\n![\"RmFicvQBAkgBqJyMcQxUZibhoFCjLcSCNYDXUEhmz2Zf3jEC87jjYiceTyIaB3JnrFLh5ibjQQBCozYupUkT2icDsTA\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgBqJyMcQxUZibhoFCjLcSCNYDXUEhmz2Zf3jEC87jjYiceTyIaB3JnrFLh5ibjQQBCozYupUkT2icDsTA.gif\")
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<\/figure><\/div>\n\n<\/div>\n<\/div>\n
\u5173\u952e\u8bcd\uff1a\u4e34\u5e8a\u80bf\u7624 ASCO 2017<\/div>\n
\u6458\u8981 \u00a0Poster \u00a0Presentation<\/div>\n
\u5efa\u8bae\u7528\u65f6\uff1a5\u5206\u949f<\/div>\n
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\u3010\u6295\u521b\u672a\u6765\u3011\u4e00\u5e74\u4e00\u5ea6\u7684ASCO\uff08\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u5e74\u4f1a\uff09\u662f\u4e34\u5e8a\u80bf\u7624\u9886\u57df\u6c34\u5e73\u6700\u9ad8\u7684\u76db\u4f1a\u4e4b\u4e00\u30022017\u7684ASCO\uff086\u67082\u65e5-6\u65e5\uff09\u5728\u5bc6\u6b47\u6839\u6e56\u7554\u3001\u8457\u540d\u56fd\u9645\u91d1\u878d\u4e2d\u5fc3\u4e4b\u4e00\u7684\u829d\u52a0\u54e5\u5e02\u521a\u521a\u843d\u5e55\u3002ASCO 2017\u6709\u54ea\u4e9b\u770b\u70b9\uff1f\u57fa\u56e0\u6167\u548c\u5927\u5bb6\u4e00\u8d77\u4f1a\u4e0a\u57fa\u56e0\u5065\u5eb7\u9886\u57df\u524d\u77bb\u6280\u672f\u8981\u70b9\u548c\u4ea7\u4e1a\u8981\u95fb\uff0c\u4ee5\u98e8\u6295\u521b\u5bb6\u548c\u540c\u884c\u3002<\/div>\n
\u6ce8\uff1a\u6240\u6709\u6587\u5b57\u8d44\u6599\u7f16\u8bd1\u81eaASCO\u5b98\u7f51\u53ca\u57fa\u56e0\u6167\u6d77\u5916\u56e2\u961f\uff0c\u8f6c\u8f7d\u8bf7\u8054\u7cfb\u6388\u6743\u3002<\/div>\n
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\n![\"RmFicvQBAkgD49vyRiaQcdTPicD05kRdyeHxs32icNrVAgNLn8Je9ZhSXXJagCEdTfE726a9R9uNXe2usHWJTwc60g\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgD49vyRiaQcdTPicD05kRdyeHxs32icNrVAgNLn8Je9ZhSXXJagCEdTfE726a9R9uNXe2usHWJTwc60g.png\")
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<\/figure><\/div>\n\n\u56fe\uff0cASCO 2017 logo\u3002\u6765\u81eaASCO\u5b98\u7f51<\/div>\n\n
\n![\"RmFicvQBAkgD49vyRiaQcdTPicD05kRdyeHnrICSpZXdAbC986ImHllpKtF1XGGOhGzcRia2ZMPp2pbAR7LtPGskkw\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgD49vyRiaQcdTPicD05kRdyeHnrICSpZXdAbC986ImHllpKtF1XGGOhGzcRia2ZMPp2pbAR7LtPGskkw.jpeg\")
<\/figure><\/div>\n\n
<\/figure><\/div>\n\n\u56fe\uff0cASCO\u4f1a\u8bae\u63a0\u5f71\u3002\u6765\u81eaASCO\u5b98\u7f51<\/div>\n
\u6982\u8981\u7eb5\u89c8<\/div>\n
#\u5173\u952e\u8bcd\u673a\u67841CAR-T\u514d\u75ab\u6cbb\u7597\u3001\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u897f\u5b89\u4ea4\u5927\u3001\u5357\u4eac\u4f20\u5947\u751f\u72692\u963f\u96f7\u66ff\u5c3c\u3001\u80ba\u764c\uff08\u6cd5\uff09\u91cc\u5c14\u91cc\u5c14\u5927\u5b66\u533b\u96623\u7b2c\u4e8c\u4ee3EGFR TKI\u3001\u80ba\u764c\u9999\u6e2f\u5927\u5b66\u3001\u8f89\u745e4\u963f\u96f7\u66ff\u5c3c\u3001\u80ba\u764c\uff08\u7f8e\uff09\u9a6c\u8428\u8bf8\u585e\u5dde\u7efc\u5408\u533b\u9662\u3001\u7f57\u6c0f5\u5e15\u59a5\u73e0\u5355\u6297\u3001HER2\u9633\u6027\u65e9\u671f\u4e73\u817a\u764c\u4e73\u817a\u56fd\u9645\u534f\u4f5c\u7ec4\u3001\u7f57\u6c0f6\u5965\u62c9\u5e15\u5c3c\u3001\u4e73\u817a\u764c\uff08\u7f8e\uff09\u6885\u5965\u8bca\u6240\u764c\u75c7\u4e2d\u5fc3\u3001\u516c\u5171\u8d44\u52a97\u963f\u6bd4\u7279\u9f99\u3001\u524d\u5217\u817a\u764c\uff08\u6cd5\uff09Paris-Sud\u5927\u5b66\uff0cJanssen8\u9996\u4e2a\u4e0d\u533a\u5206\u80bf\u7624\u7c7b\u578b\u7684\u53e3\u670d\u7597\u6cd5\uff08\u7f8e\uff09\u7eaa\u5ff5\u65af\u9686\u51ef\u7279\u7433\u764c\u75c7\u4e2d\u5fc3\u3001Loxo\n
