{"id":11006,"date":"2017-02-17T17:47:46","date_gmt":"2017-02-17T09:47:46","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&#038;mid=100000277&#038;idx=1&#038;sn=027a6b6690467c8f2afdca6fbdaf807e&#038;chksm=6b72b0a25c0539b4789c9c445b36c652def4d95c5ff5dab665487889299e40f5c8a14388516a#rd"},"modified":"2026-04-09T14:13:05","modified_gmt":"2026-04-09T06:13:05","slug":"5410057","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2017\/02\/17\/5410057\/","title":{"rendered":"miRNA\u6cbb\u7597\u5f00\u542f\u764c\u75c7\u6cbb\u7597\u7684\u65b0\u65f6\u4ee3"},"content":{"rendered":"<p><!-- wechat_content_hash: 6d992174d591cb8e --><\/p>\n<div>\u6167\u666e<\/div>\n<div>\u9760\u8c31\u7684\u57fa\u56e0\u5065\u5eb7\u8d44\u8baf<\/div>\n<div>\u5173\u952e\u8bcd\uff1amiRNA\u6cbb\u7597<\/div>\n<div>\u80bf\u7624 \u5316\u5b66\u4fee\u9970 \u5bfc\u5165\u7cfb\u7edf<\/div>\n<div>miRNA\u9776\u6807 \u4e34\u5e8a\u8bd5\u9a8c<\/div>\n<div>\u5efa\u8bae\u7528\u65f6\uff1a7\u5206\u949f<\/div>\n<div><\/div>\n<div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBG0JUGXHialg4JYFmuEf3C3FagvsT9ds1C2Nu2L6ics32s0o1PJwzXiaFeYKBCoHOAhxCeJxZO2UBew.jpeg\" alt=\"RmFicvQBAkgBG0JUGXHialg4JYFmuEf3C3FagvsT9ds1C2Nu2L6ics32s0o1PJwzXiaFeYKBCoHOAhxCeJxZO2UBew\"\/><\/figure><\/div>\n\n<\/div>\n<div style=\"text-align: center;\">\u56fe\uff1amicroRNA\u5728\u751f\u547d\u6d3b\u52a8\u4e2d\u53c2\u4e0e\u8f6c\u5f55\u540e\u57fa\u56e0\u8868\u8fbe\u8c03\u63a7\uff0c\u6765\u81eaNIH<\/div>\n<div><\/div>\n<div>\u5728\u53d1\u73b0\u7b2c\u4e00\u4e2amicroRNA\uff08miRNA\uff09\u540e\u7684\u4e8c\u5341\u591a\u5e74\u91cc\uff0cmiRNA\u751f\u7269\u5b66\u9886\u57df\u5df2\u7ecf\u5927\u5927\u6269\u5c55\u3002\u57fa\u4e8e\u591a\u4e2a\u764c\u75c7\u75c5\u4f8b\u7684\u529f\u80fd\u5b66\u7684\u7814\u7a76\u8bc1\u5b9e\uff0cmiRNA\u5931\u8c03\u4e0e\u764c\u75c7\u5b58\u5728\u56e0\u679c\u5173\u7cfb\uff0cmiRNA\u53ef\u4ee5\u4f5c\u4e3a\u80bf\u7624\u6291\u5236\u5242\u6216\u764c\u57fa\u56e0\uff08oncomiR\uff09\u3002miRNA\u6a21\u62df\u7269\u548c\u9776\u5411miRNA\u7684\u5206\u5b50\uff08antimiR\uff09\u5728\u4e34\u5e8a\u524d\u53d1\u5c55\u4e2d\u663e\u793a\u51fa\u6781\u5927\u7684\u524d\u666f\u3002<\/div>\n<div>\u51e0\u79cdmiRNA\u9776\u5411\u6cbb\u7597\u5df2\u7ecf\u8fbe\u5230\u4e34\u5e8a\u5f00\u53d1\uff1a<\/div>\n<div>\u80bf\u7624\u6291\u5236\u5242miRNA