\n![\"RmFicvQBAkgBqJyMcQxUZibhoFCjLcSCNYDXUEhmz2Zf3jEC87jjYiceTyIaB3JnrFLh5ibjQQBCozYupUkT2icDsTA\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBqJyMcQxUZibhoFCjLcSCNYDXUEhmz2Zf3jEC87jjYiceTyIaB3JnrFLh5ibjQQBCozYupUkT2icDsTA.gif\")
<\/figure><\/div>\n\n<\/div>\n
<\/figure><\/div>\n\n<\/div>\n\u5173\u952e\u8bcd\uff1aGrail Cirina \u764c\u75c7\u65e9\u671f\u8bca\u65ad<\/div>\n
\u5efa\u8bae\u7528\u65f6\uff1a5\u5206\u949f<\/div>\n
<\/div>\n
<\/div>\n
\uff08\u6839\u636eCirina\u5b98\u7f51\uff09\u8fd1\u65e5\uff0cGrail\u548cCirina\uff0c\u4e24\u5bb6\u6db2\u4f53\u6d3b\u68c0\u516c\u53f8\u51b3\u5b9a\u5408\u5e76\uff0c\u4e13\u6ce8\u4e8e\u65e9\u671f\u764c\u75c7\u68c0\u6d4b\u3002Grail\u662fillumina\u57282016\u5e74\u8054\u5408\u591a\u5bb6\u8d44\u672c\u521b\u7acb\uff1bCirina\u662f2014\u5e74\u9999\u6e2f\u4e2d\u6587\u5927\u5b66\u3001\u65e0\u521bDNA\u8bca\u65ad\u4e0e\u7b5b\u67e5\u7684\u6743\u5a01\u5362\u715c\u660e\u6559\u6388(Dennis Lo)\u7387\u9886\u56e2\u961f\u521b\u7acb\u3002<\/div>\n
\u539f\u521b\u7248\u6743\uff0c\u8f6c\u8f7d\u8bf7\u5728\u9996\u884c\u6ce8\u660e\u6765\u6e90\uff1a\u57fa\u56e0\u6167<\/div>\n
<\/div>\n
<\/div>\n
\n\n
\n![\"RmFicvQBAkgAkiat6VicJ2sH7VdECXQiaknIyrFgRH11no1JswXYaxSj3Sw7nF60OGkC67iaD3RBV4vPNlUXLouibbFw\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgAkiat6VicJ2sH7VdECXQiaknIyrFgRH11no1JswXYaxSj3Sw7nF60OGkC67iaD3RBV4vPNlUXLouibbFw.jpeg\")
<\/figure><\/div>\n\n<\/div>\n
<\/figure><\/div>\n\n<\/div>\n\u56fe\uff1aPress conference on December 9, 2010: CUHK researchers decode fetal genomic map from maternal blood (Lo et al Sci Transl Med 2010;2:61ra91).\u6765\u6e90\uff1aCUHK\u5b98\u7f51\u3002<\/div>\n
<\/div>\n
<\/div>\n
\u5408\u5e76\u540e\uff0c\u5362\u715c\u660e\u5c06\u6210\u4e3a\u8054\u5408\u5b9e\u4f53\u7684\u79d1\u5b66\u8054\u5408\u521b\u59cb\u4eba\uff08scientific co-founder\uff09\uff0c\u5e76\u5c06\u52a0\u5165Grail\u7684\u79d1\u5b66\u54a8\u8be2\u59d4\u5458\u4f1a\u3002<\/div>\n
<\/div>\n
\u5362\u715c\u660e\u6559\u6388\uff0c\u57fa\u56e0\u884c\u4e1a\u7684\u4eba\u90fd\u4e0d\u964c\u751f\uff0c\u4ed6\u4e0d\u4ec5\u662f\u9999\u6e2f\u4e2d\u6587\u5927\u5b66\u6559\u6388\uff0c\u674e\u5609\u8bda\u5065\u5eb7\u79d1\u5b66\u7814\u7a76\u6240\u6240\u957f\uff0c\u8fd8\u662f\u82f1\u56fd\u7687\u5bb6\u5b66\u4f1a\u4f1a\u5458\uff0c\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u5916\u7c4d\u9662\u58eb\uff0c\u9999\u6e2f\u79d1\u5b66\u9662\u9662\u58eb\u3002\u4f5c\u4e3a\u65e0\u521bDNA\u4ea7\u524d\u68c0\u6d4b\u5960\u57fa\u4eba\uff0c2016\u5e749\u6708\u8363\u83b7\u672a\u6765\u79d1\u5b66\u5927\u5956 \u201c\u751f\u547d\u79d1\u5b66\u5956\u201d \u4ee5\u53ca \u201c\u6c64\u68ee\u8def\u900f\u5f15\u6587\u6842\u51a0\u5956”\uff0c\u5e76\u4e00\u5ea6\u6210\u4e3a\u8bfa\u8d1d\u5c14\u5956\u7684\u70ed\u95e8\u5019\u9009\u4eba\u3002<\/div>\n