\u00a0<\/div>\n
\u5185\u5bb9\u7ec6\u8282\uff1a<\/div>\n
\u5173\u952e\u8bcd\uff1a\u514d\u75ab\u6cbb\u7597 \u591a\u53d1\u6027\u9aa8\u9ad3\u7624<\/div>\n
1. CAR-T\u514d\u75ab\u6cbb\u7597\u6301\u7eed\u7f13\u89e3\u591a\u53d1\u6027\u9aa8\u9ad3\u7624<\/div>\n<\/div>\n\n
\n![\"RmFicvQBAkgD49vyRiaQcdTPicD05kRdyeHMlExKIy1YtZrQibkJeRq6Xp6Bicd7CsBjic9AhNn7EicbhQu4VPWaczwOA\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgD49vyRiaQcdTPicD05kRdyeHMlExKIy1YtZrQibkJeRq6Xp6Bicd7CsBjic9AhNn7EicbhQu4VPWaczwOA.jpeg\")
<\/figure><\/div>\n\n<\/div>\n
<\/figure><\/div>\n\n<\/div>\n\u56fe\uff1aCAR-T\u514d\u75ab\u6cbb\u7597\u601d\u8def\uff1b\u6765\u6e90\u4e8eOncLive<\/div>\n
\u3010\u6458\u8981\u5185\u5bb9\u3011\u5728\u4e00\u9879\u65e9\u671f\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c94\uff05\uff0833\/35\uff09\u7684\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u63a5\u53d7\u4e86\u4e00\u79cd\u65b0\u578b\u514d\u75ab\u6cbb\u7597\u65b9\u6cd5\u2014\u2014\u9776\u5411B\u7ec6\u80de\u6210\u719f\u86cb\u767d\u6216BCMA \u7684\u5d4c\u5408\u6297\u539f\u53d7\u4f53(CAR)T\u7ec6\u80de\u514d\u75ab\u6cbb\u7597\uff0c \u83b7\u5f97\u4e34\u5e8a\u7f13\u89e3\u3002\u5927\u591a\u6570\u60a3\u8005\u53ea\u6709\u8f7b\u5fae\u7684\u526f\u4f5c\u7528\u300219\u4f8b\u60a3\u8005\u968f\u8bbf\u65f6\u95f4\u8d85\u8fc74\u4e2a\u6708\uff0c\u4e0e\u56fd\u9645\u9aa8\u9ad3\u7624\u5de5\u4f5c\u7ec4\uff08IMWG\uff09\u7684\u6548\u679c\u8bc4\u4f30\u7684\u9884\u8bbe\u65f6\u95f4\u4e00\u81f4\uff0c\u5176\u4e2d14\u4f8b\u8fbe\u5230\u4e25\u683c\u5b8c\u5168\u7f13\u89e3\uff08sCR\uff09\u6807\u51c6\uff0c1\u4f8b\u60a3\u8005\u8fbe\u5230\u90e8\u5206\u7f13\u89e3\uff0c4\u4f8b\u8fbe\u5230\u975e\u5e38\u597d\u7684\u90e8\u5206\u7f13\u89e3\uff08VgPR\uff09\u6807\u51c6\u3002<\/div>\n
\u3010\u7814\u7a76\u56e2\u961f\u3011\u897f\u5b89\u4ea4\u901a\u5927\u5b66\u7b2c\u4e8c\u9644\u5c5e\u533b\u9662\u8d75\u4e07\u7ea2\u6559\u6388\uff0c\u5408\u4f5c\u4f19\u4f34\u5357\u4eac\u4f20\u5947\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8.<\/div>\n
\u53c2\u8003\uff1ahttp:\/\/abstracts.asco.org\/199\/AbstView_199_189230.html<\/div>\n
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\u5173\u952e\u8bcd\uff1a\u514d\u75ab\u6cbb\u7597 \u95f4\u76ae\u7624<\/div>\n
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2. \u65e9\u671f\u7814\u7a76\u5c55\u671b\u9996\u4f8b\u95f4\u76ae\u7624\u514d\u75ab\u6cbb\u7597<\/div>\n
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\n![\"RmFicvQBAkgDH207icdaj4R9Hkd4PXI5M6ibAskhtE3MyQfSpicib86eiaFf40FHzf0KsgBL8CCiclFAspVNFVksvuCHA\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDH207icdaj4R9Hkd4PXI5M6ibAskhtE3MyQfSpicib86eiaFf40FHzf0KsgBL8CCiclFAspVNFVksvuCHA.png\")
<\/figure><\/div>\n\n<\/div>\n
<\/figure><\/div>\n\n<\/div>\n\u56fe\uff1anivolumab+ipilimumab\uff1b\u6765\u6e90\u4e8e\u4e92\u8054\u7f51<\/div>\n