miR-34\u7684\u6a21\u62df\u7269\u5176\u8fbe\u5230\u7528\u4e8e\u6cbb\u7597\u764c\u75c7\u7684\u4e34\u5e8aI\u671f\u8bd5\u9a8c<\/div>\n<div>\u9488\u5bf9miR-122\u7684antimiRs\uff0c\u5176\u8fbe\u5230\u7528\u4e8e\u6cbb\u7597\u809d\u708e\u7684II\u671f\u8bd5\u9a8c<\/div>\n<div><\/div>\n<div><\/div>\n<div>\u5173\u4e8emiRNA<\/div>\n<div><\/div>\n<div><\/div>\n<div><\/div>\n<div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBG0JUGXHialg4JYFmuEf3C3jaYgc80fZSpeN1LeJNbewDzOSQPmwaLIeqcicVsFajF4jT4smQqSBHA.png\" alt=\"RmFicvQBAkgBG0JUGXHialg4JYFmuEf3C3jaYgc80fZSpeN1LeJNbewDzOSQPmwaLIeqcicVsFajF4jT4smQqSBHA\"\/><\/figure><\/div>\n\n<\/div>\n<div style=\"text-align: center;\">\u56fe\uff1amiRNA\u7684\u5f62\u6210\uff0c\u6765\u81eadoi:10.1038\/nrd.2016.246<\/div>\n<div><\/div>\n<div>miRNA\u662f\u771f\u6838\u751f\u7269\u4e2d\u5e7f\u6cdb\u5b58\u5728\u7684\u4e00\u79cd\u957f\u7ea621\u523023\u4e2a\u6838\u82f7\u9178\u7684\u6838\u7cd6\u6838\u9178\uff08RNA\uff09\u5206\u5b50\uff0c\u53ef\u8c03\u8282\u5176\u4ed6\u57fa\u56e0\u7684\u8868\u8fbe\uff0c\u4f46\u65e0\u6cd5\u8fdb\u4e00\u6b65\u8f6c\u8bd1\u6210\u86cb\u767d\u8d28\u7684RNA\uff0c\u5c5e\u4e8e\u975e\u7f16\u7801RNA\u3002miRNA\u901a\u8fc7\u4e0e\u76ee\u6807\u4fe1\u4f7f\u6838\u7cd6\u6838\u9178(mRNA)\u7ed3\u5408\uff0c\u8fdb\u800c\u6291\u5236\u8f6c\u5f55\u540e\u7684\u57fa\u56e0\u8868\u8fbe, \u5728\u8c03\u63a7\u57fa\u56e0\u8868\u8fbe\u3001\u7ec6\u80de\u5468\u671f\u3001\u751f\u7269\u4f53\u53d1\u80b2\u65f6\u5e8f\u7b49\u65b9\u9762\u8d77\u91cd\u8981\u4f5c\u7528\u3002miRNA\u4ece\u521d\u7ea7\u8f6c\u5f55\u672c\uff08primary transcript\uff09\uff0c\u4e5f\u5c31\u662fpri-miRNA\uff0c\u8f6c\u53d8\u6210\u4e3a\u79f0\u4e3apre-miRNA\u7684\u830e\u73af\u7ed3\u6784\uff0c\u6700\u540e\u6210\u4e3a\u5177\u6709\u529f\u80fd\u7684miRNA\u3002 \u7b2c\u4e00\u4e2amiRNA\u662f1989\u5e74Victor\u5728\u79c0\u4e3d\u9690\u6746\u7ebf\u866b ( C. elegans) \u53d1\u73b0 lin-4 miRNA\u3002miRNA\u5206\u5b50\u7684\u4e00\u7aef\u6298\u56de\u6765\u5f62\u6210\u4e0d\u5b8c\u5168\u7684\u4e92\u8865\u914d\u5bf9\uff0c\u5f62\u6210\u5178\u578b\u7684&#8221;\u53d1\u5361\u7ed3\u6784&#8221;\u3002<\/div>\n<div><\/div>\n<div><\/div>\n<div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBG0JUGXHialg4JYFmuEf3C3AnVOiaMo9057Zp0akaFM1UuuFFK1icVj29X4VibOP54UONxtLAh5WCVaA.jpeg\" alt=\"RmFicvQBAkgBG0JUGXHialg4JYFmuEf3C3AnVOiaMo9057Zp0akaFM1UuuFFK1icVj29X4VibOP54UONxtLAh5WCVaA\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe\uff1amiRNA\u7684\u201c\u53d1\u5361\u201d\u7ed3\u6784\uff0c\u6765\u81eawiki<\/div>\n<div>miRNA\u548c\u764c\u75c7\u5fae\u73af\u5883