{"id":11014,"date":"2017-01-23T07:58:36","date_gmt":"2017-01-22T23:58:36","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&#038;mid=100000126&#038;idx=1&#038;sn=31fc0573debb2706f9eb1bfc33b935d5&#038;chksm=6b72b3c95c053adf8c83fa6f072ff3d381ca228e602cd5a229b15597b7989571ed3134f8785e#rd"},"modified":"2026-04-03T11:16:31","modified_gmt":"2026-04-03T03:16:31","slug":"9957100","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2017\/01\/23\/9957100\/","title":{"rendered":"\u6167\u8bfe03 | wANNOVAR\u57fa\u56e0\u7a81\u53d8\u529f\u80fd\u6ce8\u91ca\u8f6f\u4ef6\u4f7f\u7528\u64cd\u4f5c\u89c6\u9891\u4ecb\u7ecd"},"content":{"rendered":"<p><!-- wechat_content_hash: c9d7cb8484f6c883 --><\/p>\n<div>\u6167\u8bfe<\/div>\n<div>wANNOVAR &#8212; \u738b\u51ef\u6559\u6388<\/div>\n<div>\u5173\u952e\u8bcd\uff1a\u57fa\u56e0\u7a81\u53d8 \u529f\u80fd\u6ce8\u91ca \u00a0ANNOVAR wANNOVAR \u00a0annotation mutation variant<\/div>\n<div>\u9605\u8bfb\u7528\u65f6\uff1a\u7ea610\u5206\u949f\uff0c\u542b\u89c6\u9891\u7ea66\u5206\u949f<\/div>\n<div>\u5185\u5bb9\u7b80\u4ecb\uff1a\u201c\u5de5\u6b32\u5584\u5176\u4e8b\uff0c\u5fc5\u5148\u5229\u5176\u5668\u201d\u3002\u5728\u8de8\u5b66\u79d1\u3001\u8de8\u4ea7\u4e1a\u7684\u7cbe\u51c6\u533b\u5b66\u9886\u57df\uff0c\u63d0\u4f9b\u5206\u6790\u548c\u8fde\u63a5\u7684\u5de5\u5177\u975e\u5e38\u91cd\u8981\u3002\u56e0\u6b64\uff0c\u57fa\u56e0\u6167\u5efa\u7acb\u300a\u6167\u8bfe\u300b\u5e73\u53f0\uff0c\u9080\u8bf7\u9876\u5c16\u7684\u4e13\u5bb6\u89c6\u9891\u4ecb\u7ecd\u4e1a\u754c\u5e38\u7528\u5de5\u5177\u7684\u7b80\u77ed\u6559\u7a0b\uff0c\u63d0\u9ad8\u534f\u4f5c\u6548\u7387\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u57fa\u56e0\u6570\u636e\u5206\u6790\u7cfb\u5217<\/div>\n<div>\u57fa\u56e0\u68c0\u6d4b\u5728\u4e34\u5e8a\u5e94\u7528\u4e2d\u53d7\u5230\u8d8a\u6765\u8d8a\u591a\u7684\u5173\u6ce8\uff0c\u800c\u5927\u90e8\u5206\u57fa\u56e0\u68c0\u6d4b\u6570\u636e\u5206\u6790\u8f6f\u4ef6\u6216\u751f\u7269\u4fe1\u606f\u5de5\u5177\u6709\u4e00\u5b9a\u64cd\u4f5c\u95e8\u69db\uff0c\u800c\u4e14\u662f\u82f1\u6587\u754c\u9762\uff0c\u5bf9\u4e8e\u56fd\u5185\u5f88\u591a\u4e34\u5e8a\u533b\u751f\u800c\u8a00\u4f7f\u7528\u4ee5\u53ca\u8f6f\u4ef6\u672c\u8eab\u7684\u63a8\u5e7f\u6709\u4e00\u5b9a\u7684\u74f6\u9888\u3002\u5728\u738b\u4f1f\u8001\u5e08\u7684\u5021\u5bfc\u548c\u201c\u9057\u4f20\u75c5\u57fa\u56e0\u89e3\u8bfb\u4e0e\u8bca\u7597\u5fae\u4fe1\u201d\u7fa4\u6709\u5173\u4e13\u5bb6\u6307\u5bfc\u4e0b\uff0c\u57fa\u56e0\u6167\u7ec4\u7ec7\u884c\u4e1a\u4e13\u5bb6\u5bf9\u5e38\u7528\u751f\u7269\u4fe1\u606f\u5de5\u5177\u8fdb\u884c\u4e2d\u6587\u64cd\u4f5c\u89c6\u9891\u5f55\u5236\u7cfb\u5217\u6d3b\u52a8\u3002<\/div>\n<div>\u00a0 \u00a0 \u00a0 \u7b2c\u4e09\u671f\u9080\u8bf7\u4e86wANNOVAR\u5f00\u53d1\u8005\u4e4b\u4e00\u54e5\u4f26\u6bd4\u4e9a\u5927\u5b66\u738b\u51ef\u6559\u6388\uff0c\u89c6\u9891\u4eb2\u6388\u8868\u578b\u548c\u57fa\u56e0\u5173\u8054\u5206\u6790\u5de5\u5177 wANNOVAR\u7684\u64cd\u4f5c\u4f7f\u7528\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u56de\u987e\uff1a\u00a0\u00a0\u00a0<\/div>\n<div>01. OMIM\u9057\u4f20\u75c5\u6570\u636e\u5e93- \u8d39\u57ce\u513f\u7ae5\u533b\u9662\u90ed\u4e00\u7136\u535a\u58eb\u00a0\uff08\u89c1\u201c\u57fa\u56e0\u6167\u8ba2\u9605\u53f7\u201d\u5386\u53f2\u6d88\u606f\uff09<\/div>\n<div>02. Phenolyzer\u8868\u578b\u5206\u6790\u5de5\u5177 &#8212; \u54e5\u4f26\u6bd4\u4e9a\u5927\u5b66\u738b\u51ef\u6559\u6388\uff08\u89c1\u201c\u57fa\u56e0\u6167\u8ba2\u9605\u53f7\u201d\u5386\u53f2\u6d88\u606f\uff09<\/div>\n<div>\u00a0<\/div>\n<div>\u7b2c\u4e8c\u671f\u89c6\u9891\u7b80\u4ecb<\/div>\n<div>1. \u738b\u51ef\u6559\u6388\u7b80\u4ecb<\/div>\n<div>\u7f8e\u56fd\u54e5\u4f26\u6bd4\u4e9a\u5927\u5b66\u57fa\u56e0\u7ec4\u533b\u5b66\u6240\u62c5\u4efb\u4e34\u5e8a\u4fe1\u606f\u5b66\u4e3b\u4efb\u3001\u751f\u7269\u533b\u5b66\u4fe1\u606f\u5b66\u7cfb\u526f\u6559\u6388\uff0c\u5317\u4eac\u5e0c\u671b\u7ec4\u9996\u5e2d\u79d1\u5b66\u5bb6\uff0cPhenolyzer\u3001ANNOVAR\/wANNOVAR\u7684\u5f00\u53d1\u8005\u4e4b\u4e00\u3002<\/div>\n<div>2. wANNOVAR<\/div>\n<div>\u7b80\u4ecb\uff1aANNOVAR\uff08ANNOtate VARiation\uff09\u662f\u5e38\u7528\u7684\u57fa\u56e0\u7a81\u53d8\u529f\u80fd\u6ce8\u91ca\u8f6f\u4ef6\uff0c\u5b83\u57fa\u4e8e\u7528\u6237\u6307\u5b9a\u7684\u6570\u636e\u5e93\u548c\u6ce8\u91ca\u6a21\u5f0f\uff0c\u5bf9\u57fa\u56e0\u6216\u57fa\u56e0\u7a81\u53d8\u8fdb\u884c\u5feb\u901f\u548c\u7b80\u5355\u5730\u529f\u80fd\u6ce8\u91ca\u3002\u73b0\u5728\u901a\u8fc7\u4e00\u4e2a\u7528\u6237\u53cb\u597d\u7f51\u9875\u754c\u9762wANNOVAR\uff0c\u5b9e\u73b0\u4e86ANNOVAR\u7684\u5927\u90e8\u5206\u529f\u80fd\u3002<\/div>\n<div>\u5728\u7ebf\u7f51\u5740\uff1ahttp:\/\/wannovar.wglab.org\/<\/div>\n<div>\u53d1\u8868\u6587\u732e\uff1a<\/div>\n<div>1. Yang H, Wang K. Genomic variant annotation and prioritization with ANNOVAR and wANNOVAR. Nature Protocols, 10:1556-1566, 2015<\/div>\n<div>2. Chang X, Wang K. wANNOVAR: annotating genetic variants for personal genomes via the web. Journal of Medical Genetics, 49:433-436, 2012<\/div>\n<div>3. Wang K, Li M, Hakonarson H. ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Research, 38:e164, 2010<\/div>\n<div>\u00a0<\/div>\n<div>3.