\u3010\u6458\u8981\u5185\u5bb9\u3011\u6076\u6027\u80f8\u819c\u95f4\u76ae\u7624\uff08MPM\uff09\u662f\u4e00\u79cd\u7f55\u89c1\u80bf\u7624\uff0c\u4f46\u53d1\u751f\u7387\u6b63\u5728\u5347\u9ad8\u3002\u8be5\u80bf\u7624\u901a\u5e38\u4e0e\u77f3\u68c9\u66b4\u9732\u76f8\u5173\uff0c\u4e14\u60a3\u8005\u7684\u4e2d\u4f4d\u751f\u5b58\u671f\u4ec5\u670913~15\u4e2a\u6708\u3002\u60a3\u8005\u867d\u7136\u7ecf\u8fc7\u521d\u59cb\u5316\u7597\u6cbb\u7597\uff0c\u4f46\u8d85\u8fc750%\u5728\u505c\u6b62\u6cbb\u7597\u540e6\u4e2a\u6708\u5185\u51fa\u73b0\u590d\u53d1\u3002\u76ee\u524d\u5c1a\u65e0MPM\u60a3\u8005\u7684\u6709\u6548\u6cbb\u7597\u65b9\u6848\u3002II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u65e9\u671f\u53d1\u73b0\u8868\u660e\uff0c\u514d\u75ab\u6cbb\u7597\u53ef\u80fd\u51cf\u7f13\u590d\u53d1\u540eMPM\u7684\u751f\u957f\u3002 \u572812\u5468\u65f6\uff0c44\uff05\u7684\u63a5\u53d7nivolumab (Opdivo)\u7684\u60a3\u8005\u548c50%\u63a5\u53d7nivolumab+ipilimumab (Yervoy)\u60a3\u8005\u4e2d\uff0c\u80bf\u7624\u6ca1\u6709\u6076\u5316\u3002 \u5728125\u4f8b\u60a3\u8005\u5e73\u5747\u968f\u8bbf10.4\u4e2a\u6708\u540e\uff0c\u76f4\u5230\u764c\u75c7\u6076\u5316\u7684\u4e2d\u4f4d\u6570\uff0c\u5355\u72ec\u4f7f\u7528nivolumab\u00a0\u4e3a4\u4e2a\u6708\uff0cnivolumab \u548cipilimumab\u4e3a5.6\u6708\u3002\u526f\u4f5c\u7528\u6700\u5e38\u89c1\u7684\u662f\u7532\u72b6\u817a\u95ee\u9898\uff0c\u7ed3\u80a0\u708e\u75c7\u548c\u76ae\u75b9\u3002 nivolumab+ ipilimumab\u7ec4\u7684\u4e25\u91cd\u526f\u4f5c\u7528\u66f4\u4e3a\u5e38\u89c1\uff0c\u5176\u4e2d\u53d1\u751f\u4e09\u4f8b\u6cbb\u7597\u76f8\u5173\u7684\u6b7b\u4ea1\u3002<\/div>\n
\u3010\u7814\u7a76\u56e2\u961f\u3011\u6cd5\u56fd\uff0c\u6cd5\u56fd\u91cc\u5c14\u91cc\u5c14\u5927\u5b66\u533b\u9662\uff0cArnaud Scherpereel<\/div>\n
\u53c2\u8003\uff1ahttp:\/\/abstracts.asco.org\/199\/AbstView_199_189230.html<\/div>\n
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\u5173\u952e\u8bcd\uff1aNSCLC \u00a0\u7b2c\u4e8c\u4ee3EGFR-TKI<\/div>\n
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3. \u00a0\u7b2c\u4e8c\u4ee3EGFR TKI\u5c06\u80ba\u764c\u98ce\u9669\u964d\u4f4e\u4e8641%<\/div>\n
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\n\n
\n![\"RmFicvQBAkgDH207icdaj4R9Hkd4PXI5M6ibffjh2CKKox7kABbRr5Q2BbZf7muR4lQK0C76XjvbyUHRJ9KxfjuUg\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDH207icdaj4R9Hkd4PXI5M6ibffjh2CKKox7kABbRr5Q2BbZf7muR4lQK0C76XjvbyUHRJ9KxfjuUg.jpeg\")
<\/figure><\/div>\n\n<\/div>\n
<\/figure><\/div>\n\n<\/div>\n\u56fe\uff1aNSCLC\u548cEGFR\uff1b\u6765\u6e90\u4e8eresearch gate.<\/div>\n
\u3010\u6458\u8981\u5185\u5bb9\u3011\u6bcf\u5e74\u5168\u7403\u7ea6\u670914\u4e07\u4eba\uff08\u4ec5\u5728\u7f8e\u56fd15,000\u4eba\uff09\u88ab\u8bca\u65ad\u60a3\u6709\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff09\u9633\u6027NSCLC\uff08\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff09\uff0c\u4f34\u968f\u8fc7\u5ea6\u6d3b\u5316\u7684EGFR\u86cb\u767d\u8d28\u7684\u9057\u4f20\u7269\u8d28\u6539\u53d8\uff0c\u5176\u4fc3\u8fdb\u764c\u7ec6\u80de\u7684\u751f\u957f\u3002 EGFR\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08TKI\uff09\u662f\u65b0\u8bca\u65ad\u7684EGFR\u9633\u6027NSCLC\u60a3\u8005\u7684\u6807\u51c6\u6cbb\u7597\u65b9\u6cd5\u3002 \u8fd9\u9879\u7814\u7a76\u662fEGFR