\n![\"RmFicvQBAkgBqJyMcQxUZibhoFCjLcSCNYDXUEhmz2Zf3jEC87jjYiceTyIaB3JnrFLh5ibjQQBCozYupUkT2icDsTA\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBqJyMcQxUZibhoFCjLcSCNYDXUEhmz2Zf3jEC87jjYiceTyIaB3JnrFLh5ibjQQBCozYupUkT2icDsTA.gif\")
<\/figure><\/div>\n\n<\/div>\n
<\/figure><\/div>\n\n<\/div>\n<\/div>\n
\u5173\u952e\u8bcd\uff1a\u57fa\u56e0\u68c0\u6d4b \u751f\u80b2\u5065\u5eb7\u764c\u75c7\u4f53\u68c0 \u57fa\u56e0\u6253\u62d0<\/div>\n
\u6307\u5bfc\u7528\u836f \u7f55\u89c1\u75c5\u8bca\u65ad\u00a0\u519c\u4e1a\u80b2\u79cd\u00a0<\/div>\n
\u57fa\u56e0\u6cbb\u7597 \u65b0\u836f\u7814\u53d1 \u00a0<\/div>\n
\u5efa\u8bae\u7528\u65f6\uff1a7\u5206\u949f<\/div>\n
\u60a8\u662f\u505a\u4ec0\u4e48\u7684\uff1f<\/div>\n
\u57fa\u56e0\u884c\u4e1a\u2026\u2026<\/div>\n
\u597d\u9ad8\u7aef\u554a\uff01\u662f\u505a\u4ec0\u4e48\u7684\uff1f\u6709\u4ec0\u4e48\u7528\uff1f\u2026\u2026<\/div>\n
\u6211\u4eec\u77e5\u9053\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\u4e0e\u767b\u6708\u3001\u539f\u5b50\u5f39\u8ba1\u5212\u9f50\u540d\u3002\u800c\u57fa\u56e0\u6280\u672f\u5bf9\u8001\u767e\u59d3\u6709\u4ec0\u4e48\u7528\uff1f\u4e0d\u7528\u7701\u7565\u53f7\uff0c\u6211\u4eec\u5c1d\u8bd5\u7528\u4e5d\u4e2a\u771f\u5b9e\u7684\u6545\u4e8b\uff0c\u4e13\u5c5e\u5206\u4eab\u7ed9\u57fa\u56e0\u6167\u8bfb\u8005\uff0c\u8c08\u8c08\u57fa\u56e0\u6280\u672f\u7684\u7528\u5904\u3002\u6b22\u8fce\u7559\u8a00\u8ba8\u8bba\u3002\uff08\u58f0\u660e\uff1a\u4ec5\u4f9b\u5b66\u4e60\u53c2\u8003\uff0c\u4e0d\u4f5c\u4e3a\u51b3\u7b56\u4f9d\u636e\uff09<\/div>\n
<\/div>\n
\u539f\u521b\u6587\u7ae0\uff0c\u6b22\u8fce\u8f6c\u8f7d\uff0c\u8f6c\u8f7d\u8bf7\u6ce8\u660e\u6765\u6e90<\/div>\n
\u611f\u8c22\u8427\u82b3\u6743\u3001\u674e\u6728\u7b49\u8bfb\u8005\u5bf9\u672c\u6587\u63d0\u4f9b\u90e8\u5206\u7d20\u6750<\/div>\n
<\/div>\n
<\/div>\n
<\/div>\n
1. \u65e0\u521b\u4ea7\u524d\u68c0\u6d4b\u5e2e\u52a9\u751f\u4e00\u4e2a\u5065\u5eb7\u5b9d\u5b9d<\/div>\n
<\/div>\n
\n\n
\n![\"RmFicvQBAkgCJiaziaBkdnjAJyjeW8BQQ2syM5EqPMibJtZTsJMxiaib8DianV8YR9fbNUbqiaKmLu3nBW5NkIxCgibKoww\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCJiaziaBkdnjAJyjeW8BQQ2syM5EqPMibJtZTsJMxiaib8DianV8YR9fbNUbqiaKmLu3nBW5NkIxCgibKoww.jpeg\")
<\/figure><\/div>\n\n<\/div>\n
<\/figure><\/div>\n\n<\/div>\n\u56fe\uff1a2017\u5e74\u9999\u6e2f\u4e2d\u6587\u5927\u5b66\u533b\u5b66\u9662\u526f\u9662\u957f\u5362\u715c\u660e\u56e0\u4e3a\u5f00\u521b\u65e0\u521b\u4ea7\u524d\u57fa\u56e0\u68c0\u6d4b\uff0c\u88ab\u6388\u4e88\u9996\u5c4a\u672a\u6765\u79d1\u5b66\u5927\u5956\u201c\u751f\u547d\u79d1\u5b66\u5956\u201d\u3002\u56fe\u7247\u6765\u81ea\u7f51\u6613\u79d1\u6280\u3002<\/div>\n
<\/div>\n
<\/div>\n
\uff08\u771f\u5b9e\u6848\u4f8b\uff0c\u4eba\u540d\u4e3a\u5316\u540d\uff09\u6653\u897f\u7684\u8001\u5a46\u6000\u5b55\u540e\u505a\u4e86\u5510\u6c0f\u7b5b\u67e5\uff0c\u68c0\u67e5\u62a5\u544a\u663e\u793a\u9ad8\u98ce\u9669\u3002\u533b\u751f\u544a\u8bc9\u5979\u9700\u8981\u5c3d\u5feb\u505a\u8fdb\u4e00\u6b65\u68c0\u67e5\u2014\u2014\u505a\u7f8a\u6c34\u7a7f\u523a\u6216\u8005\u65e0\u521bDNA\u68c0\u67e5\uff08NIPT\uff09\u3002\u6653\u897f\u7684\u8001\u5a46\u5413\u54ed\u4e86\u3002\u636e\u8bf4\u7f8a\u6c34\u7a7f\u523a\u5927\u6982\u67090.5%-1%\u7684\u6d41\u4ea7\u98ce\u9669\u3002\u6653\u897f\u7ecf\u8fc7\u4e86\u89e3\u540e\uff0c\u63a8\u8350\u8001\u5a46\u5728\u67d0\u673a\u6784\u505a\u4e86\u65e0\u521bDNA\u68c0\u67e5\uff0c\u8fc7\u4e86\u4e03\u516b\u5929\u540e\uff0c\u68c0\u6d4b\u7ed3\u679c\u51fa\u6765\u4e86\uff0c\u662f\u4f4e\u98ce\u9669\u3002\u57282015\u5e74\u4e0b\u534a\u5e74\uff0c\u559c\u83b7\u53ef\u7231\u5065\u5eb7\u7684\u5b9d\u5b9d\u3002<\/div>\n
