{"id":10975,"date":"2017-05-16T04:14:43","date_gmt":"2017-05-15T20:14:43","guid":{"rendered":"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&#038;mid=100000695&#038;idx=1&#038;sn=1bdaf78f9641fb62a8e8869fae9d0822&#038;chksm=6b72b1005c05381663049f089068500c639a1d9d73efe46427a8899d7712f657710e9d64be85#rd"},"modified":"2026-04-09T09:55:23","modified_gmt":"2026-04-09T01:55:23","slug":"1005698-2","status":"publish","type":"post","link":"https:\/\/www.geneclub.net.cn\/index.php\/2017\/05\/16\/1005698-2\/","title":{"rendered":"Nature\u5b50\u520a\uff1actDNA\u6280\u672f\u8d2f\u7a7f\u764c\u75c7\u7ba1\u7406\u5168\u5468\u671f"},"content":{"rendered":"<p><!-- wechat_content_hash: d8b045589a7b021f --><\/p>\n<div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBqJyMcQxUZibhoFCjLcSCNYDXUEhmz2Zf3jEC87jjYiceTyIaB3JnrFLh5ibjQQBCozYupUkT2icDsTA.gif\" alt=\"RmFicvQBAkgBqJyMcQxUZibhoFCjLcSCNYDXUEhmz2Zf3jEC87jjYiceTyIaB3JnrFLh5ibjQQBCozYupUkT2icDsTA\"\/><\/figure><\/div>\n\n<\/div>\n<div><\/div>\n<div>\u5173\u952e\u8bcd\uff1a\u6db2\u4f53\u6d3b\u68c0 ctDNA<\/div>\n<div>\u764c\u75c7\u65e9\u7b5b\u3001\u8bca\u65ad\u548c\u9884\u540e\u76d1\u6d4b<\/div>\n<div>\u5efa\u8bae\u7528\u65f6\uff1a8\u5206\u949f<\/div>\n<div>\u57fa\u56e0\u7ec4\u76f8\u5173\u6280\u672f\u7684\u53d1\u5c55\uff0c\u4f7f\u5f97ctDNA\u4e0d\u4ec5\u505c\u7559\u5728\u79d1\u7814\uff0c\u4e5f\u9010\u6e10\u6df1\u5165\u5230\u4e34\u5e8a\u8f6c\u5316\u5e94\u7528\u4e2d\uff0c\u5728\u764c\u75c7\u7684\u65e9\u7b5b\u3001\u8bca\u65ad\u548c\u9884\u540e\u76d1\u6d4b\u7b49\u5168\u5468\u671f\u5065\u5eb7\u7ba1\u7406\u4e2d\uff0c\u626e\u6f14\u7740\u91cd\u8981\u7684\u89d2\u8272\u30024\u6708\u7684\u300aNature Reviews Cancer\u300b\u4e2d\u5c31ctDNA\u6280\u672f\u7684\u4e34\u5e8a\u5e94\u7528\u8fdb\u884c\u4e86\u7cfb\u7edf\u7efc\u8ff0\uff0c\u672c\u6587\u7b80\u4ecb\u4e3b\u8981\u4fe1\u606f\uff0c\u6b22\u8fce\u6307\u6b63\u8ba8\u8bba\u3002\u5728\u516c\u4f17\u53f7\u5bf9\u8bdd\u6846\u56de\u590d\u201cctDNA\u201d\u53ef\u83b7\u5f97\u6587\u732e\u5168\u6587pdf\u3002<\/div>\n<div><\/div>\n<div>\u4f5c\u8005\uff1a\u57fa\u56e0\u6167\uff08\u6b22\u8fce\u8f6c\u8f7d\uff0c\u8f6c\u8f7d\u8bf7\u6ce8\u660e\u6765\u6e90\uff09<\/div>\n<div><\/div>\n<div><\/div>\n<div><\/div>\n<div>1. \u4ececfDNA\u53d1\u73b0\u5230ctDNA<\/div>\n<div><\/div>\n<div><\/div>\n<div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCJiaziaBkdnjAJyjeW8BQQ2sicwzaUuibia2zzYoShxia3EiaTkUuC318QWumVfxe6yGrGddNgiaCqrZV89A.png\" alt=\"RmFicvQBAkgCJiaziaBkdnjAJyjeW8BQQ2sicwzaUuibia2zzYoShxia3EiaTkUuC318QWumVfxe6yGrGddNgiaCqrZV89A\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe1\uff1acfDNA\u7684\u6765\u6e90\u548c\u53d8\u5316\u5f62\u5f0f\uff0c\u56fe\u6765\u81eaNature