TKI\u7684\u7b2c\u4e00\u4e2aIII\u671f\u6bd4\u8f83\u7814\u7a76\u3002\u7ed3\u679c\u53d1\u73b0\uff0c\u5bf9\u4e8e\u65b0\u8bca\u65ad\u4e3a\u665a\u671f\u7684EGFR\u9633\u6027NSCLC\u60a3\u8005\uff0c\u4e0e\u8be5\u75be\u75c5\u7684\u6807\u51c6\u9776\u5411\u836f\u7269\u4e4b\u4e00EGFR\u6291\u5236\u5242\u5409\u975e\u66ff\u5c3c\uff08Iressa\uff09\u76f8\u6bd4\uff0c\u7b2c\u4e8c\u4ee3EGFR\u6291\u5236\u5242dacomitinib\u5c06\u60a3\u8005\u7684\u75be\u75c5\u98ce\u9669\u964d\u4f4e\u4e8641%\uff0c\u5e76\u989d\u5916\u5ef6\u7f13\u75c5\u60c5\u6076\u5316\u8fbe5.5\u4e2a\u6708\u4e4b\u4e45\u3002<\/div>\n
\u3010\u7814\u7a76\u56e2\u961f\u3011\u4e2d\u56fd\u9999\u6e2f\u5927\u5b66\u7684Tony Mok\u6559\u6388\uff0c\u83b7\u8f89\u745e\uff08Pfizer\uff09\u8d44\u52a9\u3002<\/div>\n
\u53c2\u8003\uff1ahttp:\/\/abstracts.asco.org\/199\/AbstView_199_192638.html<\/div>\n
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\u5173\u952e\u8bcd\uff1a\u80ba\u764c \u00a0\u963f\u96f7\u66ff\u5c3c \u00a0\u514b\u5511\u66ff\u5c3c<\/div>\n
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4. \u00a0\u963f\u96f7\u66ff\u5c3c\u5ef6\u7f13\u80ba\u764c\u6076\u5316\u65f6\u95f4\u6bd4\u514b\u5511\u66ff\u5c3c\u591a\u4e00\u5e74<\/div>\n
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\n\n
\n![\"RmFicvQBAkgDH207icdaj4R9Hkd4PXI5M6o1gUcPa7PwZP4vhJ0rjzkW0Zl8FylJ4j7FbMduzElX5WWnH1icdrWQQ\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDH207icdaj4R9Hkd4PXI5M6o1gUcPa7PwZP4vhJ0rjzkW0Zl8FylJ4j7FbMduzElX5WWnH1icdrWQQ.jpeg\")
<\/figure><\/div>\n\n<\/div>\n
<\/figure><\/div>\n\n<\/div>\n\u56fe\uff1aAlectinib\u836f\u7269\u7ed3\u6784\uff1b\u6765\u6e90\uff1adrugdiscovery<\/div>\n
\u3010\u6458\u8981\u5185\u5bb9\u3011\u9996\u4e2a\u4e13\u95e8\u9488\u5bf9ALK\u7684\u836f\u7269Crizotinib\uff08\u514b\u5511\u66ff\u5c3c\uff09\u4e8e2011\u5e74\u88abFDA\u6279\u51c6\u3002\u5f88\u591a\u60a3\u8005\u56e0\u6b64\u53d7\u76ca\uff0c\u4f46\u764c\u75c7\u901a\u5e38\u5728\u4e00\u5e74\u5185\u518d\u6b21\u5f00\u59cb\u751f\u957f\u3002 Alectinib\uff08\u963f\u96f7\u66ff\u5c3c\uff09\u662f\u4e00\u79cd\u4e0b\u4e00\u4ee3ALK\u6291\u5236\u5242\uff0c\u57282015\u5e74\u88ab\u6279\u51c6\u7528\u4e8e\u5bf9Crizotinib\u8010\u53d7\u7684\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u3002\u4e0eCrizotinib\u76f8\u6bd4\uff0cAlectinib\u5c06\u764c\u98ce\u9669\u964d\u4f4e\u4e8653\uff05\uff0c\u5c06\u4e2d\u4f4d\u65f6\u95f4\u5ef6\u957f\u7ea615\u4e2a\u6708\uff08\u537325.7\u4e2a\u6708\uff09\u3002<\/div>\n
\u3010\u7814\u7a76\u56e2\u961f\u3011\u9a6c\u8428\u8bf8\u585e\u5dde\u7efc\u5408\u533b\u9662\uff08Massachusetts General Hospital\uff09\u764c\u75c7\u4e2d\u5fc3\u80f8\u8154\u80bf\u7624\u79d1\u4e3b\u4efbAlice Tsang Shaw\u3002\u83b7\u7f57\u6c0f\u516c\u53f8\uff08Roche\uff09\u57fa\u91d1\u8d44\u52a9\u3002<\/div>\n
\u53c2\u8003\uff1ahttp:\/\/abstracts.asco.org\/199\/AbstView_199_185951.html<\/div>\n
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\u5173\u952e\u8bcd\uff1aHER2+\u65e9\u671f\u4e73\u817a\u764c \u00a0\u5e15\u59a5\u73e0\u5355\u6297<\/div>\n
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5. \u00a0\u5e15\u59a5\u73e0\u5355\u6297\u53ef\u964d\u4f4eHER2\u9633\u6027\u65e9\u671f\u4e73\u817a\u764c\u60a3\u8005\u590d\u53d1\u98ce\u9669<\/div>\n