\u5728\u8fd9\u4e2a\u8fc7\u7a0b\u4e2d\uff0c\u6653\u897f\u4e86\u89e3\u5230\u8868\u59d0\u901a\u8fc7\u8bd5\u7ba1\u5a74\u513f\u6280\u672f\u751f\u4e86\u4e00\u5bf9\u53cc\u80de\u80ce\uff0c\u6709\u4e00\u4e2a\u662f\u5510\u6c0f\u7efc\u5408\u5f81\u7684\u60a3\u513f\u3002\u539f\u672c\u65e0\u521bDNA\u68c0\u67e5\u7ed3\u679c\u663e\u793a21\u4e09\u4f53\u7efc\u5408\u5f81\u9ad8\u98ce\u9669\u3002\u533b\u751f\u5efa\u8bae\u505a\u7f8a\u6c34\u7a7f\u523a\u4ee5\u786e\u8ba4\u80ce\u513f\u5230\u5e95\u6709\u6ca1\u6709\u95ee\u9898\u3002\u4e00\u4e2a\u5b9d\u5b9d\u7684\u7f8a\u6c34\u7a7f\u523a\u7ed3\u679c\u6b63\u5e38\uff0c\u53e6\u4e00\u4e2a\u5b9d\u5b9d\u7684\u7ed3\u679c\u56e0\u4e3a\u7f8a\u6c34\u57f9\u517b\u5931\u8d25\u7ed3\u679c\u6ca1\u6709\u51fa\u6765\u3002\u8868\u59d0\u6ca1\u6709\u518d\u505a\u68c0\u67e5\uff0c\u7ed3\u679c\u751f\u51fa\u7684\u53cc\u80de\u80ce\u4e2d\u6709\u4e00\u4e2a\u662f\u5510\u6c0f\u7efc\u5408\u5f81\u7684\u60a3\u513f\u3002<\/div>\n
<\/div>\n\n
\u3010\u65e0\u521b\u4ea7\u524d\u57fa\u56e0\u68c0\u6d4b\uff0cNIPT\u3011NIPT\u57282007\u5e74\u88ab\u8bc1\u660e\u4e34\u5e8a\u5e94\u7528\u4ef7\u503c[1]\u3002\u76ee\u524d\u56fd\u5185\u516c\u5f00\u62a5\u9053\u7684NIPT\u6837\u672c\u6570\u8d85\u8fc7300\u4e07\u3002NIPT\u7ed3\u679c\u9ad8\u98ce\u9669\u4ecd\u9700\u7f8a\u6c34\u7a7f\u523a\u786e\u8ba4\uff0c\u4f46\u4f4e\u98ce\u9669\u4e00\u822c\u65e0\u9700\u7ecf\u8fc7\u7f8a\u6c34\u7a7f\u523a\uff0c\u964d\u4f4e\u6d41\u4ea7\u98ce\u9669\u3002\u6df1\u5733\u3001\u91cd\u5e86\u7b49\u5730\u5c06NIPT\u7eb3\u5165\u533b\u4fdd\u3002\u95fd\uff0c\u9102\uff0c\u6e58\uff0c\u82cf\u3001\u5ddd\u3001\u8d35\u7b49\u5730\u7269\u4ef7\u5c40\u5bf9NIPT\u660e\u786e\u5b9a\u4ef7\u3002<\/div>\n
<\/div>\n
<\/div>\n
<\/div>\n
2. \u90ed\u53f0\u94ed\u5ba3\u5e03\u5341\u5e74\u52a9\u529b\u4e73\u764c\u548c\u8840\u764c\u57fa\u56e0\u68c0\u6d4b<\/div>\n
<\/div>\n
\n\n
\n![\"RmFicvQBAkgCJiaziaBkdnjAJyjeW8BQQ2swKibshZawW27jaoyNP8FgxhHEwxW1I7CKYiciaV1UT732gq8YjKeYibl0w\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCJiaziaBkdnjAJyjeW8BQQ2swKibshZawW27jaoyNP8FgxhHEwxW1I7CKYiciaV1UT732gq8YjKeYibl0w.jpeg\")
<\/figure><\/div>\n\n<\/div>\n
<\/figure><\/div>\n\n<\/div>\n\u56fe\uff1a\u90ed\u53f0\u94ed\u672a\u4f8610\u5e74\u652f\u4ed8\u4e73\u764c\u548c\u8840\u764c\u57fa\u56e0\u6aa2\u6e2c\u3002\u56fe\u7247\u6765\u81ea\u4e1c\u68ee\u65b0\u95fb\u4e91<\/div>\n
<\/div>\n
\uff08\u636e\u4e1c\u68ee\u65b0\u95fb\u4e91\u62a5\u9053\uff092017\u5e74\u6bcd\u4eb2\u8282\u524d\u5915\uff0c\u6c38\u9f84\u5065\u5eb7\u57fa\u91d1\u4f1a\u521b\u529e\u4eba\u3001\u9e3f\u6d77\u8463\u4e8b\u957f\u90ed\u53f0\u94ed\u51fa\u5e2d\u516c\u76ca\u6d3b\u52a8\u201c\u6c38\u9f84\u534e\u4eba\u6297\u764c\u8054\u5408\u884c\u52a8\u201d\uff0c\u5ba3\u5e03\u6c38\u9f84\u5065\u5eb7\u57fa\u91d1\u4f1a\u5728\u672a\u676510\u5e74\u5c06\u514d\u8d39\u652f\u4ed8\u4e73\u764c\u3001\u8840\u764c\u60a3\u8005\u57fa\u56e0\u68c0\u6d4b\u4e34\u5e8a\u7814\u7a76\u8ba1\u5212\uff0c\u6df1\u5165\u533b\u7597\u7814\u7a76\uff0c\u9020\u798f\u66f4\u591a\u764c\u75c7\u60a3\u8005\u3002\u7531\u4e8e\u4ea1\u59bb\u6797\u6dd1\u598212\u5e74\u524d\u56e0\u4e73\u764c\u8fc7\u4e16\uff0c\u4eca\u5e743\u6708\u90ed\u53f0\u94ed\u5728\u6c38\u9f84\u5065\u5eb7\u57fa\u91d1\u4f1a\u5ba3\u8a93\u4e0e\u53f0\u5927\u3001\u534e\u5927\u57fa\u56e0\u3001Nantworks\u3001HudsonAlpha\u5408\u4f5c\u5171\u7ec4\u6297\u764c\u8054\u76df\uff0c\u4e00\u8d77\u653b\u514b\u4e73\u764c[2]\u3002<\/div>\n
<\/div>\n\n
\u3010\u764c\u75c7\u57fa\u56e0\u68c0\u6d4b\u3011\u8d8a\u6765\u8d8a\u591a\u7684\u57fa\u56e0\u88ab\u53d1\u73b0\u4f5c\u4e3a\u67d0\u4e9b\u764c\u75c7\u7684\u53d1\u751f\u3001\u672f\u540e\u590d\u53d1\u6216\u8005\u8f6c\u79fb\u7684\u6307\u6807\uff0c\u6bd4\u5982\u4e73\u817a\u764c\u76f8\u5173\u7684BRCA1\/2\u3001HER2\u7b49\u57fa\u56e0\uff1b\u548c\u8840\u764c\u76f8\u5173\u7684BCR-ABLP210\u57fa\u56e0\u7b49\u3002\u901a\u8fc7\u5bf9\u8fd9\u4e9b\u6307\u5b9a\u57fa\u56e0\u7684\u5feb\u901f\u68c0\u6d4b\uff0c\u53ef\u4ee5\u7528\u6765\u8bca\u65ad\u764c\u75c7\u6216\u8005\u6cbb\u7597\u6307\u5bfc\u3002<\/div>\n