Reviews Cancerdoi:10.1038\/nrc.2017.7<\/div>\n<div>\u5728\u5065\u5eb7\u4eba\u7fa4\u4e2d\uff0c\u8840\u6d46\u6e38\u79bbDNA(cfDNA)\u6d53\u5ea6\u4ecb\u4e8e1-10 ng\/ml\u3002\u4eba\u7684\u8840\u6d46\u6e38\u79bb\u6838\u9178\u7247\u6bb5\uff0c\u57281949\u5e74\u9996\u5148\u7531Mandel\u548cM\u00e9tais\u9996\u6b21\u7814\u7a76\u62a5\u9053\uff1b 1977\u5e74\u62a5\u9053\u4e86\u9996\u4f8b\u764c\u75c7\u60a3\u8005\u7684cfDNA\u6c34\u5e73\uff1b1997\u5e74\uff0c\u9999\u6e2f\u4e2d\u6587\u5927\u5b66\u5362\u715c\u660e\u56e2\u961f\u5bf9\u6bcd\u4f53\u8840\u6d46\u4e2d\u80ce\u513fDNA\u5e8f\u5217\u7684\u9274\u5b9a\uff0c\u63a8\u52a8\u4e86\u57fa\u56e0\u7ec4\u6280\u672f\u4ea7\u524d\u533b\u5b66\u4e2d\u7684\u5e94\u7528\uff0c\u5176\u4e2d\u65e0\u521b\u4ea7\u524d\u57fa\u56e0\u68c0\u6d4b\uff08NIPT\uff09\u4e8e2007\u5e74\u88ab\u5362\u715c\u660e\u56e2\u961f\u9996\u6b21\u8bc1\u660e\u5e76\u8fc5\u901f\u53d1\u5c55\u6210\u4e3a\u5e7f\u6cdb\u7684\u4e34\u5e8a\u5e94\u7528\u3002<\/div>\n<div>\u00a0<\/div>\n<div>1989\u5e74\uff0cStroun\u7b49\u53d1\u73b0\u764c\u75c7\u60a3\u8005\u8840\u6d46\u4e2d\u6709\u4e00\u4e9bcfDNA\u6765\u6e90\u4e8e\u764c\u7ec6\u80de\u3002 1991\u5e74\uff0cSidransky\u7b49\u53d1\u73b0TP53\u60a3\u8005\u7684\u5c3f\u6c89\u6e23\uff08urinary sediments\uff09\u7684DNA\u643a\u5e26\u7a81\u53d8\uff0c\u8fd9\u4e3a\u57fa\u56e0\u7ec4\u5206\u6790\u65b9\u6cd5\u7684\u4f7f\u7528\u5960\u5b9a\u4e86\u6d3b\u68c0\u7684\u57fa\u7840\u3002\u57281994\u5e74\uff0c\u9996\u4f8b\u62a5\u9053\u80f0\u817a\u764c\u60a3\u8005\u5728\u8840\u6d46cfDNA\u4e2d\u68c0\u6d4b\u5230KRAS\u57fa\u56e0\u7a81\u53d8\u3002\u5bf9\u4e8e\u6bcf\u4e2a\u60a3\u8005\uff0c\u5728\u8840\u6d46\u4e2d\u53d1\u73b0\u7684KRAS\u7a81\u53d8\u4e0e\u60a3\u8005\u80bf\u7624\u4e2d\u53d1\u73b0\u7684KRAS\u7a81\u53d8\u76f8\u540c\uff0c\u4ece\u800c\u8bc1\u5b9e\u8840\u6d46\u4e2d\u7684\u7a81\u53d8DNA\u7247\u6bb5\u662f\u80bf\u7624\u6765\u6e90\u7684\uff0c cfDNA\u4e2d\u7684\u7a81\u53d8\u662f\u764c\u75c7\u7684\u9ad8\u5ea6\u7279\u5f02\u6027\u6807\u5fd7\u7269\uff0c\u8fd9\u6837\u5c31\u5f62\u6210\u4e86\u672f\u8bed\u201c\u5faa\u73af\u80bf\u7624DNA\u201d\uff08ctDNA\uff09\u3002<\/div>\n<div>\u00a0<\/div>\n<div>2. ctDNA\u5728\u764c\u75c7\u7ba1\u7406\u5168\u5468\u671f\u4e2d\u7684\u4f5c\u7528<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCJiaziaBkdnjAJyjeW8BQQ2sL2kJaLZVFhmPXXicNIWkmRBcyYHrUpRNiasl7PNeR5vLdt513sf0j7iag.png\" alt=\"RmFicvQBAkgCJiaziaBkdnjAJyjeW8BQQ2sL2kJaLZVFhmPXXicNIWkmRBcyYHrUpRNiasl7PNeR5vLdt513sf0j7iag\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe2\uff1actDNA\u5728\u75be\u75c5\u7ba1\u7406\u5168\u5468\u671f\u4e2d\u7684\u4f5c\u7528\uff0c\u56fe\u6765\u81eaNature