<\/div>\n<div>\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u7ec6\u80de\uff0c\u5982\u5185\u76ae\u7ec6\u80de\uff0c\u6210\u7ea4\u7ef4\u7ec6\u80de\u548c\u514d\u75ab\u7ec6\u80de\uff0c\u901a\u8fc7\u5206\u6ccc\u8c03\u8282\u80bf\u7624\u5fae\u73af\u5883\u751f\u7406\uff08\u5305\u62ec\u7f3a\u6c27\uff0cpH\u548c\u708e\u75c7\uff09\u7684\u56e0\u5b50\u4e0e\u764c\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\u3002miRNA\u901a\u8fc7\u9776\u5411\u53c2\u4e0e\u8fd9\u4e9b\u76f8\u4e92\u4f5c\u7528\u7684\u51e0\u4e2a\u57fa\u56e0\u6765\u8c03\u8282\u8fd9\u4e9b\u76f8\u4e92\u4f5c\u7528\uff0c\u4f5c\u4e3a\u4fc3\u8fdb\u80bf\u7624\u7684\u4fe1\u53f7\u3002<\/div>\n<div>\u00a0<\/div>\n<div>miRNA\u548c\u764c\u75c7\u76f8\u5173\u7684\u6210\u7ea4\u7ef4\u7ec6\u80de\uff08CAF\uff09<\/div>\n<div>CAF\u4e3a\u764c\u7ec6\u80de\u5728\u521d\u59cb\u6076\u6027\u80bf\u7624\u548c\u8f6c\u79fb\u8fc7\u7a0b\u4e2d\u7c98\u9644\u548c\u751f\u957f\u63d0\u4f9b\u4e86\u57fa\u8d28\u6846\u67b6\u3002\u5df2\u77e5\u5728\u5c06\u6b63\u5e38\u6210\u7ea4\u7ef4\u7ec6\u80de\u8f6c\u5316\u4e3aCAF\u4e2d\u8d77\u4f5c\u7528\u7684\u91cd\u8981miRNA\u4e4b\u4e00\u662fmiR-320\u3002\u6b63\u5e38\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2dmiR-320\u7684\u4e0b\u8c03\u5bfc\u81f4mRNA\u9776\u6807ETS2\uff08\u764c\u75c7\u7279\u5f02\u6027\u8f6c\u5f55\u56e0\u5b50\uff09\u7684\u589e\u52a0\uff0c\u5bfc\u81f4\u5305\u542b\u81f4\u764c\u6027\u5206\u6ccc\u86cb\u767d\u7684\u86cb\u767d\u9176\u4f8b\u5982\u57fa\u8d28\u91d1\u5c5e\u86cb\u767d\u9176\uff08MMP\uff09\u7684\u589e\u52a0\u3002\u867d\u7136\u6ca1\u6709\u6d4b\u8bd5\uff0c\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2dmiR-320\u7684\u66ff\u4ee3\u53ef\u4ee5\u5177\u6709\u6709\u610f\u4e49\u7684\u6297\u8f6c\u79fb\u4f5c\u7528\u3002<\/div>\n<div>\u00a0<\/div>\n<div>miRNA\u548c\u708e\u75c7\u00a0<\/div>\n<div>\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u708e\u75c7\u901a\u5e38\u901a\u8fc7\u6539\u53d8\u6210\u7ea4\u7ef4\u7ec6\u80de\u8868\u578b\u800c\u4fc3\u80bf\u7624\u53d1\u751f\u548c\u8840\u7ba1\u751f\u6210\u548c\u764c\u7ec6\u80de\u7684\u4fb5\u5165\u3002 miRNA\u53ef\u4ee5\u663e\u8457\u589e\u52a0\u708e\u75c7\u76f8\u5173\u86cb\u767d\u5982NF-\u03baB\u7684\u8868\u8fbe\uff0c\u5bfc\u81f4\u5fae\u73af\u5883\u4e2d\u7684\u80bf\u7624\u524d\u671f\u53d8\u5316\u3002 