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\n![\"RmFicvQBAkgDH207icdaj4R9Hkd4PXI5M666edyhib8OTcibYiaVC3BxgNB1zUuhAxnQ7naBOAuhuTL1Zvf3t6S7lbg\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDH207icdaj4R9Hkd4PXI5M666edyhib8OTcibYiaVC3BxgNB1zUuhAxnQ7naBOAuhuTL1Zvf3t6S7lbg.jpeg\")
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<\/figure><\/div>\n\n<\/div>\n\u56fe\uff1apertuzumab\u6291\u5236HER2\uff1b\u6765\u6e90\u4e8eDrug Discovery<\/div>\n
\u3010\u6458\u8981\u5185\u5bb9\u3011\u00a0\u5728\u4e00\u9879\u9488\u5bf94,805\u540dHER2\u9633\u6027\u65e9\u671f\u4e73\u817a\u764c\u5987\u5973\u7684III\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08APHINITY\uff09\u4e2d\uff0c\u5728\u672f\u540e\uff0c\u9664\u4e86\u6807\u51c6\u6cbb\u7597\u7684\u66f2\u59a5\u73e0\u5355\u6297\uff08\u8d6b\u8d5b\u6c40\uff09\u5916\uff0c\u989d\u5916\u670d\u7528\u7b2c\u4e8c\u79cdHER2\u9776\u5411\u836f\u7269\uff0cpertuzumab\uff08Perjeta\uff0c\u5e15\u59a5\u73e0\u5355\u6297\uff09\u00a0\uff0c\u4f7f\u65e9\u671fHER2\u9633\u6027\u4e73\u817a\u764c\u60a3\u8005\u7684\u4e73\u817a\u764c\u590d\u53d1\u6216\u6b7b\u4ea1\u98ce\u9669\uff08\u65e0\u6d78\u6da6\u6027\u75be\u75c5\u751f\u5b58\uff0ciDFS\uff09\u663e\u8457\u4e0b\u964d19%(HR=0.81; 95% CI 0.66-1.00, p=0.045)\u3002\u4ee53\u5e74\u4e3a\u65f6\u95f4\u622a\u70b9\uff0c\u4f7f\u7528\u5e15\u59a5\u73e0\u5355\u6297\u4e3a\u57fa\u7840\u7684\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u670994.1%\u6ca1\u6709\u51fa\u73b0\u4e73\u817a\u764c\u590d\u53d1\uff0c\u800c\u4f7f\u7528\u66f2\u59a5\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u6cbb\u7597\u7684\u60a3\u8005\u4e3a93.2%\u3002\u5e15\u59a5\u73e0\u5355\u6297\u6cbb\u7597\u7684\u5b89\u5168\u6027\u4e0e\u4e4b\u524d\u7684\u7814\u7a76\u7ed3\u679c\u4e00\u81f4\uff0c\u60a3\u8005\u5fc3\u810f\u4e0d\u826f\u53cd\u5e94\u4e8b\u4ef6\u53d1\u751f\u7387\u4f4e\uff0c\u4e14\u672a\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u4fe1\u53f7\u3002<\/div>\n
\u3010\u7814\u7a76\u56e2\u961f\u3011\u4e73\u817a\u56fd\u9645\u534f\u4f5c\u7ec4\u7814\u7a76\u534f\u8c03\u5458\u3001\u5fb7\u56fd\u4e73\u817a\u56fd\u9645\u534f\u4f5c\u7ec4\u8d1f\u8d23\u4eba\u3001\u5b66\u672f\u7814\u7a76\u5408\u4f5c\u4f19\u4f34Gunter von Minckwitz\u535a\u58eb\u3002\u83b7\u7f57\u6c0f\u516c\u53f8\uff08Roche\uff09\u57fa\u91d1\u8d44\u52a9\u3002<\/div>\n
\u53c2\u8003\uff1ahttp:\/\/abstracts.asco.org\/199\/AbstView_199_189357.html<\/div>\n
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\u5173\u952e\u8bcd\uff1a\u5965\u62c9\u5e15\u5c3c\u00a0BRCA\u7a81\u53d8\u76f8\u5173\u4e73\u817a\u764c<\/div>\n
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6. \u5965\u62c9\u5e15\u5c3c\u51cf\u7f13BRCA\u7a81\u53d8\u76f8\u5173\u4e73\u817a\u764c\u8fdb\u5c55<\/div>\n
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\n![\"RmFicvQBAkgDH207icdaj4R9Hkd4PXI5M6ePMLoX6Amibic5oEFzE4ic6JrlpzDSDkojgXbVzAicnRBpdecZuTvm7Xlw\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDH207icdaj4R9Hkd4PXI5M6ePMLoX6Amibic5oEFzE4ic6JrlpzDSDkojgXbVzAicnRBpdecZuTvm7Xlw.jpeg\")
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<\/figure><\/div>\n\n<\/div>\n\u56fe\uff1aBRCA\u7a81\u53d8\u7684\u4e73\u817a\u764c\u6cbb\u7597\u7b56\u7565\uff1b\u6765\u6e90\u4e8epic2fly<\/div>\n