<\/div>\n
1997\u5e74\uff0c\u5362\u715c\u660e\u6559\u6388\u9996\u6b21\u5728\u6000\u5b55\u6bcd\u4eb2\u8840\u6db2\uff08\u8840\u6d46\uff09\u4e2d\u53d1\u73b0\u80ce\u513fDNA\u7684\u5b58\u5728\u3002\u7ecf\u8fc714\u5e74\uff0c2011\u5e74\uff0c\u65e0\u521b\u4ea7\u524d\u57fa\u56e0\u68c0\u6d4b\u6280\u672f\u5f00\u59cb\u5927\u89c4\u6a21\u5728\u4e34\u5e8a\u63a8\u5e7f\u3002\u5362\u715c\u660e\u6559\u6388\u6388\u6743\u7684\u5b9e\u9a8c\u5ba4\u6280\u672f\uff0c\u4f7f\u5f97Sequenom\u7b49\u5f00\u53d1\u4e86\u5546\u7528\u7684\u65e0\u521b\u4ea7\u524d\u68c0\u6d4b\u6280\u672f\u68c0\u6d4b\u5510\u6c0f\u7efc\u5408\u5f81\u3002\u56e0\u4e3a\u5bf9\u5510\u6c0f\u7efc\u5408\u75c7\u7b5b\u67e5\u7684\u6781\u9ad8\u51c6\u786e\u7387\uff0c\u907f\u514d\u7a7f\u523a\u5e26\u6765\u7684\u6d41\u4ea7\u98ce\u9669\uff0c\u6240\u4ee5\u4ec5\u7528\u4e8610\u4e2a\u6708\uff0c\u8fd9\u9879\u68c0\u6d4b\u6280\u672f\u5c31\u5728\u7f8e\u56fd\u5f00\u59cb\u4e34\u5e8a\u7684\u63a8\u5e7f\u4e86\u3002\u76ee\u524d\u5728\u4e2d\u56fd\u7684\u5e7f\u4e1c\u3001\u798f\u5efa\u3001\u6c5f\u82cf\u7b49\u5730\u8fdb\u5165\u7269\u4ef7\u5c40\u540d\u76ee\uff0c\u5728\u6df1\u5733\u53d7\u5230\u653f\u5e9c\u8865\u8d34\uff0c\u53ea\u9700\u4e0d\u5230\u5343\u5143\u7684\u4ef7\u683c\u5c31\u53ef\u4eab\u53d7\u8fd9\u9879\u65e0\u521b\u7684\u4ea7\u524d\u57fa\u56e0\u68c0\u6d4b\u670d\u52a1\u3002<\/div>\n
<\/div>\n
\u65e0\u521b\u4ea7\u524d\u57fa\u56e0\u68c0\u6d4b\u7684\u6838\u5fc3\uff0c\u4e00\u662f\u5728\u5b55\u5987\u5916\u5468\u8840\u53d1\u73b0\u80ce\u513f\u6e38\u79bbDNA\uff08cell-free fetal DNA\uff0ccffDNA\uff09\uff1b\u4e8c\u662f\u57fa\u4e8e\u9ad8\u901a\u91cf\u6d4b\u5e8f\u6280\u672f\u5bf9DNA\u8fdb\u884c\u68c0\u6d4b\u5206\u6790\uff0c\u5b9e\u73b0\u65e0\u521b\u7684\u4ea7\u524d\u68c0\u6d4b\u3002<\/div>\n
\u800c\u8fd9\u4e0e\u7528\u4e8e\u65e0\u521b\u80bf\u7624\u68c0\u6d4b\u7684\u6db2\u4f53\u6d3b\u68c0\u6280\u672f\u5f02\u66f2\u540c\u5de5\u3002\u764c\u75c7\u75c5\u4eba\u8840\u6db2\u4e2d\u4f1a\u5b58\u5728\u5c11\u91cf\u6e38\u79bb\u7684\u5faa\u73af\u80bf\u7624\u7ec6\u80de\uff08Cycling Tumor Cells\uff0c CTC\uff09\uff0c\u574f\u6b7b\u7684\u764c\u7ec6\u80de\u4ea6\u4f1a\u91ca\u653e\u5c11\u91cf\u7684\u5faa\u73af\u80bf\u7624DNA\uff08circulating tumor DNA\uff0c ctDNA\uff09\u5230\u8840\u6db2\u4e2d\uff0c\u901a\u8fc7\u68c0\u6d4b\u4ece\u80bf\u7624\u539f\u53d1\u6216\u8f6c\u79fb\u90e8\u4f4d\u91ca\u653e\u5230\u8840\u6db2\u4e2d\u7684CTC\u6216ctDNA\u6765\u68c0\u6d4b\u764c\u75c7\uff0c\u5373\u6db2\u4f53\u6d3b\u68c0\uff08Liquid Biopsy\uff09\u3002\u4e0e\u624b\u672f\u6d3b\u68c0\u548c\u7a7f\u523a\u6d3b\u68c0\u4e0d\u540c\uff0c\u6db2\u4f53\u6d3b\u68c0\u76f4\u63a5\u4ece\u8840\u6db2\u7b49\u4f53\u6db2\u4e2d\u68c0\u6d4b\u80bf\u7624\u7ec6\u80de\u6216\u80bf\u7624\u6838\u9178\uff0c\u5373\u4e3a\u65e0\u521b\u80bf\u7624\u68c0\u6d4b\u3002<\/div>\n