LIN28- let-7\u4ecb\u5bfc\u7684\u7ec6\u80de\u56e0\u5b50\u767d\u4ecb\u7d20-6\u7ea7\u8054\u7684\u53bb\u6291\u5236\uff0c\u5bfc\u81f4\u764c\u7ec6\u80de\u4e2dNF-\u03baB\u7684\u6d3b\u5316\uff0c\u8fd9\u5bfc\u81f4\u708e\u75c7\u4fe1\u53f7\u7684\u8fdb\u4e00\u6b65\u589e\u52a0\u3002\u901a\u8fc7let-7\u6a21\u62df\u7269\u7684\u9012\u9001\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7834\u574f\u8fd9\u79cd\u6b63\u53cd\u9988\u73af\u53ef\u5bfc\u81f4\u5267\u70c8\u7684\u6548\u5e94\u3002 let-7\u5728\u764c\u7ec6\u80de\u4e2d\u7684\u8868\u8fbe\u51cf\u5c11\u589e\u6b96\u5e76\u589e\u5f3a\u51cb\u4ea1\uff0c\u5e76\u4e14\u5f53\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u7ec6\u80de\u4e2d\u8868\u8fbe\u65f6\uff0c\u53ef\u4ee5\u51cf\u5c11\u708e\u75c7\uff0c\u5bfc\u81f4\u5bf9\u4e8e\u80bf\u7624\u751f\u957f\u8f83\u4e0d\u5229\u3002 miR-155\u662f\u5173\u952e\u7684\u81f4\u764cmiRNA\uff0c\u9776\u5411SHIP1\uff0c\u4e00\u79cd\u53c2\u4e0e\u514d\u75ab\u5e94\u7b54\u8c03\u8282\u7684\u86cb\u767d\u8d2881\u3002 \u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\uff0c\u7528pH\u8bf1\u5bfc\u7684\u8de8\u819c\u5b9a\u4f4d\u80bd\u7f00\u5408\u7684antimiR-155\u6cbb\u7597\u5bfc\u81f4\u663e\u7740\u7684\u80bf\u7624\u51cf\u5c11\u3002 \u603b\u4e4b\uff0c\u5728\u9776\u5411\u5df2\u77e5\u5728\u764c\u7ec6\u80de\u4e2d\u5177\u6709\u4fc3\u80bf\u7624\u529f\u80fd\u7684miRNA\u4e4b\u524d\uff0c\u9700\u8981\u9996\u5148\u4ed4\u7ec6\u8bc4\u4f30\u5b83\u4eec\u5728\u80bf\u7624\u5fae\u73af\u5883\u7684\u7ec6\u80de\u4e2d\u7684\u4f5c\u7528\u3002\u4ee5\u7efc\u5408\u65b9\u5f0f\u6d4b\u8bd5\u8fd9\u6837\u7684miRNA\u7684\u4f5c\u7528\u5c06\u63d0\u4f9b\u5173\u4e8emiRNA\u7684\u80cc\u666f\u4f9d\u8d56\u6027\u529f\u80fd\u7684\u4fe1\u606f\uff0c\u5e76\u4e14\u5c06\u6709\u52a9\u4e8e\u9274\u5b9a\u7528\u4e8e\u764c\u75c7\u6cbb\u7597\u7684\u5408\u9002\u9776\u6807\u3002<\/div>\n<div>\u00a0<\/div>\n<div>miRNA\u6cbb\u7597\u7684\u5316\u5b66\u4fee\u9970<\/div>\n<div>1. \u57fa\u4e8emiRNA\u7684\u6cbb\u7597\u5242<\/div>\n<div>miRNA\u6a21\u62df\u7269<\/div>\n<div>miRNA\u6a21\u62df\u7269\u662f\u4e0e\u76f8\u5e94\u7684miRNA\u5e8f\u5217\u5339\u914d\u7684\u5408\u6210\u53cc\u94fe\u5c0fRNA\u5206\u5b50\uff0c\u56e0\u6b64\u529f\u80fd\u4e0a\u65e8\u5728\u8865\u5145\u75be\u75c5\u4e2d\u4e22\u5931\u7684miRNA\u8868\u8fbe\u3002<\/div>\n<div>\u00a0<\/div>\n<div>miRNA\uff08\u4e5f\u79f0\u4e3aantimiR\uff09\u6291\u5236\u5242<\/div>\n<div>antimiR\u662f\u5355\u94fe\u7684\u57fa\u4e8e\u7b2c\u4e00\u4ee3\u53cd\u4e49\u5be1\u6838\u82f7\u9178\uff08ASO\uff09\uff0c\u5176\u5df2\u88ab\u8bbe\u8ba1\u4e3a\u9776\u5411mRNA\u6216\u7528\u9501\u5b9a\u6838\u9178