\u3010\u6458\u8981\u5185\u5bb9\u3011\u4e00\u9879\u6765\u6d89\u53ca300\u4f8b\u5973\u6027\u60a3\u8005\u7684III\u671f\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\uff0c\u53ef\u80fd\u5f15\u5165PARP\u6291\u5236\u5242\u5965\u62c9\u5e15\u5c3c\uff08Olaparib\uff09\u4f5c\u4e3a\u4e73\u817a\u764c\u7684\u65b0\u578b\u6cbb\u7597\u65b9\u6cd5\u3002\u4e0e\u6807\u51c6\u5316\u7597\u76f8\u6bd4\uff0c\u53e3\u670d\u836f\u7269\u5965\u62c9\u5e15\u5c3c\u5c06\u665a\u671fBRCA\u7a81\u53d8\u76f8\u5173\u4e73\u817a\u764c\u7684\u8fdb\u5c55\u51e0\u7387\u964d\u4f4e\u4e8642\uff05\uff0c\u8fdb\u5c55\u5ef6\u7f13\u5927\u7ea63\u4e2a\u6708\u3002<\/div>\n
\u3010\u7814\u7a76\u56e2\u961f\u3011\u7ebd\u7ea6\u7eaa\u5ff5\u65af\u9686\u51ef\u7279\u7433\u764c\u75c7\u4e2d\u5fc3Mark E. Robson\u6559\u6388\uff0c\u7531\u963f\u65af\u5229\u5eb7\u8d44\u52a9\u3002<\/div>\n
\u53c2\u8003\uff1ahttp:\/\/abstracts.asco.org\/199\/AbstView_199_186720.html<\/div>\n
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\u5173\u952e\u8bcd\uff1a\u963f\u6bd4\u7279\u9f99 \u8f6c\u79fb\u6027\u524d\u5217\u817a\u764c<\/div>\n
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7.\u00a0\u963f\u6bd4\u7279\u9f99\u5ef6\u957f\u8f6c\u79fb\u6027\u524d\u5217\u817a\u764c\u751f\u5b58\u671f15\u4e2a\u6708<\/div>\n
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\n![\"RmFicvQBAkgDH207icdaj4R9Hkd4PXI5M6HL179teQkKH8PlEjWBucAbiaQqGicUHORNE5sWvibmY2rtiaQHiaCiaZ0xxA\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDH207icdaj4R9Hkd4PXI5M6HL179teQkKH8PlEjWBucAbiaQqGicUHORNE5sWvibmY2rtiaQHiaCiaZ0xxA.jpeg\")
<\/figure><\/div>\n\n<\/div>\n
<\/figure><\/div>\n\n<\/div>\n\u56fe\uff1aZytiga\uff1b\u6765\u6e90\u4e8eOncLive<\/div>\n
\u3010\u6458\u8981\u5185\u5bb9\u3011\u524d\u5217\u817a\u764c\u751f\u957f\u7531\u777e\u916e\u5f15\u8d77\u3002\u96c4\u6fc0\u7d20\u53bb\u52bf\u6cbb\u7597\u6216\u8005ADT\uff08androgen deprivation therapy\uff0c\u96c4\u6027\u6fc0\u7d20\u963b\u65ad\u6cbb\u7597\uff09\u662f\u5bf9\u6fc0\u7d20\u654f\u611f\u6027\u524d\u5217\u817a\u764c\u7684\u6807\u51c6\u4e00\u7ebf\u65b9\u6848\u3002FDA\u4e4b\u524d\u5df2\u7ecf\u6279\u51c6\u5c06\u963f\u6bd4\u7279\u9f99\u7528\u4e8e\u5df2\u4f7f\u7528ADT\u4f46\u75be\u75c5\u6076\u5316\u7684\u8f6c\u79fb\u6027\u524d\u5217\u817a\u764c\u60a3\u8005\u3002\u5bf9\u4e8e\u786e\u8bca\u7684\u9ad8\u98ce\u9669\u3001\u8f6c\u79fb\u6027\u524d\u5217\u817a\u764c\u7537\u6027\u6765\u8bf4\uff0c\u5c06\u963f\u6bd4\u7279\u9f99\uff08Zytiga\uff09\u548c\u6cfc\u5c3c\u677e\u9f99\uff08prednisolone\uff09\u6dfb\u52a0\u5230\u6807\u51c6\u6fc0\u7d20\u6cbb\u7597\u4f1a\u964d\u4f4e\u8fd9\u4e9b\u60a3\u8005\u7684\u6b7b\u4ea1\u673a\u4f1a\u9ad8\u8fbe38%\u3002\u5728\u4e00\u9879\u5305\u542b1200\u4f8b\u7537\u6027\u7684III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u963f\u6bd4\u7279\u9f99\u4e5f\u4f1a\u5c06\u4e2d\u4f4d\u764c\u75c7\u6076\u5316\u65f6\u95f4\u4ece14.8\u4e2a\u6708\u5ef6\u957f\u523033\u4e2a\u6708\u3002<\/div>\n
\u3010\u7814\u7a76\u56e2\u961f\u3011\u6cd5\u56fdParis-Sud\u5927\u5b66\u764c\u75c7\u533b\u5b66\u90e8\u8d1f\u8d23\u4ebaKarim Fizazi\u6559\u6388\uff0c\u7531\u6768\u68ee\u7814\u53d1\u4e2d\u5fc3\uff08Janssen Research and Development\uff09\u8d44\u52a9\u3002<\/div>\n