Reviews Cancerdoi:10.1038\/nrc.2017.7<\/div>\n<div>\u57fa\u4e8ectDNA\u7b49\u6db2\u4f53\u6d3b\u68c0\u6280\u672f\u5728\u4e34\u5e8a\u53ef\u4ee5\u5e94\u7528\u4e8e\uff1a<\/div>\n<div>\u764c\u75c7\u65e9\u7b5b\/\u8bca\u65ad\uff1a\u5bf9\u4e8e\u75c7\u72b6\u60a3\u8005\uff0c\u5177\u5907\u654f\u611f\u548c\u7279\u5f02\u6027\u7684\u764c\u75c7\u68c0\u6d4b\u53ef\u80fd\u52a0\u5feb\u8bca\u65ad\u548c\u6cbb\u7597\u7684\u65f6\u95f4\u3002\u5bf9\u4e8e\u4eba\u7fa4\u6c34\u5e73\uff0cctDNA\u4f5c\u4e3a\u75be\u75c5\u6807\u5fd7\u7269\u7684\u80bf\u7624\u7b5b\u67e5\u53ef\u4ee5\u5728\u75c7\u72b6\u660e\u663e\u4e4b\u524d\u8fdb\u884c\u5e72\u9884\u3002<\/div>\n<div>\u9884\u540e\uff0c\u6b8b\u7559\u75be\u75c5\u548c\u590d\u53d1\u98ce\u9669\u8bc4\u4f30\uff1a\u8bc4\u4f30\u8fdb\u5c55\u98ce\u9669\u5bf9\u4e8e\u9009\u62e9\u6cbb\u7597\u81f3\u5173\u91cd\u8981\u3002\u7ecf\u6cbb\u7597\u540e\uff0c\u786e\u5b9a\u60a3\u6709\u590d\u53d1\u98ce\u9669\u9ad8\u7684\u60a3\u8005\u53ef\u7528\u4e8e\u5206\u5c42\u8f85\u52a9\u6cbb\u7597\u3002<\/div>\n<div>\u6cbb\u7597\u9009\u62e9\uff1a\u65b0\u578b\u5206\u5b50\u9776\u5411\u6cbb\u7597\u548c\u514d\u75ab\u6cbb\u7597\u6539\u8fdb\u4e86\u60a3\u8005\u5206\u5b50\u5206\u578b\u548c\u6cbb\u7597\u5206\u5c42\u3002\u76ee\u524d\uff0c\u80bf\u7624\u6d3b\u7ec4\u7ec7\u83b7\u5f97\u80bf\u7624\u8bca\u65ad\u7684\u91d1\u6807\u51c6\uff0c\u4f46\u4e0d\u6613\u83b7\u5f97\uff0c\u5e76\u4e14\u5b83\u4eec\u53d7\u80bf\u7624\u5f02\u8d28\u6027\u5e72\u6270\uff0c\u4ece\u800c\u5bfc\u81f4\u5047\u9634\u6027\u7ed3\u679c\u3002<\/div>\n<div>\u6cbb\u7597\u76d1\u6d4b\uff1a\u4f20\u7edf\u7684\u76d1\u6d4b\u65b9\u6cd5\u7cbe\u5ea6\u6709\u9650\uff0c\u540c\u65f6\u5b58\u5728\u8f83\u9ad8\u6210\u672c\u548c\u8f90\u5c04\u5371\u5bb3\u3002\u6db2\u4f53\u6d3b\u68c0\u53ef\u4ee5\u968f\u8fde\u7eed\u91cd\u590d\u76d1\u6d4b\uff0c\u5bf9\u60a3\u8005\u7684\u98ce\u9669\u8f83\u5c0f\uff0c\u540c\u65f6\u63d0\u4f9b\u51c6\u786e\u7684\u80bf\u7624\u76f8\u5173\u4fe1\u606f\u8bfb\u3002<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"is-resized\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCJiaziaBkdnjAJyjeW8BQQ2sW3MEgqNEGLGO7qXQ3F2cTEXAv2awJuYrW04C8LUmqkYDOOec2pZAtg.png\" alt=\"RmFicvQBAkgCJiaziaBkdnjAJyjeW8BQQ2sW3MEgqNEGLGO7qXQ3F2cTEXAv2awJuYrW04C8LUmqkYDOOec2pZAtg\" style=\"aspect-ratio:1;width:20px;height:auto\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe3\uff1a\u4f7f\u7528\u6db2\u4f53\u6d3b\u68c0\u7684\u81ea\u9002\u5e94\u6216\u53cd\u5e94\u6027\u6cbb\u7597\u793a\u4f8b\uff0c\u56fe\u6765\u81eaNature Reviews