\uff08LNA\uff09\u4fee\u9970\u3002\u5177\u67092&#8242;-O-\u7532\u6c27\u57fa\u4e59\u57fa\u4fee\u9970\u7684AntimiR\u4e5f\u79f0\u4e3a\u62ee\u6297\u5242\u3002\u8fd9\u4e9b\u5408\u6210\u7684\u5c0fRNA\u5206\u5b50\u5177\u6709\u4e0e\u5f85\u6291\u5236\u7684miRNA\u4e92\u8865\u7684\u5e8f\u5217\uff0c\u5e76\u901a\u8fc7\u4e0e\u5176\u5f3a\u70c8\u7ed3\u5408\u800c\u963b\u65ad\u76f8\u5e94miRNA\u7684\u529f\u80fd\u3002<\/div>\n<div>\u591a\u5e74\u6765\uff0c\u901a\u8fc7\u5bf9\u6838\u82f7\u9178\u4e3b\u94fe\u7684\u5316\u5b66\u4fee\u9970\uff0c\u5df2\u7ecf\u5b9e\u73b0\u4e86miRNA\u6a21\u62df\u7269\u548cantimiR\u7684\u7ed3\u5408\u4eb2\u548c\u529b\u3001\u7a33\u5b9a\u6027\u548c\u9776\u8c03\u8282\u4f5c\u7528\u7684\u663e\u8457\u6539\u8fdb\u3002<\/div>\n<div>\u00a0<\/div>\n<div>2. miRNA\u5316\u5b66\u4fee\u9970\u7684\u6311\u6218\u548c\u7b56\u7565<\/div>\n<div>\u57fa\u4e8eRNA\u7684\u6cbb\u7597\u7b56\u7565\uff08\u5305\u62ec\u5355\u94fe\u6216\u53cc\u94fe\u5be1\u6838\u82f7\u9178\uff09\u7684\u6311\u6218\u4e4b\u4e00\u662f\u901a\u8fc7\u8840\u6e05\u4e2d\u6216\u7ec6\u80de\u5185\u541e\u7ec6\u80de\u533a\u5ba4\u4e2d\u7684\u6838\u7cd6\u6838\u9178\u9176\u964d\u89e3\u5be1\u6838\u82f7\u9178\u7684\u53ef\u80fd\u6027<\/div>\n<div>\u4e3a\u4e86\u907f\u514d\u7ec6\u80de\u5185\u7684\u964d\u89e3\u7684\u95ee\u9898\uff0c\u5df2\u7ecf\u7814\u7a76\u4e86\u4e24\u79cd\u4e0d\u540c\u7684\u7b56\u7565\uff1a<\/div>\n<div>\u6539\u53d8\u5be1\u6838\u82f7\u9178\u5316\u5b66\u6027\u8d28\uff0c\u53ef\u4ee5\u901a\u8fc7\u7532\u57fa\u5316\u6216LNAs\uff0c\u6765\u4fee\u9970\u6838\u82f7\u9178\u6216RNA\u9aa8\u67b6\uff0c\u6216\u901a\u8fc7\u6dfb\u52a0\u786b\u4ee3\u78f7\u9178\u916f\u7c7b\u57fa\u56e2<\/div>\n<div>\u5f00\u53d1\u7528\u4e8e\u5305\u5c01RNA\u4ee5\u7528\u4e8e\u4fdd\u62a4\u548c\u5141\u8bb8\u5185\u4f53\u9003\u9038\u7684\u9012\u9001\u8f7d\u4f53\u3002\u76ee\u524d\u53ef\u7528\u7684\u5546\u4e1amiRNA\u6a21\u62df\u7269\u901a\u5e38\u901a\u8fc7\u8fc7\u5ba2\u94fe\uff08passenger strand\uff09\u7684\u7532\u57fa\u5316\u4fee\u9970\u4ee5\u589e\u52a0\u7a33\u5b9a\u6027\uff0c\u5e76\u4e14\u4f7f\u7528LNA\u5316\u5b66\u4fee\u9970\u6297miR\u3002\u7136\u800c\uff0c\u5f00\u53d1\u5316\u5b66\u4fee\u9970\u7684miRNA\u6cbb\u7597\u5242\u7684\u5927\u90e8\u5206\u52aa\u529b\u81f4\u529b\u4e8eantimiR\u7684\u5f00\u53d1\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u764c\u75c7\u7b49\u75be\u75c5\u6cbb\u7597\u7684\u4e34\u5e8a\u524d\u6a21\u578b\u4e2dmiRNA\u9776\u6807<\/div>\n<div>\u5305\u62ec\u77e5\u540d\u7684let-7\u5bb6\u65cf\uff0cmiR-34a\uff0c