<\/div>\n
<\/div>\n
3. \u201c\u57fa\u56e0\u8eab\u4efd\u8bc1\u201d<\/div>\n
<\/div>\n
\n\n
\n![\"RmFicvQBAkgDTTtM10Y5bicZEW4XEicsr1NSJ0gscjGIMoKAdcZVczmh0f9SZQjlVGryCgwV5ibKqEH9QHqfhWvM9A\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDTTtM10Y5bicZEW4XEicsr1NSJ0gscjGIMoKAdcZVczmh0f9SZQjlVGryCgwV5ibKqEH9QHqfhWvM9A.png\")
<\/figure><\/div>\n\n<\/div>\n
<\/figure><\/div>\n\n<\/div>\n\u56fe\uff1a\u4e2d\u56fd\u516c\u5b89\u90e8\u5efa\u7acb\u5168\u7403\u9996\u4e2a\u201c\u6253\u62d0DNA\u4fe1\u606f\u5e93\u201d\u3002\u56fe\u7247\u6765\u81ea\u65b0\u534e\u89c6\u9891\uff082016\u5e7401\u670817\u65e5\uff09[3]<\/div>\n
<\/div>\n
\uff08\u6839\u636e\u65b0\u534e\u7f51\u91cd\u5e86\u9891\u9053\u62a5\u9053\uff092015\u5e74\uff0c38\u5c81\u7684\u7da6\u6c5f\u4eba\u738b\u67d0\u600e\u4e48\u4e5f\u6ca1\u60f3\u5230\uff0c\u5979\u5931\u8e2a\u4e8612\u5e74\u591a\u7684\u513f\u5b50\u4f1a\u518d\u6b21\u56de\u5230\u5979\u7684\u6000\u62b1\u3002\u7da6\u6c5f\u8b66\u65b9\u501f\u52a9\u5168\u56fd\u67e5\u627e\u88ab\u62d0\u513f\u7ae5DNA\u4fe1\u606f\u7cfb\u7edf\uff0c\u8f97\u8f6c\u798f\u5efa\u3001\u5e7f\u4e1c\u7b49\u5730\uff0c\u7ec8\u5c06\u8fd9\u540d\u88ab\u62d0\u7537\u5b69\u6210\u529f\u89e3\u6551\u3002<\/div>\n
\uff08\u6839\u636e\u516c\u5b89\u90e8\u5b98\u7f51\uff09\u516c\u5b89\u90e8\u4e8e2009\u5e74\u5efa\u7acb\u4e86\u4e16\u754c\u4e0a\u7b2c\u4e00\u4e2a\u201c\u6253\u62d0DNA\u4fe1\u606f\u5e93\u201d\u3002\u8fd1\u4e24\u5e74\u6765\uff0c\u8fdb\u4e00\u6b65\u5b8c\u5584\u4e86\u7f51\u4e0a\u6bd4\u5bf9\u548c\u7ebf\u4e0b\u8c03\u67e5\u6838\u5b9e\u7b49\u5de5\u4f5c\uff0c\u622a\u81f3\u52302017\u5e742\u6708\uff0c\u5df2\u5e2e\u52a94500\u4f59\u540d\u88ab\u62d0\u591a\u5e74\u7684\u513f\u7ae5\u4e0e\u5bb6\u4eba\u56e2\u805a[4]\u3002<\/div>\n
<\/div>\n
\n\n<\/div>\n
\u3010\u201c\u57fa\u56e0\u8eab\u4efd\u8bc1\u201d\u3011\u5bb9\u989c\u53ef\u4ee5\u6539\uff0c\u751a\u81f3\u6307\u7eb9\u53ef\u80fd\u635f\u574f\u3002\u4f46\u6211\u4eec\u6bcf\u4e2a\u4eba\u72ec\u4e00\u65e0\u4e8c\u7684\u57fa\u56e0\u662f\u4f34\u968f\u4e00\u751f\u3002\u901a\u8fc7\u56fa\u5b9a\u4e0d\u53d8\u7684\u9057\u4f20\u6807\u8bb0\u4f4d\u70b9\uff0c\u53ef\u4ee5\u786e\u5b9a\u4e00\u4e2a\u4eba\u7684\u8eab\u4efd\u548c\u9057\u4f20\u5173\u7cfb\uff0c\u662f\u4e00\u79cd\u975e\u5e38\u51c6\u786e\u4e14\u64cd\u4f5c\u6027\u76f8\u5bf9\u8f83\u5f3a\u7684\u6280\u672f\u3002\u76f8\u4fe1\u4e0d\u8fdc\u7684\u5c06\u6765\uff0c\u6211\u4eec\u7684\u8eab\u4efd\u8bc1\u4e0a\u4f1a\u643a\u5e26\u57fa\u56e0\u4fe1\u606f\uff0c\u53ef\u80fd\u662f\u7269\u8d28\uff0c\u4e5f\u53ef\u80fd\u662f\u6570\u5b57\u5f62\u5f0f\u3002<\/div>\n
<\/div>\n
<\/div>\n
<\/div>\n
4. \u907f\u514d\u201c\u836f\u7269\u81f4\u804b\u201d\u7c7b\u4f3c\u60b2\u5267<\/div>\n
<\/div>\n
\n\n
\n![\"RmFicvQBAkgDTTtM10Y5bicZEW4XEicsr1N6icIxyvttYr3Sxd5bXar2tJ0Bd0jicTz23ED2Mu02MAysd4hUxVB8HibA\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDTTtM10Y5bicZEW4XEicsr1N6icIxyvttYr3Sxd5bXar2tJ0Bd0jicTz23ED2Mu02MAysd4hUxVB8HibA.jpeg\")
<\/figure><\/div>\n\n<\/div>\n
<\/figure><\/div>\n\n<\/div>\n\u56fe\uff1a\u5343\u624b\u89c2\u97f3\u3002\u56fe\u6765\u81ea\u7f51\u6613\u3002<\/div>\n
<\/div>\n
\uff08\u6839\u636e\u5357\u65b9\u65e5\u62a5\u548c\u592e\u89c6\u62a5\u9053\uff092005\u5e74\u7684\u592e\u89c6\u6625\u665a\u4e0a\uff0c\u7531\u4e2d\u56fd\u6b8b\u75be\u4eba\u827a\u672f\u56e2\u8868\u6f14\u7684\u821e\u8e48\u300a\u5343\u624b\u89c2\u97f3\u300b\uff0c\u534e\u7f8e\u4e4b\u5185\u5145\u6ee1\u7075\u52a8\uff0c\u5e26\u7ed9\u89c2\u4f17\u6781\u5927\u9707\u64bc\u3002\u66f4\u540e\u6765\u6839\u636e\u62a5\u9053\u5e26\u6765\u66f4\u5927\u9707\u64bc\u7684\u662f\uff0c\u8fd9\u4e2a\u821e\u8e48\u8868\u6f14\u7684\u5168\u90e8\u90fd\u662f\u804b\u54d1\u6f14\u5458\u3002\u800c\u975e\u5e38\u9057\u61be\u7684\u662f\uff0c21\u4f4d\u804b\u54d1\u6f14\u5458\u4e2d\uff0c\u670918\u4f4d\u662f\u7531\u836f\u7269\u5bfc\u81f4\u7684