Cancer\u00a0doi:10.1038\/nrc.2017.7<\/div>\n<div>\u8fde\u7eed\u7684\u6db2\u4f53\u6d3b\u68c0\u53ef\u4ee5\u9274\u5b9a\u653e\u7597\u548c\u5316\u7597\u7684\u53cd\u5e94\u548c\u8fdb\u5c55\uff0c\u4e34\u5e8a\u533b\u751f\u4ece\u800c\u53ef\u80fd\u80fd\u591f\u9009\u62e9\u6cbb\u7597\u7279\u522b\u662f\u9776\u5411\u76f8\u5173\u7a81\u53d8\u7684\u57fa\u56e0\u3002 \u8fd9\u79cd\u9002\u5e94\u6027\u6216\u53cd\u5e94\u6027\u76d1\u6d4b\u548c\u6cbb\u7597\u53ef\u4ee5\u6210\u4e3a\u4e00\u4e2a\u5faa\u73af\uff0c\u5e76\u4e14\u57fa\u4e8ectDNA\u7684\u5feb\u901f\u5206\u6790\u52a0\u5feb\uff0c\u4ece\u51e0\u4e2a\u5c0f\u65f6\u5230\u51e0\u4e2a\u6708\uff0c\u5bf9\u65e9\u671f\u52a8\u529b\u5b66\u8fdb\u884c\u5206\u6790\u4ee5\u5e94\u5bf9\u6cbb\u7597\u3002<\/div>\n<div>\u00a0<\/div>\n<div>3. ctDNA\u5206\u6790\u6280\u672f\u5e73\u53f0\u7684\u6bd4\u8f83<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCJiaziaBkdnjAJyjeW8BQQ2sqh51RqVkGs0bbjXSZqY9eyHEsvMJOoLdKFnQ58ICFicKy7y3ZSNiaYrg.png\" alt=\"RmFicvQBAkgCJiaziaBkdnjAJyjeW8BQQ2sqh51RqVkGs0bbjXSZqY9eyHEsvMJOoLdKFnQ58ICFicKy7y3ZSNiaYrg\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe4\uff1actDNA\u5206\u6790\u6280\u672f\u5e73\u53f0\u7684\u6bd4\u8f83\uff0c\u56fe\u6765\u81eaNature Reviews Cancer\u00a0doi:10.1038\/nrc.2017.7<\/div>\n<div>\u4eceSingle-locus\u5230\u9776\u5411\u6d4b\u5e8f\u5230\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\uff0c\u6210\u672c\u3001\u5468\u671f\u968f\u8986\u76d6\u5ea6\u4e0a\u5347\uff0c\u540c\u65f6\u9664\u4e86\u6d4b\u5e8f\u4e4b\u5916\uff0c\u8fd8\u5305\u62ecddPCR\u7b49\u6280\u672f\uff0c\u5728\u5b9e\u9645\u5e94\u7528\u65f6\u9700\u5e73\u8861\u8003\u8651\u3002\u53c2\u89c1\u4e0a\u8868\u3002<\/div>\n<div>\u00a0<\/div>\n<div>4. ctDNA\u5206\u6790\u4e2d\u7684\u6ce8\u610f\u4e8b\u9879<\/div>\n<div>\u5982\u4e0b\u56fe\uff0c\u5728ctDNA\u5206\u6790\u4e2d\uff0c\u9700\u8003\u8651\uff1a<\/div>\n<div>\u964d\u4f4e\u80cc\u666f\u566a\u97f3\uff08\u5982\u56fe6\uff0c\u5bf9low-burden disease\u91c7\u53d6\u591a\u91cd\u7a81\u53d8\u68c0\u6d4b\u6765\u964d\u4f4e\u566a\u97f3\uff09<\/div>\n<div>\u8fd1\u7aef\u53d6\u6837\uff08\u5728\u80bf\u7624\u90e8\u4f4d\u63a5\u8fd1\u7684\u4f53\u6db2\u6216\u7ec6\u80de\u5b66\u6807\u672c\u7684\u53d6\u6837\u53ef\u80fd\u4f1a\u83b7\u5f97\u8f83\u9ad8\u6d53\u5ea6\u7684ctDNA\uff09<\/div>\n<div>ctDNA\u5bcc\u96c6\u5206\u6790<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCJiaziaBkdnjAJyjeW8BQQ2sXiaI3kHEziagRQlFPdiawicrowAqbo6iaibjvEgKTaN0CbjfUNLTb60aqarQ.png\" alt=\"RmFicvQBAkgCJiaziaBkdnjAJyjeW8BQQ2sXiaI3kHEziagRQlFPdiawicrowAqbo6iaibjvEgKTaN0CbjfUNLTb60aqarQ\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe5\uff1actDNA\u5206\u6790\u4e2d\u91cd\u8981\u4e8b\u9879\uff0c\u56fe\u6765\u81eaNature