miR-143\u7b49\uff0c\u5bf9\u5e94\u591a\u79cd\u5b9e\u4f53\u7624\u764c\u75c7\u3001B\u7ec6\u80de\u6dcb\u5df4\u7624\u3001\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u3001\u6dcb\u5df4\u6027\u767d\u8840\u75c5\u3001\u4e19\u578b\u809d\u708e\u7b49\u75be\u75c5\u548c\u764c\u75c7\u7684\u6cbb\u7597\u3002<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBG0JUGXHialg4JYFmuEf3C3gOfmMxZdbYKEtmXAFIEFpod7pjMYyumXK75eqbvflL684E6jEaSLFA.png\" alt=\"RmFicvQBAkgBG0JUGXHialg4JYFmuEf3C3gOfmMxZdbYKEtmXAFIEFpod7pjMYyumXK75eqbvflL684E6jEaSLFA\"\/><\/figure><\/div>\n\n<\/div>\n<div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBG0JUGXHialg4JYFmuEf3C3f28jBgibb31PNzdFHUCxibl0uM4Fonmfzl3aTVvVwRpS0VbFDpaiadKOw.png\" alt=\"RmFicvQBAkgBG0JUGXHialg4JYFmuEf3C3f28jBgibb31PNzdFHUCxibl0uM4Fonmfzl3aTVvVwRpS0VbFDpaiadKOw\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u8868\uff1a\u764c\u75c7\u7b49\u75be\u75c5\u6cbb\u7597\u7684\u4e34\u5e8a\u524d\u6a21\u578b\u4e2dmiRNA\u9776\u6807\uff0c\u6765\u81eadoi:10.1038\/nrd.2016.246<\/div>\n<div>miRNA\u6cbb\u7597\u7684\u5bfc\u5165\u7cfb\u7edf<\/div>\n<div>\u75c5\u6bd2\u8f7d\u4f53<\/div>\n<div>\u805a\u4e19\u4ea4\u916f\u5171\u4e59\u4ea4\u916f\u9897\u7c92\uff08Poly(lactide-co-glycolide) particles\uff09<\/div>\n<div>\u4e2d\u6027\u8102\u8d28\u4e73\u5242 \uff08Neutral lipid emulsions\uff09<\/div>\n<div>\u4e2d\u6027\u8102\u8d28\u4f531,2-\u4e8c\u6cb9\u9170\u57fa-sn-\u7518\u6cb9-3-\u78f7\u8102\u9170\u80c6\u78b1\uff08Neutral liposome 1,2-dioleoyl-sn-glycero-3-phosphatidylcholine\uff09<\/div>\n<div>EnGeneIC \u8f7d\u4f53\u7eb3\u7c73\u7ec6\u80de\uff08EnGeneIC Delivery Vehicle nanocells\uff09<\/div>\n<div>\u5408\u6210\u805a\u4e59\u70ef\u4e9a\u80fa<\/div>\n<div>\u6811\u679d\u72b6\u805a\u5408\u7269<\/div>\n<div>\u73af\u7cca\u7cbe<\/div>\n<div>\u805a\u4e59\u4e8c\u9187<\/div>\n<div>\u58f3\u805a\u7cd6<\/div>\n<div>N-\u4e59\u9170\u57fa-D-\u534a\u4e73\u7cd6\u80fa<\/div>\n<div>\u00a0<\/div>\n<div>miRNA\u6cbb\u7597\u7684\u5173\u952e\u6b65\u9aa4<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBG0JUGXHialg4JYFmuEf3C3D6Kfoq4Z4OLWMKXqJJ8OSg.jpg\" alt=\"RmFicvQBAkgBG0JUGXHialg4JYFmuEf3C3D6Kfoq4Z4OLWMKXqJJ8OSg\"\/><\/figure><\/div>\n\n<\/div>\n<div><\/div>\n<div style=\"text-align: center;\">\u56fe\uff1amiRNA\u6cbb\u7597\u7684\u5173\u952e\u6b65\u9aa4\uff0c\u6765\u81eadoi:10.1038\/nrd.2016.246<\/div>\n<div><\/div>\n<div>miRNA\u6cbb\u7597\u5305\u62ec\uff1a<\/div>\n<div>\u901a\u8fc7\u5206\u6790\u60a3\u8005\u6837\u54c1\uff0c\u9009\u62e9\u7684miRNA\u5019\u9009\u7269<\/div>\n<div>\u4f7f\u7528\u7ec4\u7ec7\u57f9\u517b\u9610\u660emiRNA\u5019\u9009\u7269\u5bf9\u75be\u75c5\u7684\u751f\u7269\u5b66\u548c\u76f8\u5173\u6027<\/div>\n<div>\u57fa\u4e8e\u4f53\u5185\u6a21\u578b\u7684\u9a8c\u8bc1\u3002\u76ee\u524d\uff0c\u6709\u51e0\u4e2a\u516c\u5171\u6570\u636e\u5e93\uff08\u6bd4\u5982mirbase,miR2Disease,miRCancer,mirtarbase\u7b49\uff09\uff0c\u5305\u542b\u6765\u81ea\u5404\u79cd\u5065\u5eb7\u548c\u75be\u75c5\u7ec4\u7ec7\u7684\u57fa\u56e0\u7ec4\u548c\u86cb\u767d\u8d28\u7ec4\u6570\u636e\u3002\u5c06\u8fd9\u4e9b\u6570\u636e\u4e0e\u751f\u7269\u9a8c\u8bc1\u7ed3\u5408\u53ef\u4ee5\u6709\u52a9\u4e8e\u9274\u5b9a\u6709\u5e0c\u671b\u7684\u5019\u9009miRNA\u3002<\/div>\n<div>\u4f53\u5185\u5e94\u7528\u7684miRNA\u6a21\u62df\u7269\u548cantimiR\u7684\u5316\u5b66\u4fee\u9970\u548c\u9012\u9001\u7cfb\u7edf\u7684\u5f00\u53d1\u3002\u901a\u8fc7\u5316\u5b66\u4fee\u9970\uff0c\u4f8b\u5982\u6dfb\u52a02&#8242;-O-\u7532\u57fa\u6216\u9501\u5b9a\u6838\u9178\uff08LNA\uff09\u3002\u9664\u4e86\u5bf9\u5c0fRNA\u5206\u5b50\u7684\u5316\u5b66\u4fee\u9970\u4e4b\u5916\uff0c\u5df2\u7ecf\u5f00\u53d1\u4e86\u51e0\u79cd\u5305\u5c01\u65b9\u6cd5\uff0c\u6539\u8fdb\u5411\u75be\u75c5\u90e8\u4f4d\u7684\u9012\u9001\u3002\u4e00\u4e9b\u5e38\u7528\u7684\u9012\u9001\u7cfb\u7edf\u662f\u8102\u8d28\u7eb3\u7c73\u7c92\u5b50\uff0c\u4f8b\u5982\u4e2d\u6027\u8102\u8d28\u4e73\u6db2\uff08NLE\uff09\u6216\u5177\u6709\u8fde\u63a5\u7684\u9776\u5411\u90e8\u5206\u7684\u6811\u679d\u72b6\u805a\u5408\u7269\u590d\u5408\u7269\u3002\u5c06\u8fd9\u4e9b\u9012\u9001\u7cfb\u7edf\u7ffb\u8bd1\u6210\u4e34\u5e8a\u7684\u5173\u952e\u6311\u6218\u662f\u6f5c\u5728\u7684\u514d\u75ab\u523a\u6fc0\u6548\u5e94\u548c\u7f3a\u4e4f\u7279\u5f02\u6027\u9776\u5411\u75be\u75c5\u90e8\u4f4d\u3002<\/div>\n<div>\u4f7f\u7528\u556e\u9f7f\u52a8\u7269\u548c\u975e\u4eba\u7075\u957f\u7c7b\u52a8\u7269\u6a21\u578b\u7684\u4e25\u683c\u7684\u75be\u75c5\u7279\u5f02\u6027\u4f53\u5185\u6d4b\u8bd5\u3002\u9700\u8981\u4ed4\u7ec6\u8bc4\u4f30\u6bd2\u6027\u6570\u636e\u548c\u76ee\u6807\u8bc4\u4f30\uff0c\u4ee5\u907f\u514d\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7684\u65e9\u671f\u5931\u8d25\u3002<\/div>\n<div><\/div>\n<div><\/div>\n<div><\/div>\n<div>miRNA\u6cbb\u7597\u7684\u4e34\u5e8a\u8bd5\u9a8c<\/div>\n<div><\/div>\n<div><\/div>\n<div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBG0JUGXHialg4JYFmuEf3C3NJMTEbI5wm4DQTNhJHvd6RIQX8UK6ksPlkm4P4Myx5QWbvoia3KFEbw.png\" alt=\"RmFicvQBAkgBG0JUGXHialg4JYFmuEf3C3NJMTEbI5wm4DQTNhJHvd6RIQX8UK6ksPlkm4P4Myx5QWbvoia3KFEbw\"\/><\/figure><\/div>\n\n<\/div>\n<div