\u8033\u804b\u3002\u836f\u7269\u8033\u804b\u4e3b\u8981\u662f\u7531\u4e8e\u4f7f\u7528\u6bd2\u6027\u5242\u91cf\u7684\u6c28\u57fa\u7cd6\u7519\u7c7b\u6297\u751f\u7d20\uff0c\u6216\u8005\u643a\u5e26\u836f\u7269\u654f\u611f\u6027\u7684\u57fa\u56e0\u7a81\u53d8\uff08\u6bd4\u5982A1555G\u57fa\u56e0\uff09\u3002\u5e38\u7528\u7684\u6c28\u57fa\u7cd6\u82f7\u7c7b\u6297\u751f\u7d20\u9664\u4e86\u4eba\u4eec\u6240\u719f\u6089\u94fe\u9709\u7d20\u4ee5\u5916\uff0c\u8fd8\u6709\u5361\u90a3\u9709\u7d20\u3001\u6838\u7cd6\u9709\u7d20\u3001\u5e86\u5927\u9709\u7d20\u7b49[5]\u3002<\/div>\n
\n\n<\/div>\n
\u3010\u57fa\u56e0\u68c0\u6d4b\u6307\u5bfc\u7528\u836f\u3011\u836f\u7269\u7684\u6bd2\u526f\u4f5c\u7528\uff0c\u9664\u4e86\u81ea\u8eab\u6210\u5206\uff0c\u8fd8\u548c\u4eba\u7684\u57fa\u56e0\u6709\u5173\u7cfb\u3002\u901a\u8fc7\u57fa\u56e0\u7b5b\u67e5\uff0c\u901a\u8fc7\u8f83\u4f4e\u7684\u6210\u672c\u63d0\u524d\u9884\u77e5\u836f\u7269\u654f\u611f\u6027\uff0c\u53ef\u4ee5\u907f\u514d\u8fd9\u6837\u4eba\u4e3a\u60b2\u5267\u7684\u53d1\u751f\u3002\u547c\u5401\u66f4\u591a\u836f\u7269\u654f\u611f\u6027\u57fa\u56e0\u7eb3\u5165\u65b0\u751f\u513f\u7b5b\u67e5\u3002<\/div>\n
<\/div>\n
<\/div>\n
5. \u7f55\u89c1\u75c5\uff0c\u5bfb\u5e38\u836f<\/div>\n
<\/div>\n
\n\n
\n![\"RmFicvQBAkgDTTtM10Y5bicZEW4XEicsr1NibDuDpM7Bcs12kapZNqH4yH5Z8RYHYjCHeBkmhsVnT8fgXUTS3ricdwQ\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDTTtM10Y5bicZEW4XEicsr1NibDuDpM7Bcs12kapZNqH4yH5Z8RYHYjCHeBkmhsVnT8fgXUTS3ricdwQ.jpeg\")
<\/figure><\/div>\n\n<\/div>\n
<\/figure><\/div>\n\n<\/div>\n\u56fe\uff1aBVVL\u7efc\u5408\u5f81\u60a3\u8005\u63a5\u53d7\u57fa\u56e0\u8bca\u65ad\u4faf\uff0c\u670d\u7528\u7ef4\u751f\u7d20B2\u7684\u6cbb\u7597\u60c5\u5f62\uff0c\u56fe\u7247\u6765\u81eaCold Spring Harb Mol Case[6]<\/div>\n
<\/div>\n
\uff08\u771f\u5b9e\u6848\u4f8b,Nature Genetics\u62a5\u9053\uff09\u5728\u5317\u6b27\u7684\u51b0\u5c9b\uff0c\u6709\u8fd9\u6837\u4e00\u4e2a\u4e0d\u5e78\u7684\u5bb6\u5ead\uff0c\u4e24\u4e2a\u5973\u5b69, 5\u5c81\u65f6\u60a3\u6e10\u8fdb\u6027\u773c\u76f2, \u8033\u804b, \u8188\u808c\u65e0\u529b\uff0c\u53d1\u75c5\u56db\u5e74\u4e4b\u540e\u5c1d\u8bd5\u4e86\u5404\u79cd\u8bca\u65ad\u624b\u6bb5\u8fd8\u672a\u786e\u8bca\uff0c\u5bf9\u7236\u6bcd\u548c\u4e24\u5b69\u5b50\u8fdb\u884c\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u540e\uff0c\u53d1\u73b0\u57fa\u56e0SLC52A2\u7a81\u53d8\uff0c\u8fdb\u4e00\u6b65\u8bca\u65ad\u4e3aBVVL\u7efc\u5408\u5f81\u3002BVVL\u7efc\u5408\u5f81\u662f\u4e00\u79cd\u4e34\u5e8a\u7f55\u89c1\u75be\u75c5,\u5f71\u54cd\u795e\u7ecf\u548c\u808c\u8089\u53d1\u80b2\u3002\u81f4\u75c5\u539f\u56e0\u7684\u57fa\u56e0\u7a81\u53d8\u5f71\u54cd\u4e86\u6838\u9ec4\u7d20\u8f6c\u8fd0\u5b50\u529f\u80fd\uff0c\u63a5\u53d7\u9ad8\u5242\u91cf\u9ad8\u5242\u91cf\u6838\u9ec4\u7d20\u2014\u2014\u4e5f\u5c31\u662f\u7ef4\u751f\u7d20B2\uff0c\u75c5\u60c5\u5f97\u5230\u7f13\u89e3\u63a7\u5236[7]\u3002<\/div>\n
<\/div>\n
<\/div>\n\n
\u3010\u7f55\u89c1\u75c5\u8bca\u65ad\u3011\u7f55\u89c1\u75c5\uff0c\u7528\u8001\u767e\u59d3\u7684\u8bdd\u8bf4\u7591\u96be\u6742\u75c7\uff0c\u5b83\u7684\u590d\u6742\u6027\u5e76\u4e0d\u5728\u4e8e\u201c\u6cbb\u201d\uff0c\u800c\u662f\u201c\u8bca\u201d\u3002\u901a\u8fc7\u57fa\u56e0\u68c0\u6d4b\uff0c\u8054\u5408\u5bb6\u7cfb\u5206\u6790\u7b49\u53ef\u4ee5\u53d1\u73b0\u7f55\u89c1\u75c5\u75c7\u72b6\u5bf9\u5e94\u7684\u57fa\u56e0\u7a81\u53d8\uff0c\u627e\u5230\u75c5\u6839\u3002\u5bf9\u4e8e\u67d0\u4e9b\u5f15\u8d77\u4ee3\u8c22\u5f02\u5e38\u7684\u75be\u75c5\uff0c\u901a\u8fc7\u4ee3\u507f\u6cbb\u7597\uff0c\u5f80\u5f80\u4f1a\u51fa\u73b0\u4e0a\u6587\u7684\u60c5\u5f62\uff0c\u201c\u7f55\u89c1\u75c5\uff0c\u5bfb\u5e38\u836f\u201d\u7684\u6b22\u559c\u7ed3\u679c\u3002<\/div>\n
<\/div>\n
<\/div>\n
<\/div>\n
6. \u5206\u5b50\u80b2\u79cd\u589e\u4ea7\u6297\u75c5<\/div>\n
<\/div>\n
