液体活检与测序技术在肿瘤精准治疗的应用

液体活检与测序技术在肿瘤精准治疗的应用

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文 | 许明炎(海普洛斯CEO)
本文是纯技术分享。许明炎博士应邀在华夏病理网做《液体活检与测序技术在肿瘤精准治疗中的应用》报告,笔者取得许博士授权,分享课件PPT。
 
PPT内容概要
#1 三种液体活检的介绍和对比
1) CTC捕获技术和应用
2) ctDNA检测技术和应用
3) 外泌体(Exosome)检测技术和应用
 
#2 各种检测技术对比
一代测序,NGS,ddPCR, ARMS
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1)癌症治疗痛点
取样,疗效评估,耐药位点难
2)液体活检包含的对象
CTC, ctDNA, Exosome
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1)CTC 简介
2)CTC复集方法
免疫,物理
3)CTC 鉴定技术
免疫荧光法,流式细胞术,RT-PCR, FISH, 单细胞单细胞测序
4) CTC的应用
早期筛查,疗效评估,肿瘤分级,个体化治疗,耐药监测
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1)ctDNA简介和特点
2)ctDNA检测技术
PCR(ddPCR, ARMS), 目标区域捕获测序(NGS, Sanger)。
3)ctDNA临床应用
肿瘤进化追踪,预后评估,肿瘤异质性评估等。
4)ctDNA 临床检测实例
易瑞沙用药指导
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1)外泌体(Exosome)简介
2)外泌体检测方法
离心法,免疫磁珠法,PEG-base沉淀法,Exosome提取试剂盒
3)外泌体的应用
肿瘤早期诊断,肿瘤转移监测
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5
CTC, ctDNA和外泌体(Exosome)的对比
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液体活检检测技术的比较
一代测序,二代测序(NGS),ddPCR,ARMS等
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【声明】
内容源自作者,仅供学习参考。版权归作者所有,转载需授权,并注明作者,出处和原文链接。
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