style=\"text-align: center;\">\u56fe\uff1amiRNA\u6cbb\u7597\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u6765\u81eadoi:10.1038\/nrd.2016.246<\/div>\n<div><\/div>\n<div><\/div>\n<div>\u516c\u4f17\u53f7\u5bf9\u8bdd\u6846\u56de\u590d\u201cmiRNA\u201d\u5373\u53ef\u83b7\u5f97\u4e3b\u8981\u53c2\u8003\u6587\u732epdf<\/div>\n<div><\/div>\n<div>\u53c2\u8003\uff1a<\/div>\n<div>1\uff09MicroRNA\u00a0therapeutics: towards a new era for the management of cancer and other diseases<\/div>\n<div>2\uff09Bartel, D. P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116, 281\u2013297 (2004).<\/div>\n<div>3\uff09Lee, R. C., Feinbaum, R. L. &amp; Ambros, V. The C. elegans heterochronic gene lin\u20104 encodes small RNAs with antisense complementarity to lin\u201014. Cell 75, 843\u2013854 (1993). Discovery of the first miRNA, lin\u20104, and elucidation of its function in development.\u00a0<\/div>\n<div>4\uff09Reinhart, B. J. et al. The 21-nucleotide let\u20107 RNA regulates developmental timing in Caenorhabditis elegans. Nature 403, 901\u2013906 (2000). Discovery of the second miRNA, let\u20107, and description of its role of in the development of C. elegans.\u00a0<\/div>\n<div>5\uff09Pasquinelli, A. E. et al. Conservation of the sequence and temporal expression of let\u20107 heterochronic regulatory RNA. Nature 408, 86\u201389 (2000).<\/div>\n<div><\/div>\n<div><\/div>\n<div><\/div>\n<div>\u66f4\u591a\u5e72\u8d27<\/div>\n<div>\u5173\u6ce8\u4ee5\u4e0b\u59ca\u59b9\u516c\u4f17\u53f7\uff0c\u83b7\u53d6\u4e0b\u5217\u5e72\u8d27<\/div>\n<div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/eicZhoGYCfyZYwdCafib0wr4HxcjzHjllGtQPicsLaPhtHQl6lC53yibmAuLhFKscjSicsAGB8skX2tnsC80micOlwhw.jpg\" alt=\"eicZhoGYCfyZYwdCafib0wr4HxcjzHjllGtQPicsLaPhtHQl6lC53yibmAuLhFKscjSicsAGB8skX2tnsC80micOlwhw\"\/><\/figure><\/div>\n\n<\/div>\n<div><\/div>\n<div><\/div>\n<div>\u7cbe\u51c6\u533b\u7597\u5927\u5496\u8bba\u9053\u00a0 \u8d75\u6d77\u6d9b | \u59da\u5b8f |\u00a0\u987e\u5927\u592b|\u00a0\u9ec4\u5c1a\u5fd7\u00a0|\u00a0\u7ea2\u6749\u8d44\u672c\u6768\u4e91\u971e\u00a0|\u00a0WeGene\u9648\u94a2 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