\n\n
\n![\"RmFicvQBAkgDTTtM10Y5bicZEW4XEicsr1NLvA3ib9m0syibAtoOY8aapjysIJAC4VlRZO4FTbuUs39ZXWSWxvibwf0A\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDTTtM10Y5bicZEW4XEicsr1NLvA3ib9m0syibAtoOY8aapjysIJAC4VlRZO4FTbuUs39ZXWSWxvibwf0A.png\")
<\/figure><\/div>\n\n<\/div>\n
<\/figure><\/div>\n\n<\/div>\n\u56fe\uff1a\u57fa\u56e0\u7ec4\u8f85\u52a9\u5206\u5b50\u80b2\u79cd\u540e\uff0c\u63d0\u9ad8\u4e86\u8c37\u5b50\u7684\u5149\u5408\u4f5c\u7528\u6548\u7387\u53ca\u7a57\u5b50\u4ea7\u91cf<\/div>\n
<\/div>\n
\u901a\u8fc7\u57fa\u56e0\u5206\u578b\u5e73\u53f0\uff0c\u83b7\u53d6\u4e86\u91cd\u8981\u519c\u4e1a\u6027\u72b6\u76f8\u5173\u7684\u5b9a\u4f4d\uff0c\u8fdb\u884c\u4f18\u52bf\u57fa\u56e0\u7ec4\u5408\uff08\u7c7b\u4f3c\u6742\u4ea4\u6c34\u7a3b\u7684\u65b9\u5f0f\uff09\uff0c\u4eceF1\u4ee3\u5f00\u59cb\u5230\u6700\u540e\u83b7\u5f97\u5b8c\u6574\u7684\u6539\u826f\u690d\u682a\u53ea\u670912\u4e2a\u6708\u65f6\u95f4\uff0c\u4e00\u5e74\u53ef\u4ee5\u5b8c\u62106\u4e2a\u4e16\u4ee3\u7684\u7279\u6027\u6539\u826f\u3002\u5927\u5927\u7f29\u77ed\u4e86\u80b2\u79cd\u65f6\u95f4\u3002\u540c\u65f6\u7ed3\u679c\u663e\u793a\uff0c\u8c37\u5b50\u7684\u5149\u5408\u4f5c\u7528\u63d0\u9ad8\u4e86\uff0c\u660e\u663e\u63d0\u9ad8\u4e86\u7a57\u5b50\u4ea7\u91cf\u3002\u76ee\u524d\u9009\u80b2\u79cd\u7684\u6750\u6599\u5728\u8d35\u5dde\u3001\u6e56\u5357\u7b49\u5730\u8bd5\u79cd\u6548\u679c\u5f88\u597d\u3002<\/div>\n
<\/div>\n
<\/div>\n\n
\u3010\u57fa\u56e0\u5206\u578b\u8f85\u52a9\u5206\u5b50\u80b2\u79cd\u3011\u4f20\u7edf\u7684\u80b2\u79cd\u51ed\u7ecf\u9a8c\u548c\u8089\u773c\u89c2\u5bdf\uff0c\u96be\u4ee5\u590d\u5236\u4e14\u65f6\u95f4\u548c\u6210\u672c\u96be\u4ee5\u63a7\u5236\uff0c\u8fc7\u7a0b\u662f\u4e00\u53ea\u201c\u9ed1\u5323\u5b50\u201d\u3002\u5206\u5b50\u80b2\u79cd\u6253\u5f00\u201c\u9ed1\u5323\u5b50\u201d\uff0c\u901a\u8fc7\u57fa\u56e0\u578b\u7cbe\u51c6\u5b9a\u4f4d\u6027\u72b6\u4f4d\u70b9\uff0c\u901a\u8fc7\u8ba1\u7b97\u5206\u6790\u6765\u7b5b\u9009\u548c\u7ec4\u5408\uff0c\u518d\u7ed3\u5408\u4f20\u7edf\u80b2\u79cd\uff0c\u5b9e\u73b0\u7cbe\u51c6\uff0c\u5feb\u901f\u7684\u6548\u679c\u3002\u80b2\u79cd\u4e0d\u4ec5\u9650\u4e8e\u519c\u4f5c\u7269\u3001\u8fd8\u5305\u62ec\u755c\u7267\u3001\u6c34\u4ea7\u7b49\u3002<\/div>\n
<\/div>\n
<\/div>\n
<\/div>\n
7. \u9776\u5411\u836f\u7ed9\u5750\u8f6e\u690514\u5e74\u7684\u7537\u5b69\u63d0\u4f9b\u5e0c\u671b<\/div>\n
<\/div>\n
\n\n
\n![\"RmFicvQBAkgCJiaziaBkdnjAJyjeW8BQQ2sfuEHjQ33ZbLHYnWA9mGiakGBf0XwjrcSQBxBzUGsjCrVXRSYbHL18nA\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCJiaziaBkdnjAJyjeW8BQQ2sfuEHjQ33ZbLHYnWA9mGiakGBf0XwjrcSQBxBzUGsjCrVXRSYbHL18nA.png\")
<\/figure><\/div>\n\n<\/div>\n
<\/figure><\/div>\n\n<\/div>\n\u56fe\uff1a\u60a3SMA\u7684\u60a3\u8005\u4e39\u5c3c\u3002\u6765\u81eaNexstar Broadcasting<\/div>\n
<\/div>\n
\uff08\u636eKORN\u62a5\u9053\uff09\u5728\u4e39\u5c3c6\u4e2a\u6708\u5927\u65f6\uff0c\u533b\u751f\u544a\u8bc9\u4ed6\u7684\u7236\u6bcd\u53ef\u4ee5\u505a\u6700\u540e\u7684\u544a\u522b\u4e86\uff0c\u4ed6\u88ab\u8bca\u65ad\u4e3a\u4e00\u79cd\u53ebSMA\uff08\u810a\u9ad3\u6027\u808c\u840e\u7f29\u75c7\uff09\u7684\u91cd\u578b\u75be\u75c5[8]\u3002\u4e39\u5c3c\u7684\u7236\u6bcd\u6ca1\u6709\u653e\u5f03\uff0c\u505a\u4e86\u65e0\u6570\u6b21\u624b\u672f\uff0c\u4e39\u5c3c\u4e24\u5c81\u5f00\u59cb\u5750\u5728\u8f6e\u6905\u91cc\u3002SMA\u7684\u53d1\u75c5\u539f\u56e0\u662fSMN1\u57fa\u56e0\u7684\u7a81\u53d8\u5bfc\u81f4SMN\u86cb\u767d\u7f3a\u5931\u30022016\u5e74FDA\u6279\u51c6\u4e86\u4e00\u79cd\u53eb\u505aSpinraza\u7684SMA\u836f\u7269\u2014\u2014\u5b83\u80fd\u4fee\u590dSMN2\u57fa\u56e0\u6765\u589e\u52a0SMN\u86cb\u767d\u7684\u4ea7\u751f\u3002\u4e39\u5c3c\u7684\u533b\u751f\u7ed9\u4ed6\u6ce8\u5c04\u8fd9\u79cd\u836f\u7269\u540e\uff0c\u4ed6\u7684\u53f3\u81c2\u53ef\u4ee5\u6446\u52a8\u5230\u80f8\u524d\uff0c\u624b\u6307\u53ef\u4ee5\u591f\u5230\u81ea\u5df1\u7684\u811a\uff0c\u73b0\u5728\u4e0a\u9ad8\u4e2d\uff0c\u4ee3\u6570\u548c\u7269\u7406\u5f88\u597d\u3002<\/div>\n