<\/div>\n
<\/div>\n
<\/div>\n
\n\n
\n![\"RmFicvQBAkgAkiat6VicJ2sH7VdECXQiaknI79CsVpgCZpgxda5TaaGtyXQ4IAKqntbZgW5W8DZJKicznqXIBHibIjFw\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgAkiat6VicJ2sH7VdECXQiaknI79CsVpgCZpgxda5TaaGtyXQ4IAKqntbZgW5W8DZJKicznqXIBHibIjFw.png\")
<\/figure><\/div>\n\n<\/div>\n
<\/figure><\/div>\n\n<\/div>\n\u56fe\uff1aCirina\u516c\u53f8\u7684logo\uff0c\u6765\u81eaCirina\u5b98\u7f51\u3002<\/div>\n
<\/div>\n
Cirina\u521b\u7acb\u4e09\u5e74\u6709\u4f59\uff0c\u65e9\u4e8eGrail\u3002<\/div>\n
2014\u5e74\uff0c\u5362\u715c\u660e\u6559\u6388\u548c\u5fb7\u8bda\u8d44\u672c\uff08Decheng Capital\uff09\u5171\u540c\u521b\u7acb\u4e86Cirina\u3002\u516c\u53f8\u7684\u603b\u90e8\u4f4d\u4e8e\u9999\u6e2f\uff0c\u7814\u7a76\u56e2\u961f\u5219\u5206\u5e03\u4e8e\u9999\u6e2f\u548c\u52a0\u5dde\u5357\u65e7\u91d1\u5c71\uff0c\u5f00\u53d1\u764c\u75c7\u65e9\u671f\u68c0\u6d4b\u4ea7\u54c1\u3002\u540e\u6765\uff0cManeesh Jain\u53d7\u8058\u62c5\u4efb\u9996\u5e2d\u6267\u884c\u5b98\uff08CEO\uff09\u3002<\/div>\n
<\/div>\n
Cirina\u57282016\u5e7410\u6708\u83b7\u5f971200\u4e07\u7f8e\u91d1\u7684A\u8f6e\u878d\u8d44\uff0c\u6295\u8d44\u65b9\u4e3a\u5fb7\u8bda\u8d44\u672c\u3002 \u5728\u5b98\u7f51\u76ee\u524d\u5c1a\u65e0\u516c\u5e03\u7684\u4ea7\u54c1\u53ca\u670d\u52a1\u3002Jain\u66fe\u53d7\u5a92\u4f53\u91c7\u8bbf\u8868\u793aCirina\u8ba1\u52122017\u5e74\u5728\u7f8e\u56fd\u6216\u4e9a\u6d32\u63a8\u51fa\u7b2c\u4e00\u4e2a\u68c0\u6d4b\u4ea7\u54c1\uff0cCirina\u516c\u53f8\u5df2\u7ecf\u5728\u7f8e\u56fd\u548c\u4e9a\u6d32\u4e0e\u5408\u4f5c\u4f19\u4f34\u5f00\u5c55\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/div>\n
<\/div>\n
\u53c2\u4e0eCirina\u521b\u7acb\u548cA\u8f6e\u878d\u8d44\u7684\u5fb7\u6210\u8d44\u672c\u7684\u521b\u59cb\u5408\u4f19\u4eba\u517c\u8463\u4e8b\u603b\u7ecf\u7406\u5d14\u7fe0\u5c06\u52a0\u5165Grail\u8463\u4e8b\u4f1a\u3002<\/div>\n
<\/div>\n
<\/div>\n
\n\n
\n![\"RmFicvQBAkgAkiat6VicJ2sH7VdECXQiaknIj8icKms9pBZog6osj0EtllYs7KVPzwvGiaGdPot4Vqiar2O0icFv2KYloQ\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgAkiat6VicJ2sH7VdECXQiaknIj8icKms9pBZog6osj0EtllYs7KVPzwvGiaGdPot4Vqiar2O0icFv2KYloQ.png\")
<\/figure><\/div>\n\n
<\/figure><\/div>\n\n\u7531\u4e8e\u521b\u7acb\u80cc\u666f\u548c\u5de8\u989d\u878d\u8d44\uff0cGrail\u4ece\u4e00\u5f00\u59cb\u5c31\u662f\u5907\u53d7\u77a9\u76ee\u7684\u660e\u661f\u516c\u53f8\u3002<\/div>\n
