7d\uff09"},"content":{"rendered":"

<\/p>\n

Geneclub<\/div>\n
\u57fa\u56e0\u6167<\/div>\n
\u5173\u952e\u8bcd\uff1a\u8c6a\u534e\u7248\u8bfa\u8d1d\u5c14\u5956 \u79d1\u5b66\u7a81\u7834\u5956 Yuri Milner \u6469\u6839\u57fa\u5fb7\u66fc \u624e\u5361\u4f2f\u683c Wnt\u4fe1\u53f7\u901a\u8def \u7ec6\u80de\u81ea\u566c \u810a\u9ad3\u5c0f\u8111\u5171\u6d4e\u5931\u8c03\u548cRett\u7efc\u5408\u5f81 RNA\u6838\u7cd6\u4f53 DNA\u635f\u4f24<\/div>\n
\u9605\u8bfb\u7528\u65f6\uff1a\u542b1332\u5b57 \uff0c\u7ea63\u5206\u949f<\/div>\n
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\u6269\u5c55\u6027\u9605\u8bfb\u4f53\u9a8c<\/div>\n
1\u79d1\u5b66\u7a81\u7834\u5956\uff08\u8c6a\u534e\u7248\u8bfa\u8d1d\u5c14\u5956\uff09\u00a0<\/div>\n
\u79d1\u666e\u7a81\u7834\u5956\uff08Breakthrough Prize\uff09\uff0c\u7531\u4fc4\u7f57\u65af\u98ce\u9669\u6295\u8d44\u5bb6Yuri Milner\uff08Yuri\u4e5f\u662fFacebook\u3001Twitter\uff0cAirbnb\u3001\u963f\u91cc\u5df4\u5df4\uff0c\u4eac\u4e1c\u3001\u5c0f\u7c73\u7b49\u4f01\u4e1a\u7684\u6295\u8d44\u4eba\uff09\uff0c\u8054\u5408Facebook\u516c\u53f8\u521b\u59cb\u4eba\u9a6c\u514b\u00b7 \u624e\u514b\u4f2f\u683c\uff0c\u548cGoogle\u516c\u53f8\u521b\u59cb\u4eba\u8c22\u5c14\u76d6\u00b7\u5e03\u6797\u7b49\u4eba\u5171\u540c\u8bbe\u7acb\uff0c\u7528\u6765\u8868\u5f70\u5728\u751f\u547d\u79d1\u5b66\u3001\u57fa\u7840\u7269\u7406\u5b66\u4ee5\u53ca\u6570\u5b66\u9886\u57df\u505a\u51fa\u6770\u51fa\u8d21\u732e\u7684\u4eba\u3002\u6bcf\u4f4d\u83b7\u5956\u8005\u83b7\u5f97\u5956\u91d1300\u4e07\u7f8e\u91d1\uff0c\u8d85\u8fc7\u8bfa\u8d1d\u5c14\u5956\uff0c\u88ab\u79f0\u4e4b\u4e3a\u201c\u8c6a\u534e\u7248\u8bfa\u8d1d\u5c14\u5956\u201d\u3002<\/div>\n
\uff08\u9644\uff1aYuri\u4ecb\u7ecd\uff1ahttp:\/\/mt.sohu.com\/20160513\/n449354400.shtml\uff09<\/div>\n
\u00a0<\/div>\n
22016\u5e74\u79d1\u5b66\u7a81\u7834\u5956\u516c\u5e03<\/div>\n
\u6839\u636e\u79d1\u5b66\u7a81\u7834\u5956\uff08Breakthrough Prize\uff09\u5b98\u7f51\uff08https:\/\/breakthroughprize.org\/\uff09\u62a5\u9053\uff0c12\u67084\u65e5\uff08\u7f8e\u56fd\u65f6\u95f4\uff09\u665a10\u70b9\uff0c \u79d1\u5b66\u7a81\u7834\u5956\u5728\u7845\u8c37NASA\u827e\u59c6\u65af\u7814\u7a76\u4e2d\u5fc3\u516c\u5e03\u3002\u4e94\u4f4d\u79d1\u5b66\u5bb6\u6210\u4e3a\u751f\u547d\u79d1\u5b66\u9886\u57df\u7684\u83b7\u5956\u8005\uff0c\u5176\u4e2d\u5206\u5b50\u751f\u7269\u5b66\u5907\u53d7\u5173\u6ce8\uff0c\u5305\u62ecWnt\u4fe1\u53f7\u901a\u8def\uff0c\u810a\u9ad3\u5c0f\u8111\u5171\u6d4e\u5931\u8c03\u548cRett\u7efc\u5408\uff0cRN\u5728\u6838\u7cd6\u4f53\u4e2d\u7684\u4f5c\u7528\uff0c\u771f\u6838\u7ec6\u80de\u611f\u77e5\u548c\u5e94\u7b54DNA\u635f\u4f24\u7b49\u3002\u9664\u6b64\u4e4b\u5916\u662f\u4eca\u5e74\u83b7\u5f97\u8bfa\u8d1d\u5c14\u751f\u7406\u6216\u533b\u5b66\u5956\u7684\u7ec6\u80de\u81ea\u566c\u3002<\/div>\n\n
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\"RmFicvQBAkgBdjahCneB3E3WzqNt5CXsw4jPeQgfDibiajToThA12vfNCC4wPw3WuImjTrwDzb1L7p1jE28icfNkYQ\"\/<\/figure><\/div>\n\n