<\/div>\n\n
\u3010\u9776\u5411\u836f\u6cbb\u7597\u3011\u6709\u7684\u75be\u75c5\u56e0\u4e3a\u57fa\u56e0\u7a81\u53d8\u5f15\u8d77\uff0c\u9488\u5bf9\u8fd9\u4e9b\u57fa\u56e0\u7684\u4fee\u590d\u7684\u5206\u5b50\u9776\u5411\u836f\uff0c\u53ef\u4ee5\u9488\u5bf9\u6027\u5730\u63d0\u9ad8\u60a3\u8005\u751f\u5b58\u7387\u3002\u7c7b\u4f3cSMA\u7684\u9776\u5411\u836fSpinraza\u8fd8\u6709\uff0cALS\u7684\u9776\u5411\u836fRadicava\uff0c\u767d\u8840\u75c5\u9776\u5411\u836fRydapt\u7b49\u3002<\/div>\n
<\/div>\n
<\/div>\n
<\/div>\n
8. \u57fa\u56e0\u6cbb\u7597<\/div>\n
<\/div>\n
\n\n
\n![\"RmFicvQBAkgDTTtM10Y5bicZEW4XEicsr1NGrcPNJ1cSWVQicmYLNLxG5Dx4092lKKy8DgAPEnyObvDvczrKNyscLw\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDTTtM10Y5bicZEW4XEicsr1NGrcPNJ1cSWVQicmYLNLxG5Dx4092lKKy8DgAPEnyObvDvczrKNyscLw.jpeg\")
<\/figure><\/div>\n\n<\/div>\n
<\/figure><\/div>\n\n<\/div>\n\u56fe\uff1a\u7f3a\u4e4f\u817a\u82f7\u8131\u6c28\u9176\u57fa\u56e0\uff08ada\u57fa\u56e0\uff09\u800c\u60a3\u5148\u5929\u6027\u4f53\u6db2\u514d\u75ab\u7f3a\u9677\u75c5\u7684\u7f8e\u56fd\u5973\u5b69\u63a5\u53d7\u57fa\u56e0\u6cbb\u7597.\u56fe\u7247\u6765\u81eaNIH\u5b98\u7f51<\/div>\n
<\/div>\n
(NIH\u5b98\u7f51\u62a5\u9053) \u00b71900\u5e74\uff0c\u4e00\u4e2a\u56db\u5c81\u7684\u7f8e\u56fd\u5973\u5b69\u56e0\u7f3a\u4e4fADA\u57fa\u56e0\uff0c\u800c\u6709\u60a3\u5148\u5929\u6027\u4f53\u6db2\u514d\u75ab\u7f3a\u9677\u75c5\u3002\u8fd9\u79cd\u75c5\u80fd\u7528PEG-ADA\u6cbb\u7597\uff0c\u4f46\u8fd9\u79cd\u836f\u7269\u5341\u5206\u6602\u8d35\uff08\u7ea660,000\u7f8e\u5143\/\u5e74\uff09\u3002\u800c\u4e14\u5fc5\u987b\u901a\u8fc7\u6301\u7eed\u9759\u8109\u6ce8\u5c04\u6765\u7ef4\u6301\u7597\u6548\u3002<\/div>\n
\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\uff08NIH)\u7684W. Anderson\u535a\u58eb\u56e2\u961f\u5bf9\u5176\u91c7\u7528\u57fa\u56e0\u6cbb\u7597\u65b9\u6848\uff0c\u5373\u91c7\u53d6\u5148\u5c06\u4eba\u4f53\u6b63\u5e38ADA\u57fa\u56e0\u63d0\u53d6\u4e4b\u540e\u8fdb\u884c\u514b\u9686\uff0c\u7528\u6765\u66ff\u6362\u53cd\u8f6c\u5f55\u75c5\u6bd2\u7684\u539f\u6709\u57fa\u56e0\uff0c\u968f\u540e\u5c06\u60a3\u8005\u7684\u6dcb\u5df4\u7ec6\u80de\u53d6\u51fa\u4f5c\u4f53\u5916\u57f9\u517b\uff0c\u7136\u540e\u7528\u9006\u8f6c\u5f55\u75c5\u6bd2\u5c06\u6b63\u5e38ADA\u57fa\u56e0\u8f6c\u5165\u57f9\u517b\u7684\u6dcb\u5df4\u7ec6\u80de\u4e2d\uff0c\u518d\u5c06\u8fd9\u4e9b\u8f6c\u57fa\u56e0\u6dcb\u5df4\u7ec6\u80de\u56de\u8f93\u5230\u60a3\u8005\u7684\u4f53\u5185\uff0c\u7ecf\u8fc7\u591a\u6b21\u6cbb\u7597\uff0c\u60a3\u8005\u7684\u514d\u75ab\u529f\u80fd\u8d8b\u4e8e\u6b63\u5e38\uff0c\u80fd\u591f\u4e0a\u5b66\u5e76\u8fc7\u4e0a\u4e86\u6b63\u5e38\u7684\u751f\u6d3b[9]\u3002<\/div>\n
<\/div>\n\n
\u3010\u57fa\u56e0\u6cbb\u7597\u3011\u5f53\u6211\u4eec\u8c08\u5230\u6cbb\u7597\u548c\u79fb\u690d\u65f6\uff0c\u9664\u4e86\u7cfb\u7edf\u3001\u5668\u5b98\u548c\u7ec4\u7ec7\u5c42\u9762\uff0c\u57fa\u56e0\u4e5f\u662f\u4e00\u4e2a\u7ef4\u5ea6\u3002\u5f53\u67d0\u4e9b\u5bfc\u81f4\u75be\u75c5\u7684\u57fa\u56e0\u53d1\u751f\u5f02\u5e38\u65f6\uff0c\u53ef\u4ee5\u5c06\u5916\u6e90\u6b63\u5e38\u57fa\u56e0\u5bfc\u5165\u9776\u7ec6\u80de\uff0c\u4ee5\u7ea0\u6b63\u6216\u8865\u507f\u56e0\u57fa\u56e0\u7f3a\u9677\u548c\u5f02\u5e38\u5f15\u8d77\u7684\u75be\u75c5\uff0c\u8fbe\u5230\u6cbb\u7597\u76ee\u7684\u3002\u76ee\u524d\u5e94\u7528\u5728\u90e8\u5206\u75be\u75c5\u4e2d\uff0c\u968f\u7740\u57fa\u56e0\u7ec4\u6280\u672f\u7684\u53d1\u5c55\uff0c\u5e94\u7528\u8303\u56f4\u6709\u671b\u6269\u5927\u3002<\/div>\n
<\/div>\n
<\/div>\n
<\/div>\n
9. \u65b0\u836f\u7814\u53d1\u00a0<\/div>\n
<\/div>\n
\n\n