Reviews Cancer\u00a0doi:10.1038\/nrc.2017.7<\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgCJiaziaBkdnjAJyjeW8BQQ2siafJ9SdrdfObgiaWDN2arMkwrnUDcdiaTkRFm2aSx3V1F8dym9EXxVAsw.png\" alt=\"RmFicvQBAkgCJiaziaBkdnjAJyjeW8BQQ2siafJ9SdrdfObgiaWDN2arMkwrnUDcdiaTkRFm2aSx3V1F8dym9EXxVAsw\"\/><\/figure><\/div>\n\n<div style=\"text-align: center;\">\u56fe6\uff1a\u591a\u91cd\u7a81\u53d8\u68c0\u6d4b\u964d\u4f4e\u566a\u97f3\uff0c\u56fe\u6765\u81eaNature Reviews Cancer\u00a0doi:10.1038\/nrc.2017.7<\/div>\n<div>6. \u672a\u6765\u53d1\u5c55\u524d\u666f\u548c\u6311\u6218<\/div>\n<div>\u4ece\u6982\u5ff5\u5230\u9a8c\u8bc1\u7684\u7406\u8bba\u7814\u7a76\uff08Proof-of-concept\uff09\u4e3actDNA\u4e34\u5e8a\u5e94\u7528\u6253\u4e0b\u575a\u5b9e\u57fa\u7840\uff0c\u8bc1\u660e\u4e86ctDNA\u6280\u672f\u53ef\u80fd\u662f\u836f\u7269\u5f00\u53d1\u3001\u80bf\u7624\u5f02\u8d28\u6027\u548c\u514b\u9686\u8fdb\u5316\u7814\u7a76\u7684\u91cd\u8981\u6280\u672f\u624b\u6bb5\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u6bd4\u8f83\u660e\u786e\u7684\u662f\uff0c\u672a\u6765\u7684\u968f\u673a\u8bd5\u9a8c\u5c06\u57fa\u4e8ectDNA\u6307\u5bfc\u75be\u75c5\u7ba1\u7406\u548c\u4e34\u5e8a\u51b3\u7b56\u6807\u51c6\uff0cEMA\uff08\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\uff09\u5c31\u5236\u5b9a\u4e86\u76f8\u5173\u8bd5\u9a8c\u8bbe\u8ba1\u7684\u5b9e\u8df5\u6307\u5357\u3002\u5bf9\u4e8ectDNA\u6280\u672f\u5728\u6cbb\u7597\u76d1\u6d4b\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u8fdb\u884c\u4e2d\u3002\u5728\u4e00\u9879\u8bd5\u9a8c\u4e2d\uff0c\u6b63\u5728\u76d1\u6d4b\u63a5\u53d7\u5384\u6d1b\u66ff\u5c3c\u6cbb\u7597\u7684NSCLC\u60a3\u8005\uff0c\u5982\u679c\u6297\u8840\u6e05\u7a81\u53d8\u51fa\u73b0\u5728\u4e03\u8840\u6d46\u4e2d\uff0c\u5219\u4f1a\u989d\u5916\u8fdb\u884c\u626b\u63cf\u4ee5\u53d1\u73b0\u75be\u75c5\u8fdb\u5c55\u7684\u5176\u4ed6\u8ff9\u8c61\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u9700\u8981\u8fdb\u4e00\u6b65\u592f\u5b9e\u7684\u91cd\u70b9\u662f\uff0c\u66f4\u597d\u5730\u4e86\u89e3cfDNA\u548cctDNA\u7684\u8d77\u6e90\u548c\u751f\u7269\u5b66\uff0c\u5c06\u6709\u52a9\u4e8e\u6db2\u4f53\u6d3b\u68c0\u7684\u5b9e\u65bd\uff0c\u7279\u522b\u662f\u5bf9\u4e8ecfDNA\u7684\u91ca\u653e\u548c\u6e05\u9664\u673a\u5236\uff0c\u5728\u6cbb\u7597\u671f\u95f4\u4e0d\u540c\u65f6\u95f4\u70b9\u7684\u5f71\u54cd\u3002\u5bf9\u4e8ectDNA\u6d4b\u91cf\u7684\u52a8\u529b\u5b66\u548c\u91cd\u73b0\u6027\u7684\u7814\u7a76\u5c06\u53d8\u5f97\u8d8a\u6765\u8d8a\u91cd\u8981\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u4e0