\u738b\u51ef\u6559\u6388\u89c6\u9891\u4ecb\u7ecdwANNOVAR\u4f7f\u7528\u65b9\u6cd5<\/div>\n<div>\uff08\u7ea66\u5206\u949f\uff0c\u5efa\u8bae\u5728wifi\u73af\u5883\u4e0b\u89c2\u770b\uff09<\/div>\n<div><iframe src=\"https:\/\/v.qq.com\/txp\/iframe\/player.html?vid=l0366keoxp9\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/div>\n<div>\u00a0<\/div>\n<div>\u58f0\u660e<\/div>\n<div>1. \u00a0\u57fa\u56e0\u6167\u79c9\u6301\u4e25\u8c28\u3001\u5ba2\u89c2\u3001\u4e2d\u7acb\u7684\u6001\u5ea6\u7ec4\u7ec7\u7b56\u5212\u548c\u5236\u4f5c\u672c\u671f\u89c6\u9891\uff0c\u867d\u529b\u6c42\u5b8c\u7f8e\uff0c\u4f46\u96be\u514d\u6709\u7455\u75b5\uff0c\u6b22\u8fce\u6307\u6b63\u3002\u4ee5\u4e0a\u5185\u5bb9\u4ec5\u4ee3\u8868\u5609\u5bbe\u4e2a\u4eba\u89c2\u70b9\uff08\u7ecf\u5609\u5bbe\u5ba1\u6838\uff09\uff0c\u4e0d\u4ee3\u8868\u57fa\u56e0\u7acb\u573a\u3002\u00a0<\/div>\n<div>2. \u4ee5\u4e0a\u5185\u5bb9\u662f\u57fa\u56e0\u6167\u7b56\u5212\u3001\u9080\u8bf7\u884c\u4e1a\u4e13\u5bb6\u53c2\u4e0e\u5f55\u5236\u3002\u7248\u6743\u5c5e\u4e8e\u4f5c\u8005\u548c\u57fa\u56e0\u6167\uff08\u5317\u4eac\u57fa\u56e0\u754c\u79d1\u6280\u4fe1\u606f\u54a8\u8be2\u6709\u9650\u516c\u53f8\uff09\u3002\u6b22\u8fce\u8f6c\u53d1\u5230\u670b\u53cb\u5708\uff1b\u8f6c\u8f7d\u8bf7\u8054\u7cfb\u540e\u53f0\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u884c\u7814\u3001\u54a8\u8be2\u3001\u4f1a\u8bae\u3001\u54c1\u5ba3\uff1a<\/div>\n<div>\u7535\u8bdd\uff1a010-56527551 \/ 400-088-7466<\/div>\n<div>\u5730\u5740\uff1a\u5317\u4eac\u5e02\u6d77\u6dc0\u533a\u4e2d\u5173\u6751\u5927\u88571\u53f7<\/div>\n<div>\u5b98\u7f51\uff1awww.geneclub.net.cn<\/div>\n<div>\u90ae\u7bb1\uff1ainfo@genonet.cn<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgB8QiahwaAtgMNxBhg3iaWezjficrlPDUHRiatK5XVbqLTMzbfotghSePKicZmg09OIINib2zcjHibF0NwyQ.jpg\" alt=\"RmFicvQBAkgB8QiahwaAtgMNxBhg3iaWezjficrlPDUHRiatK5XVbqLTMzbfotghSePKicZmg09OIINib2zcjHibF0NwyQ\"\/><\/figure><\/div>","protected":false},"excerpt":{"rendered":"<p>wANNOVAR\u5f00\u53d1\u8005\u54e5\u4f26\u6bd4\u4e9a\u5927\u5b66\u738b\u51ef\u6559\u6388\u8bb2\u89e3 &#8211;\u57fa\u56e0\u6167\u51fa\u54c1<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"close","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[2083],"class_list":["post-11014","post","type-post","status-publish","format-standard","hentry","category-thinktank","tag-2083"],"_links":{"self":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts\/11014","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/comments?post=11014"}],"version-history":[{"count":3,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts\/11014\/revisions"}],"predecessor-version":[{"id":14593,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts\/11014\/revisions\/14593"}],"wp:attachment":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/media?parent=11014"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/categories?post=11014"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/tags?post=11014"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}