\n![\"RmFicvQBAkgDTTtM10Y5bicZEW4XEicsr1NP9mA7W6OjlUfWOkYaTNfLKAD0OsyWaxr9hYasPvVyQRLLkC7wUks7w\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDTTtM10Y5bicZEW4XEicsr1NP9mA7W6OjlUfWOkYaTNfLKAD0OsyWaxr9hYasPvVyQRLLkC7wUks7w.jpeg\")
<\/figure><\/div>\n\n<\/div>\n
<\/figure><\/div>\n\n<\/div>\n\u56fe\uff1a\u57fa\u56e0\u6570\u636e\u5206\u6790\u63d0\u4f9b\u65b0\u836f\u7814\u53d1\u7684\u7ebf\u7d22\u3002\u56fe\u7247\u6765\u81eaNIH<\/div>\n
<\/div>\n
\u5728\u6cd5\u56fd\u4e00\u4e2a\u6709\u9057\u4f20\u6027\u9ad8\u80c6\u56fa\u9187\u75be\u75c5\u5bb6\u65cf\u91cc\uff0c\u57fa\u56e0\u6570\u636e\u5206\u6790\u6307\u5411PCSK9\u57fa\u56e0\u7a81\u53d8\u3002\u540e\u6765\u88ab\u7f8e\u56fd\u5fb7\u514b\u8428\u65af\u5dde\u7684\u4e00\u4f4d\u7f55\u89c1\u7684\u4f4e\u8840\u8102\u60a3\u8005Tracy\u518d\u6b21\u9a8c\u8bc1\u3002\u57fa\u56e0PCSK9\u88ab\u786e\u5b9a\u4e3a\u836f\u7269\u964d\u8102\u9776\u70b9\u30022015\u5e74PCSK9\u6291\u5236\u5242Repatha\u548cPraluent\u95ee\u4e16\uff0c\u62ef\u6551\u4e86\u5168\u4e16\u754c\u65e0\u6570\u9ad8\u80c6\u56fa\u9187\u60a3\u8005\uff0c\u51cf\u5c11\u4e86\u51cf\u5c11\u5fc3\u8840\u7ba1\u75be\u75c5\u53d1\u751f\u7387\u548c\u6b7b\u4ea1\u7387[10]\u3002<\/div>\n
<\/div>\n
<\/div>\n\n
\u3010\u57fa\u56e0\u5206\u6790\u534f\u52a9\u65b0\u836f\u9776\u70b9\u53d1\u73b0\u3011\u836f\u7269\u7814\u53d1\u7684\u5468\u671f\u548c\u6210\u672c\u8d85\u51fa\u666e\u901a\u4eba\u7684\u60f3\u8c61\uff0cIpilimumab\u836f\u7269\u5c31\u8fbe30\u5e74[11]\u3002\u4e00\u65b9\u9762\u57fa\u56e0\u4f5c\u4e3a\u65b0\u836f\u9776\u70b9\uff0c\u7279\u522b\u662f\u4eba\u7fa4\u961f\u5217\u7814\u7a76\uff0c\u67d0\u79cd\u7a0b\u5ea6\u4e0a\u63d0\u4f9b\u4e86\u836f\u7269\u7814\u53d1\u7684\u6548\u7387\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u6211\u4eec\u5bf9\u7f55\u89c1\u75c5\u7684\u8ba4\u8bc6\u548c\u5206\u6790\uff0c\u4e3a\u5e38\u89c1\u75c5\u7684\u836f\u7269\u7814\u53d1\u63d0\u4f9b\u9776\u70b9\u7ebf\u7d22\u3002<\/div>\n
<\/div>\n
\u4ee5\u4e0a\u6545\u4e8b\u7684\u51fa\u5904\u8bf7\u53c2\u8003\u6587\u672b\u53c2\u8003\u8d44\u6599\u3002<\/div>\n
\u8bfb\u4e86\u8fd9\u4e9b\u6545\u4e8b\uff0c\u60a8\u6709\u4f55\u611f\u60f3\uff1f\u6b22\u8fce\u7559\u8a00\u3002<\/div>\n
<\/div>\n
<\/div>\n
<\/div>\n
\u60a8\u53ef\u80fd\u8fd8\u611f\u5174\u8da3\u7684 \u2193<\/div>\n
<\/div>\n
20+CEO\u5e2e\u60a8\u89e3\u7b54\uff1a\u57fa\u56e0\u884c\u4e1a\u662f\u505a\u4ec0\u4e48\u7684\uff1f<\/a><\/div>\n
\u57fa\u56e0\u6167\u4e3a\u300a\u57fa\u56e0\u7ec4\u9769\u547d\u300b\u4f5c\u5e8f<\/a><\/div>\n
\u534f\u548c\u3001\u5409\u56e0\u52a0\u3001\u4f18\u8baf\u4e13\u5bb6\u8c08\u80bf\u7624\u7cbe\u51c6\u533b\u7597<\/a><\/div>\n
\u9646\u7956\u5b8f\u3001\u8d75\u67cf\u95fb\u3001\u84dd\u707f\u8f89\u8c08\u5fae\u751f\u7269\u7ec4<\/a><\/div>\n
\u4ece\u57fa\u56e0\u5927\u6570\u636e\u5230\u4e34\u5e8a\u5e94\u7528\u6709\u591a\u8fdc\uff1f<\/a><\/div>\n
<\/div>\n
<\/div>\n
<\/div>\n
\n\n
\n![\"RmFicvQBAkgC0avckNia9q4ZYtSsGWlTxlSjuIocJWRhNOLgBHDRXibCk61GiappiaVc0dMibibnFmEJxX1rA2ZR3wzGQ\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgC0avckNia9q4ZYtSsGWlTxlSjuIocJWRhNOLgBHDRXibCk61GiappiaVc0dMibibnFmEJxX1rA2ZR3wzGQ.gif\")
<\/figure><\/div>\n\n<\/div>\n
<\/figure><\/div>\n\n<\/div>\n<\/div>\n
\n\n
\n![\"RmFicvQBAkgBicOicQvFu5myrw1PNqAmics3yZcXP7OeskBkKTLic0ia4uyQjNGhpRuE33kv7lT3cPuxicCzXU7ZGMqDg\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBicOicQvFu5myrw1PNqAmics3yZcXP7OeskBkKTLic0ia4uyQjNGhpRuE33kv7lT3cPuxicCzXU7ZGMqDg.png\")
<\/figure><\/div>\n\n<\/div>\n
<\/figure><\/div>\n\n<\/div>\n<\/div>\n
<\/div>\n
<\/div>\n
\u53c2\u8003\u8d44\u6599\uff1a<\/div>\n
1.\u00a0Jonathan C. M. Wan Charles et. al. Liquid biopsies come of age: towards implementation of circulating tumour DNA,Nature Reviews Cancer 17, 223\u2013238 (2017) doi:10.1038\/nrc.2017.7<\/div>\n
2.\u00a0http:\/\/www.ettoday.net\/news\/20170513\/923738.htm<\/div>\n
<\/div>\n