e\u5176\u4ed6\u751f\u7269\u6807\u5fd7\u7269\u7684\u76f8\u6bd4\uff0cctDNA\u5177\u6709\u8f83\u5f3a\u7684\u654f\u611f\u6027\u548c\u7279\u5f02\u6027\uff0c\u540c\u65f6\uff0c\u91c7\u7528\u591a\u7ef4\u5ea6\u751f\u7269\u6807\u8bb0\u7684\u7814\u7a76\u65b9\u6cd5\uff0c\u53ef\u4ee5\u66f4\u5168\u9762\u5730\u4e86\u89e3\u60a3\u8005\u7684\u75be\u75c5\u3002\u4f8b\u5982\uff0c\u603bcfcDNA\u6d53\u5ea6\u4e0e\u75be\u75c5\u72b6\u6001\u548c\u9884\u540e\u6709\u5173\u3002 cfDNA\u7684\u8868\u89c2\u9057\u4f20\u5b66\u5206\u6790\u53ef\u4ee5\u9274\u5b9a\u764c\u57fa\u56e0\u8d85\u7532\u57fa\u5316\u3001\u5f15\u8d77cfDNA\u7247\u6bb5\u7684\u7ec6\u80de\u7c7b\u578b\u6216\u6ca1\u600e\u4e48\u53d1\u751f\u4f53\u7ec6\u80de\u7a81\u53d8\u7684\u80bf\u7624\u5fae\u73af\u5883\u7684\u4fe1\u606f\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u6db2\u4f53\u6d3b\u68c0\u7684\u4e34\u5e8a\u5e94\u7528\u5c06\u53d6\u51b3\u4e8e\u60a3\u8005\u548c\u4e34\u5e8a\u533b\u751f\uff0c\u6bd4\u5982\u57fa\u7840\u8bbe\u65bd\u3001\u6210\u672c\u7b49\u3002\u7ec4\u7ec7\u6d3b\u68c0\u5c06\u7ee7\u7eed\u5728\u764c\u75c7\u7ba1\u7406\u4e2d\u53d1\u6325\u7740\u5173\u952e\u4f5c\u7528\uff0c\u7279\u522b\u662f\u5bf9\u4e8e\u764c\u75c7\u7684\u7ec4\u7ec7\u5b66\u8bca\u65ad\u548c\u5206\u7c7b\u3002\u672a\u6765\u533b\u9662\u5b9e\u9a8c\u5ba4\u53ef\u4ee5\u5728\u672c\u5730\u5206\u6790\uff0c\u4f46\u76ee\u524dCTC\u548cctDNA\u6837\u54c1\u7531\u4e13\u4e1a\u5b9e\u9a8c\u5ba4\u5904\u7406\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u6bcd\u4f53\u8840\u6d46DNA\u7684\u5355\u5206\u5b50\uff08\u7b2c\u4e09\u4ee3\uff09\u6d4b\u5e8f\u7684\u53ef\u884c\u6027\u9996\u5148\u57282015\u5e74\u5f97\u5230\u8bc1\u5b9e\uff0c\u968f\u540e\u8bc1\u660e\u53ef\u4ee5\u68c0\u6d4b\u7ec6\u80de\u7cfbDNA\u4e2d\u7684\u7ed3\u6784\u53d8\u5f02\uff08SV)\u3002\u8fd9\u79cd\u6280\u672f\u7684\u5728\u57c3\u535a\u62c9\u75c5\u6bd2\u6d41\u884c\u671f\u95f4\u7684\u5b9e\u5730\u57fa\u56e0\u7ec4\u76d1\u6d4b\u5f97\u5230\u4e86\u5f88\u597d\u5e94\u7528\uff0c\u53ef\u590d\u5236\u6027\u5f88\u597d\u3002\u76ee\u524d\uff0c\u8fd9\u6837\u7684\u5e73\u53f0\u53d7\u5230\u9ad8\u9519\u8bef\u7387\u7684\u9650\u5236\uff1b\u4e0e\u6b64\u540c\u65f6\uff0c\u77ed\u5e8f\u5217\u6d4b\u5e8f\u65b9\u6cd5\u4e2d\uff0c\u6587\u5e93\u51c6\u5907\u65b9\u6cd5\u9700\u8981\u4f18\u5316\u3002<\/div>\n<div>\u00a0<\/div>\n<div>EMA\u548cFDA\u521d\u6b65\u6279\u51c6\u4e86\u5bf9\u8840\u6d46\u4e2d\u7a81\u53d8\u68c0\u6d4b\u4f5c\u4e3a\u4f34\u968f\u8bca\u65ad[2-4]\u3001\u4ee5\u53ca\u6700\u8fd1\u7684\u7684ctDNA\u6307\u5bfc\u4e34\u5e8a\u8bd5\u9a8c[5-7]\uff0c\u4ee3\u8868\u4e86\u6db2\u4f53\u6d3b\u68c0\u5728\u4e2a\u4f53\u5316\u80bf\u7624\u8bca\