\u56fe\u4e00\uff1a\u79d1\u5b66\u7a81\u7834\u5956\u9881\u5956\u73b0\u573a\u6765\u6e90\uff1ahttp:\/\/www.dailymail.co.uk\/<\/p>\n

\u5728\u79d1\u5b66\u5bb6\u4eae\u76f8\u4e4b\u524d\uff0c\u8ba9\u6211\u4eec\u5148\u770b\u770b\uff1a<\/div>\n
32016\u5e74\u79d1\u5b66\u7a81\u7834\u5956\u9881\u5956\u8d85\u5f3a\u9635\u5bb9<\/div>\n
1\uff09\u5730\u70b9\uff1a\u7845\u8c37NASA\u827e\u59c6\u65af\u7814\u7a76\u4e2d\u5fc3<\/div>\n
2\uff09\u5956\u91d1\uff1a\u6bcf\u4eba300\u4e07\u7f8e\u5143<\/div>\n
3\uff09\u4e3b\u8981\u4e3b\u6301\u4eba\uff1a<\/div>\n\n
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\"RmFicvQBAkgBdjahCneB3E3WzqNt5CXswT9pey7aLd7ErwWp06frGGrYGML7EJhK3DUia1bCnyamicSKr0UuzI0hQ\"\/<\/figure><\/div>\n\n

\u56fe\u4e8c \u53f3\u4e00 \u6469\u6839\u57fa\u5fb7\u66fc\uff08Morgan Freeman\uff09\u6765\u6e90\uff1ahttp:\/\/www.dailymail.co.uk\/<\/p>\n

4\uff09\u9881\u5956\u5609\u5bbe\u5217\u8868\uff1a<\/div>\n\n
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\"RmFicvQBAkgBdjahCneB3E3WzqNt5CXswgodt3aPHb9fFgc8wpibnDCIxgBU7emEyAPgWkcrk6vdicYJ0URXgwibeA\"\/<\/figure><\/div>\n\n

\u56fe\u4e09 \u5de6\u4e00\u8303\u00b7\u8fea\u585e\u5c14\uff08Vin Diesel\uff09\uff0c \u53f3\u4e00 \u624e\u514b\u4f2f\u683c\uff08Mark Zuckerberg\u00a0\uff09<\/p>\n