Illumina\u5927\u4e2d\u534e\u533a\u603b\u7ecf\u7406\u8d75\u745e\u6797\u66fe\u63a5\u53d7\u57fa\u56e0\u6167\u4e13\u8bbf\u8c08\u5230\uff0cGrail\uff08\u4ee5\u53caHelix\uff09\u90fd\u662fillumina\u63a8\u8fdb\u6d4b\u5e8f\u6280\u672f\u5e7f\u6cdb\u5e94\u7528\u7684\u6218\u7565\u7684\u4e00\u90e8\u5206\u3002<\/div>\n
\u00a0<\/div>\n
2016\u5e7410\u6708\uff0cGrail\u662f\u7531Illumina\u548cARCH Venture Partners \u6295\u8d44\u516c\u53f8\u76841\u4ebf\u7f8e\u5143\u878d\u8d44\u800c\u6210\u7acb\uff0c\u53c2\u4e0e\u6295\u8d44\u7684\u8fd8\u5305\u62ec\u6bd4\u5c14\u76d6\u8328\uff0c\u4ee5\u53caARCH Venture Partners\u3001 Bezos Expeditions\u548cSutter Hill Ventures\u7b49\u3002<\/div>\n
2017\u5e743\u6708\uff0cGrail\u5ba3\u5e03B\u8f6e\u878d\u8d44\u7ed3\u679c\uff0c\u83b7\u5f97\u7531ARCH Venture Partners\u548cJohnson & Johnson Innovation\u8054\u5408\u9886\u6295\u7684\u8d85\u8fc79\u4ebf\u7f8e\u91d1\u7684\u878d\u8d44\u3002\u4e9a\u9a6c\u900a\u3001\u9ea6\u80af\u9521\u3001\u9ed8\u514b\uff08Merck)\u4ee5\u53ca\u817e\u8baf\u53c2\u4e0e\u8ddf\u6295\uff0c\u5176\u4ed6\u8ddf\u6295\u65b9\u8fd8\u5305\u62ecBristol-Myers Squibb, Celgene\u4ee5\u53caVarian Medical Systems\u7b49\u3002<\/div>\n
\u00a0<\/div>\n
\u521b\u4e1a\u521d\uff0cGrail\u5bf9\u5916\u5ba3\u79f0\u81f4\u529b\u4e8e\u5f00\u53d1\u4e00\u79cd\u4e0d\u8d85\u8fc71000\u7f8e\u5143\u7684\u764c\u75c7\u6db2\u4f53\u6d3b\u68c0\u6280\u672f\u30022016\u5e741\u6708\uff0cGrail\u5728JP\u6469\u6839\u5065\u5eb7\u533b\u7597\u5e74\u4f1a\u4e0a\u5ba3\u5e03\u79f0\uff0c\u5c06\u201c\u901a\u8fc7\u8840\u6db2\u7b5b\u67e5\u53d1\u73b0\u90a3\u4e9b\u6ca1\u6709\u75c7\u72b6\u7684\u65e9\u671f\u764c\u75c7\u60a3\u8005”\uff0c \u5e76\u8ba1\u5212\u5728\u672a\u67653\u5e74\u5168\u9762\u63a8\u5e7fpan tumor\u68c0\u6d4b\u3002<\/div>\n
Grail\u5df2\u7ecf\u63a8\u51fa\u4e86\u4e24\u9879\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5176\u4e2d\u4e00\u9879\u4e0eMayo Clinic\u548cSutter Health\u5408\u4f5c\uff0c\u57fa\u4e0b\u4e00\u4ee3\u9ad8\u901a\u91cf\u57fa\u56e0\u6d4b\u5e8f\u6280\u672f\u7528\u4e8e\u65e9\u671f\u4e73\u817a\u764c\u68c0\u6d4b\u3002<\/div>\n
\u8d44\u672c\u548c\u6280\u672f\u7684\u878d\u5408\uff0c\u884c\u4e1a\u7684\u5e76\u8d2d\u6574\u5408\uff0c\u8ba9\u6211\u4eec\u671f\u5f85\u540e\u7eed\u843d\u5730\u5e02\u573a\u548c\u5e94\u7528\u7684\u6545\u4e8b\u3002<\/div>\n
\u00a0<\/div>\n
\u53c2\u8003\u8d44\u6599\uff1a<\/div>\n
1.http:\/\/cirina.com\/<\/div>\n
2.https:\/\/grail.com\/<\/div>\n
3.\u00a0https:\/\/www.genomeweb.com\/cancer\/grail-and-cirina-merge-focus-early-cancer-detection<\/div>\n