u7597\u4e2d\u7684\u5173\u952e\u91cc\u7a0b\u7891\u3002\u63a5\u4e0b\u6765\uff0c\u9700\u8981\u8fdb\u4e00\u6b65\u63a2\u7d22ctDNA\u7684\u751f\u7269\u5b66\uff0c\u6539\u8fdb\u6280\u672f\uff0c\u4f7f\u764c\u75c7\u65e0\u521b\u5206\u5b50\u8bca\u65ad\u7684\u5e94\u7528\u8303\u56f4\u8d8a\u6765\u8d8a\u5e7f\uff0c\u4e3a\u57fa\u56e0\u7ec4\u7814\u7a76\u5f00\u8f9f\u65b0\u9014\u5f84\u540c\u65f6\u52a9\u529b\u53ef\u80fd\u7684\u4e34\u5e8a\u51b3\u7b56\uff0c\u4f7f\u60a3\u8005\u53d7\u76ca\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u6587\u672b\u66f4\u591a\u63a8\u8350\u76f8\u5173\u539f\u521b\u6587\u7ae0\u2193<\/div>\n<div>\u53c2\u8003\u8d44\u6599\uff1a<\/div>\n<div>1. Jonathan C. M. Wan Charles et. al. Liquid biopsies come of age: towards implementation of circulating tumour DNA,Nature Reviews Cancer 17, 223\u2013238 (2017) doi:10.1038\/nrc.2017.7<\/div>\n<div>2.\u00a0Garc\u00eda-Olmo, D. C. et al. Cell-free nucleic acids circulating in the plasma of colorectal cancer patients induce the oncogenic transformation of susceptible cultured cells. Cancer Res. 70, 560\u2013567 (2010).<\/div>\n<div>3.\u00a0European Medicines Agency. Iressa: public assessment report \u2014 product information. EMA http:\/\/ www.ema.europa.eu\/docs\/en_GB\/document_library\/ EPAR_-_Product_Information\/human\/001016\/ WC500036358.pdf (2016).<\/div>\n<div>4.\u00a0European Medicines Agency. Tagrisso: public assessment report \u2014 product information. EMA http:\/\/ www.ema.europa.eu\/docs\/en_GB\/document_library\/ EPAR_-_Product_Information\/human\/004124\/ WC500202022.pdf (2016).<\/div>\n<div>5.\u00a0US National Library of Medicine. ClinicalTrials.gov https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02284633 (2015).\u00a0<\/div>\n<div>6. US National Library of Medicine. ClinicalTrials.gov https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02743910 (2016).\u00a0<\/div>\n<div>7. International Standard Randomised Controlled Trials Number Registry. isrctn.com http:\/\/www.isrctn.com\/ ISRCTN16945804 (2016).<\/div>\n<div>\u00a0<\/div>\n<div>\u60a8\u53ef\u80fd\u8fd8\u611f\u5174\u8da3\u7684 \u2193<\/div>\n<div><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&amp;mid=2247483948&amp;idx=1&amp;sn=5b1780b34b89fdbc069f47561c580125&amp;chksm=eb72b09bdc05398dfe9337f806f7ef95ca3190a5d3827cd7535bd2eb4e1e1af5dfe834445842&amp;scene=21#wechat_redirect\">miRNA\u6cbb\u7597\u5f00\u542f\u764c\u75c7\u6cbb\u7597\u7684\u65b0\u65f6\u4ee3<\/a><\/div>\n<div><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&amp;mid=2247484291&amp;idx=1&amp;sn=fc660d68d5eeb0997cfe8657399ce3b2&amp;chksm=eb72