\u6765\u6e90\uff1ahttp:\/\/www.dailymail.co.uk\/<\/div>\n
Daniel Ek\uff1a CEO\uff0c \u5168\u7403\u6700\u5927\u7684\u6b63\u7248\u6d41\u5a92\u4f53\u97f3\u4e50\u670d\u52a1\u5e73Spotify\u7684Hiroshi Mikitani\uff1aCEO\uff0c\u65e5\u672c\u6700\u5927\u7535\u5b50\u5546\u5e97\u8857\u7ecf\u8425\u8005\u4e50\u5929\u682a\u5f0f\u4f1a\u793eRakuten<\/div>\n
Sundar Pichai\uff1a CEO\uff0c\u8c37\u6b4c<\/div>\n
Susan Wojcicki \uff1aCEO \uff0cYouTube<\/div>\n
Sergey Brin : \u79d1\u5b66\u7a81\u7834\u5956\u521b\u59cb\u4eba\uff0c\u8c37\u6b4c\u8054\u5408\u521b\u59cb\u4eba<\/div>\n
Anne Wojcicki\uff1a\u79d1\u5b66\u7a81\u7834\u5956\u521b\u59cb\u4eba\uff0c23andme\u521b\u59cb\u4eba<\/div>\n
Mark Zuckerberg and Priscilla Chan: \u79d1\u5b66\u7a81\u7834\u5956\u521b\u59cb\u4eba\uff0cFacebook\u521b\u59cb\u4eba\u53ca\u5176\u592b\u4eba<\/div>\n
Yuri and Julia Milner\uff1a\u7845\u8c37\u9876\u7ea7\u6295\u8d44\u5bb6Yuri\u592b\u5987<\/div>\n
Alex Rodriguez, Will.i.am, Jeremy Irons, Mark and Scott Kelly, , Sienna Miller, Bryce Dallas Howard, Vin Diesel, Kevin Durant, Dev Patel\uff1a\u4f53\u80b2\u3001\u5f71\u89c6\u7b49\u5404\u754c\u660e\u663e<\/div>\n
\u00a0<\/div>\n
4\u3001\u79d1\u5b66\u7a81\u7834\u5956\u7684\u751f\u547d\u79d1\u5b66\u5956\u9886\u57df\u4e94\u4f4d\u83b7\u5956\u8005\uff1a<\/div>\n
Stephen J. Elledge\uff0cDNA\u635f\u4f24\u7814\u7a76<\/div>\n
\u54c8\u4f5b\u5927\u5b66\u533b\u5b66\u9662\u9057\u4f20\u5b66\u7cfb\u9057\u4f20\u4e0e\u533b\u5b66\u7cfb\u6559\u6388<\/div>\n\n
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\"RmFicvQBAkgBdjahCneB3E3WzqNt5CXswRWB9qycQ4ibRU9gWREDQtmhjUuz72YxGcgjiaqkY2yIZUXAf6sWTZnGA\"\/<\/figure><\/div>\n\n

\u56fe\u56db Stephen J. Elledge \u00a0\u56fe\u7247\u6765\u6e90\uff1abbs.0513.org<\/p>\n

Stephen J. Elledge\u9610\u660e\u4e86\u771f\u6838\u7ec6\u80de\u5982\u4f55\u611f\u77e5\u548c\u5e94\u7b54DNA\u635f\u4f24\uff0c\u5e76\u5bf9\u4e86\u89e3\u764c\u75c7\u7684\u53d1\u5c55\u548c\u63a2\u7d22\u6cbb\u7597\u65b9\u5f0f\u63d0\u4f9b\u4e86\u65b0\u7684\u7ebf\u7d22\u3002<\/div>\n
\u4e2a\u4eba\u4e3b\u9875\uff1ahttp:\/\/www.hhmi.org\/scientists\/stephen-j-elledge<\/div>\n
\u76f8\u5173\u6587\u732e\uff1aThe DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4<\/div>\n
\u6587\u732e\u4e0b\u8f7d\uff1a<\/div>\n
https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4942138\/<\/div>\n
\u00a0<\/div>\n
Harry F. Noller\uff0c\u6838\u7cd6\u4f53\u4e2dRNA\u7814\u7a76<\/div>\n
\u52a0\u5dde\u5927\u5b66\u5723\u514b\u9c81\u65af\u5206\u6821\u5206\u5b50\u751f\u7269\u5b66\u6559\u6388\uff0cRNA\u5206\u5b50\u751f\u7269\u5b66\u4e2d\u5fc3\u4e3b\u4efb\u3002<\/div>\n\n
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\"RmFicvQBAkgBdjahCneB3E3WzqNt5CXswYoyLqExz5aicpzU1yNBvPltEplXLGdcVxeibkvkDjFvSz7qnDibkm9TYA\"\/<\/figure><\/div>\n\n

\u56fe\u4e94 Harry F. Noller \u00a0\u56fe\u7247\u6765\u6e90\uff1awww.cn-healthcare.com<\/p>\n