3.\u00a0http:\/\/news.xinhuanet.com\/video\/2016-01\/17\/c_128636057.htm<\/div>\n
4.\u00a0http:\/\/www.mps.gov.cn\/n2255079\/n4876594\/n4974590\/n4974593\/c5624815\/content.html<\/div>\n
5.\u00a0http:\/\/news.163.com\/16\/0301\/07\/BH295RRF00014AED.html<\/div>\n
<\/div>\n
6.\u00a0Petrovski et al. Exome sequencing results in successful riboflavin treatment of a rapidly progressive neurological condition, 2015, Cold Spring Harb Mol Case Stud 1: a000257<\/div>\n
7.\u00a0Daniel F Gudbjartsson et.al. Large-scale whole-genome sequencing of the Icelandic population\uff0c 2015; doi:10.1038\/ng.3247<\/div>\n
8.\u00a0http:\/\/wric.com\/2017\/05\/06\/in-depth-hope-for-16-year-old-california-boy-fighting-rare-genetic-disease\/<\/div>\n
9.\u00a0https:\/\/history.nih.gov\/exhibits\/genetics\/sect4.htm<\/div>\n
10. Nat Genet 2003;34:154\u2013156<\/div>\n
11. Nature Reviews Drug Discovery doi:10.1038\/nrd.2015.35<\/div>\n
<\/div>\n
<\/div>\n
<\/div>\n
\u5173\u4e8e\u57fa\u56e0\u6167<\/div>\n
\u5728\u7cbe\u51c6\u533b\u7597\u9886\u57df\u6574\u5408\u53d1\u5c55\u671f\uff0c\u57fa\u56e0\u6167\u4f5c\u4e3a\u7cbe\u51c6\u533b\u7597\u884c\u4e1a\u4e92\u8054\u7f51\u4fe1\u606f\u5e73\u53f0\uff0c\u7ed3\u5408\u8fd1\u5341\u5e74\u884c\u4e1a\u5b9e\u8df5\u7ecf\u9a8c\uff0c\u4e92\u8054\u7f51\u4ea7\u54c1\u548c\u5927\u6570\u636e\u56e2\u961f\uff0c\u8fde\u63a5\u4e13\u5bb6\u3001\u4ea7\u4e1a\u548c\u8d44\u672c\uff1b\u8fd0\u7528Web 4.0\u642d\u5efa\u884c\u4e1a\u4fe1\u606f\u6570\u636e\u5e93\uff0c\u4e3a\u4f01\u4e1a\u51b3\u7b56\u63d0\u4f9b\u5e02\u573a\u6570\u636e\u652f\u6301\uff1b\u4e3a\u4e13\u5bb6\u63d0\u4f9b\u4e3a\u884c\u4e1a\u6218\u7565\u54a8\u8be2\u7684\u5e73\u53f0\u3002\u8df5\u884c\u201c\u4f7f\u8fde\u63a5\u4ea7\u751f\u4ef7\u503c\uff0c\u8ba9\u77e5\u8bc6\u83b7\u5f97\u5c0a\u91cd\u201d\u7684\u7406\u5ff5\uff0c\u6253\u9020\u57fa\u56e0\u5065\u5eb7\u884c\u4e1a\u4fe1\u606f\u548c\u54a8\u8be2\u5e73\u53f0\u3002<\/div>\n
<\/div>\n
\u884c\u7814\u3001\u54a8\u8be2\u3001\u4f1a\u8bae\u3001\u54c1\u5ba3\u7b49\u670d\u52a1\uff1a<\/div>\n
\u7535\u8bdd\uff1a010-56527551 \/ 400-088-7466<\/div>\n
\u5730\u5740\uff1a\u5317\u4eac\u5e02\u6d77\u6dc0\u533a\u4e2d\u5173\u6751\u5927\u88571\u53f7<\/div>\n
\u5b98\u7f51\uff1awww.geneclub.net.cn<\/div>\n
\u90ae\u7bb1\uff1ainfo@genonet.cn<\/div>\n
<\/div>\n\n
\n![\"RmFicvQBAkgBbTDs37k3bfNpBUGSCsEkyk2T1InvsgcA0RZkzDLlBHdQJFa1aa2NaxnHIWnplV3NVHiaSbOzokXA\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBbTDs37k3bfNpBUGSCsEkyk2T1InvsgcA0RZkzDLlBHdQJFa1aa2NaxnHIWnplV3NVHiaSbOzokXA.jpeg\")
<\/figure><\/div>\n\n
<\/figure><\/div>\n\n\u57fa\u56e0\u6167<\/div>\n
\u57fa\u56e0\u5065\u5eb7\u884c\u4e1a\u4fe1\u606f\u670d\u52a1<\/div>\n
\u6ce8\uff1a\u7f29\u7565\u56fe\u6765\u81ea\u300a\u820c\u5c16\u4e0a\u7684\u4e2d\u56fd\u7b2c\u4e8c\u5b63\u300b\u4e4b\u300a\u4e09\u9910\u300b<\/div>\n
\u00a0<\/div>","protected":false},"excerpt":{"rendered":"
\u57fa\u56e0\u6167\u4e13\u4e1a\u51fa\u54c1<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[1422,1553],"class_list":["post-10976","post","type-post","status-publish","format-standard","hentry","category-industryresearch","tag-1422","tag-1553"],"_links":{"self":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts\/10976","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/comments?post=10976"}],"version-history":[{"count":3,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts\/10976\/revisions"}],"predecessor-version":[{"id":14493,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts\/10976\/revisions\/14493"}],"wp:attachment":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/media?parent=10976"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/categories?post=10976"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/tags?post=10976"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}