b134dc0538228d2a8ba9033f26850a35e84acc890b18e90fae89408f2d30b40fab5b6fc7&amp;scene=21#wechat_redirect\">\u57fa\u56e0\u6280\u672f\u5982\u4f55\u6539\u53d8\u4eba\u7c7b\u672a\u6765\uff1f\u300a\u57fa\u56e0\u7ec4\u9769\u547d\u300b\u5e8f<\/a><\/div>\n<div><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&amp;mid=2247483725&amp;idx=1&amp;sn=eb346469c660be197ba9122613a30ac1&amp;chksm=eb72b3fadc053aece2cc6df4217889af96d96e8c185846e82d7c0c9f6359a39c14cb7df2ee6b&amp;scene=21#wechat_redirect\">\u534f\u548c\u5927\u592b\/\u5409\u56e0\u52a0\/\u4f18\u8baf\u533b\u5b66\u4e13\u5bb6\u8c08\u80bf\u7624\u7cbe\u51c6\u533b\u7597<\/a><\/div>\n<div><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&amp;mid=2247484272&amp;idx=1&amp;sn=58f57ba372be5c5772735ee4ae39e366&amp;chksm=eb72b1c7dc0538d1283bcb579d2869dbfa983eead512d08266f1842867c12b4e569830003b97&amp;scene=21#wechat_redirect\">\u64cd\u5200 Google\u201c\u4e07\u4eba\u5065\u5eb7\u9879\u76ee\u201d\u662f\u4ec0\u4e48\u516c\u53f8\uff1f<\/a><\/div>\n<div><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzI3NjUzOTM1Mg==&amp;mid=2247484079&amp;idx=1&amp;sn=2464a8d03fb3c1de17e71e62aedb7cca&amp;chksm=eb72b018dc05390e592c63dc2d89ab2f4cf95c1ecf31c4f6b4f6f5e5e166f0462633e6f6ad79&amp;scene=21#wechat_redirect\">\u57fa\u56e0\u4e91\uff1aBGI\/WuXiNextCODE\/GeneDock\u540c\u53f0<\/a><\/div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgC0avckNia9q4ZYtSsGWlTxlSjuIocJWRhNOLgBHDRXibCk61GiappiaVc0dMibibnFmEJxX1rA2ZR3wzGQ.gif\" alt=\"RmFicvQBAkgC0avckNia9q4ZYtSsGWlTxlSjuIocJWRhNOLgBHDRXibCk61GiappiaVc0dMibibnFmEJxX1rA2ZR3wzGQ\"\/><\/figure><\/div>\n\n<\/div>\n<div>\n\n<div class=\"wp-block-image aligncenter\">\n<figure class=\"\"><img decoding=\"async\" src=\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBicOicQvFu5myrw1PNqAmics3yZcXP7OeskBkKTLic0ia4uyQjNGhpRuE33kv7lT3cPuxicCzXU7ZGMqDg.png\" alt=\"RmFicvQBAkgBicOicQvFu5myrw1PNqAmics3yZcXP7OeskBkKTLic0ia4uyQjNGhpRuE33kv7lT3cPuxicCzXU7ZGMqDg\"\/><\/figure><\/div>\n\n<\/div>\n<div><\/div>\n<div><\/div>\n<div><\/div>\n<div>\u5173\u4e8e\u57fa\u56e0\u6167<\/div>\n<div>\u5728\u7cbe\u51c6\u533b\u7597\u9886\u57df\u6574\u5408\u53d1\u5c55\u671f\uff0c\u57fa\u56e0\u6167\u4f5c\u4e3a\u7cbe\u51c6\u533b\u7597\u884c\u4e1a\u4e92\u8054\u7f51\u4fe1\u606f\u5e73\u53f0\uff0c\u7ed3\u5408\u8fd1\u5341\u5e74\u884c\u4e1a\u5b9e\u8df5\u7ecf\u9a8c\uff0c\u4e92\u8054\u7f51\u4ea7\u54c1\u548c\u5927\u6570\u636e\u56e2\u961f\uff0c\u8fde\u63a5\u4e13\u5bb6\u3001\u4ea7\u4e1a\u548c\u8d44\u672c\uff0c\u6574\u5408\u5404\u65b9\u8d44\u6e90\uff1b\u8fd0\u7528Web 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