Harry F. Noller\u53d1\u73b0RNA\u5728\u5f62\u6210\u6838\u7cd6\u4f53\u7684\u6d3b\u6027\u4e2d\u5fc3\u7684\u4e2d\u5fc3\u5730\u4f4d\uff0c\u662f\u6240\u6709\u7ec6\u80de\u4e2d\u86cb\u767d\u8d28\u5408\u6210\u7684\u57fa\u672c\u673a\u5236\uff0c\u4ece\u800c\u5c06\u73b0\u4ee3\u751f\u7269\u5b66\u548c\u751f\u547d\u7684\u8d77\u6e90\u8fde\u63a5\uff0c\u5e76\u89e3\u91ca\u4e86\u5929\u7136\u6297\u751f\u7d20\u5bf9\u86cb\u767d\u8d28\u5408\u6210\u7684\u7834\u574f\u3002<\/div>\n
\u4e2a\u4eba\u4e3b\u9875\uff1ahttp:\/\/mcd.ucsc.edu\/faculty\/noller.html<\/div>\n
\u76f8\u5173\u6587\u732e\uff1aInitiation of translation in bacteria by a structured eukaryotic IRES RNA.<\/div>\n
\u6587\u732e\u4e0b\u8f7d\uff1ahttps:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25652826<\/div>\n
\u00a0<\/div>\n
Roeland Nusse\uff0cWnt\u901a\u8def\u7814\u7a76<\/div>\n
\u65af\u5766\u798f\u5927\u5b66\u53d1\u80b2\u751f\u7269\u5b66\u6559\u6388\u548c\u970d\u534e\u5fb7\u4f11\u65af\u533b\u5b66\u7814\u7a76\u6240\u7814\u7a76\u5458<\/div>\n\n
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\"RmFicvQBAkgBdjahCneB3E3WzqNt5CXsw6PpMlEBoW11IIfs7lJZxVoeDRqpL0eclZHs50putSMiabWib1L4zNvMw\"\/<\/figure><\/div>\n\n

\u56fe\u516d Roeland Nusse \u00a0\u56fe\u7247\u6765\u6e90\uff1abbs.0513.org<\/p>\n

Roeland Nusse\u662fWnt\u53d1\u73b0\u8005\u4e4b\u4e00\uff0c\u5bf9Wnt\u901a\u8def\u8fdb\u884c\u4e86\u5f00\u521b\u6027\u7814\u7a76\u3002 Wnt\u901a\u8def\u662f\u662f\u751f\u7269\u53d1\u80b2\uff0c\u764c\u75c7\u548c\u5e72\u7ec6\u80de\u751f\u7269\u5b66\u4e2d\u5173\u952e\u7684\u7ec6\u80de\u95f4\u4fe1\u53f7\u7cfb\u7edf\u4e4b\u4e00\u3002<\/div>\n
\u4e2a\u4eba\u4e3b\u9875\uff1ahttps:\/\/med.stanford.edu\/profiles\/roeland-nusse<\/div>\n
\u76f8\u5173\u6587\u732e\uff1aAn integral program for tissue renewal and regeneration: Wnt signaling and stem cell control<\/div>\n
\u6587\u4ef6\u4e0b\u8f7d\uff1ahttp:\/\/science.sciencemag.org\/content\/346\/6205\/1248012<\/div>\n
\u00a0<\/div>\n
Yoshinori Ohsumi\uff0c\u7ec6\u80de\u81ea\u566c\u7814\u7a76<\/div>\n
\u65e5\u672c\u5206\u5b50\u7ec6\u80de\u751f\u7269\u5b66\u5bb6\u3002\u73b0\u4efb\u7efc\u5408\u7814\u7a76\u5927\u5b66\u9662\u5927\u5b66\u540d\u8a89\u6559\u6388\u3001\u57fa\u7840\u751f\u7269\u5b66\u7814\u7a76\u6240\u540d\u8a89\u6559\u6388<\/div>\n\n
\n
\"RmFicvQBAkgBdjahCneB3E3WzqNt5CXswP3iaKkS54j1mDGzJ17OPje84j7dx0mJOic9usFGya0dOwXRse22nkMcw\"\/<\/figure><\/div>\n\n