\u53c2\u8003\uff1ahttp:\/\/abstracts.asco.org\/199\/AbstView_199_181729.html<\/div>\n
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\u5173\u952e\u8bcd\uff1a\u201c\u5e7f\u8c31\u201d\u80bf\u7624\u9776\u5411\u836f<\/div>\n
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8. \u00a0\u9996\u4e2a\u4e0d\u533a\u5206\u80bf\u7624\u7c7b\u578b\u7684\u53e3\u670d\u7597\u6cd5<\/div>\n
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\n![\"RmFicvQBAkgDH207icdaj4R9Hkd4PXI5M6mszGnQQvbnCgx0uUsPgTSGRl4o0HXNlAvxS5gctniaP1h4xic4R5mvZQ\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/RmFicvQBAkgDH207icdaj4R9Hkd4PXI5M6mszGnQQvbnCgx0uUsPgTSGRl4o0HXNlAvxS5gctniaP1h4xic4R5mvZQ.png\")
<\/figure><\/div>\n\n<\/div>\n
<\/figure><\/div>\n\n<\/div>\n\u56fe\uff1aLarotrectinib\u5728TRK\u878d\u5408\u7684\u764c\u75c7\u96c6\u5408\u4e2d\u7684\u529f\u6548\uff0c\u56fe\u6765\u6e90\u4e8eLoxo Oncology<\/div>\n
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\u3010\u6458\u8981\u5185\u5bb9\u3011Loxo Oncology\u516c\u53f8\u5728\u4f1a\u4e0a\u516c\u5e03\u4e86\u6297\u764c\u836f\u7269Larotrectinib \uff08LOXO-101\uff09\u76843\u4e2a\u6b63\u5728\u8fdb\u884c\u7684I\u671f\u3001II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\uff0c\u62a5\u544a\u4e8655\u4f8bTRK\u878d\u5408\u60a3\u8005\uff0812\u540d\u513f\u7ae5\u548c43\u540d\u6210\u4eba\uff09\u7684\u8bd5\u9a8c\u6210\u679c\uff0c\u7b2c\u4e00\u4e2a\u9776\u5411\u3001\u53e3\u670d\u3001\u4e0d\u9650\u80bf\u7624\u7c7b\u578b\u7684\u9776\u5411\u836flarotrectinib\uff08\u7531Loxo\u516c\u53f8\u5f00\u53d1\uff09\u572817\u79cd\u4e0d\u540c\u7c7b\u578b\u665a\u671f\u80bf\u7624\u60a3\u8005\uff08\u5305\u62ec\u513f\u7ae5\u548c\u6210\u5e74\u4eba\uff09\u7684\u4e34\u5e8a\u8bd5\u9a8c\u663e\u793a\u4f7f\u7528larotrectinib\u6cbb\u7597\uff0c76%\u7684\u60a3\u8005\u8fbe\u5230\u7f13\u89e3\uff0c\u5728\u5f00\u59cb\u6cbb\u7597\u540e79%\u7684\u60a3\u8005\u7f13\u89e3\u53ef\u6301\u7eed12\u4e2a\u6708\u3002 larotrectinib\u662f\u4e00\u79cd\u5f3a\u6548\u3001\u53e3\u670d\u3001\u9009\u62e9\u6027\u539f\u808c\u7403\u86cb\u767d\u53d7\u4f53\u6fc0\u9176\uff08TRK\uff09\u6291\u5236\u5242\u3002TRK\u662f\u4e00\u79cd\u795e\u7ecf\u5143\u523a\u6fc0\u56e0\u5b50\uff0c\u901a\u5e38\u53ea\u5728\u80da\u80ce\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u5177\u6709\u6d3b\u6027\uff0c\u4f46\u5728\u4e00\u4e9b\u60c5\u51b5\u4e0b\uff0cTRK\u57fa\u56e0\u53ef\u4ee5\u4e0e\u5176\u4ed6\u57fa\u56e0\u878d\u5408\u5e76\u91cd\u65b0\u6fc0\u6d3b\uff0c\u5bfc\u81f4\u5404\u79cd\u7c7b\u578b\u7684\u764c\u75c7\u53d1\u751f\u3002Larotrectinib\u4e0d\u9488\u5bf9\u7279\u5b9a\u7c7b\u578b\u7684\u5b9e\u4f53\u7624\uff0c\u53ef\u7528\u4e8e\u6240\u6709\u8868\u8fbeTRK\u7684\u764c\u75c7\u60a3\u8005\u3002 \u540c\u65f6\uff0cLoxo Oncology\u5df2\u7ecf\u5f00\u53d1\u51fa\u7b2c\u4e8c\u4ee3TRK\u878d\u5408\u57fa\u56e0\u7a81\u53d8\u6291\u5236\u5242LOXO-195\uff0c\u7528\u4e8e\u6cbb\u7597\u90a3\u4e9b\u5bf9LOXO-101\u4ea7\u751f\u8010\u836f\u6027\u7684\u60a3\u8005\uff0cLOXO-195\u7684\u521d\u6b65\u4e34\u5e8a\u6570\u636e\u5df2\u53d1\u8868\u4e8eAACR\u65d7\u4e0b\u7684Cancer Discovery\u6742\u5fd7\u3002<\/div>\n