4.\u00a0http:\/\/www.prnews.cn\/press_release\/346719.htm?from=timeline&isappinstalled=0<\/div>\n
\u00a0<\/div>\n
\u5173\u4e8e\u884c\u4e1a\u6574\u5408\uff0c\u60a8\u8fd8\u4f1a\u611f\u5174\u8da3\u7684<\/div>\n
\u76d8\u70b924\u5bb6\u57fa\u56e0\u76f8\u5173\u4e0a\u5e02\u4f01\u4e1a\uff08\u542b\u5e74\u62a5\uff09<\/a><\/div>\n
\u8c08\u8c08\u8de8\u754c\u8fdb\u519b\u57fa\u56e0\u4ea7\u4e1a\u7684\u4f01\u4e1a\u4e86\uff08\u4e0a\uff09<\/a><\/div>\n
9\u4e2a\u4e0e\u60a8\u6709\u5173\u7684\u771f\u5b9e\u6545\u4e8b\uff1a\u57fa\u56e0\u68c0\u6d4b\u7684\u7528\u5904<\/a><\/div>\n
\u57fa\u56e0\u6167\u4e3a\u300a\u57fa\u56e0\u7ec4\u9769\u547d\u300b\u4f5c\u5e8f<\/a><\/div>\n
\u00a0<\/div>\n
\u9996\u4e2a\u4e13\u6ce8\u4e8e\u57fa\u56e0\u884c\u4e1a\u6570\u636e\u5e93\uff1a\u4f18\u8109\u901a<\/div>\n\n
\n![\"RmFicvQBAkgC0avckNia9q4ZYtSsGWlTxlSjuIocJWRhNOLgBHDRXibCk61GiappiaVc0dMibibnFmEJxX1rA2ZR3wzGQ\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgC0avckNia9q4ZYtSsGWlTxlSjuIocJWRhNOLgBHDRXibCk61GiappiaVc0dMibibnFmEJxX1rA2ZR3wzGQ.gif\")
<\/figure><\/div>\n\n<\/div>\n
<\/figure><\/div>\n\n<\/div>\n<\/div>\n
\u70b9\u51fb\u67e5\u770b\u201c\u4f18\u8109\u901a\u201d \u4ecb\u7ecd\uff08\u767e\u5ea6\u641c\u7d22\u201c\u57fa\u56e0\u6167\u201d\u53ef\u8fdb\u5165\uff09\u00a0<\/a><\/div>\n
<\/div>\n
<\/div>\n
\n\n
\n![\"RmFicvQBAkgDibFpXLmDUiayOs0bRyXN9FaL3SCzoc0mM9YSLFMLmKgac4Q3eFzWEGS3xgW3LMOUicf9cJStdlwYhQ\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDibFpXLmDUiayOs0bRyXN9FaL3SCzoc0mM9YSLFMLmKgac4Q3eFzWEGS3xgW3LMOUicf9cJStdlwYhQ.jpeg\")
<\/figure><\/div>","protected":false},"excerpt":{"rendered":"
<\/figure><\/div>","protected":false},"excerpt":{"rendered":"\u884c\u4e1a\u7684\u5e76\u8d2d\u6574\u5408\u52a0\u901f<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[2470],"class_list":["post-10968","post","type-post","status-publish","format-standard","hentry","category-industryresearch","tag-2470"],"_links":{"self":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts\/10968","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/comments?post=10968"}],"version-history":[{"count":3,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts\/10968\/revisions"}],"predecessor-version":[{"id":14494,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts\/10968\/revisions\/14494"}],"wp:attachment":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/media?parent=10968"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/categories?post=10968"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/tags?post=10968"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}