\u56fe\u4e03 Yoshinori Ohsumi \u56fe\u7247\u6765\u6e90\uff1an-tv.de<\/p>\n

Yoshinori Ohsumi\u56e0\u4e3a\u7ec6\u80de\u81ea\u566c\u7814\u7a76\u83b7\u5f972017\u5e74\u8bfa\u8d1d\u5c14\u751f\u7406\u6216\u533b\u5b66\u5956\u3002<\/div>\n
\u4e2a\u4eba\u4e3b\u9875\uff1a<\/div>\n
https:\/\/www.researchgate.net\/profile\/Yoshinori_Ohsumi\/publications<\/div>\n
\u76f8\u5173\u6587\u732e\uff1aStructural Basis for Receptor-Mediated Selective Autophagy of Aminopeptidase I Aggregates<\/div>\n
\u6587\u732e\u4e0b\u8f7d\uff1a\u00a0<\/div>\n
https:\/\/www.researchgate.net\/profile\/Nobuo_Noda\/publication\/304196070_Structural_Basis_for_Receptor-Mediated_Selective_Autophagy_of_Aminopeptidase_I_Aggregates\/links\/577da2b108aed39f598f7e4a.pdf<\/div>\n
\u00a0<\/div>\n
\u8d1d\u52d2\u513f\u79d1\u795e\u7ecf\u9057\u4f20\u5b66 Huda Yahya Zoghbi<\/div>\n
\u8d1d\u52d2\u533b\u5b66\u9662\u513f\u79d1\uff0c\u5206\u5b50\u548c\u4eba\u7c7b\u9057\u4f20\u5b66\uff0c\u795e\u7ecf\u75c5\u5b66\u548c\u795e\u7ecf\u79d1\u5b66\u7cfb\u6559\u6388\uff0c\u970d\u534e\u5fb7\u4f11\u65af\u533b\u5b66\u7814\u7a76\u6240\u7814\u7a76\u5458\uff0c\u5fb7\u514b\u8428\u65af\u513f\u7ae5\u533b\u9662NRI\u795e\u7ecf\u75c5\u5b66\u7814\u7a76\u6240\uff08NRI\uff09\u4e3b\u4efb<\/div>\n\n
\n
\"RmFicvQBAkgBdjahCneB3E3WzqNt5CXsw1xH0XB3iaxGQuvSJXZpPKZ767wgBlicTWobLb3vh9cCfaHw9dA3P7oog\"\/<\/figure><\/div>\n\n

\u56fe\u516b Huda Yahya Zoghbi \u00a0\u56fe\u7247\u6765\u6e90\uff1ahttps:\/\/www.bcm.edu<\/p>\n

Huda Yahya Zoghbi\u53d1\u73b0\u810a\u9ad3\u5c0f\u8111\u6027\u5171\u6d4e\u5931\u8c03\u548cRett\u7efc\u5408\u5f81\u7684\u9057\u4f20\u539f\u56e0\u548c\u751f\u5316\u673a\u5236\uff0c\u63ed\u793a\u4e86\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u548c\u795e\u7ecf\u75be\u75c5\u7684\u53d1\u75c5\u673a\u5236\u3002<\/div>\n
\u4e2a\u4eba\u4e3b\u9875\uff1ahttps:\/\/www.bcm.edu\/people\/view\/huda-zoghbi-m-d\/b1855108-ffed-11e2-be68-080027880ca6<\/div>\n
\u76f8\u5173\u6587\u732e\uff1aAn AT-hook domain in MeCP2 determines the clinical course of Rett syndrome and related disorders.<\/div>\n
\u6587\u732e\u4e0b\u8f7d\uff1a<\/div>\n
https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmid\/23452848\/<\/div>\n
\u00a0<\/div>\n
\u53c2\u8003\u7f51\u7ad9\uff1a<\/div>\n
1\uff09https:\/\/breakthroughprize.org\/News\/34<\/div>\n
2\uff09http:\/\/www.dailymail.co.uk\/sciencetech\/article-4001294\/Morgan-Freeman-Mark-Zuckerberg-Yuri-Milner-host-Breakthrough-Awards-Gala-gives-19-million-funding-world-s-scientists.html<\/div>\n
3\uff09https:\/\/www.bcm.edu<\/div>\n
4\uff09https:\/\/www.researchgate.net\/<\/div>\n
5\uff09https:\/\/med.stanford.edu\/<\/div>\n
6\uff09http:\/\/mcd.ucsc.edu<\/div>\n
7\uff09https:\/\/www.ncbi.nlm.nih.gov\/<\/div>\n<\/div>\n
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