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\u3010\u7814\u7a76\u56e2\u961f\u3011\u7eaa\u5ff5\u65af\u9686\u51ef\u7279\u7433\u764c\u75c7\u4e2d\u5fc3\u65e9\u671f\u836f\u7269\u5f00\u53d1\u4e3b\u4efbDavid Hyman \u6559\u6388\uff0c\u7531Loxo Oncology, Inc.\u8d44\u52a9\u3002<\/div>\n
\u53c2\u8003\uff1ahttp:\/\/abstracts.asco.org\/199\/AbstView_199_195112.html<\/div>\n
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\u656c\u8bf7\u671f\u5f85\u4e0b\u7bc7<\/div>\n
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\n![\"cZV2hRpuAPhrxQU1opLkENnCB9ArIxUwWq26RwicbQNpQN3ubDHibBSJfI6PzP0icQfn0s21DvR4xKYyPEs741UXQ\"\/](\"https:\/\/www.geneclub.net.cn\/wp-content\/uploads\/images\/cZV2hRpuAPhrxQU1opLkENnCB9ArIxUwWq26RwicbQNpQN3ubDHibBSJfI6PzP0icQfn0s21DvR4xKYyPEs741UXQ.jpg\")
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\u60a8\u53ef\u80fd\u8fd8\u4f1a\u611f\u5174\u8da3\u7684\uff1a<\/div>\n
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\u80bf\u7624\u7cbe\u51c6\u533b\u5b66\u8c03\u7814\u62a5\u544a\uff08130\u9875PPT\uff09<\/a><\/div>\n
\u4e09\u4eba\u884c | \u534f\u548c\u75c5\u7406\u5927\u592b\/\u5409\u56e0\u52a0\/\u4f18\u8fc5<\/a><\/div>\n
\u5927\u5496 | Sidney Kimmel\u764c\u75c7\u4e2d\u5fc3\u6768\u864e\u5c71\u6559\u6388<\/a><\/div>\n
\u5927\u5496 | \u601d\u8def\u8fea\u521b\u59cb\u4eba\u718a\u78ca<\/a><\/div>\n
\u5927\u5496 | \u9ec4\u5c1a\u5fd7\/\u6c88\u4ea6\u5e73\/\u7941\u9e23\u7b49\u4e34\u5e8a\u5927\u5496<\/a><\/div>\n
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\u4e09\u4eba\u884c | \u534e\u5927\u57fa\u56e0\/\u660e\u7801\u751f\u7269\/\u805a\u9053\u8c08\u751f\u7269\u4e91<\/a><\/div>\n
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<\/figure><\/div>\n\n
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\u57fa\u56e0\u6167\uff08\u6df1\u5733\u3001\u5317\u4eac\uff09\u7b49\u60a8\u6765 info@genonet.cn<\/div>\n
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<\/figure><\/div>\n\n
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<\/figure><\/div>\n\n\n
<\/figure><\/div>\n\n\n<\/p>\n","protected":false},"excerpt":{"rendered":"
\u201c\u4e00\u7f51\u6253\u5c3d\u201dASCO 2017 \u4e34\u5e8a\u80bf\u7624\u524d\u6cbf\u6280\u672f\u8981\u70b9<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"close","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[1947,2154],"class_list":["post-10966","post","type-post","status-publish","format-standard","hentry","category-industryresearch","tag-asco-2","tag-2154"],"_links":{"self":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts\/10966","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/comments?post=10966"}],"version-history":[{"count":4,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts\/10966\/revisions"}],"predecessor-version":[{"id":14487,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/posts\/10966\/revisions\/14487"}],"wp:attachment":[{"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/media?parent=10966"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/categories?post=10966"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.geneclub.net.cn\/index.php\/wp-json\/wp\/v2\/tags?post=10966"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}